<?xml version="1.0" encoding="utf-8"?>
<export-example>
  <doc>
    <id>40936</id>
    <completedYear/>
    <publishedYear>2017</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>S267</pageFirst>
    <pageLast>S267</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>258</volume>
    <type>conferenceobject</type>
    <publisherName>Elsevier Ltd.</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Evidence for particle-specific and coating-related uptake of silver nanoparticles</title>
    <abstract language="eng">Present data indicate that the quantification of silver nanoparticle internalization revealed a clear particle-specific and coatingrelated uptake. Furthermore, a high amount of silver nanoparticles is taken up in cell models of higher complexity. Thus, an underestimation of particle effects in vitro might be prevented by considering cell models with greater proximity to the in vivo situation.</abstract>
    <parentTitle language="eng">Toxicology Letters</parentTitle>
    <identifier type="doi">10.1016/j.toxlet.2016.06.1938</identifier>
    <identifier type="issn">0378-4274</identifier>
    <enrichment key="eventName">52nd Congress of the European-Societies-of-Toxicology (EUROTOX)</enrichment>
    <enrichment key="eventPlace">Seville, Spain</enrichment>
    <enrichment key="eventStart">04.09.2016</enrichment>
    <enrichment key="eventEnd">07.09.2016</enrichment>
    <enrichment key="date_peer_review">10.07.2017</enrichment>
    <author>D. Lichtenstein</author>
    <author>Th. Meyer</author>
    <author>L. Böhmert</author>
    <author>H. Sieg</author>
    <author>S. Juling</author>
    <author>Andreas Thünemann</author>
    <author>I. E. Lopies</author>
    <author>A. Bräuning</author>
    <author>A. Lampen</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Small-angle X-ray scattering</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>SAXS</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Nanoparticle</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Silver</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>46317</id>
    <completedYear/>
    <publishedYear>2018</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>lecture</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Self-healing materials: structure elucidation with SAXS</title>
    <abstract language="eng">Healable materials could play an important role in reducing the environmental footprint of our modern technological society through extending the life cycles of consumer products and constructions. Future technologies require smart materials with advanced properties including responsiveness to external stimuli and particularly the ability to autonomously repair inflicted damage. The introduction of reversible connections in the polymer architecture, either in a non-covalent fashion, such as in supramolecular polymers, or by using dynamic covalent chemistry. One facile approach involves the implementation of reversible polymer networks as they offer high mechanical strength and thermal properties that are readily modified by the nature of the connecting dynamic bonds and the crosslinking density. In this context, small-angle scattering allows a detailed insight into the network structure of self-healing polymers either in bulk materials or in form of hydrogels. Here we report on how small-angle scattering can contribute to reveal the network structure. A first example is the conditional repair by locally switching the thermal healing capability of dynamic covalent polymers with light.&#13;
 Typical experimental SAXS curves of a photo- and thermal switchable polymer are shown. The scattering pattern show three characteristics. Region 1 is dominated by a forward scattering interpreted as resultant from large scale inhomogeneities of the bulk polymers (characterized by a first correlation length). The second scattering contribution can be interpreted as resultant from the network and is characterized by its entanglement distance. The mesh size of this network can be described by a second correlation length. Region 3 of the scattering pattern is dominated by a broad peak. Taking all effects into account, we approximate the total scattering as a sum of the three scattering contributions. In particular, the Debye-Büche function is used for I1 the Ornstein-Zernike function for the crosslinking contribution I2 and a Lorentzian peak function. &#13;
 We discussed this simple and more sophisticated approaches for revealing network structures. Examples of studies from hydrogel networks are provided as important materials with polymeric networks in life science applications. Finally, the determination of mesh size distributions as a function of temperature, time and healing efficiency is discussed in detail.</abstract>
    <enrichment key="eventName">XVII International Small Angle Scattering Conference - SAS2018</enrichment>
    <enrichment key="eventPlace">Traverse City, Michigan, USA</enrichment>
    <enrichment key="eventStart">7.10.2018</enrichment>
    <enrichment key="eventEnd">12.10.2018</enrichment>
    <enrichment key="InvitedTalks">0</enrichment>
    <author>Andreas Thünemann</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Small-angle x-ray scattering</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Nanomaterial</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Saxs</value>
    </subject>
    <collection role="ddc" number="620">Ingenieurwissenschaften und zugeordnete Tätigkeiten</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
    <collection role="literaturgattung" number="">Präsentation</collection>
  </doc>
  <doc>
    <id>33337</id>
    <completedYear/>
    <publishedYear>2015</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>5300104-1</pageFirst>
    <pageLast>5300104-4</pageLast>
    <pageNumber/>
    <edition/>
    <issue>2</issue>
    <volume>51</volume>
    <type>article</type>
    <publisherName>Institute of Electrical and Electronics Engineers</publisherName>
    <publisherPlace>New York, NY</publisherPlace>
    <creatingCorporation>Magnetics Society</creatingCorporation>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">How hydrodynamic fractionation influences MPI performance of resovist</title>
    <abstract language="eng">We studied the magnetic resonance imaging liver contrast agent Resovist by a variety of magnetic measurement techniques, in order to understand the physical mechanism of their high magnetic particle imaging (MPI) performance, wirh a focus on the size-dependent contributions of the MPI signal. To this end, we used asymmetric flow field-flow fractionation to separate Resovist into a set of fractions with defined hydrodynamic diameters. The individual fractions were magnetically characterized by static magnetization and magnetorelaxometry measurements to obtain the corresponding effective magnetic anisotropy and effective size distribution parameters. In addition, the MPI performance of each fraction was assessed by magnetic particle spectroscopy. We observed an MPI signal gain of about 100% with respect to their iron amount for the best fraction. Relating these finding to the results from magnetic characterization provides more insight into mechanisms of MPI performance of Resovist. This knowledge may help to improve the design of novel MPI tracers.</abstract>
