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  <doc>
    <id>53062</id>
    <completedYear/>
    <publishedYear>2021</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>56</pageFirst>
    <pageLast>73</pageLast>
    <pageNumber/>
    <edition/>
    <issue>1</issue>
    <volume>284</volume>
    <type>article</type>
    <publisherName>Wiley-Blackwell</publisherName>
    <publisherPlace>Oxford</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">QUAREP-LiMi: A community-driven initiative to establish guidelines for quality assessment and reproducibility for instruments and images in light microscopy</title>
    <abstract language="eng">A modern day light microscope has evolved from a tool devoted to making primarily empirical observations to what is now a sophisticated, quantitative device that is an integral part of both physical and life science research. Nowadays, microscopes are found in nearly every experimental laboratory. However, despite their prevalent use in capturing and quantifying scientific phenomena, neither a thorough understanding of the principles underlying quantitative imaging techniques nor appropriate knowledge of how to calibrate, operate and maintain microscopes can be taken for granted. This is clearly demonstrated by the well-documented and widespread difficulties that are routinely encountered in evaluating acquired data and reproducing scientific experiments. Indeed, studies have shown that more than 70% of researchers have tried and failed to repeat another scientist’s experiments, while more than half have even failed to reproduce their own experiments1. One factor behind the reproducibility crisis of experiments published in scientific journals is the frequent underreporting of imaging methods caused by a lack of awareness and/or a lack of knowledge of the applied technique2,3. Whereas quality control procedures for some methods used in biomedical research, such as genomics (e.g., DNA sequencing, RNA-seq) or cytometry, have been introduced (e.g. ENCODE4), this issue has not been tackled for optical microscopy instrumentation and images. Although many calibration standards and protocols have been published, there is a lack of awareness and agreement on common Standards and guidelines for quality assessment and reproducibility5.&#13;
In April 2020, the QUality Assessment and REProducibility for instruments and images in Light Microscopy (QUAREP-LiMi) initiative6 was formed. This initiative comprises imaging scientists from academia and industry who share a common interest in achieving a better understanding of the performance and limitations of microscopes and improved quality control (QC) in light microscopy. The ultimate goal of the QUAREP-LiMi initiative is to establish a set of common QC standards, guidelines, metadata models7,8, and tools9,10, including detailed protocols, with the ultimate aim of improving reproducible advances in scientific research.&#13;
This White Paper 1) summarizes the major obstacles identified in the field that motivated the launch of the QUAREP-LiMi initiative; 2) identifies the urgent need to address these obstacles in a grassroots manner, through a community of Stakeholders including, researchers, imaging scientists11, bioimage analysts, bioimage informatics developers, corporate partners, Funding agencies, standards organizations, scientific publishers, and observers of such; 3) outlines the current actions of the QUAREPLiMi initiative, and 4) proposes future steps that can be taken to improve the dissemination and acceptance of the proposed guidelines to manage QC.&#13;
To summarize, the principal goal of the QUAREP-LiMi initiative is to improve the overall quality and reproducibility of light microscope image data by introducing broadly accepted standard practices and accurately captured image data metrics.</abstract>
    <parentTitle language="eng">Journal of microscopy</parentTitle>
    <identifier type="doi">10.1111/jmi.13041</identifier>
    <identifier type="issn">1365-2818</identifier>
    <identifier type="urn">urn:nbn:de:kobv:b43-530629</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="date_peer_review">05.08.2021</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>G. Nelson</author>
    <author>U. Boehm</author>
    <author>S. Bagley</author>
    <author>P. Bajcsy</author>
    <author>J. Bischof</author>
    <author>C. M. Brown</author>
    <author>A. Dauphin</author>
    <author>I. M. Dobbie</author>
    <author>J. E. Eriksson</author>
    <author>O. Faklaris</author>
    <author>J. Fernandez-Rodriguez</author>
    <author>A. Ferrand</author>
    <author>L, Gelman</author>
    <author>A. Gheisari</author>
    <author>H. Hartmann</author>
    <author>C. Kukat</author>
    <author>A. Laude</author>
    <author>M. Mitkovski</author>
    <author>S. Munck</author>
    <author>A. J. North</author>
    <author>T. Rasse</author>
    <author>Ute Resch-Genger</author>
    <author>L. C. Schuetz</author>
    <author>A. Seitz</author>
    <author>C. Strambio-De-Castillia</author>
    <author>J. R. Swedlow</author>
    <author>I. Alexopoulos</author>
    <author>K. Aumayr</author>
    <author>S. Avilov</author>
    <author>G.-J. Bakker</author>
    <author>R. R. Bammann</author>
    <author>A. Bassi</author>
    <author>H. Beckert</author>
    <author>S. Beer</author>
    <author>Y. Belyaev</author>
    <author>J. Bierwagen</author>
    <author>K. A. Birngruber</author>
    <author>M. Bosch</author>
    <author>J. Breitlow</author>
    <author>L. A. Cameron</author>
    <author>J. Chalfoun</author>
    <author>J. J. Chambers</author>
    <author>C.-L. Chen</author>
    <author>E. Conde-Sousa</author>
    <author>A. D. Corbett</author>
    <author>F. P. Cordelieres</author>
    <author>E. Del Nery</author>
    <author>R. Dietzel</author>
