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    <id>56920</id>
    <completedYear/>
    <publishedYear>2022</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>466</pageFirst>
    <pageLast>474</pageLast>
    <pageNumber/>
    <edition/>
    <issue>3</issue>
    <volume>23</volume>
    <type>article</type>
    <publisherName>Royal Society of Chemistry</publisherName>
    <publisherPlace>Cambridge</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Combining a hybrid chip and tube microfluidic system with fluorescent molecularly imprinted polymer (MIP) core–shell particles for the derivatisation, extraction, and detection of peptides with N-terminating phosphorylated tyrosine</title>
    <abstract language="eng">The reliable identification and quantitation of phosphorylated amino acids, peptides and proteins is one of the key challenges in contemporary bioanalytical research, an area of particular interest when attempting to diagnose and treat diseases at an early stage. We have developed a synthetic probe for targeting phosphorylated amino acids, based on core–shell submicron-sized particles consisting of a silica core, coated with a molecularly imprinted polymer (MIP) shell. The MIP layer contains a fluorescent probe crosslinker which binds selectively to phosphorylated tyrosine (pY) moieties with a significant imprinting factor (IF) and responds with a "light-up” fluorescence signal. The bead-based ratiometric detection scheme has been successfully transferred to a microfluidic chip format and its applicability to rapid assays has been exemplarily shown by discriminating a pY-terminating oligopeptide against its nonphosphorylated counterpart. Such miniaturised devices could lead to an automated pY or pY N-terminated peptide measurement system in the future. The setup combines a modular microfluidic system for amino acid derivatisation, extraction (by micropillar co-flow) and selective adsorption and detection with the fluorescent MIP core–shell particle probes. A miniaturised optical assembly for low-light fluorescence measurements was also developed, based on miniaturised opto-electronic parts and optical fibres. The emission from the MIP particles upon binding of pY or pY N-terminated peptides could be monitored in real-time.</abstract>
    <parentTitle language="eng">Lab on a Chip</parentTitle>
    <identifier type="doi">10.1039/d2lc00955b</identifier>
    <identifier type="urn">urn:nbn:de:kobv:b43-569204</identifier>
    <identifier type="issn">1473-0197</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="date_peer_review">30.01.2023</enrichment>
    <enrichment key="PaperofMonth">1</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>Samual Burnage</author>
    <author>Jérémy Bell</author>
    <author>Wei Wan</author>
    <author>Evgeniia Kislenko</author>
    <author>Knut Rurack</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Microfluidics</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Molecularly imprinted polymers</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Phosphorylated peptides</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fluorescence</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Core-shell particles</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.9 Chemische und optische Sensorik</collection>
    <collection role="themenfelder" number="">Umwelt</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei für die Öffentlichkeit verfügbar ("Open Access")</collection>
    <collection role="unnumberedseries" number="">Wissenschaftliche Artikel der BAM</collection>
    <collection role="themenfelder" number="">Sensorik</collection>
    <thesisPublisher>Bundesanstalt für Materialforschung und -prüfung (BAM)</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-bam/files/56920/D2LC00955B.pdf</file>
  </doc>
  <doc>
    <id>59544</id>
    <completedYear/>
    <publishedYear>2024</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>621</pageFirst>
    <pageLast>627</pageLast>
    <pageNumber/>
    <edition/>
    <issue>2</issue>
    <volume>4</volume>
    <type>article</type>
    <publisherName>American Chemical Society (ACS)</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">On-Site Analytical Tool Based on Crude Oil Fluorescence and Chemometrics for the Rapid Determination of the Nature and Essential Properties of Oil Spills</title>
    <abstract language="eng">With the reduction of large oil spills because of stricter regulations and safety measures, the question of how to manage smaller oil spills arises. Few on-site analytical tools are available for first responders or other law enforcement personnel to rapidly test for crude oil in the early management of localized polluted areas. The approach reported here relies on well-described computer-assisted multivariate data analysis of the intrinsic fluorescence fingerprints of crude oils to build a multivariate model for the rapid classification of crude oils and the prediction of their properties. Thanks to a dedicated robust portable reader, the method allowed classification and accurate prediction of various properties of crude oil samples like density (according to API, the American Petroleum Institute and viscosity as well as composition parameters such as volume fractions of paraffins or aromatics. In this way, autonomous operation in on-site or in-the-field applications becomes possible based on the direct (undiluted and untreated) measurement of samples and a rapid, tablet-operated readout system to yield a robust and simple analytical test with superior performance. Testing in real-life scenarios allowed the successful classification and prediction of a number of oil spill samples as well as weathered samples that closely resemble samples collected by first responders.</abstract>
    <parentTitle language="eng">ACS ES&amp;T Water</parentTitle>
    <identifier type="doi">10.1021/acsestwater.3c00648</identifier>
    <identifier type="urn">urn:nbn:de:kobv:b43-595442</identifier>
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CRC Press: Boca Raton, 1993; p 128."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","volume-title":"Oil Spill Response Performance Review of Skimmers","author":"Schulze R.","year":"1998","DOI":"10.1520\/MNL34-EB"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/acs.energyfuels.5b02952"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1186\/s13065-016-0211-y"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1080\/15275920600667104"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.139516"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.marpolbul.2013.02.026"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2018.08.231"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.fuel.2018.09.098"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.143354"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1364\/AO.29.003218"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/es60048a005"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2021.125723"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2020.112193"},{"key":"ref25\/cit25","doi-asserted-by":"crossref","unstructured":"Johann, S.; Mansurova, M.; Kohlhoff, H.; Gkertsos, A.; Neumann, P. P.; Bell, J.; Bartholmai, M. Wireless Mobile Sensor Device for In Situ Measurements with Multiple Fluorescent Sensors, 2018 IEEE SENSORS; New Delhi, India, 2018; pp 1\u22124.","DOI":"10.1109\/ICSENS.2018.8589666"},{"key":"ref26\/cit26","unstructured":"SEOS Science\nEducation through Earth Observation for High Schools\n(SEOS), 2024 https:\/\/seos-project.eu\/. (accessed\nJanuary 2024)."},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1080\/15481603.2022.2107113"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2023.108466"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1039\/D2EW00112H"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1002\/etc.3015"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2018.05.111"},{"key":"ref32\/cit32","volume-title":"The Archimedes 2 Experiment","author":"Gillot R. H.","year":"1987"},{"key":"ref33\/cit33","unstructured":"CEDRE Donges Refinery, 2024, http:\/\/wwz.cedre.fr\/en\/Resources\/Spills\/Spills\/Donges-Refinery. (accessed January 2024)."},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.2971\/jeos.2014.14029"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/ef950159a"},{"key":"ref36\/cit36","unstructured":"Davis, J. C. Statistics and Data Analysis in Geology, 3rd ed. John Wiley &amp; Sons: New York, 2002; p 656."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","volume-title":"Predictive Inference: An Introduction","author":"Giesser S.","year":"1993","edition":"1","DOI":"10.1007\/978-1-4899-4467-2"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0247028"},{"key":"ref39\/cit39","unstructured":"Esbensen, K. H.; Guyot, D.; Westad, F.; Houmoller, L. P. Multivariate Data Analysis: In Practice: An Introduction to Multivariate Data Analysis and Experimental Design, 5th ed. CAMO Software: Oslo, 2002; p 598."},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.2136\/sssaj2001.652480x"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.aqpro.2015.02.058"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/es3015138"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.3390\/jmse9010097"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-46301-w"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1007\/BF00394763"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1021\/jp811229q"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1021\/acs.iecr.1c02744"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodcont.2021.108536"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.14467"}],"container-title":["ACS ES&amp;amp;T Water"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsestwater.3c00648","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsestwater.3c00648","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T09:20:49Z","timestamp":1707470449000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsestwater.3c00648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,1]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2,9]]}},"alternative-id":["10.1021\/acsestwater.3c00648"],"URL":"http:\/\/dx.doi.org\/10.1021\/acsestwater.3c00648","relation":{},"ISSN":["2690-0637","2690-0637"],"issn-type":[{"value":"2690-0637","type":"print"},{"value":"2690-0637","type":"electronic"}],"subject":["Water Science and Technology","Environmental Chemistry","Chemistry (miscellaneous)","Chemical Engineering (miscellaneous)"],"published":{"date-parts":[[2024,2,1]]}}}</enrichment>
