Dokument-ID Dokumenttyp Autoren/innen Persönliche Herausgeber/innen Haupttitel Abstract Auflage Verlagsort Verlag Herausgeber (Institution) Erscheinungsjahr Titel des übergeordneten Werkes Jahrgang/Band ISBN Veranstaltung Veranstaltungsort Beginndatum der Veranstaltung Enddatum der Veranstaltung Ausgabe/Heft Erste Seite Letzte Seite URN DOI Lizenz Datum der Freischaltung OPUS4-44831 Zeitschriftenartikel Sin, DWM.; Wong, YC.; Lehmann, Andreas; Schneider, Rudolf; Kakoulides, E.; Lin, TT.; Liu, QD.; Cabillic, J.; Lardy-fontan, S.; Nammoonnoy, J. CCQM-K126: low polarity organic in water: carbamazepine in surface water This study aimed to assess the measurement capabilities of participating National Metrology Institutes/ Designated Institutes (NMIs/DIs) and expert laboratories in determining of low-polarity organics in surface water. This comparison was organized by Government Laboratory, Hong Kong (GLHK). At the CCQM Organic Analysis Working Group (OAWG) Meeting held in November 2012 in Hong Kong, GLHK initially proposed a CCQM key comparison and a parallel pilot study programme on pharmaceuticals in surface water. Further discussion at the CCQM Meeting held in April 2014 in Paris, the OAWG approved a CCQM Track C comparison (CCQM-K126) on low polarity pharmaceuticals in surface water. In the meeting, the programme was supported by more than six National Metrology Institutes/ Designated Institutes (NMIs/ DIs). CCQM-K126 officially commenced in July 2014 and had registration from nine NMIs/DIs. Participants were provided two bottles (40 mL each) of surface water and were requested to determine the mass fraction of spiked carbamazepinein in surface water. The coordinator received nine sets of results from eight NMIs/DIs in February 2015. Apart from one using an immunoassay technique, all participants applied isotope dilution liquid chromatography-tandem mass spectrometry (ID-LCMS/MS) technique as their determination technique. Bristol IOP Publ. 2017 METROLOGIA 54 Suppl. S Article 08030, 1 56 10.1088/0026-1394/54/1A/08030 2018-05-04 OPUS4-45381 Zeitschriftenartikel Dai, X.; Zhang, W.; Li, H.; Huang, T.; Li, M.; Quan, C.; Zhang, Q.; Davies, S. R.; Warren, J.; Lo, M.-F.; Kakoulides, E.; Gören, A. C.; Marbumrung, S.; Pfeifer, Dietmar; Ün, I.; Gündüz, S.; Yilmaz, H.; Kankaew, P.; Sudsiri, N.; Shearman, K.; Pookrod, P.; Polzer, J.; Radeck, W. CCQM-K104 key comparison (avermectin B(1)a) on the characterization of organic substances for chemical purity Under the Comité Consultatif pour la Quantité de Matière (CCQM), a key comparison, CCQM-K104, was coordinated by the National Institute of Metrology (NIM). The comparison was designed to demonstrate a laboratory's performance in determining the mass fraction of the main component in a complex high purity organic material. Nine NMIs or DIs participated in the comparison. Eight participants reported their results. An additional impurity was resolved from the avermectin B1a peak and was tentatively identified as an unknown impurity by NMIA (National Measurement Institute (Australia)). It was subsequently identified by NIM as a diastereoisomer of avermectin B1a at the C-26 position. Final reference value (KCRV) = 924.63 mg/g, with uncertainty (k=1) = 3.89 mg/g, and expanded uncertainty = 8.97 mg/g. The degrees of equivalence with the avermectin B1a KCRV for each participant were reported. The measurement results and degrees of equivalence should be indicative of the performance of a laboratory's measurement capability for the purity assignment of organic compounds of high structural complexity (relative molecular mass range of 500 Da -1000 Da and low polarity (-log KOW ≤ -2). 2017 Metrologia 54 2 32 10.1088/0026-1394/54/1A/08019 2018-07-05 OPUS4-45035 Forschungsbericht Dai, X.; Zhang, W.; Li, H.; Huang, T.; Li, M.; Quan, C.; Zhang, Q.; Davies, S. R; Warren, J.; Lo, M.