    <author>F. Eismann</author>
    <author>E. Fazeli</author>
    <author>A. Felscher</author>
    <author>H. Fried</author>
    <author>N. Gaudreault</author>
    <author>W. I. Goh</author>
    <author>T. Guilbert</author>
    <author>R. Hadleigh</author>
    <author>P. Hemmerich</author>
    <author>G. A. Holst</author>
    <author>M. S. Itano</author>
    <author>C. B. Jaffe</author>
    <author>H. K. Jambor</author>
    <author>S. C. Jarvis</author>
    <author>A. Keppler</author>
    <author>D. Kirchenbuechler</author>
    <author>M. Kirchner</author>
    <author>N. Kobayashi</author>
    <author>G. Krens</author>
    <author>S. Kunis</author>
    <author>J. Lacoste</author>
    <author>M. Marcello</author>
    <author>G. G. Martins</author>
    <author>D. J. Metcalf</author>
    <author>C. A. Mitchell</author>
    <author>J. Moore</author>
    <author>T. Mueller</author>
    <author>M. S. Nelson</author>
    <author>S. Ogg</author>
    <author>S. Onami</author>
    <author>A. L. Palmer</author>
    <author>P. Paul-Gilloteaux</author>
    <author>J. A. Pimentel</author>
    <author>L. Plantard</author>
    <author>S. Podder</author>
    <author>E. Rexhepaj</author>
    <author>A. Royon</author>
    <author>M. A. Saari</author>
    <author>D. Schapman</author>
    <author>V. Schoonderwoert</author>
    <author>B. Schroth-Diez</author>
    <author>S. Schwartz</author>
    <author>M. Shaw</author>
    <author>M. Spitaler</author>
    <author>M. T. Stoeckl</author>
    <author>D. Sudar</author>
    <author>J. Teillon</author>
    <author>S. Terjung</author>
    <author>R. Thuenauer</author>
    <author>C. D. Wilms</author>
    <author>G. D. Wright</author>
    <author>R. Nitschke</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fluorescence</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Microscopy</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Quality assurance</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Comparability</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Imaging</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Standards</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Reference materials</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Reliability</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Data</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Reference data</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Biology</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Medicine</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Life science</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.2 Biophotonik</collection>
    <collection role="themenfelder" number="">Chemie und Prozesstechnik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei für die Öffentlichkeit verfügbar ("Open Access")</collection>
    <collection role="unnumberedseries" number="">Wissenschaftliche Artikel der BAM</collection>
    <thesisPublisher>Bundesanstalt für Materialforschung und -prüfung (BAM)</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-bam/files/53062/jmi.13041.pdf</file>
  </doc>
  <doc>
    <id>50784</id>
    <completedYear/>
    <publishedYear>2019</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>203065</pageFirst>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue>440–441</issue>
    <volume>2019</volume>
    <type>article</type>
    <publisherName>Elsevier</publisherName>
    <publisherPlace>Amsterdam, Niederlande</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Abrasive wear behavior of austempered ductile iron with niobium additions</title>
    <abstract language="eng">Carbidic Austempered Ductile Iron (CADI) microstructures containing eutectic carbides can be produced by the addition of carbide stabilizing elements, such as chromium. Carbides formed from the addition of Cr are eutectic of M3C type. The presence of such hard phases can enhance the abrasion wear resistance of ductile iron. A new CADI can be produced by the addition of Nb. Niobium carbide particles are formed in the beginning of solidification and remain stable once they are insoluble in solid iron matrix. The dry sand abrasive wear resistance of ductile irons alloyed with 1.0, 1.8, and 2.4 wt% Nb were tested in both “as-cast” and “heat treated” conditions using standard ASTM G65. Results were compared to abrasive wear data obtained on ductile iron alloyed with 1 wt% Cr, CADI (1 wt% Cr), and the basic composition of iron without carbide stabilizing elements. In the “ascast” condition, the addition of Nb did not lead to a reduction in wear, while CADI with Nb is a promising substitute for CADI with Cr addition, because both materials showed very similar values of abrasion resistance.&#13;
Micro-ploughing and micro-cutting mechanisms were observed on the worn surfaces of ductile irons. Abrasive wear resistance of these alloys was correlated with the volume fraction of carbides.</abstract>
    <parentTitle language="eng">Wear</parentTitle>
    <identifier type="doi">10.1016/j.wear.2019.203065</identifier>
    <enrichment key="date_peer_review">14.05.2020</enrichment>
    <author>A. S. O. Pimentel</author>
    <author>W. L. Guesser</author>
    <author>W. J. R. Custódio da Silva</author>
    <author>Pedro Dolabella Portella</author>
    <author>Mathias Woydt</author>
    <author>J. Burbank</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>arbidic austempered ductile iron</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Ductile iron</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Niobium alloying</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Abrasion</value>
    </subject>
    <collection role="ddc" number="620">Ingenieurwissenschaften und zugeordnete Tätigkeiten</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
</export-example>