    <enrichment key="local_crossrefDocumentType">journal-article</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="date_peer_review">26.02.2024</enrichment>
    <enrichment key="PaperofMonth">1</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>Maria Mansurova</author>
    <author>Sergej Johann</author>
    <author>Harald Kohlhoff</author>
    <author>Knut Rurack</author>
    <author>Matthias Bartholmai</author>
    <author>Jérémy Bell</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Oil spills</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fluorescence</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>PCA</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Petroleum</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Rapid test</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Portable</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.9 Chemische und optische Sensorik</collection>
    <collection role="institutes" number="">8 Zerstörungsfreie Prüfung</collection>
    <collection role="institutes" number="">8.1 Sensorik, mess- und prüftechnische Verfahren</collection>
    <collection role="themenfelder" number="">Umwelt</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei für die Öffentlichkeit verfügbar ("Open Access")</collection>
    <collection role="unnumberedseries" number="">Wissenschaftliche Artikel der BAM</collection>
    <collection role="themenfelder" number="">Sensorik</collection>
    <thesisPublisher>Bundesanstalt für Materialforschung und -prüfung (BAM)</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-bam/files/59544/Mansurova_2024.pdf</file>
  </doc>
  <doc>
    <id>42454</id>
    <completedYear/>
    <publishedYear>2017</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>lecture</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Microfluidic platform and fluorescent sensor particles for the detection of the herbicide 2,4-D in worldwide samples</title>
    <abstract language="eng">Fluorescent sensory MIP (molecularly imprinted polymer) particles were combined with a droplet-based 3D microfluidic system for the sensitive and selective determination of 2,4-dichlorophenoxyacetic acid (2,4-D) in water samples. 2,4-D being an important and widely used herbicide to regulate plant growth, its extensive use leads to food or ground water contamination. Analytical assays based on MIP have emerged as a valuable tool in the field of environmental analysis thanks to low production costs, stability, format adaptability and their ability to recognize a wide variety of targets, such as the critical neutral organic molecules present in water: herbicides, pesticides, antibiotics, etc.&#13;
To accomplish this, a tailor-made fluorescent indicator cross-linker was designed that translates directly the binding event into an enhanced fluorescence signal. This phenoxazinone-type cross-linker was co-polymerized into a thin MIP layer grafted from the surface of silica microparticles. The latter was achieved by integration of the fluorescent core-shell MIP sensor particles into a modular microfluidic platform that allows for an in-line phase-transfer assay, extracting the analyte from aqueous sample droplets into organic phase droplets that contain the sensor particles.&#13;
This tool offering a novel simple and rapid way for the detection of herbicides, real-time fluorescence determination of 2,4-D down to 20 nM was realized with the system and applied for the analysis of worlwide surface water samples.</abstract>
    <enrichment key="eventName">INTERNATIONAL CONFERENCE ON CHEMISTRY AND THE ENVIRONMENT - ICCE 2017</enrichment>
    <enrichment key="eventPlace">Oslo, Norway</enrichment>
    <enrichment key="eventStart">18.06.2017</enrichment>
    <enrichment key="eventEnd">21.09.2017</enrichment>
    <enrichment key="InvitedTalks">0</enrichment>
    <author>Jérémy Bell</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Microfluidics</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>MIP</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fluorescence</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Pesticide</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
    <collection role="literaturgattung" number="">Präsentation</collection>
  </doc>
  <doc>
    <id>58527</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>lecture</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Fluorescence Detection of Perfluoroalkyl Carboxylic Acids with a Miniaturised Assay</title>
    <abstract language="eng">Per- and polyfluoroalkyl substances (PFAS) are a class of man-made organo-fluorine chemicals that have become environmental contaminants of emerging concern, originating from a variety of materials such as adhesive, stain- and oil-resistant coatings, firefighting foams, etc. The high strength of this C-F bond makes PFAS thermodynamically stable and resistant to (bio)degradation, thus retaining them in the environment over time. Perfluoroalkyl carboxylic acids (PFCAs), one category of the most used PFAS, consist of a fully fluorinated carbon backbone and a charged carboxylic acid headgroup, and have been classified as Substances of Very High Concern (SVHC) and added to the REACH Candidate List due to their persistence in the environment, non-biodegradability and toxicological effects.[1-2] Traditional techniques for the analysis of PFCAs include GC-MS, HRMS and HPLC-based approaches, which are laborious, not portable, costly and require trained personnel. In contrast, fluorescence assays can be designed as easy-to-operate, portable and cost-effective methods with high sensitivity and fast response. Integration of fluorescent probes with an adequately miniaturized assay enables a promising alternative for PFCAs analysis.&#13;
Here, a novel guanidine fluorescent probe has been synthesized and fully characterized for the detection of PFCAs in a biphasic extract-&amp;-detect assay. The fluorescent probe was then incorporated into polymeric matrices supported by a red dye-doped SiO2 nanoparticle to construct a dual-emission sensing platform. Such a system allows precise and selective detection of PFCAs, reducing the interference of competitors, matrix effects and other factors except for the PFCAs. The system was then employed in a droplet-based microfluidic setup which offers a portable and easy to operate detection platform.</abstract>
    <enrichment key="eventName">IMA 2023</enrichment>
    <enrichment key="eventPlace">Chania, Greece</enrichment>
    <enrichment key="eventStart">18.09.2023</enrichment>
    <enrichment key="opus.source">publish</enrichment>
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    <enrichment key="InvitedTalks">0</enrichment>
    <author>Yijuan Sun</author>
    <author>Víctor Pérez-Padilla</author>
    <author>Virginia Valderrey</author>
    <author>Jérémy Bell</author>
    <author>Kornelia Gawlitza</author>
    <author>Knut Rurack</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>PFAS</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>MIP</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fluorescence</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Microfluidics</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Fluorezsenz</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Mikrofluidik</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.9 Chemische und optische Sensorik</collection>
    <collection role="themenfelder" number="">Umwelt</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
    <collection role="literaturgattung" number="">Präsentation</collection>
    <collection role="themenfelder" number="">Sensorik</collection>
  </doc>
  <doc>
    <id>35831</id>
    <completedYear/>
    <publishedYear>2016</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>334</pageFirst>
    <pageLast>338</pageLast>
    <pageNumber/>
    <edition/>
    <issue>4</issue>
    <volume>1</volume>
    <type>article</type>
    <publisherName>American Chemical Society</publisherName>
    <publisherPlace>Washington, DC</publisherPlace>
    <creatingCorporation>American Chemical Society</creatingCorporation>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Combining a droplet-based microfluidic tubing system with gated indicator releasing nanoparticles for mercury trace detection</title>
    <abstract language="eng">A droplet-based microfluidic sensor was developed for the detection of Hg2+ traces in water. The approach uses gated mesoporous nanoparticles loaded with a fluorescent BODIPY dye. The squaraine-based gating mechanism is highly selective for Hg2+ and the indicator release mechanism ensures sensitive detection. The microfluidic system is modular and was assembled from simple PTFE/PFA tubes, while detection was realized with standard optomechanic, optic, and electronic parts. The sensor shows a stable response without memory effects and allows the detection of Hg2+ in water down to 20 ppt.</abstract>
