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  <doc>
    <id>52795</id>
    <completedYear/>
    <publishedYear>2021</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1038</pageFirst>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue>5</issue>
    <volume>9</volume>
    <type>article</type>
    <publisherName>MDPI</publisherName>
    <publisherPlace>Basel</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Microbial hotspots in lithic microhabitats inferred from DNA fractionation and metagenomics in the Atacama Desert</title>
    <abstract language="eng">The existence of microbial activity hotspots in temperate regions of Earth is driven by soil heterogeneities, especially the temporal and spatial availability of nutrients. Here we investigate whether microbial activity hotspots also exist in lithic microhabitats in one of the most arid regions of the world, the Atacama Desert in Chile. While previous studies evaluated the total DNA fraction to elucidate the microbial communities, we here for the first time use a DNA separation approach on lithic microhabitats, together with metagenomics and other analysis methods (i.e., ATP, PLFA, and metabolite analysis) to specifically gain insights on the living and potentially active microbial community. Our results show that hypolith colonized rocks are microbial hotspots in the desert environment. In contrast, our data do not support such a conclusion for gypsum crust and salt rock environments, because only limited microbial activity could be observed. The hypolith community is dominated by phototrophs, mostly Cyanobacteria and Chloroflexi, at both study sites. The gypsum crusts are dominated by methylotrophs and heterotrophic phototrophs, mostly Chloroflexi, and the salt rocks (halite nodules) by phototrophic and halotolerant endoliths, mostly Cyanobacteria and Archaea. The major environmental constraints in the organic-poor arid and hyperarid Atacama Desert are water availability and UV irradiation, allowing phototrophs and other extremophiles to play a key role in desert ecology.</abstract>
    <parentTitle language="eng">Microorganisms</parentTitle>
    <identifier type="doi">10.3390/microorganisms9051038</identifier>
    <identifier type="issn">2076-2607</identifier>
    <identifier type="urn">urn:nbn:de:kobv:b43-527959</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="date_peer_review">10.06.2021</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>D. Schulze-Makuch</author>
    <author>D. Lipus</author>
    <author>F. L. Arens</author>
    <author>M. Baque</author>
    <author>T. L. V. Bornemann</author>
    <author>J. P. de Vera</author>
    <author>M. Flury</author>
    <author>J. Froesler</author>
    <author>J. Heinz</author>
    <author>Y. Hwang</author>
    <author>S. P. Kounaves</author>
    <author>K. Mangelsdorf</author>
    <author>R. U. Meckenstock</author>
    <author>M. Pannekens</author>
    <author>A. J. Probst</author>
    <author>J. S. Saenz</author>
    <author>J. Schirmack</author>
    <author>M. Schloter</author>
    <author>P. Schmitt-Kopplin</author>
    <author>Beate Schneider</author>
    <author>J. Uhl</author>
    <author>G. Vestergaard</author>
    <author>B. Valenzuela</author>
    <author>P. Zamorano</author>
    <author>D. Wagner</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Desert ecology</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Extremophile</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Hyperarid</value>
    </subject>
    <collection role="ddc" number="628">Sanitär- und Kommunaltechnik; Umwelttechnik</collection>
    <collection role="institutes" number="">4 Material und Umwelt</collection>
    <collection role="institutes" number="">4.1 Biologische Materialschädigung und Referenzorganismen</collection>
    <collection role="themenfelder" number="">Umwelt</collection>
    <collection role="themenfelder" number="">Umwelt-Material-Interaktionen</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei für die Öffentlichkeit verfügbar ("Open Access")</collection>
    <collection role="unnumberedseries" number="">Wissenschaftliche Artikel der BAM</collection>
    <thesisPublisher>Bundesanstalt für Materialforschung und -prüfung (BAM)</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-bam/files/52795/Microbial Hotspots in Lithic Microhabitats_2021.pdf</file>
  </doc>
  <doc>
    <id>54048</id>
    <completedYear/>
    <publishedYear>2021</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>115604</pageFirst>
    <pageLast>115611</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>897</volume>
    <type>article</type>
    <publisherName>Elsevier B.V.</publisherName>
    <publisherPlace>Amsterdam</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Immunosensor based on porous gold and reduced graphene platform for the determination of EE2 by electrochemical impedance spectroscopy</title>
    <abstract language="eng">In this work, we report an electrochemical immunosensor to detect ethinylestradiol in water samples, using electrochemical impedance spectroscopy (EIS) as a detection technique. For the development of this immunosensor, the direct modification of the working electrode of a screen-printed carbon electrode was carried out. First, to reduce the resistance of the electrode, electroreduced graphene was incorporated on the surface.&#13;
Second, a porous gold structure was electrodeposited on reduced graphene by electrodeposition and the dynamic hydrogen bubble template assisted method. Thus, a marked increase in surface area was obtained for anti-EE2 antibodies immobilization. Subsequently, the specific anti-EE2 antibodies were covalently immobilized using α-lipoic acid for attaching them to the gold surface.&#13;
The electrode modified with the antibodies was incubated for 30 min in the samples containing EE2, producing the specific Antigen antibody binding. As the charge transfer resistance of a redox probe in the electrode surface is governed by the surface blocking effects, the charge transfer resistance was related to the amount of EE2 captured to realize a quantitative determination. For this, the EIS measurements were performed in a 4 mM [Fe(CN)6]4−/3− solution in 0.1 M KCl. The obtained Nyquist diagrams were adjusted using the Randles circuit as an equivalent circuit to obtain the corresponding resistances. The developed methodology showed good selectivity, precision, and sensitivity; although the LOD obtained was higher than those presented in other published articles, it turned out to be an alternative that allows the determination of ethinylestradiol using a simple disposable electrode.</abstract>
    <parentTitle language="eng">Journal of Electroanalytical Chemistry</parentTitle>
    <identifier type="doi">10.1016/j.jelechem.2021.115604</identifier>
    <identifier type="issn">1572-6657</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="date_peer_review">16.12.2021</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <author>M. L. Scala-Benuzzi</author>
    <author>G. J. A. A. Soler-Illia</author>
    <author>J. Rabia</author>
    <author>F. Battaglini</author>
    <author>Rudolf Schneider</author>
    <author>S. V. Pereira</author>
    <author>G. A. Messina</author>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Ethinylestradiol</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Biosensor</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Elektrochemisch</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Impedanz</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="ddc" number="628">Sanitär- und Kommunaltechnik; Umwelttechnik</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.8 Umweltanalytik</collection>
    <collection role="themenfelder" number="">Umwelt</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
    <collection role="themenfelder" number="">Sensorik</collection>
  </doc>
  <doc>
    <id>43315</id>
    <completedYear/>
    <publishedYear>2017</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1478</pageFirst>
    <pageLast>1489</pageLast>
    <pageNumber/>
    <edition/>
    <issue>7</issue>
    <volume>141</volume>
    <type>article</type>
    <publisherName>International Journal of Cancer</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Porphyrin modified trastuzumab improves efficacy of HER2 targeted photodynamic therapy of gastric cancer</title>
    <abstract language="eng">Gastric cancer (GC) is the 3rd deadliest cancer worldwide, due to limited treatment options and late diagnosis. Human epidermal growth factor receptor-2 (HER2) is overexpressed in similar to 20% of GC cases and anti-HER2 antibody trastuzumab in combination with conventional chemotherapy, is recognized as standard therapy for HER2-positive metastatic GC. This strategy improves GC patients' survival by 2-3 months, however its optimal results in breast cancer indicate that GC survival may be improved. A new photoimmunoconjugate was developed by conjugating a porphyrin with trastuzumab (Trast: Porph) for targeted photodynamic therapy in HER2-positive GC. Using mass spectrometry analysis, the lysine residues in the trastuzumab structure most prone for porphyrin conjugation were mapped. The in vitro data demonstrates that Trast: Porph specifically binds to HER2-positive cells, accumulates intracellularly, co-localizes with lysosomal marker LAMP1, and induces massive HER2-positive cell death upon cellular irradiation. The high selectivity and cytotoxicity of Trast: Porph based photoimmunotherapy is confirmed in vivo in comparison with trastuzumab alone, using nude mice xenografted with a HER2-positive GC cell line. In the setting of human disease, these data suggest that repetitive cycles of Trast: Porph photoimmunotherapy may be used as an improved treatment strategy in HER2-positive GC patients.</abstract>
    <parentTitle language="eng">Cancer Therapy and Prevention</parentTitle>
    <identifier type="issn">0020-7136</identifier>
    <identifier type="doi">10.1002/ijc.30844</identifier>
    <enrichment key="date_peer_review">06.12.2017</enrichment>
    <author>Rudolf Schneider</author>
    <author>B. Korsak</author>
    <author>G. M. Almeida</author>
    <author>S. Rocha</author>
    <author>C. Pereira</author>
    <author>N. Mendes</author>
    <author>H. Osorio</author>
    <author>P. M. Pereira</author>
    <author>J. M. M. Rodrigues</author>
    <author>B. Sarmento</author>
    <author>J. P. C. Tome</author>
    <author>C. Oliveira</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Photoimmunotherapy</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Photoimmunoconjugate</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Gastric cancer</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>45269</id>
    <completedYear/>
    <publishedYear>2018</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>287</pageFirst>
    <pageLast>293</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>141</volume>
    <type>article</type>
    <publisherName>Elsevier B.V.</publisherName>
    <publisherPlace>Amsterdam, NL</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Ethinylestradiol quantification in drinking water sources using a fluorescent paper based immunosensor</title>
    <abstract language="eng">In this work we report a novel paper-based analytical device read-out via LED-induced fluorescence detection (FPAD) for the quantification of the emerging pollutant ethinylestradiol (EE2) in river water samples. The PAD was used as a reaction platform for a competitive enzyme immunoassay. For the PAD development, microzones of filter paper, printed by a wax printing method, were modified with amino-functionalized SBA-15 and subsequently, anti-EE2 specific antibodies were covalently immobilized. The determination of EE2 in water was &#13;
carried out by adding a fixed concentration of EE2 conjugated with the enzyme horseradish peroxidase (HRP) to samples and standards. Then, the FPAD were added and incubated for 10 min. Finally, the detection was performed by the reaction of 10-acetyl-3,7-dihydroxyphenoxazine (ADHP) whose oxidation is catalyzed by HRP in the presence of H2O2, obtaining the highly fluorescent resorufin (R). Resorufin was detected by LED excitation at 550 nm, observing emission at 585 nm. The EE2 concentration in the samples was inversely proportional to the relative fluorescence obtained from the enzymatic reaction products. The FPAD assay showed a detection Limit (LOD) of 0.05 ng L−1 and coefficients of variation (CV) below 4.5% within-assay and below 6.5% between-assay, respectively. The results obtained show the potential suitability of our FPAD for the selective and sensitive quantification of EE2 in river water samples. In addition, it has the PADs advantages of being disposable, easy to&#13;
apply and inexpensive.</abstract>
    <parentTitle language="eng">Microchemical Journal</parentTitle>
    <identifier type="doi">10.1016/j.microc.2018.05.038</identifier>
    <identifier type="issn">0026-265X</identifier>
    <enrichment key="date_peer_review">09.08.2018</enrichment>
    <author>M. L. Scala-Benuzzi</author>
    <author>E. A. Takara</author>
    <author>M. Alderete</author>
    <author>G. J. A. A. Soler-Illia</author>
    <author>Rudolf Schneider</author>
    <author>J. Raba</author>
    <author>G. A. Messina</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Immunoassay</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Arzneimittel</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Antikörper</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>LED-induzierte Fluoreszenz</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Paper based devices</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Mesoporöses Silica</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Partikel</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="ddc" number="628">Sanitär- und Kommunaltechnik; Umwelttechnik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>44831</id>
    <completedYear/>
    <publishedYear>2017</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>Article 08030, 1</pageFirst>
    <pageLast>56</pageLast>
    <pageNumber/>
    <edition/>
    <issue>Suppl. S</issue>
    <volume>54</volume>
    <type>article</type>
    <publisherName>IOP Publ.</publisherName>
    <publisherPlace>Bristol</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">CCQM-K126: low polarity organic in water: carbamazepine in surface water</title>
    <abstract language="eng">This study aimed to assess the measurement capabilities of participating National Metrology Institutes/ Designated Institutes (NMIs/DIs) and expert laboratories in determining of low-polarity organics in surface water. This comparison was organized by Government Laboratory, Hong Kong (GLHK). &#13;
At the CCQM Organic Analysis Working Group (OAWG) Meeting held in November 2012 in Hong Kong, GLHK initially proposed a CCQM key comparison and a parallel pilot study programme on pharmaceuticals in surface water. Further discussion at the CCQM Meeting held in April 2014 in Paris, the OAWG approved a CCQM Track C comparison (CCQM-K126) on low polarity pharmaceuticals in surface water. In the meeting, the programme was supported by more than six National Metrology Institutes/ Designated Institutes (NMIs/ DIs). &#13;
CCQM-K126 officially commenced in July 2014 and had registration from nine NMIs/DIs.  Participants were provided two bottles (40 mL each) of surface water and were requested to determine the mass fraction of spiked carbamazepinein in surface water. The coordinator received nine sets of results from eight NMIs/DIs in February 2015. Apart from one using an immunoassay technique, all participants applied isotope dilution liquid chromatography-tandem mass spectrometry (ID-LCMS/MS) technique as their determination technique.</abstract>
    <parentTitle language="eng">METROLOGIA</parentTitle>
    <identifier type="doi">10.1088/0026-1394/54/1A/08030</identifier>
    <identifier type="issn">0026-1394</identifier>
    <identifier type="issn">1681-7575</identifier>
    <enrichment key="date_peer_review">04.05.2018</enrichment>
    <author>DWM. Sin</author>
    <author>YC. Wong</author>
    <author>Andreas Lehmann</author>
    <author>Rudolf Schneider</author>
    <author>E. Kakoulides</author>
    <author>TT. Lin</author>
    <author>QD. Liu</author>
    <author>J. Cabillic</author>
    <author>S. Lardy-fontan</author>
    <author>J. Nammoonnoy</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>CCQM-K126</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>ELISA</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Mass spectrometry</value>
    </subject>
    <collection role="ddc" number="628">Sanitär- und Kommunaltechnik; Umwelttechnik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>44690</id>
    <completedYear/>
    <publishedYear>2018</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>4104</pageFirst>
    <pageLast>4111</pageLast>
    <pageNumber/>
    <edition/>
    <issue>6</issue>
    <volume>90</volume>
    <type>article</type>
    <publisherName>American Chemical Society</publisherName>
    <publisherPlace>Washington, D.C., USA</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Novel electrochemical paper-based immunocapture assay for the quantitative determination of ethinylestradiol in water samples</title>
    <abstract language="eng">We report a novel and innovative electrochemical paper-based immunocapture assay (EPIA) to address the need for ultrasensitive detection of emerging pollutants without regulatory status and whose effects on environment and human health are not completely yet understood. In particular, we present the application of this system toward highly sensitive detection of the emerging pollutant ethinyl estradiol (EE2). The EPIA approach is based on the use of paper microzones modified with silica nanoparticles (SNs) and anti-EE2 specific antibodies for capture and preconcentration of EE2 from river water samples. After the preconcentration procedure, the paper microzones are placed onto a screen-printed carbon electrode modified with electrochemically reduced graphene (RG). The bound EE2 is subsequently desorbed adding a diluted solution of sulfuric acid on the paper microzones. Finally, recovered EE2 is electrochemically detected by OSWV. The proposed novel methodology showed an appropriate LOD and linear range for the quantification of EE2 for water samples with different origins. The nonsophisticated equipment required, the adequate recovery values obtained (from 97% to 104%, with a RSD less than 4.9%), and the appropriate LOD and linear range value (0.1 ng L−1 and 0.5−120 ng L−1, respectively) achieved by our immunocapture sensor present significant analytical figures of merit, particularly when the routine quantification of EE2 is considered. In addition, our System was based on electrochemical paper-based technology, which allows obtainment of portable, easy-to-use, inexpensive, and disposable devices. The EPIA can also serve as a general-purpose immunoassay platform applicable to quantitation of other drugs and emerging pollutants in environmental samples.</abstract>
    <parentTitle language="eng">Analytical Chemistry</parentTitle>
    <identifier type="doi">10.1021/acs.analchem.8b00028</identifier>
    <identifier type="issn">0003-2700</identifier>
    <identifier type="issn">1520-6882</identifier>
    <enrichment key="date_peer_review">16.04.2018</enrichment>
    <author>M. L. Scala-Benuzzi</author>
    <author>J. Raba</author>
    <author>G. J. A. A. Soler-Illia</author>
    <author>Rudolf Schneider</author>
    <author>G. A. Messina</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Immunoassay</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>EE2</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Estrogens</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Screen-printed electrode</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Square-wave voltammetry</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="ddc" number="628">Sanitär- und Kommunaltechnik; Umwelttechnik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>61806</id>
    <completedYear/>
    <publishedYear>2024</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1</pageFirst>
    <pageLast>9</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>article</type>
    <publisherName>Wiley</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Materials Design by Constructing Phase Diagrams for Defects</title>
    <abstract language="eng">Phase transformations and crystallographic defects are two essential tools todrive innovations in materials. Bulk materials design via tuning chemicalcompositions is systematized using phase diagrams. It is shown here that thesame thermodynamic concept can be applied to manipulate the chemistry atdefects. Grain boundaries in Mg–Ga system are chosen as a model system,because Ga segregates to the boundaries, while simultaneously improving thestrength and ductility of Mg alloys. To reveal the role of grain boundaries,correlated atomic-scale characterization and simulation to scope and buildphase diagrams for defects are presented. The discovery is enabled bytriggering phase transformations of individual grain boundaries through localalloying, and sequentially imaging the structural and chemical changes usingatomic-resolution scanning transmission electron microscopy. Ab initiosimulations determined the thermodynamic stability of grain boundaryphases, and found out that increasing Ga content enhances grain boundarycohesion, relating to improved ductility. The methodology to trigger, trace,and simulate defect transformation at atomic resolution enables a systematicdevelopment of defect phase diagrams, providing a valuable tool to utilizechemical complexity and phase transformations at defects.</abstract>
    <parentTitle language="eng">Advanced Materials</parentTitle>
    <identifier type="doi">10.1002/adma.202402191</identifier>
    <identifier type="issn">1521-4095</identifier>
    <identifier type="urn">urn:nbn:de:kobv:b43-618063</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="date_peer_review">28.11.2024</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>X. Zhou</author>
    <author>P. Mathews</author>
    <author>B. Berkels</author>
    <author>W. Delis</author>
    <author>S. Saood</author>
    <author>A. Alhassan</author>
    <author>P. Keuter</author>
    <author>J. Schneider</author>
    <author>S. Korte-Kerzel</author>
    <author>S. Sandlöbes</author>
    <author>D. Raabe</author>
    <author>j. Neugebauer</author>
    <author>G. Dehm</author>
    <author>Tilmann Hickel</author>
    <author>C. Scheu</author>
    <author>S. Zhang</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Automatic pattern recognition</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Defect phase diagram</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Density functional theory</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Grain boundary complexion</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Transmission electron microscopy</value>
    </subject>
    <collection role="ddc" number="620">Ingenieurwissenschaften und zugeordnete Tätigkeiten</collection>
