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  <doc>
    <id>59367</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1</pageFirst>
    <pageLast>4</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>conferenceobject</type>
    <publisherName>IEEE</publisherName>
    <publisherPlace>New York</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
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    <title language="eng">Development of a Lab-on-a-Chip for the Detection of Nerve Agents with a Handheld Device</title>
    <abstract language="eng">The development of a Lab-on-a-Chip (LoC) is presented, which can detect reactive phosphorous compounds in the gas phase in combination with an optochemical hand-held sensor. The LoC prototype contains three pairs of sensing materials containing fluorescent indicator dyes in various carrier materials. By measuring the fluorescence response to phosphoryl chloride, a surrogate compound, the detection of chemical warfare agents (CWAs) in gas phase becomes possible within seconds, introducing a novel approach to CWA detection.</abstract>
    <parentTitle language="eng">Proceedings 2023 IEEE Sensors</parentTitle>
    <identifier type="isbn">979-8-3503-0387-2</identifier>
    <identifier type="url">https://ieeexplore.ieee.org/document/10325263</identifier>
    <identifier type="doi">10.1109/SENSORS56945.2023.10325263</identifier>
    <enrichment key="eventName">2023 IEEE SENSORS Conference</enrichment>
    <enrichment key="eventPlace">Vienna, Austria</enrichment>
    <enrichment key="eventStart">29.10.2023</enrichment>
    <enrichment key="eventEnd">01.11.2023</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="date_peer_review">12.02.2024</enrichment>
    <author>Mustafa Biyikal</author>
    <author>Knut Rurack</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Lab-on-a-Chip</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Nerve agents</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Hand-held</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fluorescence</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Toxic industrial chemicals</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.9 Chemische und optische Sensorik</collection>
    <collection role="themenfelder" number="">Infrastruktur</collection>
    <collection role="themenfelder" number="">Security</collection>
    <collection role="themenfelder" number="">Umwelt</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
    <collection role="literaturgattung" number="">Graue Literatur</collection>
    <collection role="themenfelder" number="">Sensorik</collection>
  </doc>
  <doc>
    <id>51444</id>
    <completedYear/>
    <publishedYear>2020</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>poster</type>
    <publisherName/>
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    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Embedded sensor based on tandem smartphone-microfluidic device for the detection of TNT in surface and sea waters</title>
    <abstract language="eng">The globe's seas were used as dumping ground after the world wars and those millions of ammunition, most of all containing 2,4,6-trinitrotoluene (TNT), represent a pressing danger for fishermen, dredging operations, submarine cable installations and tourism. We developed an extremely selective indication method for TNT based on a specific reaction that produces a highly fluorescent compound. The indication system was integrated into a microfluidic PDMS chip for the solid-liquid extraction of TNT from water samples, offering environmental monitoring possibilities. Combining the advantages of a light-up indicator, microfluidics and a smartphone as detector, the embedded sensor allows for the remote and rapid detection of TNT down to ng in surface and sea waters.</abstract>
    <enrichment key="eventName">µTAS 2020</enrichment>
    <enrichment key="eventPlace">Online meeting</enrichment>
    <enrichment key="eventStart">05.10.2020</enrichment>
    <enrichment key="eventEnd">09.10.2020</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <author>Jérémy Bell</author>
    <author>Mustafa Biyikal</author>
    <author>Knut Rurack</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Smartphone</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Rapid test</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>TNT</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Ammunition</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Schnelltest</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Munition</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="ddc" number="624">Ingenieurbau</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.9 Chemische und optische Sensorik</collection>
    <collection role="themenfelder" number="">Infrastruktur</collection>
    <collection role="themenfelder" number="">Security</collection>
    <collection role="themenfelder" number="">Umwelt</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
    <collection role="literaturgattung" number="">Präsentation</collection>
    <collection role="themenfelder" number="">Sensorik</collection>
  </doc>
  <doc>
    <id>58541</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>lecture</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Development of a Handheld Device for the Trace Detection of Explosives</title>
