<?xml version="1.0" encoding="utf-8"?>
<export-example>
  <doc>
    <id>16658</id>
    <completedYear/>
    <publishedYear>2008</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>856</pageFirst>
    <pageLast>868</pageLast>
    <pageNumber/>
    <edition/>
    <issue>4</issue>
    <volume>84A</volume>
    <type>article</type>
    <publisherName>Wiley</publisherName>
    <publisherPlace>Hoboken, NJ</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Effect of rapidly resorbable bone substitute materials on the temporal expression of the osteoblastic phenotype in vitro</title>
    <abstract language="eng">Ideally, bioactive ceramics for use in alveolar ridge augmentation should possess the ability to activate bone formation and, thus, cause the differentiation of osteoprogenitor cells into osteoblasts at their surfaces. Therefore, in order to evaluate the osteogenic potential of novel bone substitute materials, it is important to examine their effect on osteoblastic differentiation. This study examines the effect of rapidly resorbable calcium-alkali-orthophosphates on osteoblastic phenotype expression and compares this behavior to that of β-tricalcium phosphate (TCP) and bioactive glass 45S5. Test materials were three materials (denominated GB14, GB9, GB9/25) with a crystalline phase Ca2KNa(PO4)2 and with a small amorphous portion containing either magnesium potassium phosphate (GB14) or silica phosphate (GB9 and GB9/25, which also contains Ca2P2O7); and a material with a novel crystalline phase Ca10[K/Na](PO4)7 (material denominated 352i). SaOS-2 human bone cells were grown on the substrata for 3, 7, 14, and 21 days, counted, and probed for an array of osteogenic markers. GB9 had the greatest stimulatory effect on osteoblastic proliferation and differentiation, suggesting that this material possesses the highest potency to enhance osteogenesis. GB14 and 352i supported osteoblast differentiation to the same or a higher degree than TCP, whereas, similar to bioactive glass 45S5, GB9/25 displayed a greater stimulatory effect on osteoblastic phenotype expression, indicating that GB9/25 is also an excellent material for promoting osteogenesis.</abstract>
    <parentTitle language="eng">Journal of biomedical materials research / A</parentTitle>
    <identifier type="old">18680</identifier>
    <identifier type="doi">10.1002/jbm.a.31383</identifier>
    <identifier type="issn">1549-3296</identifier>
    <identifier type="issn">1552-4965</identifier>
    <enrichment key="bibliotheksstandort">Sonderstandort: Publica-Schrank</enrichment>
    <enrichment key="date_peer_review">18.02.2008</enrichment>
    <author>C. Knabe</author>
    <author>A. Houshmand</author>
    <author>Georg Berger</author>
    <author>P. Ducheyne</author>
    <author>Renate Gildenhaar</author>
    <author>I. Kranz</author>
    <author>M. Stiller</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Bone substitute materials</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Calcium-alkali-orthophosphate ceramics</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>SaOS-2 cells</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Osteoblast differentiation</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Bioactive glass</value>
    </subject>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Physisches Exemplar in der Bibliothek der BAM vorhanden ("Hardcopy Access")</collection>
  </doc>
  <doc>
    <id>24924</id>
    <completedYear/>
    <publishedYear>2012</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>387</pageFirst>
    <pageLast>390</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>493-494</volume>
    <type>article</type>
    <publisherName>Trans Tech Publ.</publisherName>
    <publisherPlace>Aedermannsdorf</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Solubility and ingrowth behaviour of degradable and figuline calcium alkaline phosphate cements</title>
    <abstract language="eng">The thrust of the investigations presented here is to point out the degradation behaviour in vitro and the ingrowth behaviour in vivo of four different calcium alkaline phosphate cements. Two of the figuline and mouldable composites consist of the crystalline phase Ca2KNa(PO4)2 and two of the crystalline phase Ca10[K/Na](PO4)2 each containing 2wt% medium gel strength porcine gelatin. Furthermore A-TCP was added to both Ca10[K/Na](PO4)2 cements as a hardening supporting reactant. The testing material groups differ in small amorphous portions containing either silica phosphate (GB9), magnesium potassium phosphate (GB14) or diphosphates (401545 and 401545(70)). The respective composites show a monomodal particle size distribution (d50~7µm; span~4) and an average total porosity around 28vol%.For the solubility studies cylindrical samples (d=6mm; h=12mm) were stored in a 0.1mol TRIS buffer solution and incubated at 37°C for maximum 50 weeks. The storage solution was analysed and renewed every week. The results are plotted cumulative. For the in vivo studies critical size defects were dissected to mandibles in a sheep model in which a 1cm³ area of the bottom of the mandibles was surgically resected and replaced with the figuline cements whereas the mouldability allows the reconstruction of the original outer contour without draining off even when replacing upside down.</abstract>