    <collection role="institutes" number="">6 Materialchemie</collection>
    <collection role="institutes" number="">6.4 Materialinformatik</collection>
    <collection role="themenfelder" number="">Material</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei für die Öffentlichkeit verfügbar ("Open Access")</collection>
    <collection role="unnumberedseries" number="">Wissenschaftliche Artikel der BAM</collection>
    <collection role="themenfelder" number="">Materialdesign</collection>
    <thesisPublisher>Bundesanstalt für Materialforschung und -prüfung (BAM)</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-bam/files/61806/Advanced Materials - 2024 - Zhou - Materials Design by Constructing Phase Diagrams for Defects.pdf</file>
  </doc>
  <doc>
    <id>50027</id>
    <completedYear/>
    <publishedYear>2019</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>35</pageFirst>
    <pageLast>44</pageLast>
    <pageNumber/>
    <edition/>
    <issue>1</issue>
    <volume>51</volume>
    <type>article</type>
    <publisherName>Springer</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Low-Cost Fabrication of Tungsten-Rhenium Alloys for Friction Stir Welding Applications</title>
    <abstract language="eng">Friction stir welding (FSW) of high-melting temperature alloys, such as steel and Inconel, requires tooling that can survive under the applied loads at the elevated temperatures. Tungsten-Rhenium (W-Re) alloys are a suitable candidate for this application; however, the costs typically associated with achieving the required densities and grain structure for the tooling are high due to the lengthy traditional processing required. Further costs are incurred in machining the starting bar stock to the final FSW tooling configuration. An alternate processing method is used in this study to shorten the fabrication time using direct current sintering which rapidly consolidates the starting powders at lower temperatures than used in traditional powder metallurgy. Although this process enables retention of the fine grain size, the sintering time is too short to form the desired single, solid phase. Therefore, the specimens were subjected to a post-consolidation heat treatment to fully solutionize the W matrix. Once the desired density and solid solution phase was verified in coupons, the final processing parameters were used to consolidate a net shape tool for FSW.</abstract>
    <parentTitle language="eng">Metallurgical and Materials Transactions B</parentTitle>
    <identifier type="doi">10.1007/s11663-019-01726-6</identifier>
    <enrichment key="date_peer_review">12.12.2019</enrichment>
    <author>J. Schneider</author>
    <author>J. Terrell</author>
    <author>L. Ferris</author>
    <author>D. Tucker</author>
    <author>T. Leonhardt</author>
    <author>Hennig Goldbeck</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Tungsten-Rhenium</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Friction Stir Welding</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fabrication</value>
    </subject>
    <collection role="ddc" number="620">Ingenieurwissenschaften und zugeordnete Tätigkeiten</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>50464</id>
    <completedYear/>
    <publishedYear>2020</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>2248</pageFirst>
    <pageLast>2264</pageLast>
    <pageNumber/>
    <edition/>
    <issue>2</issue>
    <volume>14</volume>
    <type>article</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Cells Undergo Major Changes in the Quantity of Cytoplasmic Organelles after Uptake of Gold Nanoparticles with Biologically Relevant Surface Coatings</title>
    <abstract language="eng">Here, we use cryo soft X-ray tomography (cryo-SXT), which delivers 3D ultrastructural volumes of intact cells without chemical fixation or staining, to gain insight about nanoparticle uptake for nanomedicine. We initially used dendritic polyglycerol sulfate (dPGS) with potential diagnostic and therapeutic applications in inflammation. Although dPGS-coated gold nanoparticle (dPGS-AuNP) uptake followed a conventional endocytic/degradative pathway in human lung epithelial cell lines (A549), with cryo-SXT, we detected ∼5% of dPGS-AuNPs in the cytoplasm, a level undetectable by confocal light microscopy. We also observed ∼5% of dPGS-AuNPs in a rarely identified subcellular site, namely, lipid droplets, which are important for cellular energy metabolism. Finally, we also found substantial changes in the quantity of cytoplasmic organelles upon dPGS-AuNP uptake over the 1–6 h incubation period; the number of small vesicles and mitochondria significantly increased, and the number of multivesicular bodies and the number and volume of lipid droplets significantly decreased. Although nearly all organelle numbers at 6 h were still significantly different from controls, most appeared to be returning to normal levels. To test for generality, we also examined cells after uptake of gold nanoparticles coated with a different agent, polyethylenimine (PEI), used for nucleic acid delivery. PEI nanoparticles did not enter lipid droplets, but they induced similar, albeit less pronounced, changes in the quantity of cytoplasmic organelles. We confirmed these changes in organelle quantities for both nanoparticle coatings by confocal fluorescence microscopy. We suggest this cytoplasmic remodeling could reflect a more common cellular response to coated gold nanoparticle uptake.</abstract>
    <parentTitle language="eng">ACS NANO</parentTitle>
    <identifier type="doi">10.1021/acsnano.9b09264</identifier>
    <enrichment key="date_peer_review">02.03.2020</enrichment>
    <author>B. Kepsutlu</author>
    <author>V. Wycisk</author>
    <author>K. Achazi</author>
    <author>S. Kapishnikov</author>
    <author>A.J. Perez-Berna</author>
    <author>P. Guttmann</author>
    <author>Antje Cossmer</author>
    <author>E. Pereiro</author>
    <author>H. Ewers</author>
    <author>M. Ballauff</author>
    <author>G. Schneider</author>
    <author>J.G. McNally</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Cellular trafficking</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Confocal laser scanning microscopy</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Cytoplasmic remodeling</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Dendritic polyglycerol sulfate</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Polyethylenimine</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>3D ultrastructural analysis</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Cryo-soft X-ray tomography</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.1 Anorganische Spurenanalytik</collection>
    <collection role="themenfelder" number="">Chemie und Prozesstechnik</collection>
    <collection role="themenfelder" number="">Chemische Charakterisierung und Spurenanalytik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>50466</id>
    <completedYear/>
    <publishedYear>2020</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>2005</pageFirst>
    <pageLast>2016</pageLast>
    <pageNumber/>
    <edition/>
    <issue>8</issue>
    <volume>16</volume>
    <type>article</type>
    <publisherName>Royal Chemical Society</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Complex molecular dynamics of a symmetric model discotic liquid crystal revealed by broadband dielectric, thermal and neutron spectroscopy</title>
    <abstract language="eng">The molecular dynamics of the triphenylene-based discotic liquid crystal HAT6 is investigated by broadband dielectric spectroscopy, advanced dynamical calorimetry and neutron scattering. Differential scanning calorimetry in combination with X-ray scattering reveals that HAT6 has a plastic crystalline phase at low temperatures, a hexagonally ordered liquid crystalline phase at higher temperatures and undergoes a clearing transition at even higher temperatures. The dielectric spectra show several relaxation processes: a localized gamma-relaxation a lower temperature and a so called alpha-2-relaxation at higher temperatures. The relaxation rates of the alpha-2-relaxation have a complex temperature dependence and bear similarities to a dynamic glass transition. The relaxation rates estimated by hyper DSC, Fast Scanning calorimetry and AC Chip calorimetry have a different temperature dependence than the dielectric alpha-2-relaxation and follows the VFT-behavior characteristic for glassy dynamics. Therefore, this process is called alpha-1-relaxation. Its relaxation rates show a similarity with that of polyethylene. For this reason, the alpha-1-relaxation is assigned to the dynamic glass transition of the alkyl chains in the intercolumnar space. Moreover, this process is not observed by dielectric spectroscopy which supports its assignment. The alpha-2-relaxation was assigned to small scale translatorial and/or small angle fluctuations of the cores. &#13;
The neutron scattering data reveal two relaxation processes. The process observed at shorter relaxation times is assigned to the methyl group rotation. The second relaxation process at longer time scales agree in the temperature dependence of its relaxation rates with that of the dielectric gamma-relaxation.</abstract>
    <parentTitle language="eng">Soft Matter</parentTitle>
    <identifier type="doi">10.1039/c9sm02487e</identifier>
    <enrichment key="date_peer_review">27.02.2020</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <author>Arda Yildirim</author>
    <author>Christina Krause</author>
    <author>R. Zorn</author>
    <author>W. Lohstroh</author>
    <author>G. J. Schneider</author>
    <author>M. Zamponi</author>
    <author>O. Holerer</author>
    <author>B. Frick</author>
    <author>Andreas Schönhals</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Discotic Liquid Crystals</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="ddc" number="620">Ingenieurwissenschaften und zugeordnete Tätigkeiten</collection>
    <collection role="institutes" number="">6 Materialchemie</collection>
    <collection role="institutes" number="">6.6 Digitale Materialchemie</collection>
    <collection role="themenfelder" number="">Material</collection>
    <collection role="themenfelder" number="">Chemie und Prozesstechnik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>34336</id>
    <completedYear/>
    <publishedYear>2015</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>356</pageFirst>
    <pageLast>365</pageLast>
    <pageNumber/>
    <edition/>
    <issue>3</issue>
    <volume>16</volume>
    <type>article</type>
    <publisherName>Ernst &amp; Sohn</publisherName>
    <publisherPlace>Berlin</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Assessing and updating the reliability of concrete bridges subjected to spatial deterioration - principles and software implementation</title>
    <abstract language="eng">Inspection and maintenance of concrete bridges is a major cost factor in transportation infrastructure, and there is significant potential for using information gained during inspection to update predictive models of the performance and reliability of such structures. In this context, this paper presents an approach for assessing and updating the reliability of prestressed concrete bridges subjected to chloride-induced reinforcement corrosion. The system deterioration state is determined based on a Dynamic Bayesian Network (DBN) model that considers the spatial variability of the corrosion process. The overall system reliability is computed by means of a probabilistic structural model coupled with the deterioration model. Inspection data are included in the system reliability calculation through Bayesian updating on the basis of the DBN model. As proof of concept, a software prototype is developed to implement the method presented here. The software prototype is applied to a typical highway bridge and the influence of inspection information on the system deterioration state and the structural reliability is quantified taking into account the spatial correlation of the corrosion process. This work is a step towards developing a software tool that can be used by engineering practitioners to perform reliability assessments of ageing concrete bridges and update their reliability with inspection and monitoring data.</abstract>
    <parentTitle language="eng">Structural concrete</parentTitle>
    <identifier type="old">37467</identifier>
    <identifier type="doi">10.1002/suco.201500014</identifier>
    <identifier type="issn">1464-4177</identifier>
    <enrichment key="date_peer_review">05.10.2015</enrichment>
    <author>Ronald Schneider</author>
    <author>J. Fischer</author>
    <author>M. Bügler</author>
    <author>M. Nowak</author>
    <author>S. Thöns</author>
    <author>A. Borrmann</author>
    <author>D. Straub</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Structural reliability</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Dynamic Bayesian Networks</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Spatial deterioration</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Inspection</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Monitoring general</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Analysis and design methods</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Reinforcement</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Corrosion</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Prestressed concrete</value>
    </subject>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>30451</id>
    <completedYear/>
    <publishedYear>2014</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1804</pageFirst>
    <pageLast>1811</pageLast>
    <pageNumber/>
    <edition/>
    <issue>11</issue>
    <volume>12</volume>
    <type>article</type>
    <publisherName>RSC</publisherName>
    <publisherPlace>Cambridge</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Porphyrin conjugated with serum albumins and monoclonal antibodies boosts efficiency in targeted destruction of human bladder cancer cells</title>
    <abstract language="eng">The synthesis of a novel PS conjugated with bovine and human serum albumin (BSA and HSA) and a monoclonal antibody anti-CD104 is reported, as well as their biological potential against the human bladder cancer cell line UM-UC-3. No photodynamic effect was detected when the non-conjugated porphyrin was used. Yet, when it was coupled covalently with the mAb anti-CD104, BSA and HSA, the resulting photosensitizer conjugates demonstrated high efficacy in destroying the cancer cells, the mAb anti-CD104 efficacy overruling the albumins.</abstract>
    <parentTitle language="eng">Organic &amp; biomolecular chemistry</parentTitle>
    <identifier type="old">33424</identifier>
    <identifier type="doi">10.1039/c3ob42082e</identifier>
    <identifier type="issn">1477-0520</identifier>
    <identifier type="issn">1477-0539</identifier>
    <enrichment key="date_peer_review">31.03.2014</enrichment>
    <author>P.M.R. Pereira</author>
    <author>José Joao Carvalho</author>
    <author>S. Silva</author>
    <author>J.A.S. Cavaleiro</author>
    <author>Rudolf Schneider</author>
    <author>R. Fernandes</author>
    <author>J.P.C. Tomé</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Rinderserumalbumin</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>BSA</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Monoklonale Antikörper</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Blasenkrebs</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Konjugate</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Conjugates</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Therapeutische Antikörper</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>CD104</value>
    </subject>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>33818</id>
    <completedYear/>
    <publishedYear>2015</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>205</pageFirst>
    <pageLast>214</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>202</volume>
    <type>article</type>
    <publisherName>Elsevier</publisherName>
    <publisherPlace>New York, NY [u.a.]</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">How life history influences the responses of the clam Scrobicularia plana to the combined impacts of carbamazepine and pH decrease</title>
    <abstract language="eng">In the present study, the bivalve Scrobicularia plana, collected from two contrasting areas (pristine location and mercury contaminated area), was selected to assess the biochemical alterations imposed by pH decrease, carbamazepine (an antiepileptic) and the combined effect of both stressors. The effects on oxidative stress related biomarkers after 96 h exposure revealed that pH decrease and carbamazepine induced alterations on clams, with greater impacts on individuals from the contaminated area which presented higher mortality, higher lipid peroxidation and higher glutathione S-transferase activity. These results emphasize the risk of extrapolating results from one area to another, since the same species inhabiting different areas may be affected differently when exposed to the same stressors. Furthermore, the results obtained showed that, when combined, the impact of pH decrease and carbamazepine was lower than each stressor acting alone, which could be related to the defence mechanism of valves closure when bivalves are under higher stressful conditions.</abstract>
    <parentTitle language="eng">Environmental pollution</parentTitle>
    <identifier type="old">36939</identifier>
    <identifier type="doi">10.1016/j.envpol.2015.03.023</identifier>
    <identifier type="issn">0269-7491</identifier>
    <identifier type="issn">0013-9327</identifier>
    <identifier type="issn">1873-6424</identifier>
    <enrichment key="date_peer_review">20.08.2015</enrichment>
    <author>R. Freitas</author>
    <author>Ângela Almeida</author>
    <author>V. Calisto</author>
    <author>C. Velez</author>
    <author>A. Moreira</author>
    <author>Rudolf Schneider</author>
    <author>V.I. Esteves</author>
    <author>F. J. Wrona</author>
    <author>A.M.V.M. Soares</author>
    <author>E. Figueira</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Ocean acidification</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Biomarkers</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Oxidative stress</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Bivalves</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Pharmaceutical drugs</value>
    </subject>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>54234</id>
    <completedYear/>
    <publishedYear>2021</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1563</pageFirst>
    <pageLast>1573</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>414</volume>
    <type>article</type>
    <publisherName>Springer</publisherName>
    <publisherPlace>Heidelberg</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">A rapid magnetic bead-based immunoassay for sensitive determination of diclofenac</title>
    <abstract language="eng">Increasing contamination of environmental waters with pharmaceuticals represents an emerging threat for the drinking water quality and safety. In this regard, fast and reliable analytical methods are required to allow quick countermeasures in case of contamination. Here, we report the development of a magnetic bead-based immunoassay (MBBA) for the fast and cost-effective determination of the analgesic diclofenac (DCF) in water samples, based on diclofenac-coupled magnetic beads and a robust monoclonal anti-DCF antibody. A novel synthetic strategy for preparation of the beads resulted in an assay that enabled for the determination of diclofenac with a significantly lower limit of detection (400 ng/L) than the respective enzyme-linked immunosorbent assay (ELISA). With shorter incubation times and only one manual washing step required, the assay demands for remarkably shorter time to result (&lt; 45 min) and less equipment than ELISA. Evaluation of assay precision and accuracy with a series of spiked water samples yielded results with low to moderate intra- and inter-assay variations and in good agreement with LC–MS/MS reference analysis. The assay principle can be transferred to other, e.g., microfluidic, formats, as well as applied to other analytes and may replace ELISA as the standard immunochemical method.</abstract>
    <parentTitle language="eng">Analytical and Bioanalytical Chemistry</parentTitle>
    <identifier type="issn">1618-2650</identifier>
    <identifier type="doi">10.1007/s00216-021-03778-7</identifier>
    <identifier type="urn">urn:nbn:de:kobv:b43-542346</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="date_peer_review">24.01.2022</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>Alexander Ecke</author>
    <author>Tanja Westphalen</author>
    <author>J. Hornung</author>
    <author>M. Voetz</author>
    <author>Rudolf Schneider</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Immunoassay</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Magnetic beads</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Diclofenac</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Water analysis</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>LC-MS/MS</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="ddc" number="628">Sanitär- und Kommunaltechnik; Umwelttechnik</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.8 Umweltanalytik</collection>
    <collection role="themenfelder" number="">Umwelt</collection>
    <collection role="themenfelder" number="">Chemie und Prozesstechnik</collection>
    <collection role="themenfelder" number="">Chemische Charakterisierung und Spurenanalytik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei für die Öffentlichkeit verfügbar ("Open Access")</collection>
    <collection role="unnumberedseries" number="">Wissenschaftliche Artikel der BAM</collection>
    <thesisPublisher>Bundesanstalt für Materialforschung und -prüfung (BAM)</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-bam/files/54234/Ecke_MBBA DCF.pdf</file>
  </doc>
  <doc>
    <id>54219</id>
    <completedYear/>
    <publishedYear>2021</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1</pageFirst>
    <pageLast>6</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>conferenceobject</type>
    <publisherName>American Society of Mechanical Engineers (ASME)</publisherName>
    <publisherPlace>New York, NY</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Explainable machine learning for damage detection - In carbon fiber composite plates under varying temperature conditions</title>
