<?xml version="1.0" encoding="utf-8"?>
<export-example>
  <doc>
    <id>44561</id>
    <completedYear/>
    <publishedYear>2018</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>357</pageFirst>
    <pageLast>369</pageLast>
    <pageNumber/>
    <edition/>
    <issue>2</issue>
    <volume>18</volume>
    <type>bookpartcollection</type>
    <publisherName>Elsevier</publisherName>
    <publisherPlace>New York</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">The GDF5 mutant BB-1 enhances the bone formation induced by an injectable, poly(l-lactide-co-glycolide) acid (PLGA) fiber-reinforced, brushite-forming cement in a sheep defect model of lumbar osteopenia</title>
    <abstract language="eng">BACKGROUND CONTEXT: Targeted delivery of osteoinductive bone morphogenetic Proteins (eg, GDF5) in bioresorbable calcium phosphate cement (CPC), potentially suitable for vertebroplasty and kyphoplasty of osteoporotic vertebral fractures, may be required to counteract augmented local bone catabolism and to support complete bone regeneration. The biologically optimized GDF5 Mutant BB-1 may represent an attractive drug candidate for this purpose.&#13;
PURPOSE: The aim of the current study was to test an injectable, poly (l-lactide-co-glycolide) acid (PLGA) fiber-reinforced, brushite-forming CPC containing low-dose BB-1 in a sheep lumbar osteopenia model.&#13;
STUDY DESIGN/ SETTING: This is a prospective experimental animal study.&#13;
METHODS: Bone defects (diameter 5 mm) were generated in aged, osteopenic female sheep and were filled with fiber-reinforced CPC alone (L4; CPC+fibers) or with CPC containing different dosages.</abstract>
    <parentTitle language="eng">The Spine Journal</parentTitle>
    <identifier type="doi">10.1016/j.spinee.2017.10.002</identifier>
    <identifier type="issn">1529-9430</identifier>
    <identifier type="issn">1878-1632</identifier>
    <enrichment key="date_peer_review">23.03.2018</enrichment>
    <author>F. Gunella</author>
    <author>E. Kunisch</author>
    <author>S. Maenz</author>
    <author>V. Horbert</author>
    <author>L. Xin</author>
    <author>J. Mika</author>
    <author>J. Borowski</author>
    <author>S. Bischoff</author>
    <author>H. Schubert</author>
    <author>A. Sachse</author>
    <author>Bernhard Illerhaus</author>
    <author>Jens Günster</author>
    <author>J. Bossert</author>
    <author>K. D. Jandt</author>
    <author>F. Plöger</author>
    <author>R. W. Kinne</author>
    <author>O. Brinkmann</author>
    <author>M. Bungartz</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Bone morphogenetic protein;</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Bone regeneration;</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Micro-Computed-Tomography;</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Calcium phosphate cement;</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>GDF-5 mutant;</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Large animal model sheep;</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Osteoporotic vertebral fracture</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
</export-example>