    <abstract language="eng">With the help of the EXIST research transfer the startup True Detection System (TDS) will develop a portable and easy-to-use handheld device based on chemical-optical sensors that can detect the smallest traces of various explosives and markers (e.g. TNT, C4, ANFO, TATP, DMDNB, etc.) and pure salts (e.g. potassium nitrate) reliably and without major cross-sensitivities. The device has been developed over the last 10 years at the Federal Institute for Material Research and Testing (BAM) in cooperation with an SME. Within the next 18 months, a laboratory prototype will now be converted into a commercial device.</abstract>
    <enrichment key="eventName">Photonics Days Berlin Brandenburg</enrichment>
    <enrichment key="eventPlace">Berlin, Germany</enrichment>
    <enrichment key="eventStart">09.10.2023</enrichment>
    <enrichment key="eventEnd">10.10.2023</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="InvitedTalks">1</enrichment>
    <author>Mustafa Biyikal</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Explosives</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Trace detection</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Handheld device</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Lab-on-a-chip</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Start-up</value>
    </subject>
    <collection role="ddc" number="624">Ingenieurbau</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.9 Chemische und optische Sensorik</collection>
    <collection role="themenfelder" number="">Infrastruktur</collection>
    <collection role="themenfelder" number="">Security</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
    <collection role="literaturgattung" number="">Präsentation</collection>
  </doc>
  <doc>
    <id>61433</id>
    <completedYear/>
    <publishedYear>2024</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>lecture</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Development of a handheld device for the trace detection of explosives</title>
    <abstract language="eng">This presentation introduces a new explosives trace detector (ETD), a handheld device developed by True Detection Systems (TDS). Addressing the limitations of current handheld detectors—such as unreliable measurements and cumbersome operation— the new ETD XT-1 integrates advanced sensor technology, including a Lab-on-a-Chip, to deliver high sensitivity and accuracy. Capable of detecting trace levels of substances like TNT, TATP, and ammonium nitrate, the device offers rapid, user-friendly detection through AI/ML-enhanced algorithms. These algorithms enable precise substance identification by analyzing absorption and desorption rates, significantly reducing false positives. The XT-1 has broad applications in security, hazardous material detection, and environmental monitoring.</abstract>
    <enrichment key="eventName">Photonics Days Berlin Brandenburg</enrichment>
    <enrichment key="eventPlace">Berlin, Germany</enrichment>
    <enrichment key="eventStart">09.10.2024</enrichment>
    <enrichment key="eventEnd">10.10.2024</enrichment>
    <enrichment key="InvitedTalks">1</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <author>Mustafa Biyikal</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Explosives</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Trace detection</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Handheld device</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Lab-on-a-chip</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fluorescence</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="ddc" number="624">Ingenieurbau</collection>
    <collection role="ddc" number="628">Sanitär- und Kommunaltechnik; Umwelttechnik</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.9 Chemische und optische Sensorik</collection>
    <collection role="themenfelder" number="">Infrastruktur</collection>
    <collection role="themenfelder" number="">Security</collection>
    <collection role="themenfelder" number="">Umwelt</collection>
    <collection role="themenfelder" number="">Chemie und Prozesstechnik</collection>
    <collection role="themenfelder" number="">Chemische Charakterisierung und Spurenanalytik</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
    <collection role="literaturgattung" number="">Präsentation</collection>
    <collection role="themenfelder" number="">Sensorik</collection>
  </doc>
  <doc>
    <id>65031</id>
    <completedYear/>
    <publishedYear>2025</publishedYear>
    <thesisYearAccepted/>
    <language>deu</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>lecture</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="deu">Handgerät für den mobilen Einsatz zur Detektion von Sprengstoffspuren</title>
    <abstract language="deu">Mithilfe des EXIST-Forschungstransfers wird ein tragbares und leicht zu bedienendes Handgerät auf der Basis von chemisch-optischen Sensoren entwickelt, welches kleinste Spuren von verschiedensten Sprengstoffen und Markern (z.B. TNT, C4, ANFO, TATP, DMDNB etc.) und reine Salze (z. B. Kaliumnitrat) sicher und ohne größere Querempfindlichkeiten detektieren kann. Das Gerät wurde in den letzten 10 Jahren bei der Bundesanstalt für Materialforschung und -prüfung (BAM) entwickelt und wird von der 2024 ausgegründeten Firma Noxoon GmbH in ein kommerzielles Gerät überführt.&#13;