    <abstract language="eng">Understanding on how a machine learning model interprets data is a crucial step to verify its reliability and avoid overfitting. While the focus of the scientific community is nowadays orientated towards deep learning approaches, which are considered as black box approaches, this work presents a toolbox that is based on complementary methods of feature extraction and selection, where the classification decisions of the model are transparent and can be physically interpreted. On the example of guided wave benchmark data from the open guided waves platform, where delamination defects were simulated at multiple positions on a carbon fiber reinforced plastic plate under varying temperature conditions, the authors could identify suitable frequencies for further investigations and experiments. Furthermore, the authors presented a realistic validation scenario which ensures that the machine learning model learns global damage characteristics rather than position specific characteristics.</abstract>
    <parentTitle language="eng">Proceedings of the 48th annual review of progress in quantitative nondestructive evaluation</parentTitle>
    <identifier type="doi">10.1115/QNDE2021-75215</identifier>
    <identifier type="isbn">978-0-7918-8552-9</identifier>
    <enrichment key="eventName">48th Annual Review of Progress in Quantitative Nondestructive Evaluation</enrichment>
    <enrichment key="eventPlace">Online meeting</enrichment>
    <enrichment key="eventStart">28.07.2021</enrichment>
    <enrichment key="eventEnd">30.07.2021</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="RelatedIdentifier">https://opus4.kobv.de/opus4-bam/frontdoor/index/index/docId/53377</enrichment>
    <enrichment key="date_peer_review">05.12.2022</enrichment>
    <author>C. Schnur</author>
    <author>J. Moll</author>
    <author>Yevgeniya Lugovtsova</author>
    <author>A. Schütze</author>
    <author>T. Schneider</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Explainable machine learning</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Guided waves</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Damage detection</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Structural health monitoring</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Composite structures</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="institutes" number="">8 Zerstörungsfreie Prüfung</collection>
    <collection role="institutes" number="">8.4 Akustische und elektromagnetische Verfahren</collection>
    <collection role="themenfelder" number="">Chemie und Prozesstechnik</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
    <collection role="literaturgattung" number="">Graue Literatur</collection>
  </doc>
  <doc>
    <id>54275</id>
    <completedYear/>
    <publishedYear>2022</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1</pageFirst>
    <pageLast>20</pageLast>
    <pageNumber/>
    <edition/>
    <issue>1</issue>
    <volume>6</volume>
    <type>article</type>
    <publisherName>MDPI</publisherName>
    <publisherPlace>Basel</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Microstructure evolution in Inconel 718 produced by powder bed fusion additive manufacturing</title>
    <abstract language="eng">Inconel 718 is a precipitation strengthened, nickel-based super alloy of interest for the Additive Manufacturing (AM) of low volume, complex parts to reduce production time and cost compared to conventional subtractive processes. The AM process involves repeated rapid melting, solidification and reheating, which exposes the material to non-equilibrium conditions that affect elemental segregation and the subsequent formation of solidification phases, either beneficial or detrimental. These variations are difficult to characterize due to the small length scale within the micron sized melt pool. To understand how the non-equilibrium conditions affect the initial solidification phases and their critical temperatures, a multi-length scale, multi modal approach has been taken to evaluate various methods for identifying the initial phases formed in the as-built Inconel 718 produced by laser-powder bed fusion (L-PBF) additive manufacturing (AM). Using a range of characterization tools from the bulk differential thermal analysis (DTA) and x-ray diffraction (XRD) to spatially resolved images using a variety of electron microscopy tools, a better understanding is obtained of how these minor phases can be properly identified regarding the amount and size, morphology and distribution. Using the most promising characterization techniques for investigation of the as-built specimens, those techniques were used to evaluate the specimens after various heat treatments. During the sequence of heat treatments, the initial as-built dendritic structures recrystallized into well-defined grains whose size was dependent on the temperature. Although the resulting strength was similar in all heat treated specimens, the elongation increased as the grain size was refined due to differences in the precipitated phase distribution and morphology.</abstract>
    <parentTitle language="eng">Journal of manufacturing and materials processing</parentTitle>
    <identifier type="issn">2504-4494</identifier>
    <identifier type="doi">10.3390/jmmp6010020</identifier>
    <identifier type="urn">urn:nbn:de:kobv:b43-542758</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="date_peer_review">28.03.2022</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>J. Schneider</author>
    <author>L. Farris</author>
    <author>Gert Nolze</author>
    <author>Stefan Reinsch</author>
    <author>G. Cios</author>
    <author>T. Tokarski</author>
    <author>S. Thompson</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Metal additive manufacturing</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Inconel 718</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Heat treatment</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Grain boundary precipitates</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Laves phase</value>
    </subject>
    <collection role="ddc" number="620">Ingenieurwissenschaften und zugeordnete Tätigkeiten</collection>
    <collection role="institutes" number="">5 Werkstofftechnik</collection>
    <collection role="institutes" number="">5.1 Mikrostruktur Design und Degradation</collection>
    <collection role="themenfelder" number="">Material</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei für die Öffentlichkeit verfügbar ("Open Access")</collection>
    <collection role="unnumberedseries" number="">Wissenschaftliche Artikel der BAM</collection>
    <thesisPublisher>Bundesanstalt für Materialforschung und -prüfung (BAM)</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-bam/files/54275/10_3390_jmmp6010020.pdf</file>
  </doc>
  <doc>
    <id>54206</id>
    <completedYear/>
    <publishedYear>2022</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1</pageFirst>
    <pageLast>19</pageLast>
    <pageNumber/>
    <edition/>
    <issue>1</issue>
    <volume>22</volume>
    <type>article</type>
    <publisherName>MDPI</publisherName>
    <publisherPlace>Basel</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Towards interpretable machine learning for automated damage detection based on ultrasonic guided waves</title>
    <abstract language="eng">Data-driven analysis for damage assessment has a large potential in structural health monitoring (SHM) systems, where sensors are permanently attached to the structure, enabling continuous and frequent measurements. In this contribution, we propose a machine learning (ML) approach for automated damage detection, based on an ML toolbox for industrial condition monitoring. The toolbox combines multiple complementary algorithms for feature extraction and selection and automatically chooses the best combination of methods for the dataset at hand. Here, this toolbox is applied to a guided wave-based SHM dataset for varying temperatures and damage locations, which is freely available on the Open Guided Waves platform. A classification rate of 96.2% is achieved, demonstrating reliable and automated damage detection. Moreover, the ability of the ML model to identify a damaged structure at untrained damage locations and temperatures is demonstrated.</abstract>
    <parentTitle language="eng">Sensors</parentTitle>
    <identifier type="doi">10.3390/s22010406</identifier>
    <identifier type="issn">1424-8220</identifier>
    <identifier type="urn">urn:nbn:de:kobv:b43-542060</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="date_peer_review">21.01.2022</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>C. Schnur</author>
    <author>P. Goodarzi</author>
    <author>Yevgeniya Lugovtsova</author>
    <author>Jannis Bulling</author>
    <author>Jens Prager</author>
    <author>K. Tschöke</author>
    <author>J. Moll</author>
    <author>A. Schütze</author>
    <author>T. Schneider</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Composite structures</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Structural health monitoring</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Carbon fibre-reinforced plastic</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Interpretable machine learning</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Automotive industry</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="institutes" number="">8 Zerstörungsfreie Prüfung</collection>
    <collection role="institutes" number="">8.4 Akustische und elektromagnetische Verfahren</collection>
    <collection role="themenfelder" number="">Chemie und Prozesstechnik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei für die Öffentlichkeit verfügbar ("Open Access")</collection>
    <collection role="unnumberedseries" number="">Wissenschaftliche Artikel der BAM</collection>
    <thesisPublisher>Bundesanstalt für Materialforschung und -prüfung (BAM)</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-bam/files/54206/Schnur - 2022 - Machine Learning on OGW Dataset (MDPI Sensors).pdf</file>
  </doc>
  <doc>
    <id>56723</id>
    <completedYear/>
    <publishedYear>2021</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1</pageFirst>
    <pageLast>6</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>QNDE2021-75215</volume>
    <type>conferenceobject</type>
    <publisherName>The American Society of Mechanical Engineers (ASME)</publisherName>
    <publisherPlace>New York, USA</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Explainable Machine Learning for Damage Detection: in Carbon Fiber Composite Plates Under Varying Temperature Conditions</title>
    <abstract language="eng">Understanding on how a machine learning model interprets data is a crucial step to verify its reliability and avoid overfitting. While the focus of the scientific community is nowadays orientated towards deep learning approaches, which are considered as black box approaches, this work presents a toolbox that is based on complementary methods of feature extraction and selection, where the classification decisions of the model are transparent and can be physically interpreted. On the example of guided wave benchmark data from the open guided waves platform, where delamination defects were simulated at multiple positions on a carbon fiber reinforced plastic plate under varying temperature conditions, the authors could identify suitable frequencies for further investigations and experiments. Furthermore, the authors presented a realistic validation scenario which ensures that the machine learning model learns global damage characteristics rather than position specific characteristics.</abstract>
    <parentTitle language="eng">48th Annual Review of Progress in Quantitative Nondestructive Evaluation</parentTitle>
    <identifier type="isbn">978-0-7918-8552-9</identifier>
    <identifier type="doi">10.1115/QNDE2021-75215</identifier>
    <enrichment key="eventName">2021 48th Annual Review of Progress in Quantitative Nondestructive Evaluation</enrichment>
    <enrichment key="eventPlace">Online meeting</enrichment>
    <enrichment key="eventStart">28.07.2021</enrichment>
    <enrichment key="eventEnd">30.07.2021</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="date_peer_review">09.01.2023</enrichment>
    <author>C. Schnur</author>
    <author>J. Moll</author>
    <author>Yevgeniya Lugovtsova</author>
    <author>A. Schütze</author>
    <author>T. Schneider</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Explainable machine learning</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Guided waves</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Damage detection</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Structural health monitoring</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Composite structures</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="institutes" number="">8 Zerstörungsfreie Prüfung</collection>
    <collection role="institutes" number="">8.4 Akustische und elektromagnetische Verfahren</collection>
    <collection role="themenfelder" number="">Chemie und Prozesstechnik</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
    <collection role="literaturgattung" number="">Graue Literatur</collection>
  </doc>
  <doc>
    <id>55935</id>
    <completedYear/>
    <publishedYear>2022</publishedYear>
    <thesisYearAccepted/>
    <language>mul</language>
    <pageFirst>580</pageFirst>
    <pageLast>614</pageLast>
    <pageNumber/>
    <edition/>
    <issue>10</issue>
    <volume>59</volume>
    <type>article</type>
    <publisherName>De Gruyter</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="mul">Reproducibility and Scattering in Additive Manufacturing: Results from a Round Robin on PBF-LB/M AlSi10Mg Alloy</title>
    <title language="deu">Reproduzierbarkeit und Streuung bei der additiven Fertigung: Ergebnisse eines Ringversuchs mit einer PBF-LB/M AlSi10Mg-Legierung</title>
    <abstract language="eng">The round robin test investigated the reliability users can expect for AlSi10Mg additive manufactured specimens by laser powder bed fusion through examining powder quality, process parameter, microstructure defects, strength and fatigue. Besides for one outlier, expected static material properties could be found. Optical microstructure inspection was beneficial to determine true porosity and porosity types to explain the occurring scatter in properties. Fractographic analyses reveal that the fatigue crack propagation starts at the rough as-built surface for all specimens. Statistical analysis of the scatter in fatigue using statistical derived safety factors concludes that at a stress of 36.87 MPa the fatigue limit of 107 cycles could be reached for all specimen with a survival probability of 99.999 %.</abstract>
    <abstract language="deu">Im Rahmen eines Ringversuchs wurde durch die Untersuchung der Pulverqualität, der Prozessparameter, der Gefügefehler, der Festigkeit und der Ermüdung die Zuverlässigkeit bestimmt, die Nutzer von AlSi10Mg-Proben erwarten können, die mit pulverbettbasiertes Schmelzen mittels Laser (engl. Laser Powder Bed Fusion) gefertigt worden sind. Abgesehen von einem Ausreißer wurden die erwarteten statischen Materialeigenschaften erreicht. Eine optische Gefügeprüfung diente dazu, die tatsächliche Porosität und Arten von Porosität zu ermitteln, um die bei den Eigenschaften auftretende Streuung zu erklären. Fraktographische Unterschungen zeigen eine bei allen Proben von der rauen Oberfläche im As-built-Zustand ausgehende Ermüdungsrissausbreitung. Aus der statistischen Analyse der Streuung bezüglich der Ermüdung unter Anwendung von statistischen abgeleiteten Sicherheitsfaktoren geht hervor, dass alle Proben die Dauerfestigkeit von 107 Zyklen bei einer Spannung von 36,87 MPa mit einer Überlebenswahrscheinlichkeit von 99,999 % erreichten.</abstract>
    <parentTitle language="eng">Practical Metallography</parentTitle>
    <identifier type="issn">2195-8599</identifier>
    <identifier type="doi">10.1515/pm-2022-1018</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="date_peer_review">19.10.2022</enrichment>
    <author>M. Schneider</author>
    <author>Dirk Bettge</author>
    <author>Kai Hilgenberg</author>
    <author>M. Binder</author>
    <author>K. Dollmeier</author>
    <author>M. Dreyer</author>
    <author>B. Klöden</author>
    <author>T. Schlingmann</author>
    <author>J. Schmidt</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Additive manufacturing</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Reproducibility</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Reliability</value>
    </subject>
    <collection role="ddc" number="620">Ingenieurwissenschaften und zugeordnete Tätigkeiten</collection>
    <collection role="institutes" number="">5 Werkstofftechnik</collection>
    <collection role="institutes" number="">5.1 Mikrostruktur Design und Degradation</collection>
    <collection role="institutes" number="">9 Komponentensicherheit</collection>
    <collection role="themenfelder" number="">Material</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
    <collection role="institutes" number="">9.6 Additive Fertigung metallischer Komponenten</collection>
    <collection role="themenfelder" number="">Additive Fertigung</collection>
  </doc>
  <doc>
    <id>38497</id>
    <completedYear/>
    <publishedYear>2016</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>565</pageFirst>
    <pageLast>573</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>146</volume>
    <type>article</type>
    <publisherName>Elsevier</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Long-term exposure to caffeine and carbamazepine: Impacts on the regenerative capacity of the polychaete Diopatra neapolitana</title>
    <abstract language="eng">The toxicity induced in non-target organisms by pharmaceutical drugs has been the focus of several studies. In the aquatic environment, most of the studies have been devoted to fish and bivalves, while little is known on the impacts induced in polychaetes. The present study evaluated the impacts of carbamazepine and caffeine on the regenerative capacity of Diopatra neapolitana, a polychaete species with high ecological and economic relevance. Under laboratory controlled conditions polychaetes were exposed, during 28 days, to carbamazepine (Ctl-0.0; 0.3; 3.0; 6.0; 9.0 mg/L) and caffeine (Ctl-0.0; 0.5; 3.0; 18.0 mg/L). During the experiment, at days 11, 18, 25, 32, 39 and 46 after amputation, for each specimen, the percentage of the body width regenerated was determined and the number of new segments was counted. The regenerative capacity was assessed considering the number of days needed to achieve full regeneration and the total number of new segments. The obtained results revealed that with the increase of drugs concentrations organisms regenerated less new segments and took longer to completely regenerate.</abstract>
    <parentTitle language="eng">Chemosphere</parentTitle>
    <identifier type="doi">10.1016/j.chemosphere.2015.12.035</identifier>
    <identifier type="issn">0045-6535</identifier>
    <enrichment key="date_peer_review">30.11.2016</enrichment>
    <author>A. Pieres</author>
    <author>Ângela Almeida</author>
    <author>J. Correia</author>
    <author>V. Calisto</author>
    <author>Rudolf Schneider</author>
    <author>V. I. Esteves</author>
    <author>A. M. V. M. Soares</author>
    <author>E. Figueira</author>
    <author>R. Freitas</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Diopatra neapolitana</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Pollution</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Pharmaceutical drugs</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Regenerative capacity</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="ddc" number="628">Sanitär- und Kommunaltechnik; Umwelttechnik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>38502</id>
    <completedYear/>
    <publishedYear>2016</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>977</pageFirst>
    <pageLast>985</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>541</volume>
    <type>article</type>
    <publisherName>Elsevier B.V.</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">The impacts of pharmaceutical drugs under ocean acidification: Newdata on single and combined long-term effects of carbamazepine on Scrobicularia plana</title>
    <abstract language="eng">Ocean acidification and increasing discharges of pharmaceutical contaminants into aquatic systems are among key and/or emerging drivers of environmental change affecting marine ecosystems. A growing body of evidence demonstrates that ocean acidification can have direct and indirect impacts on marine organisms although combined effects with other stressors, namely with pharmaceuticals, have received very little attention to date. The present study aimed to evaluate the impacts of the pharmaceutical drug Carbamazepine and pH 7.1, acting alone and in combination, on the clamScrobicularia plana. For this, a long-termexposure (28 days)was conducted and a set of oxidative stress markers was investigated. The results obtained showed that S. plana was able to develop mechanisms to prevent oxidative damage when under low pH for a long period, presenting higher survival when exposed to this stressor compared to CBZ or the combination of CBZ with pH 7.1. Furthermore, the toxicity of CBZ on S. plana was synergistically increased under ocean acidification conditions (CBZ + pH 7.1): specimens survival was reduced and oxidative stress was enhanced when compared to single exposures. These findings add to the growing body of evidence that ocean acidification will act to increase the toxicity of CBZ to marine organisms,which has clear implications for coastal benthic ecosystems suffering chronic pollution from pharmaceutical drugs.</abstract>
    <parentTitle language="eng">Science of the Total Environment</parentTitle>
    <identifier type="doi">10.1016/j.scitotenv.2015.09.138</identifier>
    <enrichment key="date_peer_review">30.11.2016</enrichment>
    <author>R. Freitas</author>
    <author>Ângela Almeida</author>
    <author>V. Calisto</author>
    <author>C. Velez</author>
    <author>A. Moreira</author>
    <author>Rudolf Schneider</author>
    <author>V. I. Esteves</author>
    <author>F. J. Wrona</author>
    <author>E. Figueira</author>
    <author>A. M. V. M. Soares</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Ocean acidification</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Pharmaceuticals</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Biomarkers</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Oxidative stress</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Clams</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Long-term exposures</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="ddc" number="628">Sanitär- und Kommunaltechnik; Umwelttechnik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>38503</id>
    <completedYear/>
    <publishedYear>2016</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>150</pageFirst>
    <pageLast>166</pageLast>
    <pageNumber/>
    <edition/>
    <issue>20</issue>
    <volume>2016</volume>
    <type>article</type>
    <publisherName>World Scientific Publishing</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Photodegradation of organic pollutants in water by immobilized porphyrins and phthalocyanines</title>