-F.; Kakoulides, E.; Ceyhan Gören, A.; Marbumrung, S.; Pfeifer, Dietmar; Ün, I.; Gündüz, S.; Yilmaz, H.; Kankaew, P.; Sudsiri, N.; Shearman, K.; Pookrod, P.; Polzer, J.; Radeck, W. CCQM-K104 Key Comparison on the characterization of organic substances for chemical purity - Avermectin B1a Anwendungen von qNMR 2017 1 32 2018-05-30 OPUS4-45321 Posterpräsentation Kakoulides, E. Development of Certified Reference Materials for the calibration of breath analyzers IAPR participates in the EMPIR 16SRT02, entitled 'Certified forensic alcohol reference materials - ALCOREF' funded by EURAMET as an external funded partner. The Research in this project will address the needs for better enforcement of drink-driving legislation in several European countries, by building up long-term capacities for the production and certification of forensic alcohol reference materials, suitable for the calibration of evidential breath alcohol analyzers. The certification procedure includes characterization of the materials, assessment of homogeneity, stability, and uncertainty estimation. An interlaboratory comparison will be conducted to test the materials and capabilities developed. EMPIR 16SRT02-ALCOREF project is coordinated by BAM (DE). 2018 7th National Metrology Congress Athens, Greece 11.05.2018 12.05.2018 2018-07-04 OPUS4-47143 Zeitschriftenartikel Duewer, D. L.; Murray, J. A.; Wood, L. J.; Wise, S. A.; Hein, Sebastian; Koch, Matthias; Philipp, Rosemarie; Werneburg, Martina; Hackenberg, R.; Polzer, J.; Avila, M. A.; Serrano, V.; Kakoulides, E.; Alexopoulos, C.; Giannikopoulou, P.; Gui, E. M.; Lu, T.; Teo, T. L.; Hua, T.; Dazhou, C.; Chunxin, L.; Changjun, Y.; Hongmei, L.; Nammoonnoy, J.; Sander, L. C.; Lippa, K.; Quinn, L.; Swiegelaar, C.; Fernandes-Whaley, M.; Gören, A. C.; Gökcen, T. CCQM-K95.1 Low-polarity analytes in a botanical matrix: Polycyclic aromatic hydrocarbons (PAHs) in tea Extraction, chromatographic separation, and quantification of low-concentration organic compounds in complex matrices are core challenges for reference material producers and providers of calibration services. Evidence of successful participation in formal, relevant international comparisons is needed to document measurement capability claims made by national metrology institutes (NMIs) and designated institutes (DIs). To enable NMIs and DIs to update or establish their claims, in 2014 the Organic Analysis Working Group (OAWG) initiated CCQM-K95.1 "Low-Polarity Analytes in a Botanical Matrix: Polycyclic Aromatic Hydrocarbons (PAHs) in Tea". This was a follow-on comparison from CCQM-K95 which was completed in 2014. The polycyclic aromatic hydrocarbons (PAHs) benz[a]anthracene (BaA) and benzo[a]pyrene (BaP) are considered priority pollutants by U.S. Environmental Protection Agency and are regulated contaminants in food, pose chromatographic separation challenges, and for which exist well-characterized measurement procedures and standard materials. BaA and BaP in a smoked tea were therefore selected as representative target measurands for CCQM-K95.1. Ten NMIs participated in CCQM-K95.1. The consensus summary mass fractions for the two PAHs are in the range of (50 to 70) ng/g with relative standard deviations of (6 to 10) %. Successful participation in CCQM K95.1 demonstrates the following measurement capabilities in determining mass fraction of organic compounds, with molar mass of 100 g/mol to 500 g/mol and having polarity pKow −2, in a botanical matrix ranging in mass fraction from 10 ng/g to 1000 ng/g: (1) value assignment of primary reference standards (if in-house purity assessment carried out), (2) value assignment of single and/or multi-component organic solutions, (3) extraction of analytes of interest from the matrix, (4) cleanup and separation of analytes of interest from interfering matrix or extract components, and (5) separation and quantification using gas chromatography or liquid chromatography. IOP Science 2019 Metrologia 56 1 A 08002, 1 89 urn:nbn:de:kobv:b43-471430 10.1088/0026-1394/56/1A/08002 https://creativecommons.org/licenses/by/4.0/deed.de 2019-01-08 OPUS4-47144 Zeitschriftenartikel Duewer, D. L.; Sander, L. C.; Wise, S. A.; Philipp, Rosemarie; Hein, Sebastian; Hackenberg, R.; Polzer, J.; Avila, M. A.; Serrano, V.; Kakoulides, E.; Alexopoulos, C.; Giannikopoulou, P.; Chan, P.; Lee, H.; Tang, H.; Tang, P.; Yip, Y.; Lu, T.; Cheow, P. S.; Teo, T. L.; Sega, M.; Rolle, F.; Baek, S.; Kim, B.; Lee, S.; Cabillic, J.; Fallot, C.; Hua, T.; Dazhou, C.; Changjun, Y.; Chunxin, L.; Hongmei, L.; Lippa, K.; Itoh, N.; Quinn, L.; Prevoo-Franzsen, D.; Fernandes-Whaley, M.; Gören, A. C.; Gökcen, T.; Gündüz, S.; Krylov, A.; Mikheeva, A.; Baldan, A.; van