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  <doc>
    <id>53368</id>
    <completedYear/>
    <publishedYear>2021</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1</pageFirst>
    <pageLast>16</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>23</volume>
    <type>article</type>
    <publisherName>BioMed Central</publisherName>
    <publisherPlace>London</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">The citrullinated/native index of autoantibodies against hnRNP-DL predicts an individual "window of treatment success" in RA patients</title>
    <abstract language="eng">Background: There is a need for biomarker to identify patients “at risk” for rheumatoid arthritis (risk-RA) and to better predict the therapeutic response and in this study we tested the hypothesis that novel native and citrullinated heterogeneous nuclear ribonucleoprotein (hnRNP)-DL autoantibodies could be possible biomarkers.&#13;
Methods: Using protein macroarray and ELISA, epitope recognition against hnRNP-DL was analysed in sera from different developed RA disease and diagnosed SLE patients. Toll-like receptor (TLR) 7/9 and myeloid Differentiation primary response gene 88 (MyD88)-dependency were studied in sera from murine disease models. HnRNP-DL expression in cultivated cells and synovial tissue was analysed by indirect immunofluorescence, immunoblot and immunohistochemistry.</abstract>
    <parentTitle language="eng">Arthritis research &amp; therapy</parentTitle>
    <identifier type="issn">1478-6362</identifier>
    <identifier type="doi">10.1186/s13075-021-02603-x</identifier>
    <identifier type="urn">urn:nbn:de:kobv:b43-533682</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="date_peer_review">27.09.2021</enrichment>
    <enrichment key="RelatedIdentifier">https://nbn-resolving.org/urn:nbn:de:kobv:b43-542698</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>B. Marklein</author>
    <author>M. Jenning</author>
    <author>Zoltán Konthur</author>
    <author>T. Häupl</author>
    <author>F. Welzel</author>
    <author>U. Nonhoff</author>
    <author>S. Krobitsch</author>
    <author>D. M. Mulder</author>
    <author>M. I. Koenders</author>
    <author>V. Joshua</author>
    <author>A. P. Cope</author>
    <author>M. J. Shlomchik</author>
    <author>H.-J. Anders</author>
    <author>G. R. Burmester</author>
    <author>A. Hensvold</author>
    <author>A. I. Catrina</author>
    <author>J. Rönnelid</author>
    <author>G. Steiner</author>
    <author>K. Skriner</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Citrullinated</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Rheumatoid arthritis</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Protein-modification</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Autoantibodies</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Antigens</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.8 Umweltanalytik</collection>
    <collection role="themenfelder" number="">Umwelt</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei für die Öffentlichkeit verfügbar ("Open Access")</collection>
    <collection role="unnumberedseries" number="">Wissenschaftliche Artikel der BAM</collection>
    <collection role="themenfelder" number="">Sensorik</collection>
    <thesisPublisher>Bundesanstalt für Materialforschung und -prüfung (BAM)</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-bam/files/53368/s13075-021-02603-x.pdf</file>
  </doc>
</export-example>
