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  <doc>
    <id>53683</id>
    <completedYear/>
    <publishedYear>2021</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>103314</pageFirst>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue>11</issue>
    <volume>24</volume>
    <type>article</type>
    <publisherName>Cell Press</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Depletion of Cardiac Cardiolipin Synthase Alters Systolic and Diastolic Function</title>
    <abstract language="eng">Cardiolipin (CL) is a major cardiac mitochondrial phospholipid maintaining regular mitochondrial morphology and function in cardiomyocytes. Cardiac CL production includes ist biosynthesis and a CL-remodeling process. Here we studied the impact of CL-biosynthesis and the enzyme Cardiolipin Synthase (CLS) on cardiac function.&#13;
CLS and cardiac CL-species were significantly downregulated in cardiomyocytes following catecholamine-induced cardiac damage in mice, accompanied by increased oxygen consumption rates, signs of oxidative stress and mitochondrial uncoupling. RNAi-mediated cardiomyocyte-specific knockdown of CLS in Drosophila melanogaster resulted in marked cardiac dilatation, severe impairment of systolic performance and slower diastolic filling velocity assessed by fluorescence-based heart imaging. Finally, we showed that CL72:8 is significantly decreased in cardiac samples from patients with heart failure with reduced ejection fraction (HFrEF). In summary, we identified CLS as a regulator of cardiac function. Considering the cardiac depletion of CL-species in HFrEF, pharmacological targeting of CLS may be a promising therapeutic approach.zeige mehrzeige weniger</abstract>
    <parentTitle language="eng">iScience</parentTitle>
    <identifier type="doi">10.1016/j.isci.2021.103314</identifier>
    <identifier type="urn">urn:nbn:de:kobv:b43-536833</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="date_peer_review">29.11.2021</enrichment>
    <licence>Creative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International</licence>
    <author>E. Smeir</author>
    <author>S. Leberer</author>
    <author>A. Blumrich</author>
    <author>G. Vogler</author>
    <author>A. Vasiliades</author>
    <author>S. Dresen</author>
    <author>Carsten Jaeger</author>
    <author>Y. Gloaguen</author>
    <author>C. Klose</author>
    <author>D. Beule</author>
    <author>P. Schulze</author>
    <author>R. Bodmer</author>
    <author>A. Foryst-Ludwig</author>
    <author>U. Kintscher</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>High-resolution mass spectrometry</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Nontarget analysis</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Heart failure</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Cardiolipins</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Lipidomics</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.8 Umweltanalytik</collection>
    <collection role="themenfelder" number="">Chemie und Prozesstechnik</collection>
    <collection role="themenfelder" number="">Chemische Charakterisierung und Spurenanalytik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei für die Öffentlichkeit verfügbar ("Open Access")</collection>
    <collection role="unnumberedseries" number="">Wissenschaftliche Artikel der BAM</collection>
    <thesisPublisher>Bundesanstalt für Materialforschung und -prüfung (BAM)</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-bam/files/53683/1-s2.0-S2589004221012839-main.pdf</file>
  </doc>
</export-example>