    <parentTitle language="eng">Key engineering materials</parentTitle>
    <identifier type="old">27613</identifier>
    <identifier type="doi">10.4028/www.scientific.net/KEM.493-494.387</identifier>
    <identifier type="issn">1013-9826</identifier>
    <enrichment key="bibliotheksstandort">Sonderstandort: Publica-Schrank</enrichment>
    <enrichment key="zsBemerkung">Die Aufnahme ist grundsätzlich falsch, da es sich bei "Key engineering materials" nicht um eine Zeitschrift handelt, sondern um eine Buchreihe. Da sehr viele Artikel an diesem Eintrag hängen, wäre die Korrektur aber extrem aufwändig.  Die Buchreihe findet sich in der Master Journal List bzw. in dem Journal Citation Report selbstverständlich nicht wieder, da es ja keine Zeitschrift ist. Allerdings wird die Buchreihe sehr wohl von Thomson-Reuters für Ihre Datenbank ausgewertet, als "Book Series". Daher muss sichergestellt werden, dass die dort erscheinenden Artikel auch für die "1000-Euro-Liste" berücksichtigt werden.  Die einfachste Lösung ist es, den Eintrag als Zeitschrift zu belassen, und das Häkchen bei "In MJL/CPCI von ISI enthalten" zu setzen. Das ist zwar formal nicht ganz korrekt, erzeugt aber das richtige Ergebnis.  Jan Harloff-Puhr 16.9.2014</enrichment>
    <enrichment key="date_peer_review">05.12.2011</enrichment>
    <author>Felix Dombrowski</author>
    <author>Heidi Marx</author>
    <author>Ute Ploska</author>
    <author>Dagmar Nicolaides</author>
    <author>M. Stiller</author>
    <author>C. Knabe</author>
    <author>Georg Berger</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Calcium alkaline phosphate cement</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Gelatin</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Figuline</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Solubility</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Ingrowth behavior</value>
    </subject>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Physisches Exemplar in der Bibliothek der BAM vorhanden ("Hardcopy Access")</collection>
  </doc>
  <doc>
    <id>24989</id>
    <completedYear/>
    <publishedYear>2012</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>849</pageFirst>
    <pageLast>854</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>493-494</volume>
    <type>article</type>
    <publisherName>Trans Tech Publ.</publisherName>
    <publisherPlace>Aedermannsdorf</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Calcium alkaline phosphate scaffolds for bone regeneration 3D-fabricated by additive manufacturing</title>
    <abstract language="eng">Calcium alkaline phosphate granulates can be used for substitution of several bone defects but for the reconstruction of large skeletal parts in the maxillofacial and orthopaedic fields fitted scaffolds are preferable. Within the additive manufacturing methods, the 3D printing process offers exciting opportunities to generate defined porous scaffolds. We used a R1 printer from ProMetal Company, USA, for producing scaffolds directly from a ceramic powder. For this direct free form fabrication technology the powder has to possess a lot of specific properties both for the generation of a stable green body and also for the subsequent sintering preparation. For this printing process we prepared different granules in a fluidized bed process containing Ca2KNa(PO4)2 as main crystalline phase. Granules were characterized by different methods and several sieve fractions were used for preparing disc like and cylindrical parts. The suitability of granules for this printing process was determined by porosity and strength of produced bodies. Next to granules' performance both of these properties can be directly influenced by 3D printing process parameters. With knowledge of suitable process parameters scaffolds with different porosity in a respective desired design can be created. In this study, cylindrical scaffolds with graded porosity were produced for bone regeneration of segmental defects in maxillofacial surgery and dental implantology by tissue engineering.</abstract>
    <parentTitle language="eng">Key engineering materials</parentTitle>
    <identifier type="old">27685</identifier>
    <identifier type="doi">10.4028/www.scientific.net/KEM.493-494.849</identifier>
    <identifier type="issn">1013-9826</identifier>
    <note>Geburtsname von Wirth, Cynthia: Gomes, C. M. -  Birth name of Wirth, Cynthia: Gomes, C. M.</note>
    <enrichment key="bibliotheksstandort">Sonderstandort: Publica-Schrank</enrichment>
    <enrichment key="zsBemerkung">Die Aufnahme ist grundsätzlich falsch, da es sich bei "Key engineering materials" nicht um eine Zeitschrift handelt, sondern um eine Buchreihe. Da sehr viele Artikel an diesem Eintrag hängen, wäre die Korrektur aber extrem aufwändig.  Die Buchreihe findet sich in der Master Journal List bzw. in dem Journal Citation Report selbstverständlich nicht wieder, da es ja keine Zeitschrift ist. Allerdings wird die Buchreihe sehr wohl von Thomson-Reuters für Ihre Datenbank ausgewertet, als "Book Series". Daher muss sichergestellt werden, dass die dort erscheinenden Artikel auch für die "1000-Euro-Liste" berücksichtigt werden.  Die einfachste Lösung ist es, den Eintrag als Zeitschrift zu belassen, und das Häkchen bei "In MJL/CPCI von ISI enthalten" zu setzen. Das ist zwar formal nicht ganz korrekt, erzeugt aber das richtige Ergebnis.  Jan Harloff-Puhr 16.9.2014</enrichment>
