<?xml version="1.0" encoding="utf-8"?>
<export-example>
  <doc>
    <id>36755</id>
    <completedYear/>
    <publishedYear>2016</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>756</pageFirst>
    <pageLast>763</pageLast>
    <pageNumber/>
    <edition/>
    <issue>6</issue>
    <volume>88</volume>
    <type>article</type>
    <publisherName>WILEY-VCH Verlag GmbH &amp; Co. KGaA</publisherName>
    <publisherPlace>Weinheim, Germany</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Towards process spectroscopy in complex fermentation samples and mixtures</title>
    <abstract language="eng">Supernatants from a fermentation process of Pichia pastoris were investigated by Raman spectroscopy. Using partial least squares regression, the principal substrates glycerol and methanol could be predicted, however not the expressed protein. To gain further insight, a priori prepared calibration samples were studied by vibrational-, UV/Vis-, and fluorescence spectroscopy. For the quantification of glycerol and methanol, Raman spectroscopy was identified as the most sensitive technique, and superior to near-infrared spectroscopy, but not for protein contents below 1 g L–1. Both UV/Vis absorption and fluorescence spectroscopy are well suited for the quantification of protein, however, best results were obtained with UV/Vis absorption.</abstract>
    <parentTitle language="eng">Chemie Ingenieur Technik</parentTitle>
    <identifier type="doi">10.1002/cite.201500118</identifier>
    <identifier type="issn">0009-286X</identifier>
    <identifier type="issn">1522-2640</identifier>
    <enrichment key="date_peer_review">06.07.2016</enrichment>
    <author>Andrea Paul</author>
    <author>Peter Carl</author>
    <author>Frank Westad</author>
    <author>J.-P. Voss</author>
    <author>Michael Maiwald</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fluorescence</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>NIR spectroscopy</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Partial least squares regression</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Pichia pastoris</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Raman spectroscopy</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>UV/VIS spectroscopy</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>38361</id>
    <completedYear/>
    <publishedYear>2014</publishedYear>
    <thesisYearAccepted/>
    <language>deu</language>
    <pageFirst>P12, 34</pageFirst>
    <pageLast>34</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>conferenceobject</type>
    <publisherName>BAM Bundesanstalt für Materialforschung und -prüfung</publisherName>
    <publisherPlace>Berlin</publisherPlace>
    <creatingCorporation>Gesellschaft Deutscher Chemiker (GDCh), Arbeitskreis Prozessanalytik</creatingCorporation>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="deu">Chemometric modeling of on-line Raman spectra from miniplant operation</title>
    <abstract language="deu">The project InPROMPT aims to establish a robust hydroformylation reaction process of the alkene n-dodecene to the aldehyde n-tridecanal using a rhodium complex as catalyst in the presence of syngas. This industrial relevant production process demands further research for optimization and expansion.  For that purpose, the fiber optic coupled probe of a process Raman spectrometer is directly introduced in the product stream, which enables the recording of spectra within short control intervals.</abstract>
    <parentTitle language="deu">Tagungsband - 10. Kolloquium Arbeitskreis Prozessanalytik</parentTitle>
    <identifier type="url">http://arbeitskreis-prozessanalytik.de/images/stories/Veranstaltungen/Kolloquien/10_kolloquium_2014/tagungsband_10_kolloquium_ak_prozessanalytik_2014_hq-druck_f.pdf</identifier>
    <enrichment key="eventName">10. Kolloquium Arbeitskreis Prozessanalytik</enrichment>
    <enrichment key="eventPlace">Gerlingen, Germany</enrichment>
    <enrichment key="eventStart">25.11.2014</enrichment>
    <enrichment key="eventEnd">26.11.2014</enrichment>
    <author>Andrea Paul</author>
    <author>D. Müller</author>
    <author>E. Esche</author>
    <author>G. Wozny</author>
    <author>Michael Maiwald</author>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Reaction monitoring</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Chemometrics</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Raman spectroscopy</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Hydroformylation</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="literaturgattung" number="">Eigenverlag BAM</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>44580</id>
    <completedYear/>
    <publishedYear>2018</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>poster</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Online Raman spectroscopy for the quantitative evaluation of a Ralstonia cultivation</title>
