<?xml version="1.0" encoding="utf-8"?>
<export-example>
  <doc>
    <id>35283</id>
    <completedYear/>
    <publishedYear>2015</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>2086</pageFirst>
    <pageLast>2095</pageLast>
    <pageNumber/>
    <edition/>
    <issue>12</issue>
    <volume>26</volume>
    <type>article</type>
    <publisherName>Elsevier</publisherName>
    <publisherPlace>New York, NY</publisherPlace>
    <creatingCorporation>American Society for Mass Spectrometry</creatingCorporation>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Matrix-assisted ionization-ion mobility spectrometry-mass spectrometry: Selective analysis of a europium-PEG complex in a crude mixture</title>
    <abstract language="eng">The analytical utility of a new and simple to use ionization method, matrix-assisted ionization (MAI), coupled with ion mobility spectrometry (IMS) and mass spectrometry (MS) is used to characterize a 2-armed europium(III)-containing poly(ethylene glycol) (Eu-PEG) complex directly from a crude sample. MAI was used with the matrix 1,2-dicyanobenzene, which affords low chemical background relative to matrix-assisted laser desorption/ionization (MALDI) and electrospray ionization (ESI). MAI provides high ion abundance of desired products in comparison to ESI and MALDI. Inductively coupled plasma-MS measurements were used to estimate a maximum of 10% of the crude sample by mass was the 2-arm Eu-PEG complex, supporting evidence of selective ionization of Eu-PEG complexes using the new MAI matrix, 1,2-dicyanobenzene. Multiply charged ions formed in MAI enhance the IMS gas-phase separation, especially relative to the singly charged ions observed with MALDI. Individual components are cleanly separated and readily identified, allowing characterization of the 2-arm Eu-PEG conjugate from a mixture of the 1-arm Eu-PEG complex and unreacted starting materials. Size-exclusion chromatography, liquid chromatography at critical conditions, MALDI-MS, ESI-MS, and ESI-IMS-MS had difficulties with this analysis, or failed.</abstract>
    <parentTitle language="eng">Journal of the American society for mass spectrometry</parentTitle>
    <identifier type="doi">10.1007/s13361-015-1233-8</identifier>
    <identifier type="issn">1044-0305</identifier>
    <enrichment key="date_peer_review">25.01.2016</enrichment>
    <author>J.L. Fischer</author>
    <author>C.A. Lutomski</author>
    <author>T.J. El-Baba</author>
    <author>B.N. Siriwardena-Mahanama</author>
    <author>Steffen Weidner</author>
    <author>Jana Falkenhagen</author>
    <author>M. J. Allen</author>
    <author>S. Trimpin</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Matrix-assisted ionization ion mobility spectrometry mass spectrometry</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Europium</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Poly(ethylene glycol)</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Size-exclusion chromatography</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Liquid chromatography at critical conditions</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Electrospray ionization</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Matrix-assisted laser desorption/ionization</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Inductively coupled plasma-mass spectrometry</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>ESI</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>MALDI</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>SEC</value>
    </subject>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
</export-example>