    <parentTitle language="eng">IEEE transactions on magnetics</parentTitle>
    <identifier type="old">36427</identifier>
    <identifier type="issn">0018-9464</identifier>
    <identifier type="issn">1941-0069</identifier>
    <identifier type="doi">10.1109/TMAG.2014.2326833</identifier>
    <enrichment key="date_peer_review">04.06.2015</enrichment>
    <author>N. Löwa</author>
    <author>Patrick Knappe</author>
    <author>F. Wiekhorst</author>
    <author>D. Eberbeck</author>
    <author>Andreas Thünemann</author>
    <author>L. Trahms</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Nanotechnology</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Nanoparticles</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Asymmetric flow field-flow fractionation</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Magnetic nanoparticles (MNP)</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Magnetic particle imaging (MPI)</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Magnetic particle spectroscopy</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Magnetic separation</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Magnetorelaxometry (MRX)</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Resovist</value>
    </subject>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>22476</id>
    <completedYear/>
    <publishedYear>2010</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>5432</pageFirst>
    <pageLast>5439</pageLast>
    <pageNumber/>
    <edition/>
    <issue>23</issue>
    <volume>51</volume>
    <type>article</type>
    <publisherName>Springer</publisherName>
    <publisherPlace>Berlin</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Synthesis, characterization and fine-tuning of bimodal poly(organosiloxane) nanoparticles</title>
    <abstract language="eng">The acid catalyzed solgel type synthesis of polyorganosiloxane core-shell nanoparticles with removable PDMS core in aqueous dispersion leads to the inherent formation of a bimodal size distribution with smaller spheres having approximately 26 nm radii and larger nanoparticles with 60 nm in radius. The origin of the self-organized bimodality is investigated and finally attributed to a combination of stabilization of the growing particles due to i) a miniemulsion-type stabilization by the ultrahydrophobe PDMS and ii) by surface co-stabilization by the employed surfactant. The significant influence of temperature, pH, stirrer speed and amount of the surfactant on the particle sizes allows for the design and fine-tuning of different nanoparticles sizes and distributions.</abstract>
    <parentTitle language="eng">Polymer</parentTitle>
    <identifier type="old">25003</identifier>
    <identifier type="doi">10.1016/j.polymer.2010.09.065</identifier>
    <identifier type="issn">0032-3861</identifier>
    <identifier type="issn">1873-2291</identifier>
    <enrichment key="bibliotheksstandort">Sonderstandort: Publica-Schrank</enrichment>
    <enrichment key="date_peer_review">25.11.2010</enrichment>
    <author>Christian Scherer</author>
    <author>S. Utech</author>
    <author>S. Scholz</author>
    <author>S. Noskov</author>
    <author>P. Kindervater</author>
    <author>R. Graf</author>
    <author>Andreas Thünemann</author>
    <author>Michael Maskos</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Nanoparticles</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Polyorganosiloxane</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Field-flow fractionation (FFF)</value>
    </subject>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Physisches Exemplar in der Bibliothek der BAM vorhanden ("Hardcopy Access")</collection>
  </doc>
  <doc>
    <id>23951</id>
    <completedYear/>
    <publishedYear>2011</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>4160</pageFirst>
    <pageLast>4166</pageLast>
    <pageNumber/>
    <edition/>
    <issue>27</issue>
    <volume>1218</volume>
    <type>article</type>
    <publisherName>Elsevier</publisherName>
    <publisherPlace>Amsterdam</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Processing nanoparticles with A4F-SAXS for toxicological studies: Iron oxide in cell-based assays</title>
    <abstract language="eng">Nanoparticles are not typically ready-to-use for in vitro cell culture assays. Prior to their use in assays, powder samples containing nanoparticles must be dispersed, de-agglomerated, fractionated by size, and characterized with respect to size and size distribution. For this purpose we report exemplarily on polyphosphate-stabilized iron oxide nanoparticles in aqueous suspension. Fractionation and online particle size analysis was performed in a time-saving procedure lasting 50 min by combining asymmetrical flow field-flow fractionation (A4F) and small-angle X-ray scattering (SAXS). Narrowly distributed nanoparticle fractions with radii of gyration (Rg) from 7 to 21 nm were obtained from polydisperse samples. The A4F-SAXS combination is introduced for the preparation of well-characterized sample fractions originating from a highly polydisperse system as typically found in engineered nanoparticles. A4F-SAXS processed particles are ready-to-use for toxicological studies. The results of preliminary tests of the effects of fractionated iron oxide nanoparticles with a Rg of 15 nm on a human colon model cell line are reported.</abstract>
    <parentTitle language="eng">Journal of chromatography A</parentTitle>
    <identifier type="old">26562</identifier>
    <identifier type="doi">10.1016/j.chroma.2010.11.012</identifier>
    <identifier type="issn">0021-9673</identifier>
    <enrichment key="date_peer_review">04.07.2011</enrichment>
    <author>Patrick Knappe</author>
    <author>L. Boehmert</author>
    <author>Ralf Bienert</author>
    <author>S. Karmutzki</author>
    <author>B. Niemann</author>
    <author>A. Lampen</author>
    <author>Andreas Thünemann</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Field-flow-fractionation</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Small-angle X-ray scattering</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Nanoparticle</value>
    </subject>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>10534</id>
    <completedYear/>
    <publishedYear>2005</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>297</pageFirst>
    <pageLast>298</pageLast>
    <pageNumber/>
    <edition/>
    <issue>2</issue>
    <volume>46</volume>
    <type>article</type>
    <publisherName>American Chemical Society</publisherName>
    <publisherPlace>Newark, NJ</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Multicompartment Micelles Obtained via the Self-Assembly of a Well-Defined Triblock Macrosurfactant Prepared by RAFT Polymerization</title>