    <parentTitle language="eng">ACS Sensors</parentTitle>
    <identifier type="doi">10.1021/acssensors.5b00303</identifier>
    <identifier type="issn">2379-3694</identifier>
    <enrichment key="date_peer_review">10.11.2016</enrichment>
    <author>Jérémy Bell</author>
    <author>Estela Climent Terol</author>
    <author>Mandy Hecht</author>
    <author>Merwe Buurman</author>
    <author>Knut Rurack</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Microfluidic sensor</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Gated delivery system</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fluorescence</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Mercury</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Hybrid nanoparticles</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="ddc" number="628">Sanitär- und Kommunaltechnik; Umwelttechnik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>51956</id>
    <completedYear/>
    <publishedYear>2020</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>27</pageFirst>
    <pageLast>34</pageLast>
    <pageNumber/>
    <edition/>
    <issue>1</issue>
    <volume>6</volume>
    <type>article</type>
    <publisherName>American Chemical Society</publisherName>
    <publisherPlace>Washington, DC</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Dip Sticks Embedding Molecular Beacon-Functionalized Core−Mesoporous Shell Particles for the Rapid On-Site Detection of Microbiological Fuel Contamination</title>
    <abstract language="eng">Microbial contamination of fuels by fungi and bacteria presents risks of corrosion and fuel system fouling. In this work, a rapid test for the determination of microbial genomic DNA from aqueous fuel extracts is presented. It combines test strips coated with polystyrene core/mesoporous silica shell particles, to the surface of which modified fluorescent molecular beacons are covalently grafted, with a smartphone detection system. In the hairpin loop, the beacons incorporate a target sequence highly conserved in all bacteria, corresponding to a fragment of the 16S ribosomal RNA gene, which is also present to a significant extent in the 18S rRNA gene of fungi, allowing for broadband microbial detection. In the developed assay, the presence of genomic DNA extracts from bacteria and fungi down to ca. 20−50 μg L−1 induced a distinct fluorescence response. The optical read-out was adapted for on-site monitoring by combining a 3D-printed case with a conventional smartphone, taking advantage of the sensitivity of contemporary complementary metal oxide semiconductor (CMOS) detectors. Such an embedded assembly allowed to detect microbial genomic DNA in aqueous extracts down to ca. 0.2−0.7 mg L−1 and presents an important step toward the on-site uncovering of fuel contamination in a rapid and simple fashion.</abstract>
    <parentTitle language="eng">ACS Sensors</parentTitle>
    <identifier type="doi">10.1021/acssensors.0c01178</identifier>
    <identifier type="issn">2379-3694</identifier>
    <enrichment key="date_peer_review">06.01.2021</enrichment>
    <author>Estela Climent Terol</author>
    <author>Raul Gotor</author>
    <author>Charlie Tobias</author>
    <author>Jérémy Bell</author>
    <author>Pedro Martin-Sanchez</author>
    <author>Knut Rurack</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Bacteria</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fungi</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Rapid test</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fluorescence</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Smartphone</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Biofouling</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="ddc" number="624">Ingenieurbau</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.9 Chemische und optische Sensorik</collection>
    <collection role="themenfelder" number="">Infrastruktur</collection>
    <collection role="themenfelder" number="">Umwelt</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
    <collection role="themenfelder" number="">Sensorik</collection>
  </doc>
  <doc>
    <id>63847</id>
    <completedYear/>
    <publishedYear>2025</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1</pageFirst>
    <pageLast>10</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>article</type>
    <publisherName>American Chemical Society</publisherName>
    <publisherPlace>Washington, D.C.</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Superparamagnetic Bead-Based Microfluidic Fluoroimmunoassay Platform for Rapid Ochratoxin A Detection in Flour</title>
    <abstract language="eng">Simplification and reduction of time and costs are the primary goals in the development and use of onsite methods in diagnostics and food safety. To facilitate the transition from laboratory techniques to simple, miniaturized devices, we have developed a modular microfluidic platform. This platform integrates a competitive fluorescence immunoassay on the surface of superparamagnetic beads, serving as a complementary technique to traditional cytometry assays. In the first chip module, a fast competitive reaction (5 min) occurs, after which the particles are retained in the second module. This module consists of a PDMS chip and a permanent magnet, allowing only the fluorescent competitor to reach the detection module. Ochratoxin A (OTA) was chosen as the model analyte for device development, using fluorescein-labeled OTA as a competitor. The system efficiently separates particles, with OTA concentration directly correlated to the amount of fluorescent competitor remaining in solution after the competitive reaction. This innovative setup allows to perform rapid measurements with small sample volumes in a short time (10 min), achieving a limit of detection for OTA of 1.2 μg L–1. The system was successfully applied to the accurate determination of OTA in wheat flour spiked at regulatorily relevant concentrations. Using this device, conventional cytometry immunoassays can be seamlessly transformed into user-friendly, miniaturized analytical methods at reduced cost for applications outside of a laboratory directly at the point of need.</abstract>
    <parentTitle language="eng">ACS Sensors</parentTitle>
    <identifier type="doi">10.1021/acssensors.5c01119</identifier>
    <identifier type="urn">urn:nbn:de:kobv:b43-638472</identifier>
    <identifier type="issn">2379-3694</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="date_peer_review">11.08.2025</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>Daniel López-Puertollano</author>
    <author>Charlie Tobias</author>
    <author>Jérémy Bell</author>
    <author>A. Abad-Somovilla</author>
    <author>A. Abad-Fuentes</author>
    <author>Knut Rurack</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Bead-based assay</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fluorescence</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Immunoassay</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Microfluidics</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>mycotoxins</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="ddc" number="628">Sanitär- und Kommunaltechnik; Umwelttechnik</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.9 Chemische und optische Sensorik</collection>
    <collection role="themenfelder" number="">Umwelt</collection>
    <collection role="themenfelder" number="">Chemie und Prozesstechnik</collection>
    <collection role="themenfelder" number="">Chemische Charakterisierung und Spurenanalytik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei für die Öffentlichkeit verfügbar ("Open Access")</collection>
    <collection role="unnumberedseries" number="">Wissenschaftliche Artikel der BAM</collection>
    <collection role="themenfelder" number="">Sensorik</collection>
    <thesisPublisher>Bundesanstalt für Materialforschung und -prüfung (BAM)</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-bam/files/63847/ACS-Sens_2025-bead-based-microfluidic-fluoroimmunoassay.pdf</file>
  </doc>
  <doc>
    <id>59862</id>
    <completedYear/>
    <publishedYear>2024</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1</pageFirst>
    <pageLast>11</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>article</type>
    <publisherName>Royal Society of Chemistry (RSC)</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Polymerizable BODIPY probe crosslinker for the molecularly imprinted polymer-based detection of organic carboxylates via fluorescence</title>
    <abstract language="eng">This contribution reports the development of a polymerizable BODIPY-type fluorescent probe targeting small-molecule carboxylates for incorporation into molecularly imprinted polymers (MIPs). The design of the probe crosslinker includes a urea recognition site p-conjugated to the 3-position of the BODIPY core and two methacrylate moieties. Titration experiments with a carboxylate-expressing antibiotic, levofloxacin (LEVO), showed a blue shift of the absorption band as well as a broadening and decrease in emission, attributed to hydrogen bonding between the probe’s urea group and the carboxylate group of the antibiotic. Using this probe crosslinker, core–shell particles with a silica core and a thin MIP shell were prepared for the detection of LEVO. The MIP exhibited highly selective recognition of LEVO, with an imprinting factor of 18.1 compared to the non-imprinted polymer. Transmission electron microscopy confirmed the core–shell structure and spectroscopic studies revealed that the receptor’s positioning leads to a unique perturbation of the polymethinic character of the BODIPY chromophore, entailing the favourable responses. These features are fully preserved in the MIP, whereas no such response was observed for competitors such as ampicillin. The sensory particles allowed to detect LEVO down to submicromolar concentrations in dioxane. We have developed here for the first time a BODIPY probe for organic carboxylates and incorporated it into polymers using the imprinting technique, paving the way for BODIPY-type fluorescent MIP sensors.</abstract>
