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    <pageLast>2236</pageLast>
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    <issue>5</issue>
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    <title language="eng">Fluorinated Hexosome Carriers for Enhanced Solubility of Drugs</title>
    <abstract language="eng">Designing nanomaterials for drug encapsulation is a crucial, yet challenging, aspect for pharmaceutical development. An important step is synthesizing amphiphiles that form stable supramolecular systems for efficient drug loading. In the case of fluorinated drugs, these have superior properties and also a tendency toward reduced water solubility. For the first time, we report here fluorinated hexosome carriers made from nonionic dendritic amphiphiles, capable of encapsulating the fluorinated drug Leflunomide with high efficiency (62 ± 3%) and increasing its solubility by 12-fold. We synthesized amphiphiles with varying tail groups (fluorinated/alkylated), and their supramolecular self-assembly was investigated using cryogenic transmission electron microscopy and small-angle X-ray scattering. Furthermore, Leflunomide and its equivalent nonfluorinated counterpart were encapsulated within fluorinated and nonfluorinated assemblies. Self-assembly and encapsulation mechanisms were well supported by coarse-grained molecular simulations, yielding a fundamental understanding of the new systems.</abstract>
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    <author>Tiffany Guitton-Spassky</author>
    <author>Boris Schade</author>
    <author>Christian Zoister</author>
    <author>Eleonora Veronese</author>
    <author>Marta Rosati</author>
    <author>Francesca Baldelli Bombelli</author>
    <author>Gabriella Cavallo</author>
    <author>Andreas Thünemann</author>
    <author>Hassan Ghermezcheshme</author>
    <author>Hesam Makki</author>
    <author>Roland R. Netz</author>
    <author>Kai Ludwig</author>
    <author>Pierangelo Metrangolo</author>
    <author>Abhishek Kumar Singh</author>
    <author>Rainer Haag</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>PEFAS</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Small-angle X-ray scattering</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>SAXS</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Reference method</value>
    </subject>
    <collection role="ddc" number="620">Ingenieurwissenschaften und zugeordnete Tätigkeiten</collection>
    <collection role="institutes" number="">6 Materialchemie</collection>
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    <collection role="unnumberedseries" number="">Wissenschaftliche Artikel der BAM</collection>
    <collection role="themenfelder" number="">Advanced Materials</collection>
    <thesisPublisher>Bundesanstalt für Materialforschung und -prüfung (BAM)</thesisPublisher>
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