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  <doc>
    <id>54444</id>
    <completedYear/>
    <publishedYear>2022</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1</pageFirst>
    <pageLast>20</pageLast>
    <pageNumber/>
    <edition/>
    <issue>3</issue>
    <volume>10</volume>
    <type>article</type>
    <publisherName>MDPI</publisherName>
    <publisherPlace>Basel</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Red-Emitting Polymerizable Guanidinium Dyes as Fluorescent Probes in Molecularly Imprinted Polymers for Glyphosate Detection</title>
    <abstract language="eng">The development of methodologies to sense glyphosate has gained momentum due to its toxicological and ecotoxicological effects. In this work, a red-emitting and polymerizable guanidinium benzoxadiazole probe was developed for the fluorescence detection of glyphosate. The interaction of the fluorescent probe and the tetrabutylammonium salt of glyphosate was studied via UV/vis absorption and fluorescence spectroscopy in chloroform and acetonitrile. The selective recognition of glyphosate was achieved by preparing molecularly imprinted polymers, able to discriminate against other common herbicides such as 2,4-dichlorophenoxyacetic acid (2,4-D) and 3,6-dichloro-2-methoxybenzoic acid (dicamba), as thin layers on submicron silica particles. The limits of detection of 4.8 µM and 0.6 µM were obtained for the sensing of glyphosate in chloroform and acetonitrile, respectively. The reported system shows promise for future application in the sensing of glyphosate through further optimization of the dye and the implementation of a biphasic assay with water/organic solvent mixtures for sensing in aqueous environmental samples.</abstract>
    <parentTitle language="eng">Chemosensors</parentTitle>
    <identifier type="issn">2227-9040</identifier>
    <identifier type="doi">10.3390/chemosensors10030099</identifier>
    <identifier type="urn">urn:nbn:de:kobv:b43-544441</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="date_peer_review">20.04.2022</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>Martha Wamaitha Kimani</author>
    <author>Victor Pérez-Padilla</author>
    <author>Virginia Valderrey</author>
    <author>Kornelia Gawlitza</author>
    <author>Knut Rurack</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Glyphosate</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Guanidinium receptors</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fluorescent probes</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Molecularly imprinted polymers</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Core-shell particles</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.9 Chemische und optische Sensorik</collection>
    <collection role="themenfelder" number="">Umwelt</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei für die Öffentlichkeit verfügbar ("Open Access")</collection>
    <collection role="unnumberedseries" number="">Wissenschaftliche Artikel der BAM</collection>
    <collection role="themenfelder" number="">Sensorik</collection>
    <thesisPublisher>Bundesanstalt für Materialforschung und -prüfung (BAM)</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-bam/files/54444/Chemosensors_2022_10_99.pdf</file>
  </doc>
  <doc>
    <id>58527</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>lecture</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Fluorescence Detection of Perfluoroalkyl Carboxylic Acids with a Miniaturised Assay</title>
    <abstract language="eng">Per- and polyfluoroalkyl substances (PFAS) are a class of man-made organo-fluorine chemicals that have become environmental contaminants of emerging concern, originating from a variety of materials such as adhesive, stain- and oil-resistant coatings, firefighting foams, etc. The high strength of this C-F bond makes PFAS thermodynamically stable and resistant to (bio)degradation, thus retaining them in the environment over time. Perfluoroalkyl carboxylic acids (PFCAs), one category of the most used PFAS, consist of a fully fluorinated carbon backbone and a charged carboxylic acid headgroup, and have been classified as Substances of Very High Concern (SVHC) and added to the REACH Candidate List due to their persistence in the environment, non-biodegradability and toxicological effects.[1-2] Traditional techniques for the analysis of PFCAs include GC-MS, HRMS and HPLC-based approaches, which are laborious, not portable, costly and require trained personnel. In contrast, fluorescence assays can be designed as easy-to-operate, portable and cost-effective methods with high sensitivity and fast response. Integration of fluorescent probes with an adequately miniaturized assay enables a promising alternative for PFCAs analysis.&#13;
Here, a novel guanidine fluorescent probe has been synthesized and fully characterized for the detection of PFCAs in a biphasic extract-&amp;-detect assay. The fluorescent probe was then incorporated into polymeric matrices supported by a red dye-doped SiO2 nanoparticle to construct a dual-emission sensing platform. Such a system allows precise and selective detection of PFCAs, reducing the interference of competitors, matrix effects and other factors except for the PFCAs. The system was then employed in a droplet-based microfluidic setup which offers a portable and easy to operate detection platform.</abstract>
    <enrichment key="eventName">IMA 2023</enrichment>
    <enrichment key="eventPlace">Chania, Greece</enrichment>
    <enrichment key="eventStart">18.09.2023</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <enrichment key="InvitedTalks">0</enrichment>
    <author>Yijuan Sun</author>
    <author>Víctor Pérez-Padilla</author>
    <author>Virginia Valderrey</author>
    <author>Jérémy Bell</author>
