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    <pageLast>2784</pageLast>
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    <issue>12</issue>
    <volume>35</volume>
    <type>article</type>
    <publisherName>American Chemical Society (ACS)</publisherName>
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    <title language="eng">New Processes for Ionizing Nonvolatile Compounds in Mass Spectrometry: The Road of Discovery to Current State-of-the-Art</title>
    <abstract language="eng">This Perspective covers discovery and mechanistic aspects aswell as initial applications of novel ionization processes for use in massspectrometry that guided us in a series of subsequent discoveries, instrumentdevelopments, and commercialization. Vacuum matrix-assisted ionization onan intermediate pressure matrix-assisted laser desorption/ionization sourcewithout the use of a laser, high voltages, or any other added energy wassimply unbelievable, at first. Individually and as a whole, the variousdiscoveries and inventions started to paint, inter alia, an exciting new pictureand outlook in mass spectrometry from which key developments grew thatwere at the time unimaginable, and continue to surprise us in its simplisticpreeminence. We, and others, have demonstrated exceptional analyticalutility. Our current research is focused on how best to understand, improve, and use these novel ionization processes throughdedicated platforms and source developments. These ionization processes convert volatile and nonvolatile compounds from solid orliquid matrixes into gas-phase ions for analysis by mass spectrometry using, e.g., mass-selected fragmentation and ion mobilityspectrometry to provide accurate, and sometimes improved, mass and drift time resolution. The combination of research anddiscoveries demonstrated multiple advantages of the new ionization processes and established the basis of the successes that lead tothe Biemann Medal and this Perspective. How the new ionization processes relate to traditional ionization is also presented, as wellas how these technologies can be utilized in tandem through instrument modification and implementation to increase coverage ofcomplex materials through complementary strengths.</abstract>
    <parentTitle language="eng">Journal of the American Society for Mass Spectrometry</parentTitle>
    <identifier type="doi">10.1021/jasms.3c00122</identifier>
    <identifier type="issn">1879-1123</identifier>
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    <author>Sarah Trimpin</author>
    <author>Frank S. Yenchick</author>
    <author>Chuping Lee</author>
    <author>Khoa Hoang</author>
    <author>Milan Pophristic</author>
    <author>Santosh Karki</author>
    <author>Darrell D. Marshall</author>
    <author>I-Chung Lu</author>
    <author>Corinne A. Lutomski</author>
    <author>Tarick J. El-Baba</author>
    <author>Beixi Wang</author>
    <author>Vincent S. Pagnotti</author>
    <author>Anil K. Meher</author>
    <author>Shubhashis Chakrabarty</author>
    <author>Lorelei F. Imperial</author>
    <author>Sara Madarshahian</author>
    <author>Alicia L. Richards</author>
    <author>Christopher B. Lietz</author>
    <author>Abigail Moreno-Pedraza</author>
    <author>Samantha M. Leach</author>
    <author>Stephen C. Gibson</author>
    <author>Efstathios A. Elia</author>
    <author>Shameemah M. Thawoos</author>
    <author>Daniel W. Woodall</author>
    <author>Dean R. Jarois</author>
    <author>Eric T.J. Davis</author>
    <author>Guochao Liao</author>
    <author>Nisansala S. Muthunayake</author>
    <author>McKenna J. Redding</author>
    <author>Christian A. Reynolds</author>
    <author>Thilani M. Anthony</author>
    <author>Sashiprabha M. Vithanarachchi</author>
    <author>Paul DeMent</author>
    <author>Adeleye O. Adewale</author>
    <author>Lu Yan</author>
    <author>James Wager-Miller</author>
    <author>Young-Hoon Ahn</author>
    <author>Thomas H. Sanderson</author>
    <author>Karin Przyklenk</author>
    <author>Miriam L. Greenberg</author>
    <author>Arthur G. Suits</author>
    <author>Matthew J. Allen</author>
    <author>Srinivas B. Narayan</author>
    <author>Joseph A. Caruso</author>
    <author>Paul M. Stemmer</author>
    <author>Hien M. Nguyen</author>
    <author>Steffen Weidner</author>
    <author>Kevin J. Rackers</author>
    <author>Ana Djuric</author>
    <author>Vladimir Shulaev</author>
    <author>Tamara L. Hendrickson</author>
    <author>Christine S. Chow</author>
    <author>Mary Kay H. Pflum</author>
    <author>Scott M. Grayson</author>
    <author>Vladislav V. Lobodin</author>
    <author>Zhongwu Guo</author>
    <author>Chi-Kung Ni</author>
    <author>J. Michael Walker</author>
    <author>Ken Mackie</author>
    <author>Ellen D. Inutan</author>
    <author>Charles N. McEwen</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Mass spectrometry</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="institutes" number="">6 Materialchemie</collection>
    <collection role="institutes" number="">6.3 Strukturanalytik</collection>
    <collection role="themenfelder" number="">Chemie und Prozesstechnik</collection>
    <collection role="themenfelder" number="">Chemische Charakterisierung und Spurenanalytik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
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