    <abstract language="eng">New methods for water treatment are required as a result from an increasing awareness in the reduction of the pollution impact in the environment. In the perspective of the photo-oxidation of organic pollutants present in water, the principal incentive for the preparation of heterogeneous photocatalysts is their easy recovery from the reaction mixture, which allows their reuse in successive runs, minimizing the loss of their original photocatalytic properties. Different types of supports can be used in the immobilization of photoactive species, such as porphyrins (Pors) and phthalocyanines (Pcs). This mini-review will consider the different methodologies for the immobilization of Pors and Pcs and their photocatalytic performance in the photodegradation of organic pollutants in water, addressing also their recycling ability in successive water treatments.</abstract>
    <parentTitle language="eng">Journal of Porphyrins and Phthalocyanines</parentTitle>
    <identifier type="doi">10.1142/S108842461630007X</identifier>
    <enrichment key="date_peer_review">30.11.2016</enrichment>
    <author>L. Fernandez</author>
    <author>V. I. Esteves</author>
    <author>A. Cunha</author>
    <author>Rudolf Schneider</author>
    <author>J. P. C. Tome</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Porphyrins</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Phthalocyanines</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Water treatment</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Organic pollutants</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Advanced oxidation processes</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Heterogeneous photocatalysis</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>TiO2</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Microporous</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Nanoparticles</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="ddc" number="628">Sanitär- und Kommunaltechnik; Umwelttechnik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>38505</id>
    <completedYear/>
    <publishedYear>2016</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>456</pageFirst>
    <pageLast>463</pageLast>
    <pageNumber/>
    <edition/>
    <issue>214</issue>
    <volume>2016</volume>
    <type>article</type>
    <publisherName>Elsevier Ltd.</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Long-term exposure of polychaetes to caffeine: Biochemical alterations induced in Diopatra neapolitana and Arenicola marina</title>
    <abstract language="eng">In the last decade studies have reported the presence of several pharmaceutical drugs in aquatic environments worldwide and an increasing effort has been done to understand the impacts induced on wildlife. Among the most abundant drugs in the environment is caffeine, which has been reported as an effective chemical anthropogenic marker. However, as for the majority of pharmaceuticals, scarce information is available on the adverse effects of caffeine on marine benthic organisms, namely polychaetes which are the most abundant group of organisms in several aquatic ecossystems. Thus, the present study aimed to evaluate the biochemical alterations induced by environmentally relevant concentrations of caffeine on the polychaete species Diopatra neapolitana and Arenicola marina. The results obtained demonstrated that after 28 days exposure oxidative stress was induced in both species, especially noticed in A. marina, resulting from the incapacity of antioxidant and biotransformation enzymes to prevent cells from lipid peroxidation. The present study further revealed that D. neapolitana used glycogen and proteins as energy to develop defense mechanisms while in A. marina these reserves were maintained independently on the exposure concentration, reinforcing the low capacity of this species to fight against oxidative stress.</abstract>
    <parentTitle language="eng">Environmental Pollution</parentTitle>
    <identifier type="doi">10.1016/j.envpol.2016.04.031</identifier>
    <enrichment key="date_peer_review">30.11.2016</enrichment>
    <author>A. Pires</author>
    <author>Ângela Almeida</author>
    <author>V. Calisto</author>
    <author>Rudolf Schneider</author>
    <author>V. I. Esteves</author>
    <author>F. J. Wrona</author>
    <author>A. M. V. M. Soares</author>
    <author>E. Figueira</author>
    <author>R. Freitas</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Invertebrates</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Pharmaceuticals</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Oxidative stress biomarkers</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Energy reserves</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="ddc" number="628">Sanitär- und Kommunaltechnik; Umwelttechnik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>38508</id>
    <completedYear/>
    <publishedYear>2016</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>95</pageFirst>
    <pageLast>103</pageLast>
    <pageNumber/>
    <edition/>
    <issue>160</issue>
    <volume>2016</volume>
    <type>article</type>
    <publisherName>Elsevier Ltd.</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Caffeine impacts in the clam Ruditapes philippinarum: Alterations on energy reserves, metabolic activity and oxidative stress biomarkers</title>
    <abstract language="eng">Caffeine is known to be one of the most consumed psychoactive drugs. For this reason, caffeine is continuously released into the environment with potential impacts on inhabiting organisms. The current study evaluated the biochemical alterations induced in the clam species Ruditapes philippinarum after exposure for 28 days to caffeine (0.5, 3.0 and 18.0 mg/L). The results obtained showed that, with the increasing caffeine concentrations, an increase in clams defense mechanisms (such as antioxidant and biotransformation enzymes activity) was induced which was accompanied by an increase in protein content. Nevertheless, although an increase on defense mechanisms was observed, clams were not able to prevent cells from lipid peroxidation that increased with the increase of caffeine concentration. Furthermore, with the increase of exposure concentrations, clams increased their metabolic activity (measured by electron transport activity), reducing their energy reserves (glycogen content), to fight against oxidative stress. Overall, the present study demonstrated that caffeine may impact bivalves, even at environmentally relevant concentrations, inducing oxidative stress in organisms. The present study is an important contribution to address knowledge gaps regarding the impacts of long-term exposures to pharmaceuticals since most of the studies assessed the effects after acute exposures, most of them up to 96 h.</abstract>
    <parentTitle language="eng">Chemosphere</parentTitle>
    <identifier type="doi">10.1016/j.chemosphere.2016.06.068</identifier>
    <enrichment key="date_peer_review">30.11.2016</enrichment>
    <author>D. Cruz</author>
    <author>Ângela Almeida</author>
    <author>V. Calisto</author>
    <author>V. I. Esteves</author>
    <author>Rudolf Schneider</author>
    <author>F. J. Wrona</author>
    <author>A. M. V. M. Soares</author>
    <author>E. Figueira</author>
    <author>R. Freitas</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Bivalves</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Oxidative stress</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Pharmaceuticals</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Long-term exposure</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Environmentally relevant concentrations</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="ddc" number="628">Sanitär- und Kommunaltechnik; Umwelttechnik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>38509</id>
    <completedYear/>
    <publishedYear>2016</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>30</pageFirst>
    <pageLast>38</pageLast>
    <pageNumber/>
    <edition/>
    <issue>188</issue>
    <volume>2016</volume>
    <type>article</type>
    <publisherName>Elsevier Inc.</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Hediste diversicolor as bioindicator of pharmaceutical pollution: Results from single and combined exposure to carbamazepine and caffeine</title>
    <abstract language="eng">Several environmental stressors have been identified as key and/or emerging drivers of habitat change that could significantly influence marine near-shore ecosystems. These include increasing discharges of pharmaceutical contaminants into the aquatic coastal systems. Pharmaceutical drugs are often detected in aquatic environments but still information on their toxicity impacts on inhabiting species is scarce, especially when acting in combination. Furthermore, almost no information is available on the impacts of pharmaceuticals in polychaetes, often the most abundant taxon in benthic communities and commonly used as indicator species of environmental conditions. Therefore, the present study aimed to evaluate the biochemical alterations induced in the polychaete Hediste diversicolor, from a low contaminated area at the Ria de Aveiro lagoon (Portugal), by the antiepileptic drug carbamazepine (0.0 - control, 0.3, 3.0, 6.0 and 9.0 μg/L) and the stimulant caffeine (0.0 - control, 0.5, 3.0, and 18.0 μg/L), acting alone and in combination (0.3 CBZ + 0.5 CAF and 6.0 CBZ + 3.0 CAF). Glutathione Stransferases (GSTs), superoxide dismutase (SOD) and catalase (CAT) activities was determined in Hediste diversicolor from each condition. Lipid peroxidation (LPO), glutathione reduced and oxidized (GSH and GSSG), glycogen and electron transport system (ETS) were also measured. The results obtained clearly revealed that both drugs induced oxidative stress in H. diversicolor, shown by the increase on LPO levels and decrease on total glutathione and GSH/GSSG ratio with the increase of exposure concentrations. Furthermore, the present findings demonstrated that polychaetes biotransformation capacity as well as antioxidant defense mechanisms were not sufficiently efficient to fight against the excess of reactive oxygen species (ROS) leading to LPO when organisms were exposed to both drugs. Our results also demonstrated that polychaetes tended to decrease the activity of ETSwhen exposed to drugs, avoiding energy expenditurewhich may prevent them fromgreater damages. The present study further revealed that the impacts induced by the combination of both drugswere similar to those obtained at the highest drugs concentrations acting alone.</abstract>
    <parentTitle language="eng">Comparative Biochemistry and Physiology, Part C</parentTitle>
    <identifier type="doi">10.1016/j.cbpc.2016.06.003</identifier>
    <enrichment key="date_peer_review">30.11.2016</enrichment>
    <author>A. Pires</author>
    <author>Ângela Almeida</author>
    <author>V. Calisto</author>
    <author>Rudolf Schneider</author>
    <author>V. I. Esteves</author>
    <author>F. J. Wrona</author>
    <author>A. M. V. M. Soares</author>
    <author>E. Figueira</author>
    <author>R. Freitas</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Invertebrates</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Pharmaceuticals</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Oxidative stress biomarkers</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Energy reserves</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="ddc" number="628">Sanitär- und Kommunaltechnik; Umwelttechnik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>43302</id>
    <completedYear/>
    <publishedYear>2017</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>316</pageFirst>
    <pageLast>326</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>114</volume>
    <type>article</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Toxic effects of the antihistamine cetirizine in mussel Mytilus galloprovincialis</title>
    <abstract language="eng">Recent studies have become increasingly focused on the assessment of pharmaceuticals occurrence in aquatic ecosystems, however the potential toxicity to non-target organisms is still largely unknown. The antihistamine cetirizine is a commonly used pharmaceutical, already detected in surface waters of marine aquatic systems worldwide. In the present study Mytilus galloprovincialis mussels were exposed to a range of cetirizine concentrations (0.3, 3.0, 6.0 and 12.0 mu/L), resembling moderate to highly contaminated areas, over 28 days. The responses of different biochemical markers were evaluated in mussels whole soft tissue, and included energy-related parameters (glycogen content, GLY; protein content, PROT; electron transport system activity, ETS), and oxidative stress markers (superoxide dismutase activity, SOD; catalase activity, CAT; glutathione S-transferases activity, GSTs; lipid peroxidation levels, LPO; reduced (GSH) and oxidized (GSSG) glutathione content). The results obtained demonstrated that with the increase of exposure concentrations mussels tended to increase their energy reserves and maintain their metabolic potential, which was significantly higher only at the highest concentration. Our findings clearly revealed that cetirizine inhibited the activity of GSTs and although induced the activity of antioxidant enzymes (SOD and CAT) mussels were not able to prevent cellular damages observed through the increase of LPO associated to the increase of exposure concentrations. Thus, this study confirmed that cetirizine induces toxic effects in Mytilus galloprovincialis, which, considering their trophic relevance, wide use as bioindicator and wide spatial distribution of this species, can result in ecological and economic negative impacts at a large scale.</abstract>
    <parentTitle language="eng">WATER RESEARCH</parentTitle>
    <identifier type="doi">10.1016/j.watres.2017.02.032</identifier>
    <identifier type="issn">0043-1354</identifier>
    <enrichment key="date_peer_review">05.12.2017</enrichment>
    <author>Rudolf Schneider</author>
    <author>M. Teixiera</author>
    <author>Ângela Almeida</author>
    <author>V. Calisto</author>
    <author>V. I. Esteves</author>
    <author>F. J. Wrona</author>
    <author>A. M. V. M. Soares</author>
    <author>E. Figueira</author>
    <author>R. Freitas</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Bivalves</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Biomarkers</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Oxidative Stress</value>
    </subject>
    <collection role="ddc" number="628">Sanitär- und Kommunaltechnik; Umwelttechnik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>43304</id>
    <completedYear/>
    <publishedYear>2017</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>102</pageFirst>
    <pageLast>114</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>117</volume>
    <type>article</type>
    <publisherName>Elsevier Ltd.</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Physiological and biochemical alterations induced in the mussel Mytilus galloprovincialis after short and long-term exposure to carbamazepine</title>
    <abstract language="eng">The bivalve Mytilus galloprovincialis collected in the Ria de Aveiro, was selected to evaluate the acute and chronic effects of carbamazepine (CBZ) at environmentally relevant concentrations. CBZ is an antiepileptic drug widely found in the aquatic environment with toxic effects to inhabiting organisms. However, few studies evaluated the acute and chronic toxicity of this drug. The experiment was performed 'by exposing mussels to 0.0, 0.3, 3.0, 6.0 and 9.0 CBZ mu g/L, for 96 h and 28 days. To assess the toxicity of the drug, a battery of biomarkers related to mussels general physiological health status and oxidative stress was applied. CBZ was quantified in mussel tissues by an Enzyme-Linked Immunosorbent Assay (ELISA). The results obtained show that CBZ did not induce oxidative stress. However, our findings,demonstrated that the drug was taken up by mussels even though presenting low bioconcentration factor (BCF) values (up to 2.2). Furthermore, our results demonstrated that after a chronic exposure the physiological parameters, namely the condition and gonadosomatic indices, were negatively affected which may impair organisms' reproductive capacity with consequences to population sustainability.</abstract>
    <parentTitle language="eng">Water Research</parentTitle>
    <identifier type="doi">10.1016/j.watres.2017.03.052</identifier>
    <identifier type="issn">0043-1354</identifier>
    <enrichment key="date_peer_review">06.12.2017</enrichment>
    <author>Rudolf Schneider</author>
    <author>P. Oliveira</author>
    <author>Ângela Almeida</author>
    <author>V. Calisto</author>
    <author>V. I. Esteves</author>
    <author>F. J. Wrona</author>
    <author>A. M. V. M. Soares</author>
    <author>E. Figueira</author>
    <author>R. Freitas</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Pharmaceuticals</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Bivalves</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Oxidative Stress</value>
    </subject>
    <collection role="ddc" number="628">Sanitär- und Kommunaltechnik; Umwelttechnik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>43308</id>
    <completedYear/>
    <publishedYear>2017</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>535</pageFirst>
    <pageLast>543</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>142</volume>
    <type>article</type>
    <publisherName>Elsevier Ltd.</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Nanomagnet-photosensitizer hybrid materials for the degradation of 17 beta-estradiol in batch and flow modes</title>
    <abstract language="eng">The preparation of porphyrins and phthalocyanines covalently attached onto nanostructured magnetic supports consisting of magnetite nanoparticles coated with an amorphous silica shell is reported. The easy recovery of these heterogeneous photocatalysts, just by applying an external magnetic field, allows their reuse in multiple treatment cycles. The photocatalytic activity of the non-immobilized photosensitizers and the obtained hybrid materials was evaluated in the degradation of 17 beta-estradiol, as a model organic pollutant present in water, using batch and flow mode treatment systems, assisted by visible light radiation (4 mW cm(-2)). The flow mode system potentiated the photocatalytic capacity of these novel hybrid materials. In order to improve the process, further studies based on different photocatalyst concentration and pH conditions were performed. Reuse capacity of these materials was investigated upon three photocatalytic cycles.</abstract>
    <parentTitle language="eng">Dyes and Pigments</parentTitle>
    <identifier type="doi">10.1016/j.dyepig.2017.04.010</identifier>
    <identifier type="issn">0143-7208</identifier>
    <enrichment key="date_peer_review">06.12.2017</enrichment>
    <author>Rudolf Schneider</author>
    <author>L. Fernandez</author>
    <author>W. Borzecka</author>
    <author>Z. Lin</author>
    <author>K. Huvaere</author>
    <author>V. I. Esteves</author>
    <author>A. Cunha</author>
    <author>J. P. C. Tome</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Photodegradation</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>17 beta-Estradiol</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Porphyrin</value>
    </subject>
    <collection role="ddc" number="628">Sanitär- und Kommunaltechnik; Umwelttechnik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>45173</id>
    <completedYear/>
    <publishedYear>2018</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>120003-1</pageFirst>
    <pageLast>120003-10</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>1949</volume>
    <type>conferenceobject</type>
    <publisherName>AIP Publishing</publisherName>
    <publisherPlace/>
    <creatingCorporation>American Institute of Physics</creatingCorporation>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Volume imaging NDE and serial sectioning of carbon fiber composites</title>
    <abstract language="eng">A composite material is a combination of two or more materials with very different mechanical, thermal and electrical properties. The various forms of composite materials, due to their high material properties, are widely used as structural materials in the aviation, space, marine, automobile, and sports industries. However, some defects like voids, delamination, or inhomogeneous fiber distribution that form during the fabricating processes of composites can seriously affect the mechanical properties of the composite material. In this study, several imaging NDE techniques such as: thermography, high frequency eddy current, ultrasonic, x-ray radiography, x-ray laminography, and high resolution x-ray CT were conducted to characterize the microstructure of carbon fiber composites. Then, a 3D analysis was implemented by the destructive technique of serial sectioning for the same sample tested by the NDE methods. To better analyze the results of this work and extract a clear volume image for all features and defects contained in the composite material, an intensive comparison was conducted among hundreds of 3D-NDE and multi serial sections’ scan images showing the microstructure variation.</abstract>
    <parentTitle language="eng">AIP Conference Proceedings</parentTitle>
    <identifier type="doi">10.1063/1.5031590</identifier>
    <enrichment key="eventName">44TH ANNUAL REVIEW OF PROGRESS IN QUANTITATIVE NONDESTRUCTIVE EVALUATION</enrichment>
    <enrichment key="eventPlace">Provo, Utah, USA</enrichment>
    <enrichment key="eventStart">16.07.2017</enrichment>
    <enrichment key="eventEnd">21.07.2017</enrichment>
    <enrichment key="date_peer_review">14.06.2018</enrichment>
    <author>I. Hakim</author>
    <author>David Schumacher</author>
    <author>V. Sundar</author>
    <author>S. Donaldson</author>
    <author>A. Creuz</author>
    <author>R. Schneider</author>
    <author>J. Keller</author>
    <author>C. Browning</author>
    <author>D. May</author>
    <author>M. Abo Ras</author>
    <author>N. Meyendorf</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Carbon fiber reinforced polymers</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Non-destructive testing</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Thermography</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Eddy current</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Ultrasound</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>X-ray radiography</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>X-ray laminography</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>X-ray computed tomography</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Serial sectioning</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="ddc" number="620">Ingenieurwissenschaften und zugeordnete Tätigkeiten</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>32220</id>
    <completedYear/>
    <publishedYear>2015</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>846</pageFirst>
    <pageLast>853</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>conferenceobject</type>
