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    <title language="eng">A 3D printed bone tissue engineering scaffold composed of alginate dialdehyde-gelatine reinforced by lysozyme loaded cerium doped mesoporous silica-calcia nanoparticles</title>
    <abstract language="eng">A novel biomaterial comprising alginate dialdehyde-gelatine (ADA-GEL) hydrogel augmented by lysozyme loaded mesoporous cerium doped silica-calcia nanoparticles (Lys-Ce-MSNs) is 3D printed to create bioactive scaffolds. Lys-Ce-MSNs raise the mechanical stiffness of the hydrogel composite scaffold and induce surface apatite mineralization, when the scaffold is immersed in simulated body fluid (SBF). Moreover, the scaffolds can co-deliver bone healing (Ca and Si) and antioxidant ions (Ce), and Lys to achieve antibacterial (and potentially anticancer) properties. The nanocomposite hydrogel scaffolds can hold and deliver Lys steadily. Based on the in vitro results, the hydrogel nanocomposite containing Lys assured improved pre-osteoblast cell (MC3T3-E1) proliferation, adhesion, and differentiation, thanks to the biocompatibility of ADA-GEL, bioactivity of Ce-MSNs, and the stabilizing effect of Lys on the scaffold structure. On the other hand, the proliferation level of MG63 osteosarcoma cells decreased, likely due to the effect of Lys. Last but not least, cooperatively, alongside gentamicin (GEN), Lys brought about a proper antibacterial efficiency to the hydrogel nanocomposite scaffold against gram-positive and gram-negative bacteria. Taken together, ADA-GEL/Lys-Ce-MSN nanocomposite holds great promise for 3D printing of multifunctional hydrogel bone tissue engineering (BTE) scaffolds, able to induce bone regeneration, address infection, and potentially inhibit tumor formation and growth.</abstract>
    <parentTitle language="eng">Macromolecular bioscience</parentTitle>
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    <identifier type="doi">10.1002/mabi.202200113</identifier>
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    <author>M. Monavari</author>
    <author>R. Medhekar</author>
    <author>Q. Nawaz</author>
    <author>Mehran Monavari</author>
    <author>M. Fuentes‐Chandía</author>
    <author>S. Homaeigohar</author>
    <author>A. R. Boccaccini</author>
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      <language>eng</language>
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      <value>Materials chemistry</value>
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      <language>eng</language>
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      <value>Polymers and plastics</value>
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    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Biomaterials</value>
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    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Bioengineering</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Biotechnology</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>3D printing</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Bone tissue engineering</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Drug delivery</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Lysozyme</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Mesoporous SiO2-CaO nanoparticles</value>
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    <pageLast>11</pageLast>
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    <edition/>
    <issue/>
    <volume>131</volume>
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    <title language="eng">3D printing of alginate dialdehyde-gelatin (ADA-GEL) hydrogels incorporating phytotherapeutic icariin loaded mesoporous SiO2-CaO nanoparticles for bone tissue engineering</title>
    <abstract language="eng">3D printing enables a better control over the microstructure of bone restoring constructs, addresses the challenges seen in the preparation of patient-specific bone scaffolds, and overcomes the bottlenecks that can appear in delivering drugs/growth factors promoting bone regeneration. Here, 3D printing is employed for the fabrication of an osteogenic construct made of hydrogel nanocomposites. Alginate dialdehyde-gelatin (ADA-GEL) hydrogel is reinforced by the incorporation of bioactive glass nanoparticles, i.e. mesoporous silica-calcia nanoparticles (MSNs), in two types of drug (icariin) loading. The composites hydrogel is printed as superhydrated composite constructs in a grid structure. The MSNs not only improve the mechanical stiffness of the constructs but also induce formation of an apatite layer when the construct is immersed in simulated body fluid (SBF), thereby promoting cell adhesion and proliferation. The nanocomposite constructs can hold and deliver icariin efficiently, regardless of its incorporation mode, either as loaded into the MSNs or freely distributed within the hydrogel. Biocompatibility tests showed that the hydrogel nanocomposites assure enhanced osteoblast proliferation, adhesion, and differentiation. Such optimum biological properties stem from the superior biocompatibility of ADA-GEL, the bioactivity of the MSNs, and the supportive effect of icariin in relation to cell Proliferation and differentiation. Taken together, given the achieved structural and biological properties and effective drug delivery capability, the hydrogel nanocomposites show promising potential for bone tissue engineering.</abstract>
    <parentTitle language="eng">Materials Science &amp; Engineering C</parentTitle>
    <identifier type="doi">10.1016/j.msec.2021.112470</identifier>
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    <author>M. Monavari</author>
    <author>S. Homaeigohar</author>
    <author>M. Fuentes-Chandía</author>
    <author>Q. Nawaz</author>
    <author>Mehran Monavari</author>
    <author>A. Venkatraman</author>
    <author>A. Boccaccini</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>3D printed hydrogel</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>ADA-GEL</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Drug delivery</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Mesoporous SiO2-CaO nanoparticles</value>
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    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Bone tissue engineering</value>
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    <collection role="ddc" number="543">Analytische Chemie</collection>
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    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
    <collection role="themenfelder" number="">Advanced Materials</collection>
    <collection role="institutes" number="">VP Vizepräsident</collection>
    <collection role="institutes" number="">VP.1 eScience</collection>
  </doc>
</export-example>