    <enrichment key="date_peer_review">08.12.2011</enrichment>
    <author>Renate Gildenhaar</author>
    <author>C. Knabe</author>
    <author>Cynthia Wirth</author>
    <author>Ulf Linow</author>
    <author>A. Houshmand</author>
    <author>Georg Berger</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>3D printing</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Calcium alkaline phosphates</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Ceramic scaffolds</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Oral surgery</value>
    </subject>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Physisches Exemplar in der Bibliothek der BAM vorhanden ("Hardcopy Access")</collection>
  </doc>
  <doc>
    <id>40745</id>
    <completedYear/>
    <publishedYear>2017</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>44</pageFirst>
    <pageLast>58</pageLast>
    <pageNumber/>
    <edition/>
    <issue>1</issue>
    <volume>12</volume>
    <type>article</type>
    <publisherName>Wiley Online Library</publisherName>
    <publisherPlace/>
    <creatingCorporation>John Wiley &amp; Sons, Ltd.</creatingCorporation>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Development of a synthetic tissue engineered three- dimensional printed bioceramic-based bone graft with homogenously distributed osteoblasts and mineralizing bone matrix in vitro</title>
    <abstract language="eng">Over the last decade there have been increasing efforts to develop three-dimensional (3D) scaffolds for bone tissue Engineering from bioactive ceramics with 3D printing emerging as a promising technology. The overall objective of the present study was to generate a tissue engineered synthetic bone graft with homogenously distributed osteoblasts and mineralizing bone Matrix in vitro, thereby mimicking the advantageous properties of autogenous bone grafts and facilitating usage for reconstructing segmental discontinuity defects in vivo . To this end, 3D scaffolds were developed from a silica-containing calcium alkali orthophosphate, using, ﬁ rst, a replica technique – the Schwartzwalder – Somers method – and, second, 3D printing, (i.e. rapid prototyping). The mechanical and physical scaffold properties and their potential to facilitate homogenous colonization by osteogenic cells and extracellular bone matrix formation throughout the porous scaffold architecture were examined.&#13;
Osteoblastic cells were dynamically cultured for 7 days on both scaffold types with two different concentrations of 1.5 and 3 × 10⁹ cells/l. The amount of cells and bone matrix formed and osteogenic marker expression were evaluated using hard tissue histology, immunohistochemical and histomorphometric analysis. 3D-printed scaffolds (RPS) exhibited more micropores, greater compressive strength and silica release. RPS seeded with 3 × 10⁹ cells/l displayed greatest cell and extracellular Matrix formation, mineralization and osteocalcin expression. In conclusion, RPS displayed superior mechanical and biological properties and facilitated generating a tissue engineered synthetic bone graft in vitro, which mimics the advantageous properties of autogenous bone grafts, by containing homogenously distributed terminally differentiated osteoblasts and mineralizing bone matrix and therefore is suitable for subsequent in vivo implantation for regenerating segmental discontinuity bone defects.</abstract>
    <parentTitle language="eng">Journal of Tissue Engineering and Regenerative Medicine</parentTitle>
    <identifier type="doi">10.1002/term.2362</identifier>
    <identifier type="issn">1932-6254</identifier>
    <identifier type="issn">1932-7005</identifier>
    <enrichment key="date_peer_review">22.02.2018</enrichment>
    <author>D. Adel-Khattab</author>
    <author>F. Giacomini</author>
    <author>R. Gildenhaar</author>
    <author>G. Berger</author>
    <author>Cynthia Gomes</author>
    <author>Ulf Linow</author>
    <author>M. Hardt</author>
    <author>B. Peleska</author>
    <author>Jens Günster</author>
    <author>M. Stiller</author>
    <author>A. Houshmand</author>
    <author>K. Ghaffar</author>
    <author>A. Gamal</author>
    <author>M. El-Mofty</author>
    <author>C. Knabe</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Bone tissue engineering</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Calcium alkali orthophosphate</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Rapid prototyping</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Scaffold</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Mandible</value>
    </subject>
    <collection role="ddc" number="620">Ingenieurwissenschaften und zugeordnete Tätigkeiten</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>34957</id>
    <completedYear/>
    <publishedYear>2015</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>025008</pageFirst>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue>2</issue>
    <volume>7</volume>
    <type>article</type>
    <publisherName>IOP Publ.</publisherName>
    <publisherPlace>Philadelphia</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">3D-printed silicate porous bioceramics using a non-sacrificial preceramic polymer binder</title>