    <publisherName>Taylor &amp; Francis</publisherName>
    <publisherPlace>London</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">A software prototype for assessing the reliability of a concrete bridge superstructure subjected to chloride-induced reinforcement corrosion</title>
    <abstract language="eng">A software prototype is developed for assessing and updating the reliability of single-cell prestressed concrete box girders subjected to chloride-induced reinforcement corrosion. The underlying system model consists of two integrated sub-models: a condition model for predicting the deterioration state of the box girder and a structural model for evaluating the overall system reliability. The condition model is based on a dynamic Bayesian network (DBN) model which considers the spatial variation of the corrosion process. Inspection data are included in the calculation of the system reliability through Bayesian updating on the basis of the DBN model. To demonstrate the effect of partial inspections, the software prototype is applied to a case study of a typical highway bridge with six spans. The case study illustrates that it is possible to infer the condition of uninspected parts of the structure due to the spatial correlation of the corrosion process.</abstract>
    <parentTitle language="eng">Life-cycle of structural systems - IALCCE 2014 - 4th International symposium on life-cycle civil engineering (Proceedings)</parentTitle>
    <identifier type="old">35286</identifier>
    <identifier type="isbn">978-1-138-00120-6</identifier>
    <enrichment key="eventName">IALCCE 2014 - 4th International symposium on life-cycle civil engineering</enrichment>
    <enrichment key="eventPlace">Tokyo, Japan</enrichment>
    <enrichment key="eventStart">16.11.2014</enrichment>
    <enrichment key="eventEnd">19.11.2014</enrichment>
    <enrichment key="date_peer_review">15.12.2014</enrichment>
    <author>Ronald Schneider</author>
    <author>S. Thöns</author>
    <author>J. Fischer</author>
    <author>M. Bügler</author>
    <author>A. Borrmann</author>
    <author>D. Straub</author>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>29914</id>
    <completedYear/>
    <publishedYear>2013</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>290</pageFirst>
    <pageLast>295</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>conferenceobject</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation>International society for structural health monitoring of intelligent infrastructure</creatingCorporation>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Distributed Brillouin sensing in optical fibers: Soil displacement monitoring using sensor-equipped geogrids</title>
    <abstract language="eng">This paper reports on the application of distributed Brillouin fiber optic sensing to the monitoring of geotechnical structures. The presented approach to Brillouin sensing offers an alternative to the common pulse-based measurements by using the frequency domain analysis.&#13;
The focus of the research and field-testing work is to collect reliable structural health monitoring data from large-scale structures while preserving the System’s versatility in terms of being suitable for different application environments (soil structures, foundations, concrete construction works, pipelines etc.) and its robustness in being well functioning in harsh environments. Upon reviewing the presented application test, it is concluded that Brillouin frequency domain based monitoring, when applied to geotechnical structures, is capable of providing accurate strain readings representing deformations of the soil body, and reliable temperature readings for generating temperature profiles of the entire structure.&#13;
An overview of the frequency domain analysis of Brillouin sensing and its digital implementation is given, along with the experiences and insights drawn from an open field test of sensor-equipped geogrid mats.</abstract>
    <parentTitle language="eng">SHMII-6 - 6th International conference on structural health monitoring of intelligent infrastructure (Proceedings)</parentTitle>
    <identifier type="old">32851</identifier>
    <identifier type="isbn">978-962-367-768-4</identifier>
    <enrichment key="eventName">SHMII-6 - 6th International conference on structural health monitoring of intelligent infrastructure</enrichment>
    <enrichment key="eventPlace">Hong Kong, China</enrichment>
    <enrichment key="eventStart">09.12.2013</enrichment>
    <enrichment key="eventEnd">11.12.2013</enrichment>
    <enrichment key="date_peer_review">09.01.2014</enrichment>
    <author>N. Nöther</author>
    <author>S. Wang</author>
    <author>Aleksander Wosniok</author>
    <author>R. Glötzl</author>
    <author>J. Schneider-Glötzl</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Structural health monitoring</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Distributed sensing</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fiber-optic sensing</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Brillouin sensing</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Strain and temperature measurements</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Sensor-equipped geosynthetics</value>
    </subject>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>40320</id>
    <completedYear/>
    <publishedYear>2017</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>4007</pageFirst>
    <pageLast>4012</pageLast>
    <pageNumber/>
    <edition/>
    <issue>7</issue>
    <volume>89</volume>
    <type>article</type>
    <publisherName>ACS Publications</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Hapten-specific single-cell selection of hybridoma clones by fluorescence-activated cell sorting for the generation of monoclonal antibodies</title>
    <abstract language="eng">The conventional hybridoma screening and subcloning process is generally considered to be one of the most critical steps in hapten-specific antibody production. It is time-consuming, monoclonality is not guaranteed, and the number of clones that can be screened is limited. Our approach employs a novel hapten-specific labeling technique of hybridoma cells. This allows for fluorescence-activated cell sorting (FACS) and single-cell deposition and thereby eliminates the above-mentioned problems. A two-step staining approach is used to detect antigen specificity and antibody expression: in order to detect antigen specificity, hybridoma cells are incubated with a hapten−horseradish peroxidase conjugate (hapten−HRP), which is subsequently incubated with a fluorophore-labeled polyclonal anti-peroxidase antibody (anti-HRP−Alexa Fluor 488). To characterize the expression of membrane-bound immunoglobulin G (IgG), a fluorophore-labeled anti-mouse IgG antibody (anti-IgG−Alexa Fluor 647) is used. Hundreds of labeled hybridoma cells producing monoclonal antibodies (mAbs) specific for a hapten were rapidly isolated and deposited from a fusion mixture as single-cell clones via FACS. Enzyme-linked immunosorbent assay (ELISA) measurements of the supernatants of the sorted hybridoma clones revealed that all hapten-specific hybridoma clones secrete antibodies against the target. There are significant improvements using this high-throughput technique for the generation of mAbs including increased yield of antibody-producing hybridoma clones, ensured monoclonality of sorted cells, and reduced development times.</abstract>
    <parentTitle language="eng">Analytical Chemistry</parentTitle>
    <identifier type="doi">10.1021/acs.analchem.6b04569</identifier>
    <identifier type="issn">0003-2700</identifier>
    <identifier type="issn">1520-6882</identifier>
    <enrichment key="date_peer_review">23.05.2017</enrichment>
    <author>Martin Dippong</author>
    <author>Peter Carl</author>
    <author>C. Lenz</author>
    <author>J. A. Schenk</author>
    <author>Katrin Hoffmann</author>
    <author>Timm Schwaar</author>
    <author>Rudolf Schneider</author>
    <author>Maren Kuhne</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Monoclonal antibodies</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>FACS</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Hybridoma cells</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="ddc" number="628">Sanitär- und Kommunaltechnik; Umwelttechnik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>19662</id>
    <completedYear/>
    <publishedYear>2009</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>840</pageFirst>
    <pageLast>843</pageLast>
    <pageNumber/>
    <edition/>
    <issue>2-6</issue>
    <volume>84</volume>
    <type>article</type>
    <publisherName>North-Holland Publ. Co.</publisherName>
    <publisherPlace>Amsterdam</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Cryogenic vacuum tests of scaled down narrow support elements for the W7-X coil system</title>
    <parentTitle language="eng">Fusion engineering and design</parentTitle>
    <identifier type="old">21905</identifier>
    <identifier type="doi">10.1016/j.fusengdes.2008.11.075</identifier>
    <identifier type="issn">0920-3796</identifier>
    <enrichment key="bibliotheksstandort">Sonderstandort: Publica-Schrank</enrichment>
    <enrichment key="date_peer_review">20.07.2009</enrichment>
    <author>Thomas Gradt</author>
    <author>Thomas Schneider</author>
    <author>J. Lingertat</author>
    <author>D. Hathiramani</author>
    <author>P. Junghanns</author>
    <author>Kristin Aßmus</author>
    <author>F. Schauer</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Wendelstein 7-X</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Magnet system</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Narrow support elements</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Friction</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>MoS2</value>
    </subject>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Physisches Exemplar in der Bibliothek der BAM vorhanden ("Hardcopy Access")</collection>
  </doc>
  <doc>
    <id>19745</id>
    <completedYear/>
    <publishedYear>2009</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1192</pageFirst>
    <pageLast>1196</pageLast>
    <pageNumber/>
    <edition/>
    <issue>7-11</issue>
    <volume>84</volume>
    <type>article</type>
    <publisherName>North-Holland Publ. Co.</publisherName>
    <publisherPlace>Amsterdam</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Tribological performance of MoS2 coatings in liquid helium and at high loads</title>
    <abstract language="eng">The main part of a narrow support element (NSE) of the W7-X superconducting coil system is an aluminium bronze pad, PVD coated on its spherical surface with MoS2, which slides against the flat surface of the stainless steel coil housing, coated with MoS2 spray. The operational requirements of the NSEs are: vacuum of p &lt; 10-6 mbar, temperature T ~4 K, maximum load P ~1500 kN, typical displacement ≤5 mm, smooth sliding and no stick-slip events. The paper describes test results obtained with a downscaled NSE at T = 4.2 and 77 K. During the test the NSEs were submerged in liquid helium and nitrogen, respectively. Whereas the LN2 test ran smoothly for up to ~15,000 cycles, the test in LHe showed stick-slip from the very first cycle. The stick-slip disappeared after ~50 cycles. Post mortem analysis of the tested parts revealed that in case of LHe the sprayed MoS2 film was removed during the first 30-100 cycles by blistering and flaking. The reason for the loss of adhesion at LHe temperature is not known, several possible causes are under discussion. Further experiments under vacuum and at T ~4 K are being prepared which are expected to help in clarifying the issue.</abstract>
    <parentTitle language="eng">Fusion engineering and design</parentTitle>
    <identifier type="old">21991</identifier>
    <identifier type="doi">10.1016/j.fusengdes.2009.01.069</identifier>
    <identifier type="issn">0920-3796</identifier>
    <enrichment key="bibliotheksstandort">Sonderstandort: Publica-Schrank</enrichment>
    <enrichment key="date_peer_review">06.08.2009</enrichment>
    <author>J. Lingertat</author>
    <author>Thomas Gradt</author>
    <author>D. Hathiramani</author>
    <author>P. Junghanns</author>
    <author>M. Laux</author>
    <author>Kerstin Meine</author>
    <author>F. Schauer</author>
    <author>Thomas Schneider</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Stellarator</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Wendelstein 7-X</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Mechanical structure</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Narrow support elements</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>MoS2</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Lubrication</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>T=4K</value>
    </subject>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Physisches Exemplar in der Bibliothek der BAM vorhanden ("Hardcopy Access")</collection>
  </doc>
  <doc>
    <id>22188</id>
    <completedYear/>
    <publishedYear>2010</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1376</pageFirst>
    <pageLast>1381</pageLast>
    <pageNumber/>
    <edition/>
    <issue>6</issue>
    <volume>25</volume>
    <type>article</type>
    <publisherName>Elsevier</publisherName>
    <publisherPlace>Barking, Essex, UK</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Modified paramagnetic beads in a microfluidic system for the determination of ethinylestradiol (EE2) in river water samples</title>
    <abstract language="eng">In this work, we have developed and characterized a novel microfluidic immunoassay methodology for rapid and sensitive quantification of ethinylestradiol (EE2) in river water samples. The detection of EE2 was carried out using a competitive direct immunoassay method based on the use of anti-EE2 polyclonal antibodies immobilized on magnetic microspheres 3-aminopropyl-modified manipulated for an external removable magnet. The EE2 present in the water sample was allowed to compete with EE2-horseradish peroxidase (HPR) conjugated for the immobilized anti-EE2 antibody. The HPR, in the presence of hydrogen peroxide (H2O2) catalyzes the oxidation of catechol (Q) whose back electrochemical reduction was detected on gold electrode at 0.0 V. The response current obtained from the product of enzymatic reaction is inversely proportional to the amount of EE2 in the water sample. The electrochemical detection can be done within 1 min and total assay time was 30 min. The calculated detection limits for electrochemical detection and the ELISA procedure are 0.09 and 0.32 ng L-1 respectively and the intra- and inter-assay coefficients of variation were below 5.8%. Our electrochemical immunosensor showed higher sensitivity and lower time consumed than the standard spectrophotometric detection ELISA method, which shows the potential for assessment of EE2 in river water samples.</abstract>
    <parentTitle language="eng">Biosensors &amp; bioelectronics</parentTitle>
    <identifier type="old">24693</identifier>
    <identifier type="doi">10.1016/j.bios.2009.10.031</identifier>
    <identifier type="issn">0956-5663</identifier>
    <identifier type="issn">1873-4235</identifier>
    <enrichment key="bibliotheksstandort">Sonderstandort: Publica-Schrank</enrichment>
    <enrichment key="date_peer_review">28.10.2010</enrichment>
    <author>N.A. Martínez</author>
    <author>Rudolf Schneider</author>
    <author>G.A. Messina</author>
    <author>J. Raba</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Enzyme immunoassays</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Ethinylestradiol</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Paramagnetic beads</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Horseradish peroxidase</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Microfluidic</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Flow injection analysis</value>
    </subject>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Physisches Exemplar in der Bibliothek der BAM vorhanden ("Hardcopy Access")</collection>
  </doc>
  <doc>
    <id>62208</id>
    <completedYear/>
    <publishedYear>2025</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>373</pageFirst>
    <pageLast>412</pageLast>
    <pageNumber/>
    <edition/>
    <issue>Themed collection: Data-driven discovery in the chemical sciences</issue>
    <volume>256</volume>
    <type>article</type>
    <publisherName>Royal Society of Chemistry (RSC)</publisherName>
    <publisherPlace>Cambridge</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Discovering structure–property correlations: General discussion</title>
    <abstract language="eng">This article is a discussion of the paper "Web-BO: Towards increased accessibility of Bayesian optimisation (BO) for chemistry" by Austin M. Mroz, Piotr N. Toka, Ehecatl Antonio del Río Chanona and Kim E. Jelfs (Faraday discussions, 2025, 256, 221-234).</abstract>
    <parentTitle language="eng">Faraday discussions</parentTitle>
    <identifier type="doi">10.1039/d4fd90062f</identifier>
    <identifier type="issn">1359-6640</identifier>
    <identifier type="issn">1364-5498</identifier>
    <enrichment key="opus_doi_flag">true</enrichment>
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    <author>Andy S. Anker</author>
    <author>Alán Aspuru-Guzik</author>
    <author>Chiheb Ben Mahmoud</author>
    <author>Sophie Bennett</author>
    <author>Ksenia R. Briling</author>
    <author>Arya Changiarath</author>
    <author>Sanggyu Chong</author>
    <author>Christopher M. Collins</author>
    <author>Andrew I. Cooper</author>
    <author>Daniel Crusius</author>
    <author>Kevion K. Darmawan</author>
    <author>Basita Das</author>
    <author>Nicholas David</author>
    <author>Graeme M. Day</author>
    <author>Volker L. Deringer</author>
    <author>Fernanda Duarte</author>
    <author>Annabel Eardley-Brunt</author>
    <author>Matthew L. Evans</author>
    <author>Rob Evans</author>
    <author>Ian Fairlamb</author>
    <author>Barnabas A. Franklin</author>
    <author>Jeremy Frey</author>
    <author>Alex M. Ganose</author>
    <author>Mark Goulding</author>
    <author>Roohollah Hafizi</author>
    <author>Matthijs Hakkennes</author>
    <author>Niamh Hickey</author>
    <author>Gillian James</author>
    <author>Kim E. Jelfs</author>
    <author>Adarsh V. Kalikadien</author>
    <author>Venkat Kapil</author>
    <author>Zsuzsanna Koczor-Benda</author>
    <author>Ferdinand Krammer</author>
    <author>Heather J. Kulik</author>
    <author>Vishank Kumar</author>
    <author>Christian Kuttner</author>
    <author>Erwin Lam</author>
    <author>Yuchen Lou</author>
    <author>Eltjo Mante</author>
    <author>Jennie Martin</author>
    <author>Austin M. Mroz</author>
    <author>Tahereh Nematiaram</author>
    <author>Charles W. P. Pare</author>
    <author>Sarbani Patra</author>
    <author>James Proudfoot</author>
    <author>Branko Ruscic</author>
    <author>Matthew R. Ryder</author>
    <author>Ken Sakaushi</author>
    <author>Jörg Saßmannshausen</author>
    <author>Brett M. Savoie</author>
    <author>Nadine Schneider</author>
    <author>Philippe Schwaller</author>
    <author>Bastian Bjerkem Skjelstad</author>
    <author>Wenhao Sun</author>
    <author>Filip T. Szczypiński</author>
    <author>Steven Torrisi</author>
    <author>Katharina Ueltzen</author>
    <author>Shubham Vishnoi</author>
    <author>Aron Walsh</author>
    <author>Xinwei Wang</author>
    <author>Chloe Wilson</author>
    <author>Ruiqi Wu</author>
    <author>Jakob Zeitler</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Materials design</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Machine learning</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Automation</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Materials discovery</value>
    </subject>
    <collection role="ddc" number="620">Ingenieurwissenschaften und zugeordnete Tätigkeiten</collection>
    <collection role="institutes" number="">6 Materialchemie</collection>
    <collection role="themenfelder" number="">Material</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
    <collection role="institutes" number="">6.0 Abteilungsleitung und andere</collection>
    <collection role="themenfelder" number="">Materialdesign</collection>
  </doc>
  <doc>
    <id>639</id>
    <completedYear/>
    <publishedYear>1995</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>175</pageFirst>
    <pageLast>180</pageLast>
    <pageNumber/>
    <edition/>
    <issue>2</issue>
    <volume>5</volume>
    <type>article</type>
    <publisherName>Academ. Press</publisherName>
    <publisherPlace>Orlando, Fla.</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Double rotation and magic-angle spinning nuclear magnetic resonance study of 27Al: reexamination of the aluminium borate 9Al2O3 · 2B2O3</title>
    <abstract language="eng">27Al nuclear magnetic resonance spectra of polycrystalline aluminium borate 9Al2O3 · 2B2O3 have been measured in double rotation at 11.7 and 7.0 T and high-speed magic-angle spinning at 7.0, 9.4, 11.7, 14.1 and 17.6 T. Spinning sidebands from the satellite transitions were observed at 7.0 and 14.1 T. Each of the four structural aluminium sites [Al(IV), Al(V)(1), Al(V)(2) and Al(VI)] are observed, characterised and assigned in the spectra. The obtained parameter set gives a fully consistent interpretation in agreement with the crystal structure of the compound.</abstract>
    <parentTitle language="eng">Solid state nuclear magnetic resonance</parentTitle>
    <identifier type="old">74</identifier>
    <identifier type="doi">10.1016/0926-2040(95)00021-H</identifier>
    <identifier type="issn">0926-2040</identifier>
    <identifier type="issn">1527-3326</identifier>
    <enrichment key="date_peer_review">14.03.1997</enrichment>
    <author>D. Massiot</author>
    <author>D. Müller</author>
    <author>Thomas Hübert</author>
    <author>M. Schneider</author>
    <author>A. Kentgens</author>
    <author>B. Coté</author>
    <author>J. Coutures</author>
    <author>W. Gessner</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Aluminium</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Kernresonanz, magnetisch</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Winkel, magisch</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Doppelrotation</value>
    </subject>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Weder Datei noch physisches Exemplar vorhanden ("No Access")</collection>
  </doc>
  <doc>
    <id>2279</id>
    <completedYear/>
    <publishedYear>2003</publishedYear>
    <thesisYearAccepted/>
    <language>deu</language>
    <pageFirst>49</pageFirst>
    <pageLast>52</pageLast>
    <pageNumber/>
    <edition/>
    <issue>1/2</issue>
    <volume>63</volume>
    <type>article</type>
    <publisherName>Springer-VDI-Verl.</publisherName>
    <publisherPlace>Düsseldorf</publisherPlace>