    <parentTitle language="eng">Materials Advances</parentTitle>
    <identifier type="doi">10.1039/D3MA00476G</identifier>
    <identifier type="urn">urn:nbn:de:kobv:b43-598629</identifier>
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      <value>Dyes</value>
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    <title language="eng">Analytical platform for sugar sensing in commercial beverages using a fluorescent BODIPY "light-up" probe</title>
    <abstract language="eng">Because of the globally increasing prevalence of diabetes, the need for accurate, efficient and at best miniaturized automated analytical systems for sugar detection in medical diagnostics and the food industry is still urgent. The development of molecular probes for sugars based on boronic acid receptors offers an excellent alternative to the kinetically slow enzyme-based sugar sensors. Moreover, by coupling such chelating units with dye scaffolds like BODIPYs (boron–dipyrromethenes), highly fluorescent sugar sensing schemes can be realized. In this work, a boronic acid-functionalized BODIPY probe was developed, which binds selectively to fructose’s adjacent diols to form cyclic boronate esters. Placement of an amino group in direct neighborhood of the boronic acid moiety allowed us to obtain a broad working range at neutral pH, which distinguishes the probe from the majority of systems working only at pH &gt; 8, while still meeting the desired sensitivity in the micro-molar range due to a pronounced analyte-induced fluorescence increase. To enhance the applicability of the test in the sense described above, integration with a microfluidic chip was achieved. Here, fructose was selectively detected by fluorescence with similar sensitivity in real time on chip, and an assay for the straightforward detection of sugar in (colored) sodas without sample clean-up was established.</abstract>
    <parentTitle language="eng">Sensors and Actuators B: Chemical</parentTitle>
    <identifier type="doi">10.1016/j.snb.2017.09.201</identifier>
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    <author>Pichandi Ashokkumar</author>
    <author>Jérémy Bell</author>
    <author>Merwe Buurman</author>
    <author>Knut Rurack</author>
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    <title language="eng">Phosphorylated amino acids detection and extraction combining fluorogenic MIP core-shell particles and microfluidics</title>
    <abstract language="eng">The identification and quantification of phosphorylated amino acids, peptides and proteins is one of the key challenges in contemporary bioanalytical research, noteworthy to diagnose and treat diseases at an early stage. Small sensing devices like microfluidic chips combined with “smart” detection chemistry and simple data assessment, processing and presentation are attractive in this regard. We developed novel synthetic probes, targeting phosphorylated amino acids, based on core-shell microparticles consisting of a silica core coated with a molecularly imprinted polymer shell (MIP). These “plastic antibodies” which are extremely robust, resist denaturing solvents and high temperatures, can be reproducibly produced at low cost, can potentially overcome many of the problems in the current detection strategies. The MIP layer, containing a fluorescent probe monomer, responds to phosphorylated amino acids such as phosphorylated tyrosine (pTyr) with a significant imprinting factor, i.e. selectivity, higher than 3.5, and a “lighting-up” of its fluorescence accompanied by the development of a strongly red-shifted emission band. The bead-based ratiometric detection scheme has also been successfully transferred to a microfluidic chip format to demonstrate its applicability to rapid assays. Such a device could yield an automated pTyr measurement system in the future. The setup was built by coupling a PDMS/Teflon/glass microfluidic chip with an optical setup for fluorescence measurements able to extract and monitor pTyr concentration from 0.5–200 μM.</abstract>
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    <author>Jérémy Bell</author>
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      <value>Fluorescence</value>
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    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Integrating fluorescent molecularly imprinted polymer (MIP) sensor particles with a modular microfluidic platform for nanomolar smallmolecule detection directly in aqueous samples</title>
    <abstract language="eng">Fluorescent sensory MIP (molecularly imprinted polymer) particles were combined with a droplet-based 3D microfluidic system for the selective determination of a prototype small-molecule analyte of environmental concern, 2,4-dichlorophenoxyacetic acid or 2,4-D, at nanomolar concentration directly in water samples. A tailor-made fluorescent indicator cross-linker was thus designed that translates the binding event directly into an enhanced fluorescence signal. The phenoxazinone-type cross-linker was co-polymerized into a thin MIP layer grafted from the surface of silica microparticles following a RAFT (reversible addition-fragmentation chain transfer) polymerization protocol. While the indicator cross-linker outperformed its corresponding monomer twin, establishment of a phase-transfer protocol was essential to guarantee that the hydrogen bond-mediated signalling mechanism between the urea binding site on the indicator cross-linker and the carboxylate group of the analyte was still operative upon real sample analysis. The latter was achieved by integration of the fluorescent core-shell MIP sensor particles into a modular microfluidic platform that allows for an in-line phasetransfer assay, extracting the analyte from aqueous sample droplets into the organic phase that contains the sensor particles. Real-time fluorescence determination of 2,4-D down to 20 nM was realized with the system and applied for the analysis of various surface water samples collected from different parts of the world.</abstract>
    <parentTitle language="eng">Biosensors and Bioelectronics</parentTitle>
    <identifier type="doi">10.1016/j.bios.2017.07.053</identifier>
    <identifier type="issn">0956-5663</identifier>
    <enrichment key="date_peer_review">04.10.2017</enrichment>
    <author>Sabine Wagner</author>
    <author>Jérémy Bell</author>
    <author>Mustafa Biyikal</author>
    <author>Kornelia Gawlitza</author>
    <author>Knut Rurack</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Molecular imprinting</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Microfluidics</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fluorescence</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Core-shell particles</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Droplets</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="ddc" number="628">Sanitär- und Kommunaltechnik; Umwelttechnik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>57892</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1</pageFirst>
    <pageLast>6</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>article</type>
    <publisherName>American Chemical Society</publisherName>
    <publisherPlace>Washington, United States</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Fluorescent Hydrophobic Test Strips with Sterically Integrated Molecular Rotors for the Detection of Hydrocarbons in Water and Soil with an Embedded Optical Read-Out</title>
    <abstract language="eng">Contamination of natural bodies of water or soil with oils and lubricants (or generally, hydrocarbon derivatives such as petrol, fuels, and others) is a commonly found phenomenon around the world due to the extensive production, transfer, and use of fossil fuels. In this work, we develop a simple system for the on-field detection of total petroleum hydrocarbons (TPHs) in water and soil. The test is based on the measurement of the fluorescence signal emitted by the molecular rotor 2-[ethyl[4-[2-(4-nitrophenyl)ethenyl]phenyl]amino]ethanol (4-DNS-OH). This dye is embedded in a hydrophobic polymeric matrix (polyvinylidene fluoride), avoiding interactions with water and providing a robust support for use in a test strip fashion. Together with the strips, an embedded optical system was designed for fluorescence signal read-out, featuring a Bluetooth low-energy connection to a commercial tablet device for data processing and analysis. This system works for the detection and quantification of TPHs in water and soil through a simple extraction protocol using a cycloalkane solvent with a limit of detection of 6 ppm. Assays in surface and sea waters were conclusive, proving the feasibility of the method for in-the-field operation.</abstract>
    <parentTitle language="eng">Energy and Fuels</parentTitle>
    <identifier type="doi">10.1021/acs.energyfuels.3c01175</identifier>