    <author>Kornelia Gawlitza</author>
    <author>Knut Rurack</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>PFAS</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>MIP</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fluorescence</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Microfluidics</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Fluorezsenz</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Mikrofluidik</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.9 Chemische und optische Sensorik</collection>
    <collection role="themenfelder" number="">Umwelt</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
    <collection role="literaturgattung" number="">Präsentation</collection>
    <collection role="themenfelder" number="">Sensorik</collection>
  </doc>
  <doc>
    <id>62649</id>
    <completedYear/>
    <publishedYear>2025</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1</pageFirst>
    <pageLast>9</pageLast>
    <pageNumber/>
    <edition/>
    <issue>4</issue>
    <volume>7</volume>
    <type>article</type>
    <publisherName>American Chemical Society</publisherName>
    <publisherPlace>Washington, D.C.</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Design and Application of an Imprinted Polymer Sensor for the Dual Detection of Antibiotic Contaminants in Aqueous Samples and Food Matrices</title>
    <abstract language="eng">An innovative polymer-based dual detection microfluidic platform has been developed for the accurate and reliable sensing of trace amounts of antibiotic tetracycline in environmental and food samples. This was achieved through the production of a bespoke polymeric material formed via an imprinting technique using a fluorescent dye. Thus, this enables dual detection of tetracycline, both thermally, via analyzing the heat-transfer resistance at the solid−liquid interface, and optically, through the inner filter effect. The combination of these two methods achieved a nanomolar limit of detection for tetracycline while also providing rapid, selective, and cost-effective sensing. Additionally, this method successfully detected tetracycline levels of 0.56 μM in blank egg samples which was significantly lower than the maximum residual level of 400 μg L−1 (0.9 μM). Our work shows that this approach can be used for the efficient detection of trace antibiotics in complex environmental and food samples, offering enhanced reliability through the integration of two complementary analysis&#13;
techniques. This sensor has the potential to identify sources of antimicrobial resistance, which is crucial for targeted efforts to combat this pressing global health challenge.</abstract>
    <parentTitle language="eng">ACS Applied Polymer Materials</parentTitle>
    <identifier type="doi">10.1021/acsapm.4c03218</identifier>
    <identifier type="urn">urn:nbn:de:kobv:b43-626497</identifier>
    <identifier type="issn">2637-6105</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="date_peer_review">10.03.2025</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>O. D. Jamieson</author>
    <author>Jérémy Bell</author>
    <author>A. Hudson</author>
    <author>J. Saczek</author>
    <author>Victor Perez-Padilla</author>
    <author>G. Kaiya</author>
    <author>K. Novakovic</author>
    <author>M. Davies</author>
    <author>E. Foster</author>
    <author>J. Gruber</author>
    <author>Knut Rurack</author>
    <author>M. Peeters</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Molecularly imprinted polymers</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Antibiotics monitoring</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Orthogonal detection</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Sensors</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="ddc" number="620">Ingenieurwissenschaften und zugeordnete Tätigkeiten</collection>
    <collection role="ddc" number="628">Sanitär- und Kommunaltechnik; Umwelttechnik</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.9 Chemische und optische Sensorik</collection>
    <collection role="themenfelder" number="">Umwelt</collection>
    <collection role="themenfelder" number="">Chemie und Prozesstechnik</collection>
    <collection role="themenfelder" number="">Chemische Charakterisierung und Spurenanalytik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei für die Öffentlichkeit verfügbar ("Open Access")</collection>
    <collection role="themenfelder" number="">Sensorik</collection>
    <thesisPublisher>Bundesanstalt für Materialforschung und -prüfung (BAM)</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-bam/files/62649/ACSApplPolymMater_2025_ASAP.pdf</file>
  </doc>
  <doc>
    <id>56513</id>
    <completedYear/>
    <publishedYear>2022</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>poster</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Fluorescence detection of perfluorocarboxylic acids with core-shell particles</title>
    <abstract language="eng">Perfluorocarboxylic acids (PFCAs) are a family of compounds that consist of a fully perfluorinated carbon backbone and a carboxylic acid moiety1. PFCAs have been classified as substances of very high concern by REACH regulations due to their persistence in the environment, non biodegradability and toxicological effects2. Thus, there is significant interest in detecting PFCAs in ground, waste, surface and drinking water. Fluorescence detection is a portable, easy-to-operate and cost-effective alternative, enabling the onsite detection of these analytes e.g., with miniaturized fluidic sensors.&#13;
Here, a guanidine benzoxadiazole (BD) dye covalently attached to a polymerizable methacrylate unit was developed for the integration of the dye into polymers and on surfaces. The response behavior of the dye toward PFCAs was assessed in monophasic (EtOAc) and biphasic (EtOAc-H2O) solvent systems, the biphasic system being advantageous for the extraction of the hydrophobic organic acids from the aqueous phase. &#13;