    <creatingCorporation>BGIA, Institut für Arbeitsschutz</creatingCorporation>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="deu">Messungen der Radonexhalation aus Baustoffen unter Modellklimabedingungen</title>
    <parentTitle language="deu">Gefahrstoffe, Reinhaltung der Luft = Air quality control</parentTitle>
    <identifier type="old">2224</identifier>
    <identifier type="issn">0949-8036</identifier>
    <identifier type="issn">0039-0771</identifier>
    <identifier type="issn">1436-4891</identifier>
    <enrichment key="bibliotheksstandort">Sonderstandort: Publica-Schrank</enrichment>
    <enrichment key="bibliotheksstandort">ZS 22</enrichment>
    <enrichment key="date_peer_review">13.02.2003</enrichment>
    <author>Oliver Jann</author>
    <author>J. Köppke</author>
    <author>R. Lehmann</author>
    <author>Uwe Schneider</author>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Physisches Exemplar in der Bibliothek der BAM vorhanden ("Hardcopy Access")</collection>
  </doc>
  <doc>
    <id>29408</id>
    <completedYear/>
    <publishedYear>2013</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>397</pageFirst>
    <pageLast>405</pageLast>
    <pageNumber/>
    <edition/>
    <issue>5</issue>
    <volume>23</volume>
    <type>article</type>
    <publisherName>Danish Techn. Pr.</publisherName>
    <publisherPlace>Copenhagen</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Determination of radon exhalation from construction materials using VOC emission test chambers</title>
    <abstract language="eng">The inhalation of 222Rn (radon) decay products is one of the most important reasons for lung cancer after smoking. Stony building materials are an important source of indoor radon. This article describes the determination of the exhalation rate of stony construction materials by the use of commercially available measuring devices in combination with VOC emission test chambers. Five materials – two types of clay brick, clinker brick, light-weight concrete brick, and honeycomb brick – generally used for wall constructions were used for the experiments. Their contribution to real room concentrations was estimated by applying room model parameters given in ISO 16000-9, RP 112, and AgBB. This knowledge can be relevant, if for instance indoor radon concentration is limited by law. The test set-up used here is well suited for application in test laboratories dealing with VOC emission testing.</abstract>
    <parentTitle language="eng">Indoor air</parentTitle>
    <identifier type="old">32331</identifier>
    <identifier type="doi">10.1111/ina.12031</identifier>
    <identifier type="issn">0905-6947</identifier>
    <identifier type="issn">1600-0668</identifier>
    <enrichment key="date_peer_review">31.10.2013</enrichment>
    <author>Matthias Richter</author>
    <author>Oliver Jann</author>
    <author>J. Kemski</author>
    <author>Uwe Schneider</author>
    <author>Christian Krocker</author>
    <author>B. Hoffmann</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Radon exhalation</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Radon measurement</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Building material</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Emission test chamber</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Indoor air quality</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Real room radon concentrations</value>
    </subject>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>25656</id>
    <completedYear/>
    <publishedYear>2012</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>27</pageFirst>
    <pageLast>32</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>723</volume>
    <type>article</type>
    <publisherName>Elsevier</publisherName>
    <publisherPlace>Amsterdam</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Electrochemical detection of a powerful estrogenic endocrine disruptor: ethylestradiol in water samples through bioseparation procedure</title>
    <abstract language="eng">The synthetic estrogen ethinylestradiol (EE2) is an active component of oral contraceptives (OCs), considered as an endocrine disrupting compound (EDC). It is excreted from humans and released via sewage treatment plant effluents into aquatic environments. EDCs are any environmental pollutant chemical that, once incorporated into an organism, affects the hormonal balance of various species including humans. Its presence in the environment is becoming of great importance in water quality. This paper describes the development of an accurate, sensitive and selective method for capture, preconcentration and determination of EE2 present in water samples using: magnetic particles (MPs) as bioaffinity support for the capture and preconcentration of EE2 and a glassy carbon electrode modified with multi-walled carbon nanotubes (MWCNTs/GCE) as detection system. The capture procedure was based on the principle of immunoaffinity, the EE2 being extracted from the sample using the anti-EE2 antibodies (anti-EE2 Ab) which were previously immobilized on MPs. Subsequently the analyte desorption was done employing a sulfuric acid solution and the determination of the EE2 in the pre-concentrated solution was carried out by square wave voltammetry (SWV).&#13;
&#13;
This method can be used to determine EE2 in the range of 0.03570 ng L-1 with a detection limit (LOD) of 0.01 ng L-1 and R.S.D. &lt; 4.20%. The proposed method has been successfully applied to the determination of EE2 in water samples and it has promising analytical applications for the direct determination of EE2 at trace levels.</abstract>
    <parentTitle language="eng">Analytica chimica acta</parentTitle>
    <identifier type="old">28381</identifier>
    <identifier type="doi">10.1016/j.aca.2012.02.033</identifier>
    <identifier type="issn">0003-2670</identifier>
    <identifier type="issn">1873-4324</identifier>
    <identifier type="issn">0378-4304</identifier>
    <enrichment key="date_peer_review">29.03.2012</enrichment>
    <author>N.A. Martínez</author>
    <author>S.V. Pereira</author>
    <author>F.A. Bertolino</author>
    <author>Rudolf Schneider</author>
    <author>G.A. Messina</author>
    <author>J. Raba</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Magnetic particles</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Bioseparation</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Ethinylestradiol</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Electrochemistry</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Immunoassay</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Elektrochemischer Sensor</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Endokrine Disruptoren</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Hormone</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>EE2</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Östrogene</value>
    </subject>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>58151</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>5671</pageFirst>
    <pageLast>5677</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>95</volume>
    <type>article</type>
    <publisherName>American Chemical Society</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Fluorescence Quantum Yield Standards for the UV/Visible/NIR: Development, Traceable Characterization, and Certification</title>
    <abstract language="eng">The rational design of next generation molecular and nanoscale reporters and the comparison of different emitter classes require the determination of the fluorometric key performance parameter fluorescence quantum yield (Φf), i.e., the number of emitted photons per number of absorbed photons. Main prerequisites for reliable Φf measurements, which are for transparent luminophore solutions commonly done relative to a reference, i.e., a fluorescence quantum yield standard of known Φf, are reliable and validated instrument calibration procedures to consider wavelength-, polarization-, and time-dependent instrument specific signal contributions, and sufficiently well characterized fluorescence quantum yield standards. As the standard’s Φf value directly contributes to the calculation of the sample’s Φf, its accuracy presents one of the main sources of uncertainty of relative Φf measurements. To close this gap, we developed a first set of 12 fluorescence quantum yield standards, which absorb and emit in the wavelength region of 330−1000 nm and absolutely determined their Φf values with two independently calibrated integrating sphere setups.&#13;
Criteria for standard selection and the configuration of these novel fluorescence reference materials are given, and the certification procedure is presented including homogeneity and stability studies and the calculation of complete uncertainty budgets for the certified Φf values. The ultimate goal is to provide the community of fluorescence users with available reference materials as a basis for an improved comparability and reliability of quantum yield data since the measurement of this spectroscopic key property is an essential part of the characterization of any new emitter.</abstract>
    <parentTitle language="eng">Analytical chemistry</parentTitle>
    <identifier type="doi">10.1021/acs.analchem.2c05530</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="date_peer_review">04.09.2023</enrichment>
    <enrichment key="PaperofMonth">1</enrichment>
    <author>J. Pauli</author>
    <author>Arne Güttler</author>
    <author>T. Schneider</author>
    <author>Christian Würth</author>
    <author>Ute Resch-Genger</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Optical spectroscopy</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Traceability</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Reference product</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Dye</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fluorescence</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Quantum yield</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Reference material</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Reference data</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Certification</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Quality assurance</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="ddc" number="620">Ingenieurwissenschaften und zugeordnete Tätigkeiten</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.2 Biophotonik</collection>
    <collection role="themenfelder" number="">Umwelt</collection>
    <collection role="themenfelder" number="">Material</collection>
    <collection role="themenfelder" number="">Chemie und Prozesstechnik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
    <collection role="themenfelder" number="">Advanced Materials</collection>
    <collection role="themenfelder" number="">Sensorik</collection>
  </doc>
  <doc>
    <id>50983</id>
    <completedYear/>
    <publishedYear>2020</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>4146</pageFirst>
    <pageLast>4157</pageLast>
    <pageNumber/>
    <edition/>
    <issue>8</issue>
    <volume>51</volume>
    <type>article</type>
    <publisherName>Springer</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Using SXRR to Probe the Nature of Discontinuities in SLM Additive Manufactured Inconel 718 Specimens</title>
    <abstract language="eng">The utilization of additive manufacturing (AM) to fabricate robust structural components relies on understanding the nature of internal anomalies or discontinuities, which can compromise the structural integrity. While some discontinuities in AM microstructures stem from similar mechanisms as observed in more traditional processes such as casting, others are unique to the AM process. Discontinuities in AM are challenging to detect, due to their submicron size and orientation dependency. Toward the goal of improving structural integrity, minimizing discontinuities in an AM build requires an understanding of the mechanisms of formation to mitigate their occurrence. This study utilizes various techniques to evaluate the shape, size, nature and distribution of discontinuities in AM Inconel 718, in a non-hot isostatic pressed (HIPed) as-built, non-HIPed and direct age, and HIPed with two step age samples. Non-destructive synchrotron radiation refraction and transmission radiography (SXRR) provides additional information beyond that obtained with destructive optical microscopy. SXRR was able to distinguish between voids, cracks and lack of melt in, due to its sensitivity to the orientation of the discontinuity.</abstract>
    <parentTitle language="eng">Metallurgical and Materials Transactions A</parentTitle>
    <identifier type="doi">10.1007/s11661-020-05847-5</identifier>
    <identifier type="issn">1543-1940</identifier>
    <identifier type="urn">urn:nbn:de:kobv:b43-509836</identifier>
    <enrichment key="date_peer_review">08.07.2020</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>René Laquai</author>
    <author>Bernd R. Müller</author>
    <author>J. Schneider</author>
    <author>Andreas Kupsch</author>
    <author>Giovanni Bruno</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Additive manufacturing</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>X-ray refraction radiography</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>INCONEL 718</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Selective laser melting</value>
    </subject>
    <collection role="ddc" number="620">Ingenieurwissenschaften und zugeordnete Tätigkeiten</collection>
    <collection role="institutes" number="">8 Zerstörungsfreie Prüfung</collection>
    <collection role="institutes" number="">8.5 Röntgenbildgebung</collection>
    <collection role="themenfelder" number="">Material</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei für die Öffentlichkeit verfügbar ("Open Access")</collection>
    <collection role="unnumberedseries" number="">Wissenschaftliche Artikel der BAM</collection>
    <collection role="themenfelder" number="">Additive Fertigung</collection>
    <thesisPublisher>Bundesanstalt für Materialforschung und -prüfung (BAM)</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-bam/files/50983/Laquai_et_al_2020_SXRR_to_Probe_SLM_IN718_MetMatTransA_51.pdf</file>
  </doc>
  <doc>
    <id>53042</id>
    <completedYear/>
    <publishedYear>2021</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>2597</pageFirst>
    <pageLast>2606</pageLast>
    <pageNumber/>
    <edition/>
    <issue>13</issue>
    <volume>8</volume>
    <type>article</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Electrochemical Immunomagnetic Ochratoxin A Sensing: Steps Forward in the Application of 3,3’,5,5’- Tetramethylbenzidine in Amperometric Assays</title>
    <abstract language="deu">Electrochemical methods offer great promise in meeting the demand for user-friendly on-site devices for Monitoring important parameters. The food industry often runs own lab procedures, for example, for mycotoxin analysis, but it is a major goal to simplify analysis, linking analytical methods with smart technologies. Enzyme-linked immunosorbent assays, with photometric detection of 3,3’,5,5’-tetramethylbenzidine (TMB),form a good basis for sensitive detection. To provide a straightforward approach for the miniaturization of the detectionstep, we have studied the pitfalls of the electrochemical TMB detection. By cyclic voltammetry it was found that the TMB electrochemistry is strongly dependent on the pH and the electrode material. A stable electrode response to TMB could be achieved at pH 1 on gold electrodes. We created a smartphonebased, electrochemical, immunomagnetic assay for the detection of ochratoxin A in real samples, providing a solid basis forsensing of further analytes.</abstract>
    <parentTitle language="eng">ChemElectroChem</parentTitle>
    <identifier type="doi">10.1002/celc.202100446</identifier>
    <identifier type="urn">urn:nbn:de:kobv:b43-530421</identifier>
    <note>Geburtsname von Riedel, Soraya: Höfs, S. -  Birth name of Riedel, Soraya: Höfs, S.</note>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="date_peer_review">02.08.2021</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>Soraya Riedel</author>
    <author>Deniz Hülagü</author>
    <author>Francesca Bennet</author>
    <author>Peter Carl</author>
    <author>Sabine Flemig</author>
    <author>Thomas Schmid</author>
    <author>J. A. Schenk</author>
    <author>Vasile-Dan Hodoroaba</author>
    <author>Rudolf Schneider</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Ochratoxin A</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Amperometry</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Cyclic voltammetry</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Electrochemistry</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Immunoassay</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="ddc" number="620">Ingenieurwissenschaften und zugeordnete Tätigkeiten</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.4 Non-Target-Analytik</collection>
    <collection role="institutes" number="">1.8 Umweltanalytik</collection>
    <collection role="institutes" number="">6 Materialchemie</collection>
    <collection role="institutes" number="">6.1 Oberflächen- und Dünnschichtanalyse</collection>
    <collection role="themenfelder" number="">Umwelt</collection>
    <collection role="themenfelder" number="">Material</collection>
    <collection role="themenfelder" number="">Chemie und Prozesstechnik</collection>
    <collection role="themenfelder" number="">Chemische Charakterisierung und Spurenanalytik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei für die Öffentlichkeit verfügbar ("Open Access")</collection>
    <collection role="unnumberedseries" number="">Wissenschaftliche Artikel der BAM</collection>
    <collection role="institutes" number="">1.0 Abteilungsleitung und andere</collection>
    <collection role="themenfelder" number="">Sensorik</collection>
    <thesisPublisher>Bundesanstalt für Materialforschung und -prüfung (BAM)</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-bam/files/53042/Hoefs supporting information.pdf</file>
    <file>https://opus4.kobv.de/opus4-bam/files/53042/Electrochemical Immunomagnetic Ochratoxin A Sensing.pdf</file>
  </doc>
  <doc>
    <id>49305</id>
    <completedYear/>
    <publishedYear>2019</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>12988</pageFirst>
    <pageLast>12966</pageLast>
    <pageNumber/>
    <edition/>
    <issue>20</issue>
    <volume>91</volume>
    <type>article</type>
    <publisherName>ACS Publications</publisherName>
    <publisherPlace/>
    <creatingCorporation>American Chemical Society</creatingCorporation>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Wash-Free Multiplexed Mix-and-Read Suspension Array Fluorescence Immunoassay for Anthropogenic Markers in Wastewater</title>
    <abstract language="eng">Pharmaceuticals, certain food ingredients, and mammalian endogenous metabolic products in wastewater are mostly of human origin. They are anthropogenic markers.&#13;
Proper knowledge of their levels in wastewater helps to track sources of pollutants in natural waters and allows for calculation of removal efficiencies in wastewater Treatment plants. Here, we describe the development and application of an indirect competitive, multiplexing suspension Array fluorescence immunoassay (SAFIA) for the detection of carbamazepine (CBZ), diclofenac (DCF), caffeine (CAF), and isolithocholic acid (ILA) in wastewater, covering those classes of anthropogenic markers. The assay consists of haptens covalently conjugated to fluorescence-encoded polystyrene core/silica shell microparticles to create a site for competitive binding of the antibodies (Abs). Bound Abs are then stained with fluorophore-labeled Abs. Encoding and signaling fluorescence of the particles are determined by an automated flow cytometer.&#13;
For compatibility of the immunoassay with the 96-well microtiter plate format, a stop reagent, containing formaldehyde, is used. This enables a wash-free procedure while decreasing time-to-result. Detection limits of 140 ± 40 ng/L for CBZ, 180 ± 110 ng/L for CAF, 4 ± 3 ng/L for DCF, and 310 ± 70 ng/L for ILA are achieved, which meet the sensitivity criteria of wastewater analysis. We demonstrate the applicability of SAFIA to real wastewater samples from three different wastewater Treatment plants, finding the results in good agreement with LC-MS/MS. Moreover, the accuracy in general exceeded that from classical ELISAs. We therefore propose SAFIA as a quick and reliable approach for wastewater analysis meeting the requirements for process analytical technology.</abstract>
    <parentTitle language="eng">Analytical Chemistry</parentTitle>
    <identifier type="doi">10.1021/acs.analchem.9b03040</identifier>
    <identifier type="issn">0003-2700</identifier>
    <enrichment key="date_peer_review">18.12.2019</enrichment>
    <author>Peter Carl</author>
    <author>Dominik Sarma</author>
    <author>Bruno J. R. Gregório</author>
    <author>Kristin Hoffmann</author>
    <author>Andreas Lehmann</author>
    <author>Knut Rurack</author>
    <author>Rudolf Schneider</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Suspension Array</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Immunoassay</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Carbamazepine</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Caffeine</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Diclofenac</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>SAFIA</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="ddc" number="628">Sanitär- und Kommunaltechnik; Umwelttechnik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>52142</id>
    <completedYear/>
    <publishedYear>2021</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>40555</pageFirst>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>805</volume>
    <type>article</type>
    <publisherName>Elsevier B.V.</publisherName>
    <publisherPlace>Amsterdam</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">On the influence of heat treatment on microstructure and mechanical behavior of laser powder bed fused Inconel 718</title>
    <abstract language="eng">A range of heat treatments have been developed for wrought Inconel 718 to obtain desired properties. For additively manufactured Inconel 718, the recently developed standard ASTM F3301 provides guidance for heat treatment of powder bed fusion specimens. Although this standard is based on standards developed for wrought Inconel 718, it does not include direct aging. Since direct aging reduces the number of processing steps, it can result in a post processing cost reduction if the desired properties are obtained. In this study, we characterized the microstructure and tensile behavior of Inconel 718 specimens produced by a laser powder bed fusion process. The specimens were heat treated according to two different routines after stress relieving: a full heat Treatment versus a one-step direct aging process. Differences in the resulting texture and grain morphology were observed.&#13;