    <identifier type="issn">0887-0624</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="date_peer_review">24.07.2023</enrichment>
    <enrichment key="PaperofMonth">1</enrichment>
    <author>Maria Mansurova</author>
    <author>Raúl Gotor</author>
    <author>Sergej Johann</author>
    <author>Patrick P. Neumann</author>
    <author>Matthias Bartholmai</author>
    <author>Knut Rurack</author>
    <author>Jérémy Bell</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Test strip</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Sensor</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Smartphone</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fluorescence</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Test Streifen</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Sensoren</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Fluoreszenz</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Petrol</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Öl</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.9 Chemische und optische Sensorik</collection>
    <collection role="institutes" number="">8 Zerstörungsfreie Prüfung</collection>
    <collection role="institutes" number="">8.1 Sensorik, mess- und prüftechnische Verfahren</collection>
    <collection role="themenfelder" number="">Umwelt</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
    <collection role="themenfelder" number="">Sensorik</collection>
  </doc>
  <doc>
    <id>61045</id>
    <completedYear/>
    <publishedYear>2024</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>4626</pageFirst>
    <pageLast>4634</pageLast>
    <pageNumber/>
    <edition/>
    <issue>7</issue>
    <volume>10</volume>
    <type>article</type>
    <publisherName>ACS Publ.</publisherName>
    <publisherPlace>Washington, DC</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Microfluidic platform with precisely controlled hydrodynamic parameters and integrated features for generation of microvortices to accurately form and monitor biofilms in flow</title>
    <abstract language="eng">Microorganisms often live in habitats characterized by fluid flow, and their adhesion to surfaces in industrial systems or clinical settings may lead to pipe clogging, microbially influenced corrosion, material deterioration, food spoilage, infections, and human illness. Here, a novel microfluidic platform was developed to investigate biofilm formation under precisely controlled (i) cell concentration, (ii) temperature, and (iii) flow conditions. The developed platform central unit is a single-channel microfluidic flow cell designed to ensure ultrahomogeneous flow and condition in its central area, where features, e.g., with trapping properties, can be incorporated. In comparison to static and macroflow chamber assays for biofilm studies, microfluidic chips allow in situ monitoring of biofilm formation under various flow regimes and have better environment control and smaller sample requirements. Flow simulations and experiments with fluorescent particles were used to simulate bacteria flow in the platform cell for calculating flow velocity and direction at the microscale level. The combination of flow analysis and fluorescent strain injection in the cell showed that microtraps placed at the center of the channel were efficient in capturing bacteria at determined positions and to study how flow conditions, especially microvortices, can affect biofilm formation. The microfluidic platform exhibited improved performances in terms of homogeneity and robustness for in vitro biofilm formation. We anticipate the presented platform to be suitable for broad, versatile, and high-throughput biofilm studies at the microscale level.</abstract>
    <parentTitle language="eng">ACS biomaterials science and engineering</parentTitle>
    <identifier type="doi">10.1021/acsbiomaterials.4c00101</identifier>
    <identifier type="issn">2373-9878</identifier>
    <identifier type="urn">urn:nbn:de:kobv:b43-610450</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="date_peer_review">18.09.2024</enrichment>
    <enrichment key="PaperofMonth">1</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>Keqing Wen</author>
    <author>Anna Gorbushina</author>
    <author>Karin Schwibbert</author>
    <author>Jérémy Bell</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Topographical pattern</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>E. coli</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fluorescence</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Bacteria trapping</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Particle velocimetry</value>
    </subject>
    <collection role="ddc" number="628">Sanitär- und Kommunaltechnik; Umwelttechnik</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.9 Chemische und optische Sensorik</collection>
    <collection role="institutes" number="">4 Material und Umwelt</collection>
    <collection role="institutes" number="">4.1 Biologische Materialschädigung und Referenzorganismen</collection>
    <collection role="themenfelder" number="">Umwelt</collection>
    <collection role="themenfelder" number="">Umwelt-Material-Interaktionen</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei für die Öffentlichkeit verfügbar ("Open Access")</collection>
    <collection role="unnumberedseries" number="">Wissenschaftliche Artikel der BAM</collection>
    <collection role="institutes" number="">4.0 Abteilungsleitung und andere</collection>
    <thesisPublisher>Bundesanstalt für Materialforschung und -prüfung (BAM)</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-bam/files/61045/Wen et al 2024 ACS Biomater Sci Eng.pdf</file>
  </doc>
  <doc>
    <id>65027</id>
    <completedYear/>
    <publishedYear>2025</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1</pageFirst>
    <pageLast>16</pageLast>
    <pageNumber/>
    <edition/>
    <issue>1</issue>
    <volume>16</volume>
    <type>article</type>
    <publisherName>Springer Science and Business Media LLC</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Ratiometric detection of perfluoroalkyl carboxylic acids using dual fluorescent nanoparticles and a miniaturised microfluidic platform</title>
    <abstract language="eng">The widespread contamination of soil and water with perfluoroalkyl substances (PFAS) has caused considerable societal and scientific concern. Legislative measures and an increased need for remediation require effective on-site analytical methods for PFAS management. Here we report on the development of a green-fluorescent guanidine-BODIPY indicator monomer incorporated into a molecularly imprinted polymer (MIP) for the selective detection of perfluorooctanoic acid (PFOA). Complexation of PFOA by the indicator, which is mediated by concerted protonation-induced ion pairing-assisted hydrogen bonding, significantly enhances fluorescence in polar organic solvents. The MIP forms as a thin layer on silica nanoparticles doped with tris(bipyridine)ruthenium(II) chloride, which provides an orange emission signal as internal reference, resulting in low measurement uncertainties. Using a liquid-liquid extraction protocol, this assay enables the direct detection of PFOA in environmental water samples and achieves a detection limit of 0.11 µM. Integration into an opto-microfluidic system enables a compact and user-friendly system for detecting PFOA in less than 15 minutes.</abstract>
    <parentTitle language="eng">Nature Communications</parentTitle>
    <identifier type="issn">2041-1723</identifier>
    <identifier type="doi">10.1038/s41467-025-66872-9</identifier>
    <identifier type="urn">urn:nbn:de:kobv:b43-650270</identifier>
    <enrichment key="opus_doi_flag">true</enrichment>
    <enrichment key="local_crossrefDocumentType">journal-article</enrichment>
    <enrichment key="local_crossrefLicence">https://creativecommons.org/licenses/by/4.0</enrichment>
    <enrichment key="local_import_origin">crossref</enrichment>
    <enrichment key="local_doiImportPopulated">PersonAuthorFirstName_1,PersonAuthorLastName_1,PersonAuthorIdentifierOrcid_1,PersonAuthorFirstName_2,PersonAuthorLastName_2,PersonAuthorIdentifierOrcid_2,PersonAuthorFirstName_3,PersonAuthorLastName_3,PersonAuthorFirstName_4,PersonAuthorLastName_4,PersonAuthorIdentifierOrcid_4,PersonAuthorFirstName_5,PersonAuthorLastName_5,PersonAuthorIdentifierOrcid_5,PersonAuthorFirstName_6,PersonAuthorLastName_6,PersonAuthorIdentifierOrcid_6,PublisherName,TitleMain_1,Language,TitleAbstract_1,TitleParent_1,ArticleNumber,Issue,Volume,PublishedYear,IdentifierIssn,Enrichmentlocal_crossrefLicence</enrichment>
    <enrichment key="opus.source">doi-import</enrichment>
    <enrichment key="date_peer_review">15.12.2025</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>Yijuan Sun</author>
    <author>Víctor Pérez-Padilla</author>
    <author>Virginia Valderrey</author>
    <author>Jérémy Bell</author>
    <author>Kornelia Gawlitza</author>
    <author>Knut Rurack</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>PFAS</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Molecular imprinting</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Microfluidics</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fluorescence</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Onsite assay</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="ddc" number="620">Ingenieurwissenschaften und zugeordnete Tätigkeiten</collection>
    <collection role="ddc" number="628">Sanitär- und Kommunaltechnik; Umwelttechnik</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.9 Chemische und optische Sensorik</collection>