    <parentTitle language="eng">Polymer preprints</parentTitle>
    <identifier type="old">12146</identifier>
    <identifier type="issn">0032-3934</identifier>
    <enrichment key="bibliotheksstandort">Sonderstandort: Publica-Schrank</enrichment>
    <author>J.-F. Lutz</author>
    <author>St. Kubowicz</author>
    <author>J.-F. Baussard</author>
    <author>Andreas Thünemann</author>
    <author>H. v. Berlepsch</author>
    <author>A. Laschewsky</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Micelles</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Living polymerization</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>RAFT</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Block copolymers</value>
    </subject>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Physisches Exemplar in der Bibliothek der BAM vorhanden ("Hardcopy Access")</collection>
  </doc>
  <doc>
    <id>42438</id>
    <completedYear/>
    <publishedYear>2017</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>10726</pageFirst>
    <pageLast>10735</pageLast>
    <pageNumber/>
    <edition/>
    <issue>40</issue>
    <volume>33</volume>
    <type>article</type>
    <publisherName>Americal Chemical Society</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Impact of an artificial digestion procedure on aluminum-containing nanomaterials</title>
    <abstract language="eng">Aluminum has gathered toxicological Attention based on relevant human exposure and its suspected hazardous potential. Nanoparticles from food supplements or Food contact materials may reach the human gastrointestinal tract.&#13;
Here, we monitored the physicochemical fate of aluminum containing nanoparticles and aluminum ions when passaging an in vitro model of the human gastrointestinal tract. Smallangle X-ray scattering (SAXS), transmission electron microscopy (TEM), ion beam microscopy (IBM), secondary ion beam mass spectrometry (TOF-SIMS), and inductively coupled plasma mass spectrometry (ICP-MS) in the singleparticle mode were employed to characterize two aluminumcontaining nanomaterials with different particle core materials (Al0, γAl2O3) and soluble AlCl3. Particle size and shape remained unchanged in saliva, whereas strong Agglomeration of both aluminum nanoparticle species was observed at low pH in gastric fluid together with an increased ion release. The levels of free aluminum ions decreased in intestinal fluid and the particles deagglomerated, thus liberating primary particles again. Dissolution of nanoparticles was limited and substantial changes of their shape and size were not detected. The amounts of particle-associated phosphorus, chlorine, potassium, and calcium increased in intestinal fluid, as compared to nanoparticles in standard dispersion.&#13;
Interestingly, nanoparticles were found in the intestinal fluid after addition of ionic aluminum. We provide a comprehensive characterization of the fate of aluminum nanoparticles in simulated gastrointestinal fluids, demonstrating that orally ingested nanoparticles probably reach the intestinal epithelium. The balance between dissolution and de novo complex formation should be considered when evaluating nanotoxicological experiments.</abstract>
    <parentTitle language="eng">Langmuir</parentTitle>
    <identifier type="doi">10.1021/acs.langmuir.7b02729</identifier>
    <identifier type="issn">1520-5827</identifier>
    <identifier type="issn">0743-7463</identifier>
    <enrichment key="date_peer_review">06.11.2017</enrichment>
    <author>H. Sieg</author>
    <author>Claudia Kästner</author>
    <author>B. Krause</author>
    <author>T. Meyer</author>
    <author>A. Burel</author>
    <author>L. Böhmert</author>
    <author>D. Lichtenstein</author>
    <author>H. Jungnickel</author>
    <author>J. Tentschert</author>
    <author>P. Laux</author>
    <author>A. Braeuning</author>
    <author>I. Estreal-Lopis</author>
    <author>F. Gauffre</author>
    <author>V. Fessard</author>
    <author>J. Meijer</author>
    <author>A. Luch</author>
    <author>Andreas Thünemann</author>
    <author>A. Lampen</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Small-angle X-ray scattering</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>SAXS</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Nanoparticle</value>
    </subject>
    <collection role="ddc" number="620">Ingenieurwissenschaften und zugeordnete Tätigkeiten</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>23207</id>
    <completedYear/>
    <publishedYear>2011</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>820</pageFirst>
    <pageLast>833</pageLast>
    <pageNumber/>
    <edition/>
    <issue>2</issue>
    <volume>5</volume>
    <type>article</type>
    <publisherName>ACS Publ.</publisherName>
    <publisherPlace>Washington, DC, USA</publisherPlace>
    <creatingCorporation>American Chemical Society</creatingCorporation>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Silicification of peptide-coated silver nanoparticles - a biomimetic soft chemistry approach toward chiral hybrid core-shell materials</title>
    <abstract language="eng">Silica and silver nanoparticles are relevant materials for new applications in optics, medicine, and analytical chemistry. We have previously reported the synthesis of pH responsive, peptide-templated, chiral silver nanoparticles. The current report shows that peptide-stabilized nanoparticles can easily be coated with a silica shell by exploiting the ability of the peptide coating to hydrolyze silica precursors such as TEOS or TMOS. The resulting silica layer protects the nanoparticles from chemical etching, allows their inclusion in other materials, and renders them biocompatible. Using electron and atomic force microscopy, we show that the silica shell thickness and the particle aggregation can be controlled simply by the reaction time. Small-angle X ray scattering confirms the Ag/peptide@silica core–shell structure. UV–vis and circular dichroism spectroscopy prove the conservation of the silver nanoparticle chirality upon silicification. Biological tests show that the biocompatibility in simple bacterial systems is significantly improved once a silica layer is deposited on the silver particles.</abstract>
    <parentTitle language="eng">ACS nano</parentTitle>
    <identifier type="old">25778</identifier>
    <identifier type="doi">10.1021/nn102969p</identifier>
    <identifier type="issn">1936-0851</identifier>
    <enrichment key="date_peer_review">10.02.2011</enrichment>
    <author>P. Graf</author>
    <author>Alexandre Mantion</author>
    <author>A. Haase</author>
    <author>Andreas Thünemann</author>
    <author>A. Masic</author>
    <author>W. Meier</author>
    <author>A. Luch</author>