The ex-situ stress-strain behavior was broadly similar. However, a slight increase in yield strength was observed for the direct aged specimen. In order to understand this behavior, investigations with in-situ synchrotron Energy dispersive X-ray diffraction tensile testing revealed differences in the load partitioning among different Crystal directions. Importantly, the elastic anisotropy expressed by the magnitude of the diffraction elastic constants showed a dependency on the microstructures.</abstract>
    <parentTitle language="eng">Materials Science &amp; Engineering A</parentTitle>
    <identifier type="doi">10.1016/j.msea.2020.140555</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="date_peer_review">15.03.2021</enrichment>
    <author>Jakob Schröder</author>
    <author>Tatiana Mishurova</author>
    <author>Tobias Fritsch</author>
    <author>Itziar Serrano-Munoz</author>
    <author>Alexander Evans</author>
    <author>Maximilian Sprengel</author>
    <author>M. Klaus</author>
    <author>C. Genzel</author>
    <author>J. Schneider</author>
    <author>Giovanni Bruno</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Electron microscopy</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>X-ray analysis</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Inconel 718</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Additive Manufacturing</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Mechanical behavior</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Diffraction elastic constants</value>
    </subject>
    <collection role="ddc" number="620">Ingenieurwissenschaften und zugeordnete Tätigkeiten</collection>
    <collection role="institutes" number="">8 Zerstörungsfreie Prüfung</collection>
    <collection role="institutes" number="">8.5 Röntgenbildgebung</collection>
    <collection role="themenfelder" number="">Material</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
    <collection role="themenfelder" number="">Additive Fertigung</collection>
  </doc>
  <doc>
    <id>40062</id>
    <completedYear/>
    <publishedYear>2017</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>Article 21, 1</pageFirst>
    <pageLast>11</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>15</volume>
    <type>article</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Quantification of silver nanoparticle uptake and distribution within individual human macrophages by FIB/SEM slice and view</title>
    <abstract language="eng">Quantification of nanoparticle (NP) uptake in cells or tissues is very important for safety assessment. Often, electron microscopy based approaches are used for this purpose, which allow imaging at very high resolution. However, precise quantification of NP numbers in cells and tissues remains challenging. The aim of this study was to present a novel approach, that combines precise quantification of NPs in individual cells together with high resolution imaging of their intracellular distribution based on focused ion beam/ scanning electron microscopy (FIB/SEM) slice and view approaches.</abstract>
    <parentTitle language="eng">Journal of Nanobiotechnology</parentTitle>
    <identifier type="doi">10.1186/s12951-017-0255-8</identifier>
    <identifier type="issn">1477-3155</identifier>
    <identifier type="urn">urn:nbn:de:kobv:b43-400626</identifier>
    <enrichment key="date_peer_review">03.05.2017</enrichment>
    <licence>Creative Commons - Namensnennung 3.0</licence>
    <author>E. Guehrs</author>
    <author>M. Schneider</author>
    <author>Ch. M. Günther</author>
    <author>P. Hessing</author>
    <author>K. Heitz</author>
    <author>D. Wittke</author>
    <author>Ana López-Serrano Oliver</author>
    <author>Norbert Jakubowski</author>
    <author>J. Plendl</author>
    <author>S. Eisebitt</author>
    <author>A. Haase</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Nanoparticles</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>FIB/SEM slice and view</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Absolute dose</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Cellular internalization</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Macrophage</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei für die Öffentlichkeit verfügbar ("Open Access")</collection>
    <collection role="unnumberedseries" number="">Wissenschaftliche Artikel der BAM</collection>
    <thesisPublisher>Bundesanstalt für Materialforschung und -prüfung (BAM)</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-bam/files/40062/FIB_SEM.pdf</file>
  </doc>
  <doc>
    <id>37958</id>
    <completedYear/>
    <publishedYear>2016</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>25221</pageFirst>
    <pageLast>25229</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>18</volume>
    <type>article</type>
    <publisherName>RSC Publishing</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Pushing up the magnetisation values for iron oxide nanoparticles via zinc doping: X-ray studies on the particle's sub-nano structure of different synthesis routes</title>
    <abstract language="eng">The maximum magnetisation (saturation magnetisation) obtainable for iron oxide nanoparticles can be increased by doping the nanocrystals with non-magnetic elements such as zinc. Herein, we closely study how only slightly different synthesis approaches towards such doped nanoparticles strongly influence the resulting sub-nano/atomic structure. We compare two co-precipitation approaches, where we only vary the base (NaOH versus NH3), and a thermal decomposition route. These methods are the most commonly applied ones for synthesising doped iron oxide nanoparticles. The measurable magnetisation change upon zinc doping is about the same for all systems. However, the sub-nano structure, which we studied with Mössbauer and X-ray absorption near edge spectroscopy, differs tremendously. We found evidence that a much more complex picture has to be drawn regarding what happens upon Zn doping compared to what textbooks tell us about the mechanism. Our work demonstrates that it is crucial to study the obtained structures very precisely when “playing” with the atomic order in iron oxide nanocrystals.</abstract>
    <parentTitle language="eng">Physical Chemistry Chemical Physics</parentTitle>
    <identifier type="doi">10.1039/C6CP04221J</identifier>
    <identifier type="urn">urn:nbn:de:kobv:b43-379583</identifier>
    <enrichment key="date_peer_review">31.10.2016</enrichment>
    <licence>Creative Commons - Namensnennung 3.0</licence>
    <author>Wojciech Szczerba</author>
    <author>J. Zukrowski</author>
    <author>M. Przybylski</author>
    <author>M. Sikora</author>
    <author>O. Safonova</author>
    <author>A. Shmeliov</author>
    <author>V. Nicolosi</author>
    <author>M. Schneider</author>
    <author>T. Granath</author>
    <author>M. Oppmann</author>
    <author>M. Straßer</author>
    <author>K. Mandel</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Magnetic nanoparticles</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Zinc ferrite</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>magnetic saturation</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Mössbauer</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>XAFS</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Synthesis</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>XRD</value>
    </subject>
    <collection role="ddc" number="62">Ingenieurwissenschaften</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei für die Öffentlichkeit verfügbar ("Open Access")</collection>
    <collection role="unnumberedseries" number="">Wissenschaftliche Artikel der BAM</collection>
    <thesisPublisher>Bundesanstalt für Materialforschung und -prüfung (BAM)</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-bam/files/37958/Pushing up the magnetisation values for iron oxide nanoparticles via zinc doping.pdf</file>
  </doc>
  <doc>
    <id>37181</id>
    <completedYear/>
    <publishedYear>2016</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>5096</pageFirst>
    <pageLast>5106</pageLast>
    <pageNumber/>
    <edition/>
    <issue>17</issue>
    <volume>141</volume>
    <type>article</type>
    <publisherName>Royal Society of Chemistry</publisherName>
    <publisherPlace>Cambridge, UK</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Biomolecular environment, quantification, and intracellular interaction of multifunctional magnetic SERS nanoprobes</title>
    <abstract language="eng">Multifunctional composite nanoprobes consisting of iron oxide nanoparticles linked to silver and gold nanoparticles, Ag–Magnetite and Au–Magnetite, respectively, were introduced by endocytic uptake into cultured fibroblast cells. The cells containing the non-toxic nanoprobes were shown to be displaceable in an external magnetic field and can be manipulated in microfluidic channels. The distribution of the composite nanostructures that are contained in the endosomal system is discussed on the basis of surfaceenhanced Raman scattering (SERS) mapping, quantitative laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) micromapping, and cryo soft X-ray tomography (cryo soft-XRT). Cryo soft-XRT of intact, vitrified cells reveals that the composite nanoprobes form intra-endosomal aggregates. The nanoprobes provide SERS signals from the biomolecular composition of their surface in the endosomal environment. The SERS data indicate the high stability of the nanoprobes and of their plasmonic properties in the harsh environment of endosomes and lysosomes. The spectra point at the molecular composition at the surface of the Ag–Magnetite and Au–Magnetite nanostructures that is very similar to that of other Composite structures, but different from the composition of pure silver and gold SERS nanoprobes used for intracellular investigations. As shown by the LA-ICP-MS data, the uptake efficiency of the magnetite composites is approximately two to three times higher than that of the pure gold and silver nanoparticles.</abstract>
    <parentTitle language="eng">Analyst</parentTitle>
    <identifier type="doi">10.1039/c6an00890a</identifier>
    <identifier type="issn">0003-2654</identifier>
    <identifier type="urn">urn:nbn:de:kobv:b43-371811</identifier>
    <enrichment key="date_peer_review">30.09.2016</enrichment>
    <licence>Creative Commons - Namensnennung 3.0</licence>
    <author>T. Büchner</author>
    <author>D. Drescher</author>
    <author>V. Merk</author>
    <author>Heike Traub</author>
    <author>P. Guttmann</author>
    <author>St. Werner</author>
    <author>Norbert Jakubowski</author>
    <author>G. Schneider</author>
    <author>J. Kneipp</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Nanoparticles</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>SERS</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Cell</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>LA-ICP-MS</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>X-ray tomography</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei für die Öffentlichkeit verfügbar ("Open Access")</collection>
    <collection role="unnumberedseries" number="">Wissenschaftliche Artikel der BAM</collection>
    <thesisPublisher>Bundesanstalt für Materialforschung und -prüfung (BAM)</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-bam/files/37181/Buechner_etal_Analyst_2016_141_5096.pdf</file>
  </doc>
  <doc>
    <id>43348</id>
    <completedYear/>
    <publishedYear>2017</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>25033</pageFirst>
    <pageLast>25042</pageLast>
    <pageNumber/>
    <edition/>
    <issue>45</issue>
    <volume>121</volume>
    <type>article</type>
    <publisherName>ACS Publications</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Spectroscopic Study of the Role of Metal Ions in the Adsorption Process of Phosphate in Nanoscaled Adsorbers Based on Metal (Zn/ Fe/Zr) Oxyhydroxides</title>
    <abstract language="eng">Currently great effort is made to find materials and technologies for the recycling of phosphate from wastewater.&#13;
Herein, we present an in-depth study of the Phosphate adsorption mechanism of a promising adsorber material, a Zn−Fe−Zr oxyhydroxide-based nanostructured precipitate. The behavior of the multicomponent nanomaterial, consisting of both crystalline and amorphous parts, is investigated via X-ray absorption fine structure spectroscopy and Mössbauer spectroscopy, revealing the importance of the nanostructured composition for the phosphate adsorption. We found evidence that adsorption takes place especially in the vicinity of iron sites in the amorphous part of the material.</abstract>
    <parentTitle language="eng">The Journal of Physical Chemistry C</parentTitle>
    <identifier type="doi">10.1021/acs.jpcc.7b04773</identifier>
    <identifier type="issn">1932-7447</identifier>
    <enrichment key="date_peer_review">07.12.2017</enrichment>
    <author>Wojciech Szczerba</author>
    <author>M. Schneider</author>
    <author>J. Żukrowski</author>
    <author>Ana de Oliveira Guilherme Buzanich</author>
    <author>Heinrich Riesemeier</author>
    <author>M. Sikora</author>
    <author>K. Mandel</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Zn-Fe-Zr nanoparticles</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Adsorption of phosphate</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>XAFS</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Catalysis</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="ddc" number="620">Ingenieurwissenschaften und zugeordnete Tätigkeiten</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>26105</id>
    <completedYear/>
    <publishedYear>2012</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>557</pageFirst>
    <pageLast>563</pageLast>
    <pageNumber/>
    <edition/>
    <issue>3</issue>
    <volume>358</volume>
    <type>article</type>
    <publisherName>North-Holland Publ. Co.</publisherName>
    <publisherPlace>Amsterdam</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Silica dispersion in styrene butadiene rubber composites studied by synchrotron tomography</title>
    <abstract language="eng">By means of synchrotron X-ray computed tomography, model composites consisting of silica and styrenebutadiene rubber were studied with a very high spatial resolution. By our analysis technique we were able to determine the nano- and micro dispersion from the experimental results by our numerical analysis. These results are discussed with respect to crucial advantages of the generically 3-dimensional tomography technique as compared to 2-dimensional methods. Our quantitative analysis of the 3d images demonstrates that in the case of our model composites the filler dispersion is good, independent on the filler concentration. Our new 3-dimensional results evidence that considering only 2-d pictures may lead to ambiguities that can lead to wrong conclusions.</abstract>
    <parentTitle language="eng">Journal of non-crystalline solids</parentTitle>
    <identifier type="old">28850</identifier>
    <identifier type="doi">10.1016/j.jnoncrysol.2011.10.009</identifier>
    <identifier type="issn">0022-3093</identifier>
    <enrichment key="date_peer_review">28.06.2012</enrichment>
    <author>K. Nusser</author>
    <author>T. Mosbauer</author>
    <author>G. J. Schneider</author>
    <author>K. Brandt</author>
    <author>Gerd Weidemann</author>
    <author>Jürgen Goebbels</author>
    <author>Heinrich Riesemeier</author>
    <author>D. Göritz</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>X-ray tomography</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Silica</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Styrene butadiene rubber</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Dispersion</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>31836</id>
    <completedYear/>
    <publishedYear>2015</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>233</pageFirst>
    <pageLast>252</pageLast>
    <pageNumber/>
    <edition/>
    <issue>3</issue>
    <volume>36</volume>
    <type>article</type>
    <publisherName>Taylor &amp; Francis</publisherName>
    <publisherPlace>Philadelphia, Pa.</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Polyclonal murine and rabbit antibodies for the bile acid isolithocholic acid</title>
    <abstract language="eng">Bile acids are relevant markers for clinical research. This study reports the production of antibodies for isolithocholic acid, the isomer of the extensively studied lithocholic acid. The IgG titer and affinity maturation were monitored during the immunizations of three mice and two rabbits. In both animal models, polyclonal antibodies with a high selectivity and affinity were produced. The development of a direct competitive ELISA with a test midpoint of 0.69 ± 0.05 µg/L and a measurement range from 0.09–15 µg/L is reported. Additionally, the crystal structure of isolithocholic acid is described for the first time.</abstract>
    <parentTitle language="eng">Journal of immunoassay and immunochemistry</parentTitle>
    <identifier type="old">34885</identifier>
    <identifier type="doi">10.1080/15321819.2014.924419</identifier>
    <identifier type="issn">1532-1819</identifier>
    <identifier type="issn">1532-4230</identifier>
    <enrichment key="date_peer_review">06.11.2014</enrichment>
    <author>Stefanie Gärtner</author>
    <author>J.J. Carvalho</author>
    <author>Franziska Emmerling</author>
    <author>L.-A. Garbe</author>
    <author>Rudolf Schneider</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>ELISA</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Crystal structure</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Competitive assay</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Immunization monitoring</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>3ß-hydroxy-5ß-cholanic acid</value>
    </subject>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>65726</id>
    <completedYear/>
    <publishedYear>2026</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1</pageFirst>
    <pageLast>11</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>article</type>
    <publisherName>Royal Society of Chemistry</publisherName>
    <publisherPlace>London</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">MOF-metal nanohybrid-assisted charge transfer amplification for electrochemical biosensing of the MUC1 cancer biomarker</title>
    <abstract language="eng">Cancer is a severe disease characterized by high mortality and complex pathophysiology; however, its early and accurate diagnosis remains inadequate. Conventional diagnostic approaches often fall short, particularly for dense tissues, and are frequently invasive, costly, and of limited availability. This reinforces the need for a compact, economical, and ultrasensitive assay that is operationally simple and interpretable.&#13;
We present an efficient electrochemical detection platform for the cancer biomarker mucin 1 (MUC1). A fluorine-doped tin oxide (FTO) surface was modified with an iron-based metal–organic framework (FeMOF) intercalated with palladium nanorods (PdNR). FeMOF was prepared using Fe3+/Fe2+ precursors at a 1.2/1 mmol ratio and dual ligands, i.e. tetrahydroxy-1,4-benzoquinone and 2-aminobenzene-1,4-dicarboxylic acid. AntiMUC1 antibodies were immobilized on a modified electrode via p-phenylenediamine (PDA) (FTO/FeMOF@PdNR/PDA/antiMUC1Ab) and evaluated using electrochemical impedance spectroscopy (EIS) and voltammetry. The designed sensor demonstrated an excellent binding affinity for the MUC1 antigen. Among these techniques, the EIS method stands out for its technical performance, as evidenced by the high sensitivity (detection limit 0.074 fg mL−1), quantification limit 0.24 fg mL−1, and high analytical sensitivity (1.39 × 103 Ω fg−1 mL−1 cm−2). The negligible cross-reactivity with interferent biomolecules, rapid response (10-minute equilibrium), regenerability up to 5 cycles, high reproducibility (RSD ∼1–3%), and long-term stability (up to 35 days) further validate the suitability of the proposed MUC1 immunosensor. This study presents an ultrasensitive biosensor that is compact, cost-effective, and easy for individuals at home to use after further development into a kit-based end product. Moreover, its excellent functionality for spiked serum samples shows promise for next-generation clinical diagnostics.</abstract>
    <parentTitle language="eng">Analyst</parentTitle>
    <identifier type="doi">10.1039/D6AN00018E</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="date_peer_review">25.03.2026</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <author>Sarita Devi</author>
    <author>S. Goel</author>
    <author>S. Rani</author>
    <author>Rudolf J. Schneider</author>
    <author>R. Rohilla</author>
    <author>Surbhi Kumari</author>
    <author>N. Prabhakar</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Antibodies</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Metal-organic framework</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Immunoassay</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.8 Umweltanalytik</collection>
    <collection role="themenfelder" number="">Chemie und Prozesstechnik</collection>
    <collection role="themenfelder" number="">Chemische Charakterisierung und Spurenanalytik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>48952</id>
    <completedYear/>
    <publishedYear>2020</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>Paper 101877, 1</pageFirst>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>82</volume>
    <type>article</type>
    <publisherName>Elsevier Ltd.</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Reliability analysis of deteriorating structural systems</title>
    <abstract language="eng">Reliability analysis of deteriorating structural systems requires the solution of time-variant reliability problems.&#13;
In the general case, both the capacity of and the loads on the structure vary with time. This analysis can be approached by approximation through a series of time-invariant reliability problems, which is a potentially effective strategy for cases where direct solutions of the time-variant reliability problem are challenging, e.g. for structural systems with many elements or arbitrary load processes. In this contribution, we thoroughly Review the formulation of the equivalent time-invariant reliability problems and extend this approximation to structures for which inspection and monitoring data is available. Thereafter, we present methods for efficiently evaluating the reliability over time. In particular, we propose the combination of sampling-based methods with a FORM (first-order reliability method) approximation of the series system reliability problem that arises in the computation of the lifetime reliability. The framework and algorithms are demonstrated on a set of numerical examples, which include the computation of the reliability conditional on inspection data.</abstract>
    <parentTitle language="eng">Structural Safety</parentTitle>
    <identifier type="doi">10.1016/j.strusafe.2019.101877</identifier>