der Hout, J. W.; van der Veen, A. M. H. CCQM-K131 Low-polarity analytes in a multicomponent organic solution: Polycyclic aromatic hydrocarbons (PAHs) in acetonitrile Solutions of organic analytes of known mass fraction are typically used to calibrate the measurement processes used to determine these compounds in matrix samples. Appropriate value assignments and uncertainty calculations for calibration solutions are critical for accurate measurements. Evidence of successful participation in formal, relevant international comparisons is needed to document measurement capability claims (CMCs) made by national metrology institutes (NMIs) and designated institutes (DIs). To enable NMIs and DIs to update or establish their claims, in 2015 the Organic Analysis Working Group (OAWG) sponsored CCQM-K131 "Low-Polarity Analytes in a Multicomponent Organic Solution: Polycyclic Aromatic Hydrocarbons (PAHs) in Acetonitrile". Polycyclic aromatic hydrocarbons (PAHs) result from combustion sources and are ubiquitous in environmental samples. The PAH congeners, benz[a]anthracene (BaA), benzo[a]pyrene (BaP), and naphthalene (Nap) were selected as the target analytes for CCQM-K131. These targets span the volatility range of PAHs found in environmental samples and include potentially problematic chromatographic separations. Nineteen NMIs participated in CCQM-K131. The consensus summary mass fractions for the three PAHs are in the range of (5 to 25) μg/g with relative standard deviations of (2.5 to 3.5) %. Successful participation in CCQM-K131 demonstrates the following measurement capabilities in determining mass fraction of organic compounds of moderate to insignificant volatility, molar mass of 100 g/mol up to 500 g/mol, and polarity pKow < −2 in a multicomponent organic solution ranging in mass fraction from 100 ng/g to 100 μg/g: (1) value assignment of primary reference standards (if in-house purity assessment carried out), (2) value assignment of single and/or multi-component organic solutions, and (3) separation and quantification using gas chromatography or liquid chromatography. IOP Science 2019 Metrologia 56 1A 08003, 1 102 urn:nbn:de:kobv:b43-471442 10.1088/0026-1394/56/1A/08003 https://creativecommons.org/licenses/by/4.0/deed.de 2019-01-08 OPUS4-52435 Zeitschriftenartikel Li, X.M.; Li, H.M.; Zhang, Q.H.; Lu, X.H.; Li, S.Q.; Koch, Matthias; Polzer, J.; Hackenber, R.; Moniruzzaman, M.; Khan, M.; Kakoulides, E.; Pak-Wing, K.; Richy, ; Chi-Shing, N.; Lu, T.; Gui, E.M.; Cheow, P.S.; Teo, T.L.; Rego, E.; Garrido, B.; Carvalho, L.; Leal, R.; Violante, F.; Baek, S.Y.; Lee, S.; Choi, K.; Kim, B.; Bucar-Miklavcic, M.; Hopley, C.; Nammoonnoy, J.; Murray, J.; Wilson, W.; Toman, B.; Itoh, N.; Gokcen, T.; Krylov, A.; Mikheeva, A. CCQM-K146 low-polarity analyte in high fat food: benzo a pyrene in olive oil The demonstration of competency and equivalence for the assessment of levels of contaminants and nutrients in primary foodstuffs is a priority within the 10-year strategy for the OAWG Track A core comparisons. The measurements are core challenges for reference material producers and providers of calibration Services. This key comparison related to low polarity analytes in a high fat, low protein, low carbohydrate food matrix and Benzo[a]pyrene in edible oil was the model System selected to align with this class within the OAWG strategy. Evidence of successful participation in formal, relevant international comparisons is needed to document measurement capability claims (CMCs) made by national metrology institutes (NMIs) and designated institutes (Dis). 