    <author>A. Taubert</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Peptide-templated materials</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Silver nanoparticles</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Chiral nanoparticles</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Ag/peptide@SiO2 nanostructures</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Core-shell structures</value>
    </subject>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>50632</id>
    <completedYear/>
    <publishedYear>2020</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>2246</pageFirst>
    <pageLast>2256</pageLast>
    <pageNumber/>
    <edition/>
    <issue>3</issue>
    <volume>3</volume>
    <type>article</type>
    <publisherName>American Chemical Society</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Cellular Effects of In Vitro-Digested Aluminum Nanomaterials on Human Intestinal Cells</title>
    <abstract language="eng">Aluminum (Al) can be taken up from food, packaging, or the environment and thus reaches the human gastrointestinal tract. Its toxic potential after oral uptake is still discussed. The fate of different solid and ionic Al species during the passage through the digestive tract is the focus of this research, as well as the cellular effects caused by these different Al species. The present study combines the physicochemical processing of three recently studied Al species (metallic Al0, mineral Al2O3, and soluble AlCl3) in artificial digestion fluids with in vitro cell systems for the human intestinal barrier. Inductively coupled plasma mass spectrometry (ICP-MS) and small-angle X-ray scattering (SAXS) methods were used to characterize the Al species in the artificial digestion fluids and in cell culture medium for proliferating and differentiated intestinal Caco-2 cells. Cytotoxicity testing and cellular impedance measurements were applied to address the effects of digested Al species on cell viability and cell proliferation. Microarray-based transcriptome analyses and quantitative real-time PCR were conducted to obtain a deeper insight into cellular mechanisms of action and generated indications for cellular oxidative stress and an influence on xenobiotic metabolism, connected with alterations in associated signaling pathways. These cellular responses, which were predominantly caused by formerly ionic Al species and only at very high concentrations, were not impacted by artificial digestion. A two-directional conversion of Al between ionic species and solid particles occurred throughout all segments of the gastrointestinal tract, as evidenced by the presence of nanoscaled particles. Nevertheless, this presence did not increase the toxicity of the respective Al species.</abstract>
    <parentTitle language="eng">ACS Applied Nano Materials</parentTitle>
    <identifier type="doi">10.1021/acsanm.9b02354</identifier>
    <enrichment key="date_peer_review">07.05.2020</enrichment>
    <author>H. Sieg</author>
    <author>B.-C. Krause</author>
    <author>Claudia Kästner</author>
    <author>L. Böhmert</author>
    <author>D. Lichtenstein</author>
    <author>J. Tentschert</author>
    <author>H. Jungnickel</author>
    <author>P. Laux</author>
    <author>A. Braeuning</author>
    <author>V. Fessard</author>
    <author>Andreas Thünemann</author>
    <author>A. Luch</author>
    <author>A. Lampen</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>SAXS</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Small-angle X-ray scattering</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Nanoparticle</value>
    </subject>
    <collection role="ddc" number="620">Ingenieurwissenschaften und zugeordnete Tätigkeiten</collection>
    <collection role="institutes" number="">6 Materialchemie</collection>
    <collection role="institutes" number="">6.5 Synthese und Streuverfahren nanostrukturierter Materialien</collection>
    <collection role="themenfelder" number="">Material</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
    <collection role="themenfelder" number="">Advanced Materials</collection>
  </doc>
  <doc>
    <id>61079</id>
    <completedYear/>
    <publishedYear>2024</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>lecture</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Nanoplastics Aqueous Dispersions as Polymer Reference Materials for a Sustainable Future</title>
    <abstract language="eng">The undesirable presence of micro and nanoplastics in our environment and in food is now common knowledge. However, it is unclear whether serious dangers and risks are posed by nanoplastics. A scientifically based reliable determination of the type and quantity of nanoplastics in complex matrices is of considerable importance for the future sustainable use of polymers. Here, reference materials help in the determination of nanoplastics. In particular, colloidally stable aqueous dispersions of nanoplastics appear suitable for this purpose. We report on the current status of the development of nanoplastics as reference materials. A detailed example of reference materials for characterizing nanoplastics is provided in the form of aqueous dispersion of polypropylene. The nanoplastics samples are colloidal stable for at least two years at ambient conditions. A low zeta potential of -35 mV at a neutral pH value provides stability. An overview of their colloidal properties in different environmental conditions is presented. Next, polyethylene nanoplastics will be compared to polypropylene nanoplastics. Nanoplastics consisting of poly(ethylene terephthalate) will be discussed and finally, we report on poly(L-lactic acid) as a typical and important representative of biodegradable polymers.</abstract>
    <enrichment key="eventName">POLYMERS FOR A SUSTAINABLE FUTURE: Biennial Meeting of the GDCh-Division of Macromolecular Chemistry</enrichment>
    <enrichment key="eventPlace">Dresden, Germany</enrichment>
    <enrichment key="eventStart">16.09.2024</enrichment>
    <enrichment key="eventEnd">18.09.2024</enrichment>
    <enrichment key="InvitedTalks">1</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <author>Andreas Thünemann</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Reference Material</value>
    </subject>
    <collection role="ddc" number="620">Ingenieurwissenschaften und zugeordnete Tätigkeiten</collection>
    <collection role="institutes" number="">6 Materialchemie</collection>
    <collection role="institutes" number="">6.5 Synthese und Streuverfahren nanostrukturierter Materialien</collection>
    <collection role="themenfelder" number="">Material</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
    <collection role="literaturgattung" number="">Präsentation</collection>
    <collection role="themenfelder" number="">Advanced Materials</collection>
  </doc>
  <doc>
    <id>14521</id>
    <completedYear/>
    <publishedYear>2007</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1900</pageFirst>
    <pageLast>1911</pageLast>
    <pageNumber/>
    <edition/>
    <issue>10</issue>
    <volume>28</volume>
    <type>article</type>
    <publisherName>Elsevier</publisherName>
