Dokument-ID Dokumenttyp Autoren/innen Persönliche Herausgeber/innen Haupttitel Abstract Auflage Verlagsort Verlag Herausgeber (Institution) Erscheinungsjahr Titel des übergeordneten Werkes Jahrgang/Band ISBN Veranstaltung Veranstaltungsort Beginndatum der Veranstaltung Enddatum der Veranstaltung Ausgabe/Heft Erste Seite Letzte Seite URN DOI Lizenz Datum der Freischaltung OPUS4-41164 Beitrag zu einem Tagungsband Hahn, Marc Benjamin; Solomun, Tihomir; Meyer, Susann; Kunte, Hans-Jörg; Schröter, Maria-Astrid; Sturm, Heinz Development of a standard procedure for the irradiation of biomolecules In dosimetry the determination of the effectiveness of the damaging processes is standardized and accounted for by the radiation and tissue weighting factor. For the underlying constituents of the tissue, that is the various biomolecules, such a systematic approach doesn't exist. This makes it difficult to compare results obtained under different experimental conditions. In the following work, we will describe a method to obtain comparable values for the radiation-biomolecule interaction, measured under different conditions. This approach can lead to standardization of dosedamage relationship at the molecular level. Such approach is necessary for a better understanding of the relations between the damage of the single constituents of biological tissue and the whole - finally gaining a more complete picture of irradiation damage. International Raditation Protection Association 2017 Proceedings of the 14th IRPA International Congress 14 14th International Congress of the International Raditation Protection Association (IRPA) Cape Town, South Africa 09.05.2016 12.05.2016 1 5 2017-08-03 OPUS4-35835 Posterpräsentation Meyer, Susann Structural changes in plasmid DNA verified by gel electrophoresis and AFM: Sample radiation and damage detection Many microorganisms possess circular molecules of plasmid DNA. Their conformation may vary from more compact to relaxed forms. Structural changes have important consequences for the physiological role of plasmids and will influence plasmid transcription, replication and their susceptibility to environmental stresses. Radiation is a common form of stress and can cause structural damage to DNA such as single (SSB) and double strand breaks (DSB). Recently, it has been indicated that secondary low-energy electrons play an important role in biological damage under vacuum condition. Therefore, our studies focus on irradiating the plasmid pUC19 with low-energy electrons for the first time under physiological conditions. 2016 AFM BioMed Conference Porto, Portugal 11.04.2016 15.04.2016 2016-04-28 OPUS4-33006 Posterpräsentation Meyer, Susann The damaging effect of low energy electrons on biomolecules and cells: Mechanism of action of compatible solutes 2015 Deutsche Physikalische Gesellschaft (DPG) 2015 Deutsche Physikalische Gesellschaft (DPG) 2015 Berlin, Deutschland 2015-03-15 2015-03-20 2016-02-20