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  <doc>
    <id>62649</id>
    <completedYear/>
    <publishedYear>2025</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1</pageFirst>
    <pageLast>9</pageLast>
    <pageNumber/>
    <edition/>
    <issue>4</issue>
    <volume>7</volume>
    <type>article</type>
    <publisherName>American Chemical Society</publisherName>
    <publisherPlace>Washington, D.C.</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Design and Application of an Imprinted Polymer Sensor for the Dual Detection of Antibiotic Contaminants in Aqueous Samples and Food Matrices</title>
    <abstract language="eng">An innovative polymer-based dual detection microfluidic platform has been developed for the accurate and reliable sensing of trace amounts of antibiotic tetracycline in environmental and food samples. This was achieved through the production of a bespoke polymeric material formed via an imprinting technique using a fluorescent dye. Thus, this enables dual detection of tetracycline, both thermally, via analyzing the heat-transfer resistance at the solid−liquid interface, and optically, through the inner filter effect. The combination of these two methods achieved a nanomolar limit of detection for tetracycline while also providing rapid, selective, and cost-effective sensing. Additionally, this method successfully detected tetracycline levels of 0.56 μM in blank egg samples which was significantly lower than the maximum residual level of 400 μg L−1 (0.9 μM). Our work shows that this approach can be used for the efficient detection of trace antibiotics in complex environmental and food samples, offering enhanced reliability through the integration of two complementary analysis&#13;
techniques. This sensor has the potential to identify sources of antimicrobial resistance, which is crucial for targeted efforts to combat this pressing global health challenge.</abstract>
    <parentTitle language="eng">ACS Applied Polymer Materials</parentTitle>
    <identifier type="doi">10.1021/acsapm.4c03218</identifier>
    <identifier type="urn">urn:nbn:de:kobv:b43-626497</identifier>
    <identifier type="issn">2637-6105</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="date_peer_review">10.03.2025</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>O. D. Jamieson</author>
    <author>Jérémy Bell</author>
    <author>A. Hudson</author>
    <author>J. Saczek</author>
    <author>Victor Perez-Padilla</author>
    <author>G. Kaiya</author>
    <author>K. Novakovic</author>
    <author>M. Davies</author>
    <author>E. Foster</author>
    <author>J. Gruber</author>
    <author>Knut Rurack</author>
    <author>M. Peeters</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Molecularly imprinted polymers</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Antibiotics monitoring</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Orthogonal detection</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Sensors</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="ddc" number="620">Ingenieurwissenschaften und zugeordnete Tätigkeiten</collection>
    <collection role="ddc" number="628">Sanitär- und Kommunaltechnik; Umwelttechnik</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.9 Chemische und optische Sensorik</collection>
    <collection role="themenfelder" number="">Umwelt</collection>
    <collection role="themenfelder" number="">Chemie und Prozesstechnik</collection>
    <collection role="themenfelder" number="">Chemische Charakterisierung und Spurenanalytik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei für die Öffentlichkeit verfügbar ("Open Access")</collection>
    <collection role="themenfelder" number="">Sensorik</collection>
    <thesisPublisher>Bundesanstalt für Materialforschung und -prüfung (BAM)</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-bam/files/62649/ACSApplPolymMater_2025_ASAP.pdf</file>
  </doc>
  <doc>
    <id>54004</id>
    <completedYear/>
    <publishedYear>2021</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>5105</pageFirst>
    <pageLast>5115</pageLast>
    <pageNumber/>
    <edition/>
    <issue>15</issue>
    <volume>2</volume>
    <type>article</type>
    <publisherName>Royal Society of Chemistry</publisherName>
    <publisherPlace>Cambridge</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Dual detection of nafcillin using a molecularly imprinted polymer-based platform coupled to thermal and fluorescence read-out</title>
    <abstract language="eng">Reported here is the production of molecularly imprinted polymer (MIP) films, integrating a fluorescent moiety that serves as both an element for template interaction and signalling, for the thermal and optical detection of the beta-lactam antibiotic nafcillin. Fluorescein methacrylate (FluMa) was synthesized and introduced during the molecular imprinting process as the sole monomer and in a 1 : 1 mixture with methacrylic acid (MAA), allowing to draw first conclusions on the MIP formation potential of such a rather large and rigid monomer. At first, MIP microparticles containing FluMa were prepared by free radical polymerisation. Optical batch rebinding experiments revealed that FluMa can act as a functional monomer for selective detection of nafcillin; however, the addition of MAA as co-monomer significantly improved performance. Subsequently, thin MIP films containing FluMa were deposited onto functionalised glass slides and the influence of porogen, drying time, and monomer composition was studied. These MIP-functionalised glass electrodes were mounted into a customised 3D-printed flow cell, where changes in the liquid were either evaluated with a thermal device or using fluorescence bright field microscopy. Thermal analysis demonstrated that multiple MIP layers enhanced sensor specificity, with detection in the environmentally relevant range. The fluorescence bright field microscope investigations validated these results, showing an increase in the fluorescence intensity upon exposure of the MIP-functionalised glass slides to nafcillin solutions. These are promising results for developing a portable sensor device that can be deployed for antibiotics outside of a dedicated laboratory environment, especially if sensor design and fluorophore architecture are optimised.</abstract>
    <parentTitle language="eng">Materials Advances</parentTitle>
    <identifier type="doi">10.1039/D1MA00192B</identifier>
    <identifier type="urn">urn:nbn:de:kobv:b43-540044</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <licence>Creative Commons - CC BY-NC - Namensnennung - Nicht kommerziell 4.0 International</licence>
    <author>A.D. Hudson</author>
    <author>O. Jamieson</author>
    <author>R.D. Crapnell</author>
    <author>Knut Rurack</author>
    <author>T.C.C. Soares</author>
    <author>F. Mecozzi</author>
    <author>A. Laude</author>
    <author>J. Gruber</author>
    <author>K. Novakovic</author>
    <author>M. Peeters</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Molecularly Imprinted Polymers</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fluorescence</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Antibiotics</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Heat-transfer Measurements</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Thin films</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.9 Chemische und optische Sensorik</collection>
    <collection role="themenfelder" number="">Umwelt</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei für die Öffentlichkeit verfügbar ("Open Access")</collection>
    <collection role="unnumberedseries" number="">Wissenschaftliche Artikel der BAM</collection>
    <collection role="themenfelder" number="">Sensorik</collection>
    <thesisPublisher>Bundesanstalt für Materialforschung und -prüfung (BAM)</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-bam/files/54004/MaterAdv_2021_2_5105-5115.pdf</file>
  </doc>
</export-example>