    <collection role="themenfelder" number="">Umwelt</collection>
    <collection role="themenfelder" number="">Material</collection>
    <collection role="themenfelder" number="">Chemie und Prozesstechnik</collection>
    <collection role="themenfelder" number="">Chemische Charakterisierung und Spurenanalytik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei für die Öffentlichkeit verfügbar ("Open Access")</collection>
    <collection role="unnumberedseries" number="">Wissenschaftliche Artikel der BAM</collection>
    <collection role="themenfelder" number="">Advanced Materials</collection>
    <collection role="themenfelder" number="">Sensorik</collection>
    <thesisPublisher>Bundesanstalt für Materialforschung und -prüfung (BAM)</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-bam/files/65027/NatCommun_2025_16_10869.pdf</file>
  </doc>
  <doc>
    <id>59593</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>poster</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">A microfluidic platform for monitoring biofilm formation in flow under defined hydrodynamic conditions</title>
    <abstract language="eng">Bacterial adhesion on surfaces of medical, water and food applications may lead to infections, water or food spoilage and human illness. In comparison to traditional static and macro flow chamber assays for biofilm formation studies, microfluidic chips allow in situ monitoring of biofilm formation under various flow regimes, have better environment control and smaller sample requirements.&#13;
In this work, a novel microfluidic platform is developed to investigate biofilm adhesion under precisely controlled bacteria concentration, temperature, and flow conditions. This platform central unit is a single-inlet microfluidic flow cell with a 5 mm wide chamber designed and tested to achieve ultra-homogenous flow in the central area of chamber. Within this area, defined microstructures are integrated that will disturb the homogeneity of the flow, thus changing bacterial adhesion pattern.&#13;
Here we present the monitoring of bacterial biofilm formation in a microfluidic chip equipped with a microstructure known as micro-trap. This feature is based on a 3D bacteria trap designed by Di Giacomo et al. and successfully used to sequester motile bacteria.&#13;
At first, fluorescent particles similar in size to Escherichia coli (E. coli) are used to simulate bacteria flow inside the flow cell and at the micro-trap. The turbulences induced by the trap are analyzed by imaging and particle tracking velocimetry (PTV). Secondly, the model strain E. coli TG1, ideal and well described for biofilm studies, is used to analyze biofilm formation in the micro-trap. Therefore, a stable fluorescent strain E. coli TG1-MRE-Tn7-141 is constructed by using Tn7 transposon mutagenesis according to the method described by Schlechter et al. Sequestering of E. coli cells within the micro-trap was followed using epifluorescence microscopy.&#13;
The novel microfluidic platform shows great potential for assessment of bacterial adhesion under various flow regimes. The performance of structural feature with respect to the generation of turbulences that promote or reduce bacterial adhesion can be systematically examined.&#13;
The combination of flow analysis and fluorescent strain injection into the microfluidic chip shows that the micro-trap is useful for capturing bacteria at defined positions and to study how flow conditions, especially micro-turbulences, can affect biofilm formation. It represents a powerful and versatile tool for studying the relation between topography and bacteria adhesion.</abstract>
    <enrichment key="eventName">International Conference on Miniaturized Systems for Chemistry and Life Sciences</enrichment>
    <enrichment key="eventPlace">Katowice, Poland</enrichment>
    <enrichment key="eventStart">15.10.2023</enrichment>
    <enrichment key="eventEnd">19.10.2023</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <author>Keqing Wen</author>
    <author>Anna Gorbushina</author>
    <author>Karin Schwibbert</author>
    <author>Jérémy Bell</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Biofilm</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>E. coli</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Microfluidics</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Velocimetry</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fluorescence</value>
    </subject>
    <collection role="ddc" number="628">Sanitär- und Kommunaltechnik; Umwelttechnik</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.9 Chemische und optische Sensorik</collection>
    <collection role="institutes" number="">4 Material und Umwelt</collection>
    <collection role="institutes" number="">4.1 Biologische Materialschädigung und Referenzorganismen</collection>
    <collection role="themenfelder" number="">Umwelt</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
    <collection role="literaturgattung" number="">Präsentation</collection>
    <collection role="institutes" number="">4.0 Abteilungsleitung und andere</collection>
    <collection role="themenfelder" number="">Biokorrosion</collection>
  </doc>
  <doc>
    <id>65554</id>
    <completedYear/>
    <publishedYear>2026</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1</pageFirst>
    <pageLast>9</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>11</volume>
    <type>article</type>
    <publisherName>American Chemical Society</publisherName>
    <publisherPlace>Washington, D.C.</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Rapid Onsite Detection of Fecal Contamination in Water Using a Portable Fluorometric Assay</title>
    <abstract language="eng">Fecal pollution in water poses significant health risks, especially when contaminated sources are used for drinking and food production. Traditional water quality testing methods are expensive, slow, and require skilled personnel, limiting their accessibility. This work addresses these issues by developing a portable fluorometric assay for the detection of the fecal indicator pigment urobilin (UB). The assay uses silane-functionalized glass fiber strips impregnated with zinc chloride, providing a ‘drop-&amp;-detect’ approach with enhanced fluorescence response mediated by the unique complexation properties of ZnCl2 and UB. This approach allows for the detection of UB at sub-nanomolar concentrations in less than 1 min using a 3D-printed setup with miniaturized optical components powered by a smartphone with its camera as a detector. The results validated with a benchtop fluorometer show the effectiveness of this method. The successful application of this userfriendly, rapid, and sensitive assay to real water samples from three rivers and the influx and efflux of a wastewater treatment plant advances field-based water quality monitoring, meets the WHO’s ASSURED criteria, and supports progress toward the global clean water and sanitation goals.</abstract>
    <parentTitle language="eng">ACS Sensors</parentTitle>
    <identifier type="doi">10.1021/acssensors.5c03922</identifier>
    <identifier type="issn">2379-3694</identifier>
    <identifier type="urn">urn:nbn:de:kobv:b43-655543</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="date_peer_review">23.02.2026</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>Swayam Prakash</author>
    <author>Jérémy Bell</author>
    <author>Knut Rurack</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fecal pigment</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fluorescence</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Signal amplification</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Surface chemistry</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Water quality testing</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="ddc" number="628">Sanitär- und Kommunaltechnik; Umwelttechnik</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.9 Chemische und optische Sensorik</collection>
    <collection role="themenfelder" number="">Umwelt</collection>
    <collection role="themenfelder" number="">Chemie und Prozesstechnik</collection>
    <collection role="themenfelder" number="">Chemische Charakterisierung und Spurenanalytik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei für die Öffentlichkeit verfügbar ("Open Access")</collection>
    <collection role="unnumberedseries" number="">Wissenschaftliche Artikel der BAM</collection>
    <collection role="themenfelder" number="">Sensorik</collection>
    <thesisPublisher>Bundesanstalt für Materialforschung und -prüfung (BAM)</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-bam/files/65554/rapid-onsite-detection-of-fecal-contamination-in-water-using-a-portable-fluorometric-assay.pdf</file>
  </doc>
  <doc>
    <id>65555</id>
    <completedYear/>
    <publishedYear>2026</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1</pageFirst>
    <pageLast>19</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>7</volume>
    <type>article</type>
    <publisherName>Light Publishing Group</publisherName>
    <publisherPlace>Changchun</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Rapid fabrication of optical elements for sensing applications using a standard SLA printer</title>