The BD dye was integrated into sensory silica core-polymer shell particles for the sensing of PFCAs directly in aqueous media. Submicron SiO2 particles were functionalized with 3 (trimethoxysilyl)propyl methacrylate followed by radical polymerization with the BD dye and ethylene glycol dimethacrylate. TEM images showed a homogeneous polymer shell with a thickness of 75±2 nm.&#13;
By incorporating the BD dye into core-shell particles, lower limits of detection (1.52 µM for perfluorooctanoic acid, PFOA) were achieved if compared to the use of the neat BD dye in a biphasic assay (17.3 µM for PFOA), and excellent discrimination against inorganic acids thanks to the hydrophobic polymer shell. The particle sensory platform has proven to be an alternative for the sensing of PFCAs directly in water.</abstract>
    <enrichment key="eventName">5th International Conference on Applied Surface Science (ICASS) 2022</enrichment>
    <enrichment key="eventPlace">Palma de Mallorca, Spain</enrichment>
    <enrichment key="eventStart">25.04.2022</enrichment>
    <enrichment key="eventEnd">28.04.2022</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <author>Victor Pérez-Padilla</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>PFOA</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Emerging pollutants</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Polymer nanolayers</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fluorescence detection</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Guanidine benzoxadiazole</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Core-shell particles</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.9 Chemische und optische Sensorik</collection>
    <collection role="themenfelder" number="">Umwelt</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
    <collection role="literaturgattung" number="">Präsentation</collection>
    <collection role="themenfelder" number="">Sensorik</collection>
  </doc>
  <doc>
    <id>56514</id>
    <completedYear/>
    <publishedYear>2022</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>poster</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Direct detection of glyphosate in water with fluorescent molecularly imprinted polymer particles</title>
    <abstract language="eng">Analysis of environmental contaminants such as pesticides is increasing in importance due to frequent detection of residues in water reserves and food stuff, as well as lowering of maximum residue levels (MRLs). Molecularly imprinted polymers (MIPs) have been developed for preconcentration of these analytes prior to analysis by chromatographic techniques [1]. MIPs are prepared by polymerization of monomers in a matrix containing the analyte, followed by extraction of the analyte to obtain binding sites that are complementary to the analyte of interest. Recently, our group developed MIPs containing fluorescent reporter molecules that can be used for direct detection and quantification of 2,4-D in contaminated water. Core/shell MIP particles were employed, consisting of sub-micron silica nanoparticles coated with a MIP shell containing a fluorescent reporter whose signal was enhanced upon binding with 2,4-D in water. A limit of detection of 20 nM was attained [2]. We present here a comparable system, composed of fluorescent core-shell MIPs for the direct analysis of pesticides in environmental samples.</abstract>
    <enrichment key="eventName">UK-Poland-Ukraine Bioinspired Materials Conference</enrichment>
    <enrichment key="eventPlace">Online meeting</enrichment>
    <enrichment key="eventStart">29.11.2022</enrichment>
    <enrichment key="eventEnd">30.11.2022</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <author>Victor Pérez-Padilla</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Core-Shell Particles</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fluorescent Probes</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Molecularly Imprinted Polymers</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Glyphosate</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Guanidinium Receptors</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.9 Chemische und optische Sensorik</collection>
    <collection role="themenfelder" number="">Umwelt</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
    <collection role="literaturgattung" number="">Präsentation</collection>
    <collection role="themenfelder" number="">Sensorik</collection>
  </doc>
  <doc>
    <id>53878</id>
    <completedYear/>
    <publishedYear>2021</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>poster</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Fluorescent molecularly imprinted polymer particles for detection of environmental contaminants</title>
    <abstract language="eng">Analysis of environmental contaminants such as pesticides is increasing in importance due to frequent detection of residues in water reserves and food stuff, as well as lowering of maximum residue levels (MRLs). Molecularly imprinted polymers (MIPs) have been developed for preconcentration of these analytes prior to analysis by chromatographic techniques. MIPs are prepared by polymerization of monomers in a matrix containing the analyte, followed by extraction of the analyte to obtain binding sites that are complementary to the analyte of interest. Recently, our group developed MIPs containing fluorescent reporter molecules that can be used for direct detection and quantification of 2,4-D in contaminated water. Core/shell MIP particles were employed, consisting of submicron silica nanoparticles coated with a MIP shell containing a fluorescent reporter whose signal was enhanced upon binding with 2,4-D in water. A limit of detection of 20 nM was attained. We present here a comparable system, composed of fluorescent core-shell MIPs for the direct analysis of pesticides in environmental samples.</abstract>