    <enrichment key="date_peer_review">12.12.2019</enrichment>
    <author>D. Straub</author>
    <author>Ronald Schneider</author>
    <author>E. Bismut</author>
    <author>H.-J. Kim</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Monitoring</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Reliability</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Deterioration</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Structural systems</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Bayesian analysis</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Inspection</value>
    </subject>
    <collection role="ddc" number="624">Ingenieurbau</collection>
    <collection role="institutes" number="">7 Bauwerkssicherheit</collection>
    <collection role="institutes" number="">7.2 Ingenieurbau</collection>
    <collection role="themenfelder" number="">Infrastruktur</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>60231</id>
    <completedYear/>
    <publishedYear>2024</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1</pageFirst>
    <pageLast>7</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>271</volume>
    <type>article</type>
    <publisherName>Elsevier B.V.</publisherName>
    <publisherPlace>Amsterdam</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Microcarrier-based fluorescent yeast estrogen screen assay for fast determination of endocrine disrupting compounds</title>
    <abstract language="eng">The presence of endocrine-disrupting compounds (EDCs) in water poses a significant threat to human and animal health, as recognized by regulatory agencies throughout the world. The Yeast Estrogen Screen (YES) assay is an excellent method to evaluate the presence of these compounds in water due to its simplicity and capacity to assess the bioaccessible forms/fractions of these compounds. In the presence of a compound with estrogenic activity, Saccharomyces cerevisiae cells, containing a lacZ reporter gene encoding the enzyme β-galactosidase, are induced, the enzyme is synthesised, and released to the extracellular medium. In this work, a YES-based approach encompassing the use of a lacZ reporter gene modified strain of S. cerevisiae, microcarriers as solid support, and a fluorescent substrate, fluorescein di-β-D-galactopyranoside, is proposed, allowing for the assessment of EDCs’ presence after only 2 h of incubation. The proposed method provided an EC50 of 0.17 ± 0.03 nM and an LLOQ of 0.03 nM, expressed as 17β-estradiol. The assessment of different EDCs provided EC50 values between 0.16 and 1.2 × 103 nM. After application to wastewaters, similar results were obtained for EDCs screening, much faster, compared to the conventional 45 h spectrophotometric procedure using a commercial kit, showing potential for onsite high-throughput screening of environmental contamination.</abstract>
    <parentTitle language="eng">Talanta</parentTitle>
    <identifier type="doi">10.1016/j.talanta.2024.125665</identifier>
    <identifier type="urn">urn:nbn:de:kobv:b43-602315</identifier>
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    <licence>Creative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International</licence>
    <author>Bruno J.R. Gregório</author>
    <author>Inês I. Ramos</author>
    <author>Sara S. Marques</author>
    <author>Luísa Barreiros</author>
    <author>Luís M. Magalhães</author>
    <author>Rudolf Schneider</author>
    <author>Marcela A. Segundo</author>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Biosensoren</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>YES assay</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Endokrine Disruptoren</value>
    </subject>
    <collection role="ddc" number="628">Sanitär- und Kommunaltechnik; Umwelttechnik</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.8 Umweltanalytik</collection>
    <collection role="themenfelder" number="">Umwelt</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei für die Öffentlichkeit verfügbar ("Open Access")</collection>
    <collection role="unnumberedseries" number="">Wissenschaftliche Artikel der BAM</collection>
    <collection role="themenfelder" number="">Sensorik</collection>
    <thesisPublisher>Bundesanstalt für Materialforschung und -prüfung (BAM)</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-bam/files/60231/Microcarrier-based YES_EDC.pdf</file>
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  <doc>
    <id>32734</id>
    <completedYear/>
    <publishedYear>2015</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>2518</pageFirst>
    <pageLast>2529</pageLast>
    <pageNumber/>
    <edition/>
    <issue>9</issue>
    <volume>13</volume>
    <type>article</type>
    <publisherName>RSC</publisherName>
    <publisherPlace>Cambridge</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
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    <title language="eng">Antibodies armed with photosensitizers: from chemical synthesis to photobiological applications</title>
    <abstract language="eng">Targeting photosensitizers to cancer cells by conjugating them with specific antibodies, able to recognize and bind to tumor-associated antigens, is today one of the most attractive strategies in photodynamic therapy (PDT). This comprehensive review updates on chemical routes available for the preparation of photo-immunoconjugates (PICs), which show dual chemical and biological functionalities: photo-properties of the photosensitizer and the immunoreactivity of the antibody. Moreover, photobiological results obtained with such photo-immunoconjugates using in vitro and in vivo cancer models are also discussed.</abstract>
    <parentTitle language="eng">Organic &amp; biomolecular chemistry</parentTitle>
    <identifier type="old">35810</identifier>
    <identifier type="doi">10.1039/c4ob02334j</identifier>
    <identifier type="issn">1477-0520</identifier>
    <identifier type="issn">1477-0539</identifier>
    <enrichment key="date_peer_review">12.03.2015</enrichment>
    <author>P.M.R. Pereira</author>
    <author>B. Korsak</author>
    <author>B. Sarmento</author>
    <author>Rudolf Schneider</author>
    <author>R. Fernandes</author>
    <author>J.P.C. Tomé</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Therapeutische Antikörper</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Krebstherapie</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Photodynamische Therapie</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Konjugate</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Porphyrine</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Phthalocyanine</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Chlorine</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Kopplungsmethoden</value>
    </subject>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
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  <doc>
    <id>32322</id>
    <completedYear/>
    <publishedYear>2014</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>45</pageFirst>
    <pageLast>56</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>413</volume>
    <type>article</type>
    <publisherName>Elsevier B.V.</publisherName>
    <publisherPlace>Amsterdam</publisherPlace>
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    <belongsToBibliography>1</belongsToBibliography>
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    <title language="eng">Comparative characterization of mAb producing hapten-specific hybridoma cells by flow cytometric analysis and ELISA</title>
    <abstract language="eng">A novel method that optimizes the screening for antibody-secreting hapten-specific hybridoma cells by using flow cytometry is described. Cell clones specific for five different haptens were analyzed. We selectively double stained and analyzed fixed hybridoma cells with fluorophore-labeled haptens to demonstrate the target-selectivity, and with a fluorophore-labeled anti-mouse IgG antibody to characterize the level of surface expression of membrane-bound IgGs. ELISA measurements with the supernatants of the individual hybridoma clones revealed that antibodies from those cells, which showed the highest fluorescence intensities in the flow cytometric analysis, also displayed the highest affinities for the target antigens. The fluorescence intensity of antibody-producing cells corresponded well with the produced antibodies' affinities toward their respective antigens. Immunohistochemical staining verified the successful double labeling of the cells. Our method makes it possible to perform a high-throughput screening for hybridoma cells, which have both an adequate IgG production rate and a high target affinity.</abstract>
    <parentTitle language="eng">Journal of immunological methods</parentTitle>
    <identifier type="old">35388</identifier>
    <identifier type="doi">10.1016/j.jim.2014.07.004</identifier>
    <identifier type="issn">0022-1759</identifier>
    <identifier type="issn">1872-7905</identifier>
    <enrichment key="date_peer_review">22.12.2014</enrichment>
    <author>Maren Kuhne</author>
    <author>Martin Dippong</author>
    <author>Sabine Flemig</author>
    <author>Katrin Hoffmann</author>
    <author>K. Petsch</author>
    <author>J.A. Schenk</author>
    <author>Hans-Jörg Kunte</author>
    <author>Rudolf Schneider</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Immunization</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Hapten</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Monoclonal antibodies</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Hybridoma</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Flow cytometry</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>ELISA</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Estradiol</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Estrone</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Digoxigenin</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Zearalenone</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Aflatoxin</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>CLSM</value>
    </subject>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>709</id>
    <completedYear/>
    <publishedYear>1999</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>33</pageFirst>
    <pageLast>39</pageLast>
    <pageNumber/>
    <edition/>
    <issue>1-2</issue>
    <volume>151</volume>
    <type>article</type>
    <publisherName>North-Holland</publisherName>
    <publisherPlace>Amsterdam</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Laser-damaging as a useful tool for materials characterization by Raman microscopy</title>
    <parentTitle language="eng">Applied surface science</parentTitle>
    <identifier type="old">161</identifier>
    <identifier type="issn">0169-4332</identifier>
    <identifier type="issn">1873-5584</identifier>
    <enrichment key="date_peer_review">10.12.1999</enrichment>
    <author>Klaus Witke</author>
    <author>Dieter Klaffke</author>
    <author>Thomas Schneider</author>
    <author>J.P. Schreckenbach</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Raman-Mikroskopie</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Raman-Laser</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Laserstrahlbearbeitung</value>
    </subject>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Weder Datei noch physisches Exemplar vorhanden ("No Access")</collection>
  </doc>
  <doc>
    <id>37125</id>
    <completedYear/>
    <publishedYear>2016</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>19083</pageFirst>
    <pageLast>19092</pageLast>
    <pageNumber/>
    <edition/>
    <issue>28</issue>
    <volume>18</volume>
    <type>article</type>
    <publisherName>RSC</publisherName>
    <publisherPlace>Cambridge</publisherPlace>
    <creatingCorporation>RSC</creatingCorporation>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">pH and concentration dependence of the optical properties of thiol-capped CdTe nanocrystals in water and D2O</title>
    <abstract language="eng">The optical properties of semiconductor nanocrystals (SC NCs) are largely controlled by their size and surface chemistry, i.e., the chemical composition and thickness of inorganic passivation shells and the chemical nature and number of surface ligands as well as the strength of their bonds to surface atoms.&#13;
The latter is particularly important for CdTe NCs, which – together with alloyed CdₓHg₁₋ₓTe – are the only SC NCs that can be prepared in water in high quality without the need for an additional inorganic passivation shell. Aiming at a better understanding of the role of stabilizing ligands for the control of the application-relevant fluorescence features of SC NCs, we assessed the influence of two of the most commonly used monodentate thiol ligands, thioglycolic acid (TGA) and mercaptopropionic acid (MPA),&#13;
on the colloidal stability, photoluminescence (PL) quantum yield (QY), and PL decay behavior of a set of CdTe NC colloids. As an indirect measure for the strength of the coordinative bond of the ligands to SC NC surface atoms, the influence of the pH (pD) and the concentration on the PL properties of these colloids was examined in water and D₂O and compared to the results from previous dilution studies with a set of thiol-capped Cd₁₋ₓHgₓTe SC NCs in D₂O. As a prerequisite for these studies, the number of surface ligands was determined photometrically at different steps of purification after SC NC synthesis with Ellman’s test.&#13;
Our results demonstrate ligand control of the pH-dependent PL of these SC NCs, with MPA-stabilized CdTe NCs being less prone to luminescence quenching than TGA-capped ones. For both types of CdTe colloids, ligand desorption is more pronounced in H₂O compared to D₂O, underlining also the role of hydrogen bonding and solvent molecules.</abstract>
    <parentTitle language="eng">Physical Chemistry Chemical Physics</parentTitle>
    <identifier type="doi">10.1039/c6cp03123d</identifier>
    <identifier type="urn">urn:nbn:de:kobv:b43-371253</identifier>
    <enrichment key="date_peer_review">16.08.2016</enrichment>
    <licence>Creative Commons - Namensnennung - Nicht kommerziell 3.0</licence>
    <author>Ralf Schneider</author>
    <author>Florian Weigert</author>
    <author>V. Lesnyak</author>
    <author>S. Leubner</author>
    <author>T. Lorenz</author>
    <author>Thomas Behnke</author>
    <author>A. Dubavik</author>
    <author>J.-O. Joswig</author>
    <author>Ute Resch-Genger</author>
    <author>N. Gaponik</author>
    <author>A. Eychmüller</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Quantum dots</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fluorescence</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Ligand analysis</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Nano particles</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei für die Öffentlichkeit verfügbar ("Open Access")</collection>
    <collection role="unnumberedseries" number="">Wissenschaftliche Artikel der BAM</collection>
    <thesisPublisher>Bundesanstalt für Materialforschung und -prüfung (BAM)</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-bam/files/37125/RS_PCCP 2016_pH and concentration dependence of the optical properties of thiol-capped CdTe nanocrystals in water and D2O(1).pdf</file>
  </doc>
  <doc>
    <id>50209</id>
    <completedYear/>
    <publishedYear>2019</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>062908</pageFirst>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue>6</issue>
    <volume>37</volume>
    <type>article</type>
    <publisherName>AIP</publisherName>
    <publisherPlace>New York, NY</publisherPlace>
    <creatingCorporation>American Vacuum Society</creatingCorporation>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Thin-film metrology of tilted and curved surfaces by imaging Mueller-matrix ellipsometry</title>
    <abstract language="eng">For the vast majority of ellipsometric measurements, the application of planar substrates is mandatory and requires a proper sample alignment prior to the measurement. Here, the authors present a generalized approach of how to extract the isotropic ellipsometric sample parameters from an imaging Mueller-matrix measurement even if the sample is significantly misaligned. They validate the method by layer-thickness calculations based on imaging Mueller-matrix measurements of flat crystalline silicon samples that were misaligned on purpose. Furthermore, they also exploit this method’s capabilities to perform spatially resolved layer-thickness measurements of a single-layer indium-tin-oxide coating on a fused-silica microlens without the need of realignment or repositioning of the sample during the measurement.</abstract>
    <parentTitle language="eng">Journal of Vacuum Science &amp; Technology B</parentTitle>
    <identifier type="doi">10.1116/1.5122757</identifier>
    <identifier type="issn">2166-2746</identifier>
    <identifier type="issn">2327-9877</identifier>
    <enrichment key="eventName">8th International conference on spectroscopic ellipsometry (ICSE-8)</enrichment>
    <enrichment key="eventPlace">Barcelona, Spain</enrichment>
    <enrichment key="eventStart">26.05.2019</enrichment>
    <enrichment key="eventEnd">31.05.2019</enrichment>
    <enrichment key="date_peer_review">16.04.2020</enrichment>
    <author>M. Duwe</author>
    <author>J.-H. Quast</author>
    <author>S. Schneider</author>
    <author>Daniel Fischer</author>
    <author>Uwe Beck</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Metrology</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Thin films</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Polarization spectroscopy</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Spectroskopic Imaging</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Mueller-Matrix imaging ellipsometry</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="ddc" number="620">Ingenieurwissenschaften und zugeordnete Tätigkeiten</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>49810</id>
    <completedYear/>
    <publishedYear>2019</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>062906-1</pageFirst>
    <pageLast>062906-5</pageLast>
    <pageNumber/>
    <edition/>
    <issue>6</issue>
    <volume>37</volume>
    <type>article</type>
    <publisherName>American Vacuum Society</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Effect of curvature of spherical microscopic indentations on the ellipsometric readout</title>
    <abstract language="eng">The authors describe and interpret curvature-related changes to the ellipsometric readout. As model system for a concave curvature, a set of three spherical microscopic indents in silicon (100) of different sizes was prepared by instrumented indentation testing using a spherical indenter. For reference, these samples were characterized by AFM to reveal the topography of each structure. The concavelike indents were analyzed by Mueller-Matrix imaging ellipsometry to extract lateral intensity images of 12 elements of the Mueller-Matrix. As a result of the detailed analysis of the image elements m22, m23, and m14, it was possible to correlate intensity changes and symmetry properties to depolarization and cross polarization induced by the edge threshold and the curved surface of the indent.</abstract>
    <parentTitle language="eng">Journal of Vacuum Science &amp; Technology B 37</parentTitle>
    <identifier type="doi">10.1116/1.5122252</identifier>
    <identifier type="urn">urn:nbn:de:kobv:b43-498105</identifier>
    <enrichment key="date_peer_review">16.04.2020</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>Daniel Fischer</author>
    <author>Michael Griepentrog</author>
    <author>Uwe Beck</author>
    <author>M. Duwe</author>
    <author>J.-H. Quast</author>
    <author>S. Schneider</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Spectroskopic Imaging</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Mueller-Matrix imaging ellipsometry</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Structural anomalies</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Structural inhomogenities</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="ddc" number="620">Ingenieurwissenschaften und zugeordnete Tätigkeiten</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei für die Öffentlichkeit verfügbar ("Open Access")</collection>
    <thesisPublisher>Bundesanstalt für Materialforschung und -prüfung (BAM)</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-bam/files/49810/1.5122252.pdf</file>
  </doc>
  <doc>
    <id>25283</id>
    <completedYear/>
    <publishedYear>2012</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>63</pageFirst>
    <pageLast>70</pageLast>
    <pageNumber/>
    <edition/>
    <issue>1</issue>
    <volume>26</volume>
    <type>article</type>
    <publisherName>In vivo</publisherName>
    <publisherPlace>Athens</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Non-invasive monitoring of immunization progress in mice via IgG from feces</title>
    <abstract language="eng">A non-invasive method to monitor the humoral immune response in mice after immunization is described. From fecal pellets of an individual mouse, a sufficient amount of active immunoglobulins or their fragments can be extracted to perform a regular examination of the status of the immune response by immunoassay. Hapten-specific antibodies from the feces of mice from three immunization trials showed very similar characteristics to those obtained from serum at a given date. Therefore, it can be suspected that some serum IgG enters the intestinal lumen and ends up in the feces, where they appear to be considerably stable. Hapten-specific IgAs were not found in the feces. Being able to analyze antibody titers in feces could be an interesting animal welfare refinement to standard practice that does not entail repeated blood sampling.</abstract>
    <parentTitle language="eng">In vivo</parentTitle>
    <identifier type="old">27991</identifier>
    <identifier type="url">http://iv.iiarjournals.org/content/26/1/63.full.pdf+html</identifier>
    <identifier type="issn">0258-851x</identifier>
    <enrichment key="bibliotheksstandort">Sonderstandort: Publica-Schrank</enrichment>
    <enrichment key="date_peer_review">09.01.2012</enrichment>
    <author>José Joao Carvalho</author>
    <author>Astrid Walter</author>
    <author>Yvonne Baermann</author>
    <author>Michael G. Weller</author>
    <author>Ulrich Panne</author>
    <author>J.A. Schenk</author>
    <author>Rudolf Schneider</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Immunization monitoring</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>IgG</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Coproantibodies</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Feces</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Animal welfare</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>3R concept</value>
    </subject>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Physisches Exemplar in der Bibliothek der BAM vorhanden ("Hardcopy Access")</collection>
  </doc>
</export-example>