    <abstract language="eng">The demand for compact, high-performance optical components has driven the development of increasingly sophisticated and miniaturized optical elements, often requiring complex and costly fabrication methods. In this study, we propose a cost-effective and accessible methodology for the fabrication of lenses and free-form optics using a commercially available stereolithography (SLA) 3D printer. A systematic characterisation of six transparent photopolymer resins was conducted in terms of their spectroscopic, optical, and morphological properties, i.e., surface and dimensional properties. The evaluation encompassed parameters such as transmittance, autofluorescence, refractive index,&#13;
and surface roughness. A straightforward yet resilient printing and post-treatment protocol was formulated, facilitating the fabrication of optical components with over 80% transmittance, minimal intrinsic fluorescence, and surface quality that is compatible with exacting optical applications. The fabricated components demonstrated excellent dimensional fidelity to digital designs and high reproducibility. To demonstrate the versatility of this approach, aspherical, miniaturized, and freeform lenses were designed and integrated into three fluorogenic sensing systems, including oil (strip-based) and chlorine (microfluidic-based) detection platforms, as well as a smartphone-based SARS-CoV-2 biosensor. The integration of customized 3D-printed optics has been demonstrated to enhance signal collection and readout performance, thereby highlighting the potential of this approach to&#13;
democratize the rapid prototyping and deployment of miniaturized optical systems. This work&#13;
represents a significant advancement in the field of additive manufacturing, particularly in relation to the development of functional photonic devices. Furthermore, it opens new prospects for sensor applications in biosensing, microfluidics, imaging, and integrated optics.</abstract>
    <parentTitle language="eng">Light: Advanced Manufacturing</parentTitle>
    <identifier type="doi">10.37188/lam.2026.024</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <author>María Amparo Hernández-García</author>
    <author>Knut Rurack</author>
    <author>Jérémy Bell</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>3D-printing</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Free-form</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Prototyping</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Optical resin</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Surface finishing</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fluorescence</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Sensor</value>
    </subject>
    <collection role="ddc" number="620">Ingenieurwissenschaften und zugeordnete Tätigkeiten</collection>
    <collection role="ddc" number="628">Sanitär- und Kommunaltechnik; Umwelttechnik</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.9 Chemische und optische Sensorik</collection>
    <collection role="themenfelder" number="">Umwelt</collection>
    <collection role="themenfelder" number="">Material</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
    <collection role="themenfelder" number="">Additive Fertigung</collection>
    <collection role="themenfelder" number="">Sensorik</collection>
  </doc>
  <doc>
    <id>47923</id>
    <completedYear/>
    <publishedYear>2019</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>2250</pageFirst>
    <pageLast>2256</pageLast>
    <pageNumber/>
    <edition/>
    <issue>8</issue>
    <volume>7</volume>
    <type>article</type>
    <publisherName>Royal Society of Chemistry</publisherName>
    <publisherPlace>London, UK</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Tailored fluorescent solvatochromic test strips for quantitative on-site detection of gasoline fuel adulteration</title>
    <abstract language="eng">Gasoline adulteration is a frequent problem world-wide, because of the chance of quick, maximized profits. However, addition of cheaper ethanol or hydrocarbons like kerosene does not only result in economic damage but also poses problems for vehicles and the environment. To enable law enforcement forces, customers or enterprises to uncover such a fraudulent activity directly upon suspicion and without the need to organize for sampling and laboratory analysis, we developed a simple strip-based chemical test. Key to the favorable performance was the dedicated materials tailoring, which led to test strips that consisted of a cellulose support coated with silica, passivated with hexamethyldisilazane and functionalized covalently with a molecular probe. The probe fluoresces brightly across a broad solvent polarity range, enabling reliable quantitative measurements and data analysis with a conventional smartphone. The assays showed high reproducibility and accuracy, allowing not only for the detection of gasoline adulteration but also for the on-site monitoring of the quality of commercial E10 gasoline.</abstract>
    <parentTitle language="eng">Journal of Materials Chemistry C</parentTitle>
    <identifier type="doi">10.1039/C8TC04818E</identifier>
    <identifier type="url">https://pubs.rsc.org/en/content/articlelanding/2019/tc/c8tc04818e</identifier>
    <identifier type="urn">urn:nbn:de:kobv:b43-479231</identifier>
    <identifier type="issn">2050-7526</identifier>
    <enrichment key="date_peer_review">06.05.2019</enrichment>
    <licence>Creative Commons - CC BY-NC - Namensnennung - Nicht kommerziell 4.0 International</licence>
    <author>Raúl Gotor</author>
    <author>Jérémy Bell</author>
    <author>Knut Rurack</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Gasoline</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Adulteration</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Test strips</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Benzin</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Teststreifen</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fluorescence</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Cellulose</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Zellulose</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Fluoreszenz</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="ddc" number="628">Sanitär- und Kommunaltechnik; Umwelttechnik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei für die Öffentlichkeit verfügbar ("Open Access")</collection>
    <collection role="unnumberedseries" number="">Wissenschaftliche Artikel der BAM</collection>
    <thesisPublisher>Bundesanstalt für Materialforschung und -prüfung (BAM)</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-bam/files/47923/Gotor_JMC_C.pdf</file>
  </doc>
  <doc>
    <id>49130</id>
    <completedYear/>
    <publishedYear>2019</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>lecture</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Microfluidic analytical tool coupling a fluorescent molecular probe and a micro-hydrocyclone for the detection of water chlorination level</title>
    <abstract language="eng">Chlorination of pool water and wastewater, in food and pharmaceutical production, as well as in pesticide and paper manufacturing is a routinely used technique. However, the amount of chlorine in water must be strictly adjusted, to ensure enough concentration to kill pathogenic bacteria and viruses, while preventing too high concentrations inducing negative effects on human health. As an indicator, a molecular fluorescent probe based on a BODIPY structure was designed. This indicator exhibits a sensitive and selective fluorescence response upon increasing concentrations of hypochlorite in aqueous solvent mixtures. Real-time analyses became possible after the integration of this fluorescent indicator into newly designed 2D &amp; 3D microfluidic chips incorporating a passive sinusoidal mixer and a micro-hydrocyclone, respectively. A comparison of the two microfluidic systems, including their ability to prevent accumulation or circulation of microbubbles, has shown excellent fluidic behaviour for the micro-hydrocyclone device. This system was distinctly more robust against gas bubbles, showed a higher signal gain and allowed to halve the limit of detection to 0.02 mg L–1. The use of the 3D system to quantify the chlorine content of pool water samples for sensitive and quantitative chlorine monitoring has been demonstrated.</abstract>
    <identifier type="url">https://media.conferre.gr/index.php/photos-videos/ima2019</identifier>
    <enrichment key="eventName">Konferenz</enrichment>
    <enrichment key="eventPlace">Ioannina, Greece</enrichment>
    <enrichment key="eventStart">22.09.2019</enrichment>
    <enrichment key="eventEnd">25.09.2019</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <enrichment key="InvitedTalks">0</enrichment>
    <author>Jérémy Bell</author>
    <author>Adam Tillo</author>
    <author>Vraj P. Chauhan</author>
    <author>Jürgen Bartelmeß</author>
    <author>Knut Rurack</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Chlorine</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fluorescence</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Microfluidics</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Water</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Chlor</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Fluoreszenz</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Mikrofluidik</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Wasser</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
    <collection role="literaturgattung" number="">Präsentation</collection>
  </doc>
  <doc>
    <id>49393</id>
    <completedYear/>
    <publishedYear>2019</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>12980</pageFirst>
    <pageLast>12987</pageLast>
    <pageNumber/>
    <edition/>
    <issue>20</issue>
    <volume>91</volume>
    <type>article</type>