    <publisherPlace>Oxford</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Thyroid hormone (T3)-modification of polyethyleneglycol (PEG)-polyethyleneimine (PEI) graft copolymers for improved gene delivery to hepatocytes</title>
    <abstract language="eng">Targeting of gene vectors to liver hepatocytes could offer the opportunity to cure various acquired and inherited diseases. Efficient gene delivery to the liver parenchyma has been obscured from efficient targeting of hepatocytes. Here we show that the thyroid hormone, triiodothyronine (T3), can be used to improve the gene transfer efficiency of nonviral gene vectors to hepatocytes in vitro and to the liver of mice in vivo. T3 conjugated to the distal ends of fluorescent labeled PEG-g-dextran resulted in T3-specific cellular endosomal uptake into the hepatocellular cell line HepG2. PEG-g-PEI graft copolymers with increasing molar PEG-ratios were synthesized, complexed with plasmid DNA, and transfected into HepG2 or HeLa cells. Gene transfer efficiency decreased as the number of PEG blocks increased. T3 conjugation to PEI and the distal ends of PEG blocks resulted in T3 specific gene transfer in HepG2 cells as evidenced by reduction of gene transfer efficiency after pre-incubation of cells with excess of T3. In vivo application of T3-PEG-g-PEI based gene vectors in mice after tail vein injection resulted in a significantly 7-fold increase of gene expression in the liver compared with PEG-g-PEI based gene vectors.</abstract>
    <parentTitle language="eng">Biomaterials</parentTitle>
    <identifier type="old">16322</identifier>
    <identifier type="issn">0142-9612</identifier>
    <enrichment key="bibliotheksstandort">Sonderstandort: Publica-Schrank</enrichment>
    <enrichment key="date_peer_review">08.02.2007</enrichment>
    <author>C. Rudolph</author>
    <author>N. Sieverling</author>
    <author>U. Schillinger</author>
    <author>E. Lesina</author>
    <author>C. Plank</author>
    <author>Andreas Thünemann</author>
    <author>H. Schönberger</author>
    <author>J. Rosenecker</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Nonviral</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>PEI</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Gene transfer</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Thyroid hormone</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>T3</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Liver</value>
    </subject>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Physisches Exemplar in der Bibliothek der BAM vorhanden ("Hardcopy Access")</collection>
  </doc>
  <doc>
    <id>30100</id>
    <completedYear/>
    <publishedYear>2013</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>110</pageFirst>
    <pageLast>119</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>108</volume>
    <type>article</type>
    <publisherName>Elsevier B.V.</publisherName>
    <publisherPlace>Amsterdam</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">On the role of surface composition and curvature on biointerface formation and colloidal stability of nanoparticles in a protein-rich model system</title>
    <abstract language="eng">The need for a better understanding of nanoparticleprotein interactions and the mechanisms governing the resulting colloidal stability has been emphasised in recent years. In the present contribution, the short and long term colloidal stability of silica nanoparticles (SNPs) and silica–poly(ethylene glycol) nanohybrids (Sil–PEG) have been scrutinised in a protein model system. Well-defined silica nanoparticles are rapidly covered by bovine serum albumin (BSA) and form small clusters after 20 min while large agglomerates are detected after 10 h depending on both particle size and nanoparticle–protein ratio. Oppositely, Sil–PEG hybrids present suppressive protein adsorption and enhanced short and long term colloidal stability in protein solution. No critical agglomeration was found for either system in the absence of protein, proving that instability found for SNPs must arise as a consequence of protein adsorption and not to high ionic environment. Analysis of the small angle X-ray scattering (SAXS) structure factor indicates a short-range attractive potential between particles in the silica-BSA system, which is in good agreement with a protein bridging agglomeration mechanism. The results presented here point out the importance of the nanoparticle surface properties on the ability to adsorb proteins and how the induced or depressed adsorption may potentially drive the resulting colloidal stability.</abstract>
    <parentTitle language="eng">Colloids and surfaces B: Biointerfaces</parentTitle>
    <identifier type="old">33048</identifier>
    <identifier type="doi">10.1016/j.colsurfb.2013.02.027</identifier>
    <identifier type="issn">0927-7765</identifier>
    <identifier type="issn">1873-4367</identifier>
    <enrichment key="date_peer_review">03.02.2014</enrichment>
    <author>Guillermo Orts Gil</author>
    <author>Kishore Natte</author>
    <author>Raphael Thiermann</author>
    <author>Matthias Girod</author>
    <author>Steffi Rades</author>
    <author>Henryk Kalbe</author>
    <author>Andreas Thünemann</author>
    <author>M. Maskos</author>
    <author>Werner Österle</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Nanoparticles</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Protein corona</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Biointerface</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>BSA</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>PEG</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Colloidal stability</value>
    </subject>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>23656</id>
    <completedYear/>
    <publishedYear>2011</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>3059</pageFirst>
    <pageLast>3068</pageLast>
    <pageNumber/>
    <edition/>
    <issue>4</issue>
    <volume>5</volume>
    <type>article</type>
    <publisherName>ACS Publ.</publisherName>
    <publisherPlace>Washington, DC, USA</publisherPlace>
    <creatingCorporation>American Chemical Society</creatingCorporation>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Application of laser postionization secondary neutral mass spectrometry / time-of-flight secondary ion mass spectrometry in nanotoxicology: Visualization of nanosilver in human macrophages and cellular responses</title>