    <enrichment key="eventName">Europtrode 2021</enrichment>
    <enrichment key="eventPlace">Warsaw, Poland</enrichment>
    <enrichment key="eventStart">29.11.2021</enrichment>
    <enrichment key="eventEnd">01.12.2021</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <author>Victor Pérez-Padilla</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Glyphosate</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Guanidinium Receptors</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fluorescent Probes</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Molecularly Imprinted Polymers</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Core-Shell Particles</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.9 Chemische und optische Sensorik</collection>
    <collection role="themenfelder" number="">Umwelt</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
    <collection role="literaturgattung" number="">Präsentation</collection>
    <collection role="themenfelder" number="">Sensorik</collection>
  </doc>
  <doc>
    <id>65027</id>
    <completedYear/>
    <publishedYear>2025</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1</pageFirst>
    <pageLast>16</pageLast>
    <pageNumber/>
    <edition/>
    <issue>1</issue>
    <volume>16</volume>
    <type>article</type>
    <publisherName>Springer Science and Business Media LLC</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Ratiometric detection of perfluoroalkyl carboxylic acids using dual fluorescent nanoparticles and a miniaturised microfluidic platform</title>
    <abstract language="eng">The widespread contamination of soil and water with perfluoroalkyl substances (PFAS) has caused considerable societal and scientific concern. Legislative measures and an increased need for remediation require effective on-site analytical methods for PFAS management. Here we report on the development of a green-fluorescent guanidine-BODIPY indicator monomer incorporated into a molecularly imprinted polymer (MIP) for the selective detection of perfluorooctanoic acid (PFOA). Complexation of PFOA by the indicator, which is mediated by concerted protonation-induced ion pairing-assisted hydrogen bonding, significantly enhances fluorescence in polar organic solvents. The MIP forms as a thin layer on silica nanoparticles doped with tris(bipyridine)ruthenium(II) chloride, which provides an orange emission signal as internal reference, resulting in low measurement uncertainties. Using a liquid-liquid extraction protocol, this assay enables the direct detection of PFOA in environmental water samples and achieves a detection limit of 0.11 µM. Integration into an opto-microfluidic system enables a compact and user-friendly system for detecting PFOA in less than 15 minutes.</abstract>
    <parentTitle language="eng">Nature Communications</parentTitle>
    <identifier type="issn">2041-1723</identifier>
    <identifier type="doi">10.1038/s41467-025-66872-9</identifier>
    <identifier type="urn">urn:nbn:de:kobv:b43-650270</identifier>
    <enrichment key="opus_doi_flag">true</enrichment>
    <enrichment key="local_crossrefDocumentType">journal-article</enrichment>
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    <author>Yijuan Sun</author>
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    <author>Kornelia Gawlitza</author>
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    <title language="eng">Detection of Perfluoroalkylic Acids From Water Using a Guanidine-Based Fluorescent Probe and Microfluidic Droplet Extraction</title>
    <abstract language="eng">Perfluoroalkylic acids (PFAAs), a subclass of per- and polyfluoroalkyl substances (PFAS), are stable, widely used industrial compounds posing environmental concerns due to their persistence and toxicity. Regulatory actions and remediation strategies necessitate effective onsite analytical methods for PFAS management. We developed an optical sensing system using a fluorescent probe with a benzoxadiazole core and guanidine receptor in a droplet-based microfluidic assay to detect PFAAs in water samples with low detection limits. The PFAAs binding enhances the probe's fluorescence in organic media through protonation-mediated hydrogen bond-assisted ion pairing, exploiting two complementary supramolecular forces. Direct detection employs a liquid-liquid extraction protocol in the microfluidic device, achieving detection limits for PFOA and PFOS down to ≥0.5 µm, with a dynamic range up to 200 µm for sample volumes &lt;100 µL. HCl/KCl buffering facilitates analyte desalting and phase transfer for quantitation from surface water. Additionally, we developed a method involving a thin polymer layer of the probe and a crosslinker on submicron silica particles for direct detection of PFAAs in water. Our approaches provide sensitive, direct recognition and indication of PFAAs, advancing the field beyond indirect sensing and offering improved background suppression, rapid assay times, and a modular design for targeting other PFAS subclasses.</abstract>
    <parentTitle language="eng">Advanced Sensor Research</parentTitle>
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    <author>Víctor Pérez-Padilla</author>
    <author>Samual C. Burnage</author>
    <author>Philipp Wittwer</author>
    <author>Virginia Valderrey</author>
    <author>Jérémy Bell</author>
    <author>Kornelia Gawlitza</author>
    <author>Knut Rurack</author>
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      <value>PFAS</value>
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