16 National Metrology Institutions participated in the Track A Key Comparison CCQM-K146 Low-Polarity Analyte in high fat food: Benzo[a]pyrene in Olive Oil. Participants were requested to evaluate the mass fractions, expressed in µg/kg, of Benzo[a]pyrene in the olive oil material. The KCRV was determined from the results of all NMIs/DIs participating in the key comparison that used appropriately validated methods with demonstrated metrological traceability. Different methods such as liquid-liquid extraction, GPC and SPE were applied in the sample pretreatment and HPLC-FLD, HPLC-MS/MS, and GC-MS or GC-MS/MS were applied for detection by the participants. The mass fractions for BaP were in the range of (1.78 to 3.09) µg/kg with Standard uncertainties of (0.026 to 0.54) µg/kg, with corresponding relative Standard uncertainties from 0.9% to 21%. Five labs withdrew their result from the Statistical evaluation of the KCRV for technical reasons. One lab was excluded from the KCRV evaluation, as they did not meet the CIPM metrological traceability requirements. A Hierarchical Bayes option was selected for the KCRV value, which was determined as 2.74 µg/kg with a Standard uncertainty of 0.03 µg/kg. The 10 institutes those were included in the calculation of the consensus KCRV all agreed within their Standard uncertainties. Successful participation in CCQM-K146 demonstrates the measurement capabilities in determining mass fraction of organic compounds, with molecular mass of 100 g/mol to 500 g/mol, having low polarity pKow < -2, in mass fraction range from 0.1 µg/kg to 1000 µg/kg in a high fat, low protein, low carbohydrate food matrix. 2020 Metrologia 57 1a 08017 10.1088/0026-1394/57/1a/08017 2021-04-15 OPUS4-54188 Zeitschriftenartikel Westwood, S.; Martos, G.; Josephs, R.; Choteau, T.; Wielgosz, R.; Davies, S.; Moawad, M.; Tarrant, G.; Chan, B.; Alamgir, M.; de Rego, E.; Wollinger, W.; Garrido, B.; Fernandes, J.; de Sena, R.; Oliveira, R.; Melanson, J.; Bates, J.; Mai Le, P.; Meija, J.; Quan, C.; Huang, T.; Zhang, W.; Ma, R.; Zhang, S.; Hao, Y.; He, Y.; Song, S.; Wang, H.; Su, F.; Zhang, T.; Li, H.; Lam, W.; Wong, W.; Fung, W.; Philipp, Rosemarie; Dorgerloh, Ute; Meyer, Klas; Piechotta, Christian; Riedel, Juliane; Westphalen, Tanja; Giannikopoulou, P.; Alexopoulos, Ch.; Kakoulides, E.; Kitamaki, Y.; Yamazaki, T.; Shimizu, Y.; Kuroe, M.; Numata, M.; Pérez-Castorena, A.; Balderas-Escamilla, M.; Garcia-Escalante, J.; Krylov, A.; Mikheeva, A.; Beliakov, M.; Palagina, M.; Tkachenko, I.; Spirin, S.; Smirnov, V.; Tang Lin, T.; Pui Sze, C.; Juan, W.; Lingkai, W.; Ting, L.; Quinde, L.; Yizhao, C.; Lay Peng, S.; Fernandes-Whaley, M.; Prevoo-Franzsen, D.; Quinn, L.; Nhlapo, N.; Mkhize, D.; Marajh, D.; Chamane, S.; Ahn, S.; Choi, K.; Lee, S.; Han, J.; Baek, S.; Kim, B.; Marbumrung, S.; Jongmesuk, P.; Shearman, K.; Boonyakong, C.; Bilsel, M.; Gündüz, S.; Ün, I.; Yilmaz, H.; Bilsel, G.; Gökçen, T.; Clarkson, C.; Warren, J.; Achtar, E. Mass fraction assignment of Bisphenol-A high purity material The CCQM-K148.a comparison was coordinated by the BIPM on behalf of the CCQM Organic Analysis Working Group for NMIs and DIs which provide measurement services in organic analysis under the CIPM MRA. It was undertaken as a "Track A" comparison within the OAWG strategic plan. CCQM-K148.a demonstrates capabilities for assigning the mass fraction content of a solid organic compound having moderate molecular complexity, where the compound has a molar mass in the range (75 - 500) g/mol and is non-polar (pKow < −2), when present as the primary organic component in a neat organic solid and where the mass fraction content of the primary component in the material is in excess of 950 mg/g. Participants were required to report the mass fraction of Bisphenol A present in one supplied unit of the comparison material. Participants using a mass balance method for the assignment were also required to report their assignments of the impurity components present in the material. Methods used by the seventeen participating NMIs or DIs were predominantly based on either stand-alone mass balance (summation of impurities) or qNMR approaches, or the combination of data obtained using both methods. The results obtained using thermal methods based on freezing-point depression methods were also reported by a limited number of participants. There was excellent agreement between assignments obtained using all three approaches to assign the BPA content. The assignment of the values for the mass fraction content of BPA consistent with the KCRV was achieved by most of the comparison participants with an associated relative standard uncertainty in the assigned value in the range (0.1 - 0.5)%. IOP Publishing Bureau International des Poids et Mesures (BIPM) 2021 Metrologia 58 1A 08015 10.1088/0026-1394/58/1A/08015 