    <abstract language="eng">Silver nanoparticles (SNP) are the subject of worldwide commercialization because of their antimicrobial effects. Yet only little data on their mode of action exist. Further, only few techniques allow for visualization and quantification of unlabeled nanoparticles inside cells. To study SNP of different sizes and coatings within human macrophages, we introduce a novel laser postionization secondary neutral mass spectrometry (Laser-SNMS) approach and prove this method superior to the widely applied confocal Raman and transmission electron microscopy. With time-of-flight secondary ion mass spectrometry (TOF-SIMS) we further demonstrate characteristic fingerprints in the lipid pattern of the cellular membrane indicative of oxidative stress and membrane fluidity changes. Increases of protein carbonyl and heme oxygenase-1 levels in treated cells confirm the presence of oxidative stress biochemically. Intriguingly, affected phagocytosis reveals as highly sensitive end point of SNP-mediated adversity in macrophages. The cellular responses monitored are hierarchically linked, but follow individual kinetics and are partially reversible.</abstract>
    <parentTitle language="eng">ACS nano</parentTitle>
    <identifier type="old">26240</identifier>
    <identifier type="doi">10.1021/nn200163w</identifier>
    <identifier type="issn">1936-0851</identifier>
    <enrichment key="date_peer_review">16.05.2011</enrichment>
    <author>A. Haase</author>
    <author>H. F. Arlinghaus</author>
    <author>J. Tentschert</author>
    <author>H. Jungnickel</author>
    <author>P. Graf</author>
    <author>Alexandre Mantion</author>
    <author>F. Draude</author>
    <author>S. Galla</author>
    <author>J. Plendl</author>
    <author>M.E. Goetz</author>
    <author>A. Masic</author>
    <author>W. Meier</author>
    <author>Andreas Thünemann</author>
    <author>A. Taubert</author>
    <author>A. Luch</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Nanosilver</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Laser-SNMS</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>TOF-SIMS</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Confocal Raman microscopy</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Oxidative stress</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Protein carbonyls</value>
    </subject>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>27585</id>
    <completedYear/>
    <publishedYear>2013</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>286</pageFirst>
    <pageLast>289</pageLast>
    <pageNumber/>
    <edition/>
    <issue>1</issue>
    <volume>45</volume>
    <type>article</type>
    <publisherName>Wiley</publisherName>
    <publisherPlace>Chichester</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">ToF-SIMS and laser-SNMS analysis of macrophages after exposure to silver nanoparticles</title>
    <abstract language="eng">Silver nanoparticles (SNPs) are among the most commercialized nanoparticles because of their antibacterial effects. Besides being employed, e.g. as a coating material for sterile surfaces in household articles and appliances, the particles are also used in a broad range of medical applications. Their antibacterial properties make SNPs especially useful for wound disinfection or as a coating material for prostheses and surgical instruments. Because of their optical characteristics, the particles are of increasing interest in biodetection as well. Despite the widespread use of SNPs, there is little knowledge of their toxicity. Time-of-flight secondary ion mass spectrometry (ToF-SIMS) and laser post-ionization secondary neutral mass spectrometry (Laser-SNMS) were used to investigate the effects of SNPs on human macrophages derived from THP-1 cells in vitro. For this purpose, macrophages were exposed to SNPs. The SNP concentration ranges were chosen with regard to functional impairments of the macrophages. To optimize the analysis of the macrophages, a special silicon wafer sandwich preparation technique was employed; ToF-SIMS was employed to characterize fragments originating from macrophage cell membranes. With the use of this optimized sample preparation method, the SNP-exposed macrophages were analyzed with ToF-SIMS and with Laser-SNMS. With Laser-SNMS, the three-dimensional distribution of SNPs in cells could be readily detected with very high efficiency, sensitivity, and submicron lateral resolution. We found an accumulation of SNPs directly beneath the cell membrane in a nanoparticular state as well as agglomerations of SNPs inside the cells.</abstract>
    <parentTitle language="eng">Surface and interface analysis</parentTitle>
    <identifier type="old">30412</identifier>
    <identifier type="doi">10.1002/sia.4902</identifier>
    <identifier type="issn">0142-2421</identifier>
    <identifier type="issn">1096-9918</identifier>
    <enrichment key="date_peer_review">17.01.2013</enrichment>
    <author>F. Draude</author>
    <author>S. Galla</author>
    <author>A. Pelster</author>
    <author>J. Tentschert</author>
    <author>H. Jungnickel</author>
    <author>A. Haase</author>
    <author>Alexandre Mantion</author>
    <author>Andreas Thünemann</author>
    <author>A. Taubert</author>
    <author>A. Luch</author>
    <author>H. F. Arlinghaus</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Laser-SNMS</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>ToF-SIMS</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Life sciences</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Imaging</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Nanoparticles</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Three-dimensional depth profiling</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Silver nanoparticle</value>
    </subject>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>6301</id>
    <completedYear/>
    <publishedYear>2005</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>281</pageFirst>
    <pageLast>284</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>8</volume>
    <type>article</type>
    <publisherName>Elsevier</publisherName>
    <publisherPlace>Amsterdam</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Alternating perpendicular 1-D channels in the supramolecular structure of the copper(II) complex [Cu(pyterpy)2](PF6)2 . CH3OH . 0.5 CH2Cl2 (pyterpy = 4'-(4'''-pyridyl)-2,2':6',2''-terpyridine)</title>
    <parentTitle language="eng">Inorganic chemistry communications</parentTitle>
    <identifier type="old">6694</identifier>
    <identifier type="issn">1387-7003</identifier>
    <enrichment key="bibliotheksstandort">Sonderstandort: Publica-Schrank</enrichment>
    <enrichment key="date_peer_review">27.01.2005</enrichment>
    <author>J.P. López</author>
    <author>Werner Kraus</author>
    <author>Günter Reck</author>
    <author>Andreas Thünemann</author>
    <author>D.G. Kurth</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>4´-(4´´´-pyridyl)-2,2´:6´2´´-terpyridine</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Copper complexes</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Crystal structure</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Supramolecular chemistry</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Pi-pi stacking</value>
    </subject>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Physisches Exemplar in der Bibliothek der BAM vorhanden ("Hardcopy Access")</collection>
  </doc>
  <doc>
    <id>42875</id>
    <completedYear/>
    <publishedYear>2017</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>13087</pageFirst>