Die Vorteile des Handgeräts sind die hohe Selektivität, die hohe Sensitivität, die schnelle Detektion in wenigen Sekunden bis zur Ergebnisanzeige sowie der schnelle und das geringe Gewicht des Gerätes von 900 g.&#13;
Neben den Vorteilen findet sich auch zahlreiche Alleinstellungsmerkmale in der Benutzung des Gerätes. So können z.B.&#13;
-	reine Salze&#13;
-	Sprengstoffe in Gegenwart von Wasser&#13;
-	Sprengstoffe und Drogen in versiegelten Briefumschlägen detektiert werden.&#13;
Ein besonderes Alleinstellungsmerkmal ist, dass eine Reinigung des Handgeräts nach Messungen von stark kontaminierten Proben nicht notwendig ist.&#13;
&#13;
Für den deutschsprachigen bzw. europäischen Raum existiert noch kein vergleichbares Gerät.&#13;
&#13;
Das kommerzielle Gerät soll ab 2025 auf den Markt gebracht werden und wird einen wichtigen Beitrag zur öffentlichen Sicherheit und zum Umweltschutz leisten.</abstract>
    <enrichment key="eventName">BBK Fachkongress "Forschung für den Bevölkerungsschutz"</enrichment>
    <enrichment key="eventPlace">Bonn, Germany</enrichment>
    <enrichment key="eventStart">05.02.2025</enrichment>
    <enrichment key="eventEnd">07.02.2025</enrichment>
    <enrichment key="InvitedTalks">0</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <author>Mustafa Biyikal</author>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Explosivstoffe</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Detektion</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Handgerät</value>
    </subject>
    <collection role="ddc" number="620">Ingenieurwissenschaften und zugeordnete Tätigkeiten</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.9 Chemische und optische Sensorik</collection>
    <collection role="themenfelder" number="">Infrastruktur</collection>
    <collection role="themenfelder" number="">Security</collection>
    <collection role="themenfelder" number="">Umwelt</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
    <collection role="literaturgattung" number="">Präsentation</collection>
    <collection role="themenfelder" number="">Sensorik</collection>
  </doc>
  <doc>
    <id>65029</id>
    <completedYear/>
    <publishedYear>2025</publishedYear>
    <thesisYearAccepted/>
    <language>deu</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>lecture</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="deu">Handgeräte zur Detektion von Sprengstoffspuren</title>
    <abstract language="deu">Der Übersichtsvortrag stellt den aktuellen Stand zu Handgeräten zur Detektion von Sprengstoffspuren vor.</abstract>
    <enrichment key="eventName">Symposium Anlagensicherheit 2025</enrichment>
    <enrichment key="eventPlace">Hamburg, Germany</enrichment>
    <enrichment key="eventStart">04.02.2025</enrichment>
    <enrichment key="eventEnd">05.02.205</enrichment>
    <enrichment key="InvitedTalks">1</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <author>Mustafa Biyikal</author>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Explosivstoffe</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Detektion</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Handgerät</value>
    </subject>
    <collection role="ddc" number="620">Ingenieurwissenschaften und zugeordnete Tätigkeiten</collection>
    <collection role="ddc" number="660">Chemische Verfahrenstechnik</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.9 Chemische und optische Sensorik</collection>
    <collection role="themenfelder" number="">Infrastruktur</collection>
    <collection role="themenfelder" number="">Security</collection>
    <collection role="themenfelder" number="">Umwelt</collection>
    <collection role="themenfelder" number="">Chemie und Prozesstechnik</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
    <collection role="literaturgattung" number="">Präsentation</collection>
    <collection role="themenfelder" number="">Anlagensicherheit und Prozesssimulation</collection>
    <collection role="themenfelder" number="">Sensorik</collection>
  </doc>
  <doc>
    <id>51843</id>
    <completedYear/>
    <publishedYear>2020</publishedYear>
    <thesisYearAccepted/>
    <language>deu</language>
    <pageFirst>24071</pageFirst>
    <pageLast>24078</pageLast>
    <pageNumber/>
    <edition/>
    <issue>52</issue>
    <volume>132</volume>
    <type>article</type>
    <publisherName>Wiley-VCH</publisherName>
    <publisherPlace>Weinheim</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="deu">Multiplex‐Nachweis von Analyten auf einem einzelnen Teststreifen mit Antikörper‐gesteuerten und Indikator freisetzenden mesoporösen Nanopartikeln</title>
    <abstract language="deu">Vor dem Hintergrund der einzigartigen Modularität, hohen Empfindlichkeit und Selektivität von Antikörper‐gesteuerten Indikatorfreisetzungssystemen (gAID‐Systemen) wurde hier ein Multiplex‐Assay für drei organische Explosivstoffmoleküle (TATP, TNT, PETN) entwickelt, der es erlaubt, die Analyten gleichzeitig in flüssiger Phase mit einem einzelnen Teststreifen und einem Fluoreszenzlesegerät bzw. Smartphone als Detektor in Konzentrationen bis in den unteren ppb‐Bereich in &lt;5 min nachzuweisen. Alle drei Systeme, darunter die hier neu entwickelten Systeme für TNT und PETN, tolerieren zudem nicht nur gepufferte wässrige Modelllösungen, sondern auch komplexere Matrices. Neben einem konventionellen Teststreifen mit einem Kanal erlaubte uns die Anwendung von Wachsdrucktechnologie das Herstellen von mehrkanaligen Streifen mit vergleichbarer analytischer Leistungsfähigkeit, was das enorme Potenzial der modular aufgebauten, hybriden Biosensormaterialien im Hinblick auf eine für den Endanwender maßgeschneiderte Vor‐Ort‐Analytik unterstreicht.</abstract>