    <abstract language="eng">Spectroscopic methods possess important advantages for the observation of bioprocesses: they are robust, gain many data within a short time scale, and allow for the measurement of multiple relevant information at the same time. Next to Near-infrared spectroscopy, Raman spectroscopy is increasingly applied as a powerful online tool to monitor bioprocesses. However, Raman spectra may be obscured by straylight, cosmic rays and fluorescence. To achieve the best performance, optimal conditions for spectral quality and stability should be pursued. This comprises not only the choice of highly-sensitive equipment, but also the way of implementation into the process. Here we compared the potential of introducing a sterilized fiber optical Raman probe, and a flow-through cell into the bypass of a stirred tank reactor to monitor an autotrophic cultivation of Ralstonia eutropha where gasses are the energy and carbon sources. Raman spectra were continuously recorded over seven days and 22 samples were taken for the reference analytics of biomass, optical density, and protein. In addition, data for of phosphate and ammonium were available. The quantitative Evaluation of Raman spectra by Partial Least Squares Regression (PLSR) yielded comparable results for both approaches, however, there was a general trend of lower prediction errors with the immersion probe.&#13;
The better performance of the non-contact optic may be either related to a more representative interaction of the measurement optics with the probe or simply to the absence of probe-fouling, which was observed with the immersion optic in the interstice between window and metal frame.</abstract>
    <identifier type="url">www.bioproscale-conference.org</identifier>
    <enrichment key="eventName">5th BioProScale Symposium</enrichment>
    <enrichment key="eventPlace">Berlin, Germany</enrichment>
    <enrichment key="eventStart">20.03.2018</enrichment>
    <enrichment key="eventEnd">22.02.2018</enrichment>
    <author>Andrea Paul</author>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Raman spectroscopy</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Bioprocess</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Chemometrics</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
    <collection role="literaturgattung" number="">Präsentation</collection>
  </doc>
  <doc>
    <id>38846</id>
    <completedYear/>
    <publishedYear>2015</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>66</pageFirst>
    <pageLast>67</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>conferenceobject</type>
    <publisherName>Bundesanstalt für Materialforschung und -prüfung (BAM)</publisherName>
    <publisherPlace>Berlin</publisherPlace>
    <creatingCorporation>Gesellschaft Deutscher Chemiker (GDCh), Arbeitskreis Prozessanalytik</creatingCorporation>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Online spectroscopy in microemulsions – A process analytical approach for hydroformylation miniplant II - Calibration and prediction by Raman spectra</title>
    <abstract language="eng">The Collaborative Research Center InPROMPT aims to establish a novel process concept for the hydroformylation of long-chained olefins, using a rhodium complex as catalyst in the presence of syngas. Recently, the hydroformylation in micro-emulsions, which allows for the efficient recycling of the expensive rhodium catalyst, was found to be feasible. However, the temperature and concentration sensitive multi-phase system demands a continuous observation of the reaction to achieve an operational and economically feasible plant operation. For that purpose, we tested the potential of both NMR and Raman spectroscopy for process control assistance. The lab-scale experiments were supported by sampling for off-line GC-analysis as reference analytics. The results of the NMR experiments will be part of another contribution.</abstract>
    <parentTitle language="eng">Tagungsband - 11. Kolloquium Arbeitskreis Prozessanalytik</parentTitle>
    <enrichment key="eventName">11. Kolloquium Arbeitskreis Prozessanalytik</enrichment>
    <enrichment key="eventPlace">Wien, Austria</enrichment>
    <enrichment key="eventStart">30.11.2015</enrichment>
    <enrichment key="eventEnd">02.12.2015</enrichment>
    <author>Andrea Paul</author>
    <author>J.-P. Ruiken</author>
    <author>Klas Meyer</author>
    <author>Frank Westad</author>
    <author>M. Illner</author>
    <author>D. Müller</author>
    <author>G. Wozny</author>
    <author>Michael Maiwald</author>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Prozessanalytik</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Process analytical technology</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Prozess-Spektroskopie</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Emulsions</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Hydroformylation</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Reaction monitoring</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Raman spectroscopy</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="literaturgattung" number="">Eigenverlag BAM</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>61009</id>
    <completedYear/>
    <publishedYear>2025</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1</pageFirst>
    <pageLast>9</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>325</volume>
    <type>article</type>
    <publisherName>Elsevier B.V.</publisherName>
    <publisherPlace>Amsterdam</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Exploring the potential of a setup for combined quantification of hydrogen in natural gas – Raman and NMR spectroscopy</title>