    <pageLast>13097</pageLast>
    <pageNumber/>
    <edition/>
    <issue>45</issue>
    <volume>33</volume>
    <type>article</type>
    <publisherName>Americal Chemical Society</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Dosimetric quantification of coating-related uptake of silver nanoparticles</title>
    <abstract language="eng">The elucidation of mechanisms underlying the cellular uptake of nanoparticles (NPs) is an important topic in nanotoxicological research. Most studies dealing with silver NP uptake provide only qualitative data about internalization efficiency and do not consider NP-specific dosimetry. Therefore, we performed a comprehensive comparison of the cellular uptake of differently coated silver NPs of comparable size in different human intestinal Caco-2 cell-derived models to cover also the influence of the intestinal mucus barrier and uptake-specialized M-cells. We used a combination of the Transwell system, transmission electron microscopy, atomic absorption spectroscopy, and ion beam microscopy techniques. The computational in vitro sedimentation, diffusion, and dosimetry (ISDD) model was used to determine the effective dose of the particles in vitro based on their individual physicochemical characteristics. Data indicate that silver NPs with a similar size and shape show coating-dependent differences in their uptake into Caco-2 cells. The internalization of silver NPs was enhanced in uptake-specialized M-cells while the mucus did not provide a substantial barrier for NP internalization. ISDD modeling revealed a fivefold underestimation of dose–response relationships of NPs in in vitro assays. In summary, the present study provides dosimetry-adjusted quantitative data about the influence of NP coating materials in cellular uptake into human intestinal cells. Underestimation of particle effects in vitro might be prevented by using dosimetry models and by considering cell models with greater proximity to the in vivo situation, such as the M-cell model.</abstract>
    <parentTitle language="eng">Langmuir</parentTitle>
    <identifier type="doi">10.1021/acs.langmuir.7b01851</identifier>
    <identifier type="issn">0743-7463</identifier>
    <enrichment key="date_peer_review">14.11.2017</enrichment>
    <author>D. Lichtenstein</author>
    <author>T. Meyer</author>
    <author>L. Böhmert</author>
    <author>S. Juling</author>
    <author>C. Fahrenson</author>
    <author>S. Selve</author>
    <author>Andreas Thünemann</author>
    <author>J. Meijer</author>
    <author>I. Estrela-Lopis</author>
    <author>A. Braeuning</author>
    <author>A. Lampen</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Silver nanoparticles</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Small-angle X-ray scattering</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Saxs</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="ddc" number="620">Ingenieurwissenschaften und zugeordnete Tätigkeiten</collection>
    <collection role="ddc" number="628">Sanitär- und Kommunaltechnik; Umwelttechnik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>50288</id>
    <completedYear/>
    <publishedYear>2020</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>724</pageFirst>
    <pageLast>733</pageLast>
    <pageNumber/>
    <edition/>
    <issue>1</issue>
    <volume>3</volume>
    <type>article</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Environmental impact of ZnO nanoparticles evaluated by in vitro simulated digestion</title>
    <abstract language="eng">ZnO nanoparticles are found in different food and consumer products, and their toxicological effects are still under investigation. It is therefore important to understand their behavior in the gastrointestinal tract. Here, we used an in vitro model to assess the physicochemical fate of ZnO nanoparticles during the digestive process in artificial saliva, stomach juice, and intestinal juice. Atomic absorption spectrometry and small-angle X-ray scattering were employed to investigate two ZnO nanomaterials, one intensively characterized reference material and soluble ZnCl2 in a broad range of concentrations between 25 and 1000 μg/mL in the intestinal fluid. Because food components may influence the behavior of nanomaterials in the gastrointestinal tract, starch, milk powder, and olive oil were used to mimic carbohydrates, protein, and fat, respectively. Additionally, ion release of all Zn species was assessed in cell culture media and compared to artificial intestinal juice to investigate relevance of typical cell culture conditions in ZnO nanotoxicology. ZnCl2 as well as the ZnO species were present as particles in artificial saliva but were solubilized completely in the acidic stomach juice. Interestingly, in the intestinal fluid a concentration-independent de novo formation of particles in the nanoscale range was shown. This was the case for all particles as well as for ZnCl2, regardless of the concentration used. Neither of the food components affected the behavior of any Zn species. On the contrary, all Zn species showed a Zn-concentration-dependent ion release in common cell culture medium. This questions the suitability of cell culture studies to investigate the effect of ZnO nanoparticles on intestinal cells. Our results show that Zn-containing nanoparticles reach the intestine. This underlines the importance of determining the influence of the test environment on nanoparticle fate.</abstract>
    <parentTitle language="eng">ACS Applied Nano Materials</parentTitle>
    <identifier type="doi">10.1021/acsanm.9b02236</identifier>
    <enrichment key="date_peer_review">05.03.2020</enrichment>
    <enrichment key="RelatedIdentifier">https://opus4.kobv.de/opus4-bam/frontdoor/index/index/docId/50812</enrichment>
    <author>L. Voss</author>
    <author>Patrick E. J. Saloga</author>
    <author>V. Stock</author>
    <author>L. Böhmert</author>
    <author>A. Braeuning</author>
    <author>Andreas Thünemann</author>
    <author>A. Lampen</author>
    <author>H. Sieg</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>SAXS</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Digestion</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Zinc oxide</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Nanoparticles</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="ddc" number="620">Ingenieurwissenschaften und zugeordnete Tätigkeiten</collection>
    <collection role="ddc" number="628">Sanitär- und Kommunaltechnik; Umwelttechnik</collection>
    <collection role="institutes" number="">6 Materialchemie</collection>
    <collection role="institutes" number="">6.5 Synthese und Streuverfahren nanostrukturierter Materialien</collection>
    <collection role="themenfelder" number="">Umwelt</collection>
    <collection role="themenfelder" number="">Umwelt-Material-Interaktionen</collection>
    <collection role="themenfelder" number="">Material</collection>