    <publisherName>American Chemical Society</publisherName>
    <publisherPlace>Washington, DC</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Microfluidic Device for the Determination of Water Chlorination Levels Combining a Fluorescent meso-Enamine Boron Dipyrromethene Probe and a Microhydrocyclone for Gas Bubble Separation</title>
    <abstract language="eng">Chlorination procedures are commonly applied in swimming pool water and wastewater treatment, yet also in food, pharmaceutical, and paper production. The amount of chlorine in water needs to be strictly controlled to ensure efficient killing of pathogens but avoid the induction of negative health effects. Miniaturized microfluidic fluorescence sensors are an appealing approach here when aiming at online or at-site measurements. Two meso-enamine-substituted boron dipyrromethene (BODIPY) dyes were found to exhibit favorable indication properties, their reaction with hypochlorite leading to strong fluorescence enhancement. Real-time assays became possible after integration of these fluorescent probes with designed two-dimensional (2D) and three-dimensional (3D) microfluidic chips, incorporating a passive sinusoidal mixer and a microhydrocyclone, respectively. A comparison of the two microfluidic systems, including their abilities to prevent accumulation or circulation of microbubbles produced by the chemical indication reaction, showed excellent fluidic behavior for the microhydrocyclone-based device. After coupling to a miniaturized optical reader for fluorescence detection, the 2D microfluidic system showed a promising detection range of 0.04−0.5 mg L−1 while still being prone to bubble-induced fluctuations and suffering from considerably low signal gain. The microhydrocyclone-based system was distinctly more robust against gas bubbles, showed a higher signal gain, and allowed us to halve the limit of detection to 0.02 mg L−1. The use of the 3D system to quantify the chlorine content of swimming pool water samples for sensitive and quantitative chlorine monitoring was demonstrated.</abstract>
    <parentTitle language="eng">Analytical Chemistry</parentTitle>
    <identifier type="doi">10.1021/acs.analchem.9b03039</identifier>
    <identifier type="issn">0003-2700</identifier>
    <enrichment key="date_peer_review">18.12.2019</enrichment>
    <author>Adam Tillo</author>
    <author>Jürgen Bartelmeß</author>
    <author>Vraj P. Chauhan</author>
    <author>Jérémy Bell</author>
    <author>Knut Rurack</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Chlorine</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>BODIPY</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fluorescence</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Micro-Hydrocyclone</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Microfluidic Chip</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="ddc" number="628">Sanitär- und Kommunaltechnik; Umwelttechnik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>43103</id>
    <completedYear/>
    <publishedYear>2017</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>11594</pageFirst>
    <pageLast>11600</pageLast>
    <pageNumber/>
    <edition/>
    <issue>11</issue>
    <volume>31</volume>
    <type>article</type>
    <publisherName>American Chemical Society</publisherName>
    <publisherPlace>Washington, D.C.</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Detection of adulterated diesel using fluorescent test strips and smartphone readout</title>
    <abstract language="eng">The fluorescence properties of three molecular rotors, related to 4-dimethylamino-4-nitrostilbene (4-DNS), are studied versus different diesel/kerosene blends. In nonviscous solvents, these compounds can populate a twisted intramolecular charge transfer state which deactivates nonradiatively, successfully suppressing fluorescence emission. Solution experiments with diesel/kerosene blends showed a good linear correlation between the fluorescence intensity of the probe molecules and the diesel fraction of the blend. The dyes have been immobilized on paper, retaining their fluorescence behavior, i.e., negligible emission in the presence of nonviscous organic solvents and increasing fluorescence when the environment is increasingly viscous. When the impregnated paper is devised as a test strip, the latter is compatible with a newly designed smartphone reader system, which allows in-the-field measurements. The method can safely detect the presence of kerosene in diesel at ≥7%, which competes favorably with current standard methods for the detection of diesel adulteration.</abstract>
    <parentTitle language="eng">Energy &amp; Fuels</parentTitle>
    <identifier type="doi">10.1021/acs.energyfuels.7b01538</identifier>
    <identifier type="issn">0887-0624</identifier>
    <enrichment key="date_peer_review">08.12.2017</enrichment>
    <author>Raúl Gotor</author>
    <author>Carlo Tiebe</author>
    <author>Jörg Schlischka</author>
    <author>Jérémy Bell</author>
    <author>Knut Rurack</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fuel adulteration</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Diesel</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fluorescence</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Test strip</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Molecular rotor</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Smartphone</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei im Netzwerk der BAM verfügbar ("Closed Access")</collection>
  </doc>
  <doc>
    <id>65733</id>
    <completedYear/>
    <publishedYear>2026</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1</pageFirst>
    <pageLast>13</pageLast>
    <pageNumber/>
    <edition/>
    <issue>3</issue>
    <volume>5</volume>
    <type>article</type>
    <publisherName>Wiley-VCH</publisherName>
    <publisherPlace>Weinheim</publisherPlace>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Detection of Perfluoroalkylic Acids From Water Using a Guanidine-Based Fluorescent Probe and Microfluidic Droplet Extraction</title>
    <abstract language="eng">Perfluoroalkylic acids (PFAAs), a subclass of per- and polyfluoroalkyl substances (PFAS), are stable, widely used industrial compounds posing environmental concerns due to their persistence and toxicity. Regulatory actions and remediation strategies necessitate effective onsite analytical methods for PFAS management. We developed an optical sensing system using a fluorescent probe with a benzoxadiazole core and guanidine receptor in a droplet-based microfluidic assay to detect PFAAs in water samples with low detection limits. The PFAAs binding enhances the probe's fluorescence in organic media through protonation-mediated hydrogen bond-assisted ion pairing, exploiting two complementary supramolecular forces. Direct detection employs a liquid-liquid extraction protocol in the microfluidic device, achieving detection limits for PFOA and PFOS down to ≥0.5 µm, with a dynamic range up to 200 µm for sample volumes &lt;100 µL. HCl/KCl buffering facilitates analyte desalting and phase transfer for quantitation from surface water. Additionally, we developed a method involving a thin polymer layer of the probe and a crosslinker on submicron silica particles for direct detection of PFAAs in water. Our approaches provide sensitive, direct recognition and indication of PFAAs, advancing the field beyond indirect sensing and offering improved background suppression, rapid assay times, and a modular design for targeting other PFAS subclasses.</abstract>
    <parentTitle language="eng">Advanced Sensor Research</parentTitle>
    <identifier type="doi">10.1002/adsr.70145</identifier>
    <identifier type="urn">urn:nbn:de:kobv:b43-657330</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>Víctor Pérez-Padilla</author>
    <author>Samual C. Burnage</author>
    <author>Philipp Wittwer</author>
    <author>Virginia Valderrey</author>
    <author>Jérémy Bell</author>
    <author>Kornelia Gawlitza</author>
    <author>Knut Rurack</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>PFAS</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fluorescence</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Microfluidics</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Droplet Extraction</value>
    </subject>
    <collection role="ddc" number="543">Analytische Chemie</collection>
    <collection role="ddc" number="604">Spezielle Themen</collection>
    <collection role="institutes" number="">1 Analytische Chemie; Referenzmaterialien</collection>
    <collection role="institutes" number="">1.9 Chemische und optische Sensorik</collection>
    <collection role="institutes" number="">4 Material und Umwelt</collection>
    <collection role="institutes" number="">4.4 Thermochemische Reststoffbehandlung und Wertstoffrückgewinnung</collection>
    <collection role="themenfelder" number="">Chemie und Prozesstechnik</collection>
    <collection role="themenfelder" number="">Chemische Charakterisierung und Spurenanalytik</collection>
    <collection role="literaturgattung" number="">Verlagsliteratur</collection>
    <collection role="fulltextaccess" number="">Datei für die Öffentlichkeit verfügbar ("Open Access")</collection>
    <collection role="unnumberedseries" number="">Wissenschaftliche Artikel der BAM</collection>
    <collection role="themenfelder" number="">Gefährliche Stoffe</collection>
    <thesisPublisher>Bundesanstalt für Materialforschung und -prüfung (BAM)</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-bam/files/65733/AdvSensRes_2026_5_e70145.pdf</file>
  </doc>
</export-example>