2022-01-05 OPUS4-53740 Zeitschriftenartikel Ogrinc, N.; Rossi, A. M.; Durbiano, F.; Becker, Roland; Milavec, M.; Bogozalec Kosir, A.; Kakoulides, E.; Ozer, H.; Akcadag, F.; Goenaga-Infante, H.; Quaglia, M.; Mallia, S.; Umbricht, G.; O'Connor, G.; Guettler, B. Support for a European metrology network on food safety Food-MetNet This paper describes Food-MetNet, a coordinated preparatory initiative to establish the European Metrology Network on Food Safety (EMN-FS). Food-MetNet aims to establish a long-term ongoing dialogue between the metrology community and relevant stakeholders, in particular, European Union Reference Laboratories (EURLs), National Reference Laboratories (NRLs) and the Joint Research Centre (JRC). This dialogue is meant to support the collection of needs from stakeholders, the take-up of metrological research output and the development of the roadmaps needed to navigate future research. Elsevier 2021 Measurement: Sensors 18 1 4 10.1016/j.measen.2021.100285 2021-11-17 OPUS4-55889 Zeitschriftenartikel Philipp, Rosemarie; Lalere, B.; Gantois, F.; Sánchez, C.; Sáez, A.; Bebić, J.; Banjanac, K.; Alexopoulos, Ch.; Kakoulides, E.; Claramunt, A. V.; Janko, P.; Jotanovic, A.; Hafner-Vuk, K.; Buzoianu, M.; Mihail, R.; Fernández, M. M.; Etcheverry, J.; Mbithi Muendo, B.; Muriira Karau, G.; Silva, A.; Almirón, F.; Marajh, D.; Makgatho, P.; Visser, R.; Alaskar, A. R.; Alosaimi, A.; Alrashed, M.; Yilmaz, H.; Ün, İ.; Gündüz, S.; Topal, K.; Bilsel, M.; Karasinski, J.; Torres, J. Supplementary comparison study - measurement capabilities for the quantification of ethanol in water The accurate quantification of ethanol in water is essential for forensic applications such as blood and breath alcohol testing and for commercial applications such as the assessment of alcoholic beverages. The intercomparison EURAMET.QM-S14 is part of a capacity building project named ALCOREF "Certified forensic alcohol reference materials" that is running within the European Metrology Programme for Innovation and Research (EMPIR). The intercomparison should allow project partners and other interested National Metrology Institutes (NMIs) and Designated Institutes (DIs) to benchmark their analytical methods for the quantification of ethanol in water. The study plan was agreed by the European Association of National Metrology Institutes (EURAMET) Subcommittee Bio- and Organic Analysis (SCBOA) and the Organic Analysis Working Group (OAWG) of the Comité Consultatif pour la Quantité de Matière (CCQM) in February and April 2019, respectively. The intercomparison was coordinated by BAM. Two concentration levels relevant for the calibration and verification of evidential breath alcohol analysers were distributed to study participants. Fifteen institutes from 15 countries registered for the intercomparison and returned results. Participants mostly applied gas chromatography with flame ionisation detection (GC-FID) or mass spectroscopy (GC-MS), one participant used titrimetry and one participant employed a test bench for breath analyser calibration ("bubble train"). Participants did either in-house purity assessment of their commercial ethanol calibrants by Karl-Fischer titration, chromatographic methods, quantitative nuclear magnetic resonance spectroscopy (qNMR) and/or density measurements; or they used ethanol/water Certified Reference Materials (CRMs) from NMIs/DIs for calibration. CCQM OAWG agreed to use a consensus value from participants results that utilizes the reported uncertainties as Key Comparison Reference Value (KCRV). The Gaussian Random effects model with Hierarchical Bayesian solution (HB-REM) is a reasonable approach in this case. The KCRVs and Degrees of Equivalence (DoEs) were calculated with the NIST consensus builder version 1.2 Hierarchical Bayes procedure. Successful participation in the interlaboratory comparison has demonstrated the capabilities in determining the mass fraction of ethanol in aqueous matrices in the range 0.1 mg/g to 8 mg/g. Fourteen out of 15 participants have successfully quantified both samples, one participant successfully quantified only the lower-level (0.6 mg/g) sample. IOP Publishing 2022 Metrologia 59 1A 08015 10.1088/0026-1394/59/1A/08015 2022-10-06