    <abstract language="eng">An accurate measurement of the amount fraction of hydrogen in gas mixtures is mandatory for practical applications, requiring methods that are fast, continuous, robust, and cost-effective. This study compares the performance of Raman and benchtop NMR process spectroscopy for determining the hydrogen amount fraction in gas mixtures. A setup was designed to integrate both techniques, enabling measurements of the same sample.&#13;
Tests were conducted with gravimetrically prepared gas mixtures of reference quality ranging from 1.20 cmol/mol to 85.83 cmol/mol of hydrogen. The results demonstrate that Raman spectroscopy provides superior performance, with a minimal root mean square error (RMSE) of 0.22 cmol/mol and excellent linearity. In contrast, benchtop NMR spectroscopy faced challenges, such as overlapping peaks and longer measurement times, resulting in a higher RMSE of 0.71 cmol/mol. Raman spectroscopy proves to be particularly well-suited for&#13;
practical applications due to its high accuracy and linearity. Meanwhile, benchtop NMR spectroscopy holds potential for future enhancements through ongoing technological advances, such as higher magnetic field strengths. In summary, the results from our study indicate that Raman spectroscopy is already a serviceable method for precise hydrogen quantification, whereas benchtop NMR spectroscopy can be attributed potential for future applications.</abstract>
    <parentTitle language="eng">Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy</parentTitle>
    <identifier type="issn">1386-1425</identifier>
    <identifier type="doi">10.1016/j.saa.2024.125087</identifier>
    <identifier type="urn">urn:nbn:de:kobv:b43-610093</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="date_peer_review">16.09.2024</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>Tino Petar Golub</author>
    <author>Klas Meyer</author>
    <author>Andrea Paul</author>
    <author>Heinrich Kipphardt</author>
    <author>Dirk Tuma</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Hydrogen amount fraction</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Raman spectroscopy</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>NMR spectroscopy</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Field applicability</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="ddc" number="621">Angewandte Physik</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.4 Non-Target-Analytik</collection>
    <collection role="themenfelder" number="">Energie</collection>
    <collection role="themenfelder" number="">Chemie und Prozesstechnik</collection>
    <collection role="themenfelder" number="">Chemische Charakterisierung und Spurenanalytik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei für die Öffentlichkeit verfügbar ("Open Access")</collection>
    <collection role="unnumberedseries" number="">Wissenschaftliche Artikel der BAM</collection>
    <collection role="themenfelder" number="">Wasserstoff</collection>
    <thesisPublisher>Bundesanstalt für Materialforschung und -prüfung (BAM)</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-bam/files/61009/1-s2.0-S1386142524012538-main.pdf</file>
    <file>https://opus4.kobv.de/opus4-bam/files/61009/1-s2.0-S1386142524012538-mmc1.pdf</file>
  </doc>
  <doc>
    <id>38392</id>
    <completedYear/>
    <publishedYear>2016</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>P10, 59</pageFirst>
    <pageLast>60</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>conferenceobject</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation>GDCh</creatingCorporation>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">A Raman spectroscopic method for the monitoring of microplastics in soil</title>
    <abstract language="eng">Due to the increasing presence of microplastic particles (MP) in the Environment and the unknown risks arising from them, there is an urgent need for analytical methods that allow for an efficient identification and quantification of microplastics (MP), i.e. particles &lt; 5 mm, in environmental samples. So far, mostly timeconsuming (micro) infrared or micro-Raman spectroscopic methods are applied. Here an faster alternative Approach is presented based on a Raman processspectrometer with fiber-optical probes in combination with multivariate data analysis.</abstract>
    <parentTitle language="eng">Tagungsband – 12. Kolloquium Prozessanalytik, Berlin, 28.–30. November 2016</parentTitle>
    <enrichment key="eventName">12. Kolloquium Prozessanalytik</enrichment>
    <enrichment key="eventPlace">Berlin, Germany</enrichment>
    <enrichment key="eventStart">28.11.2016</enrichment>
    <enrichment key="eventEnd">30.11.2016</enrichment>
    <author>Andrea Paul</author>
    <author>S. Breitfeld</author>
    <author>Andreas Sauer</author>
    <author>Roland Becker</author>
    <author>Ute Kalbe</author>
    <author>Wolfram Bremser</author>
    <author>Ulrike Braun</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Raman spectroscopy</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Microplastics</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Soil</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Chemometrics</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>PLS-DA</value>
    </subject>
    <collection role="ddc" number="628">Sanitär- und Kommunaltechnik; Umwelttechnik</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
    <collection role="literaturgattung" number="">Graue Literatur</collection>
  </doc>
</export-example>