    <abstract language="eng">Silicate bioceramics possess an excellent bioactivity; however, shaping them into complex geometries is still challenging. Therefore, this paper aims to present a new strategy for the shaping of a bioglass-ceramic with controlled geometry and properties starting from a glass powder combined with a preceramic polymer, i.e. a silicon resin, and reactive fillers. The powder-based three-dimensional (3D)-printing of wollastonite (CaSiO3)-based silicate bioceramic parts was demonstrated in this work. The resin plays a dual role, as it not only acts as a non-sacrificial binder for the filler powders in the printing process but it also reacts with the fillers to generate the desired bioceramic phases. The mechanical and physical properties, i.e. ball-on-three-balls test, density, porosity and morphology, were evaluated in 3D-printed discs. These samples possessed a total porosity around 64 vol% and a biaxial flexural strength around 6 MPa. The raw materials used in this work also enabled the 3D-printing of scaffolds possessing a designed multi-scale porosity, suitable bioceramic phase assemblage and a compressive strength of 1 MPa (for cylindrical scaffolds with total porosity ~80 vol%). Solubility in TRIS/HCl and in vitro assays, i.e. viability, cytotoxicity and apoptosis assays, were also performed. In vitro tests indicated good cell viability and no cytotoxicity effect on the cells.</abstract>
    <parentTitle language="eng">Biofabrication</parentTitle>
    <identifier type="old">38107</identifier>
    <identifier type="issn">1758-5082</identifier>
    <identifier type="doi">10.1088/1758-5090/7/2/025008</identifier>
    <enrichment key="date_peer_review">25.11.2015</enrichment>
    <author>Andrea Zocca</author>
    <author>H. Elsayed</author>
    <author>E. Bernardo</author>
    <author>Cynthia Wirth</author>
    <author>M.A. Lopez-Heredia</author>
    <author>C. Knabe</author>
    <author>P. Colombo</author>
    <author>Jens Günster</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>KNN</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Glass microspheres</value>
    </subject>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>2957</id>
    <completedYear/>
    <publishedYear>2004</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>335</pageFirst>
    <pageLast>344</pageLast>
    <pageNumber/>
    <edition/>
    <issue>2</issue>
    <volume>25</volume>
    <type>article</type>
    <publisherName>Elsevier</publisherName>
    <publisherPlace>Oxford</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">The functional expression of human bone-derived cells grown on rapidly resorbable calcium phosphate ceramics</title>
    <abstract language="eng">The use of biodegradable bone substitutes is advantageous for alveolar ridge augmentation, since it avoids second-site surgery for autograft harvesting. This study examines the effect of novel, rapidly resorbable calcium phosphates on the expression of bone-related genes and proteins by human bone-derived cells (HBDC) and compares this behavior to that of tricalciumphosphate (TCP). Test materials were a-TCP, and four materials which were created from ß-Rhenanite and its derivatives: R1-ß-Rhenanite (CaNaPO4); R1/M2 composed of CaNaPO4 and MgNaPO4; R1+SiO2 composed of CaNaPO4 and 9% SiO2 (wt%); and R17-Ca2KNa(PO4)2. HBDC were grown on the substrata for 3, 5, 7, 14 and 21 days, counted and probed for various mRNAs and proteins (Type I collagen, osteocalcin, osteopontin, osteonectin, alkaline phosphatase and bone sialoprotein). All substrata supported continuous cellular growth for 21 days. At day 21, surfaces of R1+SiO2 and R17 had the highest number of HBDC. At 14 and 21 days, cells on R1 and on R1+SiO2 displayed significantly enhanced expression of all osteogenic proteins. Since all novel calcium phosphates supported cellular proliferation together with expression of bone-related proteins at least as much as TCP, these ceramics can be regarded as potential bone substitutes. R1 and R1+SiO2 had the most effect on osteoblastic differentiation, thus suggesting that these materials may possess a higher potency to enhance osteogenesis than TCP.</abstract>
    <parentTitle language="eng">Biomaterials</parentTitle>
    <identifier type="old">2986</identifier>
    <identifier type="doi">10.1016/S0142-9612(03)00525-8</identifier>
    <identifier type="issn">0142-9612</identifier>
    <enrichment key="date_peer_review">11.02.2004</enrichment>
    <author>Ch. Knabe</author>
    <author>Georg Berger</author>
    <author>Renate Gildenhaar</author>
    <author>C.R. Howlett</author>
    <author>B. Markovic</author>
    <author>H. Zreiqat</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Calcium phosphate ceramics</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Human bone-derived cells</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Cell-biomaterial interactions</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Bone substitutes</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>In situ hybridization</value>
    </subject>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Weder Datei noch physisches Exemplar vorhanden ("No Access")</collection>
  </doc>
</export-example>