    <parentTitle language="deu">Angewandte Chemie</parentTitle>
    <identifier type="doi">10.1002/ange.202009000</identifier>
    <identifier type="urn">urn:nbn:de:kobv:b43-518431</identifier>
    <identifier type="issn">1521-3757</identifier>
    <identifier type="issn">0044-8249</identifier>
    <enrichment key="RelatedIdentifier">https://nbn-resolving.org/urn:nbn:de:kobv:b43-518424</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>Estela Climent Terol</author>
    <author>Mustafa Biyikal</author>
    <author>Delia Gröninger</author>
    <author>Michael G. Weller</author>
    <author>R. Martínez Mánez</author>
    <author>Knut Rurack</author>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Multiplex</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Gesteuerten Nanopartikeln</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Explosiven</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.5 Proteinanalytik</collection>
    <collection role="institutes" number="">1.9 Chemische und optische Sensorik</collection>
    <collection role="themenfelder" number="">Umwelt</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei für die Öffentlichkeit verfügbar ("Open Access")</collection>
    <collection role="unnumberedseries" number="">Wissenschaftliche Artikel der BAM</collection>
    <collection role="themenfelder" number="">Sensorik</collection>
    <thesisPublisher>Bundesanstalt für Materialforschung und -prüfung (BAM)</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-bam/files/51843/ange.202009000_deutsch.pdf</file>
  </doc>
  <doc>
    <id>51842</id>
    <completedYear/>
    <publishedYear>2020</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>23862</pageFirst>
    <pageLast>23869</pageLast>
    <pageNumber/>
    <edition/>
    <issue>52</issue>
    <volume>59</volume>
    <type>article</type>
    <publisherName>Wiley-VCH</publisherName>
    <publisherPlace>Weinheim</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Multiplexed Detection of Analytes on Single Test Strips with Antibody-Gated Indicator-Releasing Mesoporous Nanoparticles</title>
    <abstract language="eng">Rapid testing methods for the use directly at apointof need are expected to unfold their true potential especiallywhen offering adequate capabilities for the simultaneousmeasurement of multiple analytes of interest. Considering theunique modularity,high sensitivity,and selectivity of antibody-gated indicator delivery (gAID) systems,amultiplexed assayfor three small-molecule explosives (TATP, TNT,PETN) wasthus developed, allowing to detect the analytes simultaneouslywith asingle test strip at lower ppb concentrations in the liquidphase in &lt; 5min using afluorescence reader or asmartphonefor readout. While the TNT and PETN systems were newlydeveloped here,all the three systems also tolerated harshermatrices than buffered aqueous model solutions.Besidesasingle-track strip,the outstanding modularity of the hybridbiosensor materials in combination with strip-patterningtechnologies allowed us to obtain amultichannel strip inastraightforwardmanner,offering comparable analyticalperformance while allowing to be tailored even more to theusersneed.</abstract>
    <parentTitle language="eng">Angewandte Chemie - International Edition</parentTitle>
    <identifier type="doi">10.1002/anie.202009000</identifier>
    <identifier type="issn">1433-7851</identifier>
    <identifier type="urn">urn:nbn:de:kobv:b43-518424</identifier>
    <identifier type="issn">1521-3773</identifier>
    <enrichment key="date_peer_review">16.12.2020</enrichment>
    <enrichment key="RelatedIdentifier">https://nbn-resolving.org/urn:nbn:de:kobv:b43-518431</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>Estela Climent Terol</author>
    <author>Mustafa Biyikal</author>
    <author>Delia Gröninger</author>
    <author>Michael G. Weller</author>
    <author>R. Martínez Mánez</author>
    <author>Knut Rurack</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Multiplexing</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Explosives detection</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Gated materials</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fluorescence</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.5 Proteinanalytik</collection>
    <collection role="institutes" number="">1.9 Chemische und optische Sensorik</collection>
    <collection role="themenfelder" number="">Umwelt</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei für die Öffentlichkeit verfügbar ("Open Access")</collection>
    <collection role="unnumberedseries" number="">Wissenschaftliche Artikel der BAM</collection>
    <collection role="themenfelder" number="">Sensorik</collection>
    <thesisPublisher>Bundesanstalt für Materialforschung und -prüfung (BAM)</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-bam/files/51842/Multiplexed Detection of Analytes on Single Test Strips.pdf</file>
  </doc>
</export-example>