    <collection role="themenfelder" number="">Degradationsmechanismen</collection>
    <collection role="themenfelder" number="">Chemie und Prozesstechnik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>10535</id>
    <completedYear/>
    <publishedYear>2005</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>397</pageFirst>
    <pageLast>398</pageLast>
    <pageNumber/>
    <edition/>
    <issue>2</issue>
    <volume>46</volume>
    <type>article</type>
    <publisherName>American Chemical Society</publisherName>
    <publisherPlace>Newark, NJ</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Solution Self-Assembly of Synthetic Copolymers bearing Complementary Nucleic Acid Funtionalities</title>
    <parentTitle language="eng">Polymer preprints</parentTitle>
    <identifier type="old">12147</identifier>
    <identifier type="issn">0032-3934</identifier>
    <enrichment key="bibliotheksstandort">Sonderstandort: Publica-Schrank</enrichment>
    <author>J.-F. Lutz</author>
    <author>R. Nehring</author>
    <author>Andreas Thünemann</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>DNA</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Living polymerization</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>ATRP</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Copolymers</value>
    </subject>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Physisches Exemplar in der Bibliothek der BAM vorhanden ("Hardcopy Access")</collection>
  </doc>
  <doc>
    <id>35251</id>
    <completedYear/>
    <publishedYear>2016</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>61</pageFirst>
    <pageLast>67</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>147</volume>
    <type>article</type>
    <publisherName>Elsevier B.V.</publisherName>
    <publisherPlace>Amsterdam [u.a.]</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">In operando XAFS experiments on flexible electrochromic devices based on Fe(II)-metallo-supramolecular polyelectrolytes and vanadium oxides</title>
    <abstract language="eng">Flexible electrochromic devices (ECDs) based on Fe(II)-metallo-supramolecular polyelectrolytes (Fe-MEPE) and vanadium oxide are studied in operando by means of x-ray absorption fine structure (XAFS) spectroscopy. The ECDs are blue-purple in the colored state at 0.0 V and become light yellow when a voltage of 1.6 V is applied. The XAFS studies at the K-edge of Fe(II) reveals that the absorption edge is shifted toward higher energies by 1.8 eV in the transparent state. Comparison of two different ECDs and different charge cycles demonstrates the reversibility and repeatability of the process. We attribute the shift to a charge transfer and a change of oxidation state of the ions from Fe2+ to Fe3+. The transition is not accompanied by a noticeable structural change of the octahedral coordination geometry as confirmed by analysis of the extended x-ray absorption fine structure (EXAFS) data. (C) 2015 Elsevier B.V. All rights reserved.</abstract>
    <parentTitle language="eng">Solar energy materials &amp; solar cells</parentTitle>
    <identifier type="doi">10.1016/j.solmat.2015.10.015</identifier>
    <identifier type="issn">0927-0248</identifier>
    <enrichment key="bibliotheksstandort">Sonderstandort: Publica-Schrank</enrichment>
    <enrichment key="date_peer_review">18.01.2016</enrichment>
    <author>M. Schott</author>
    <author>Wojciech Szczerba</author>
    <author>U. Posset</author>
    <author>A.S. Vuk</author>
    <author>M. Beck</author>
    <author>Heinrich Riesemeier</author>
    <author>Andreas Thünemann</author>
    <author>D. G. Kurth</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Metallo-supramolecular polyelectrolytes</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Vanadium oxide</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Electrochromism</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Electrochromic device</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Cyclic voltammetry</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>XAFS</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>44563</id>
    <completedYear/>
    <publishedYear>2018</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>255</pageFirst>
    <pageLast>266</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>113</volume>
    <type>article</type>
    <publisherName>Elsevier</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Comparative proteomic analysis of hepatic effects induced by nanosilver, silver ions and nanoparticle coating in rats</title>
    <abstract language="eng">The presence of nano-scaled particles in food and food-related products has drawn attention to the oral uptake of nanoparticles and their interactions with biological systems. In the present study, we used a toxicoproteomics approach to allow for the untargeted experimental identification and comparative analysis of cellular Responses in rat liver after repeated-dose treatment with silver nanoparticles, ions, and the coating matrix used for particle stabilization.&#13;
The proteomic analysis revealed treatment-related effects caused by exposure to silver in particulate and ionic form. Both silver species induced similar patterns of signaling and metabolic alterations. Silver-induced cellular alterations comprised, amongst others, proteins involved in metal homeostasis, oxidative stress response, and energy metabolism. However, we discovered that secondary nano-scaled structures were formed from ionic silver. Furthermore, also the coating matrix alone gave rise to the formation of nano-scaled particles.&#13;
The present data confirm, complement, and extend previous knowledge on silver toxicity in rodent liver by providing a comprehensive proteomic data set. The observation of secondary particle formation from nonparticle controls underlines the difficulties in separating particle-, ion-, and matrix coating-related effects in biological systems. Awareness of this issue will support proper evaluation of nanotoxicology-related data in the future.</abstract>
    <parentTitle language="eng">Food and Chemical Toxicology</parentTitle>
    <identifier type="doi">10.1016/j.fct.2018.01.056</identifier>
    <identifier type="issn">0278-6915</identifier>
    <identifier type="issn">1873-6351</identifier>
    <enrichment key="date_peer_review">19.04.2018</enrichment>
    <author>S. Juling</author>
    <author>L. Böhmert</author>
    <author>D. Lichtenstein</author>
    <author>A. Oberemm</author>
    <author>O. Creutzenberg</author>
    <author>Andreas Thünemann</author>
    <author>A. Braeuning</author>
    <author>A. Lampen</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Silver nanoparticles</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Small-angle X-ray scattering</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>SAXS</value>
    </subject>
    <collection role="ddc" number="620">Ingenieurwissenschaften und zugeordnete Tätigkeiten</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
</export-example>
