Dokument-ID Dokumenttyp Autoren/innen Persönliche Herausgeber/innen Haupttitel Abstract Auflage Verlagsort Verlag Herausgeber (Institution) Erscheinungsjahr Titel des übergeordneten Werkes Jahrgang/Band ISBN Veranstaltung Veranstaltungsort Beginndatum der Veranstaltung Enddatum der Veranstaltung Ausgabe/Heft Erste Seite Letzte Seite URN DOI Lizenz Datum der Freischaltung OPUS4-45035 Forschungsbericht Dai, X.; Zhang, W.; Li, H.; Huang, T.; Li, M.; Quan, C.; Zhang, Q.; Davies, S. R; Warren, J.; Lo, M.-F.; Kakoulides, E.; Ceyhan Gören, A.; Marbumrung, S.; Pfeifer, Dietmar; Ün, I.; Gündüz, S.; Yilmaz, H.; Kankaew, P.; Sudsiri, N.; Shearman, K.; Pookrod, P.; Polzer, J.; Radeck, W. CCQM-K104 Key Comparison on the characterization of organic substances for chemical purity - Avermectin B1a Anwendungen von qNMR 2017 1 32 2018-05-30 OPUS4-45381 Zeitschriftenartikel Dai, X.; Zhang, W.; Li, H.; Huang, T.; Li, M.; Quan, C.; Zhang, Q.; Davies, S. R.; Warren, J.; Lo, M.-F.; Kakoulides, E.; Gören, A. C.; Marbumrung, S.; Pfeifer, Dietmar; Ün, I.; Gündüz, S.; Yilmaz, H.; Kankaew, P.; Sudsiri, N.; Shearman, K.; Pookrod, P.; Polzer, J.; Radeck, W. CCQM-K104 key comparison (avermectin B(1)a) on the characterization of organic substances for chemical purity Under the Comité Consultatif pour la Quantité de Matière (CCQM), a key comparison, CCQM-K104, was coordinated by the National Institute of Metrology (NIM). The comparison was designed to demonstrate a laboratory's performance in determining the mass fraction of the main component in a complex high purity organic material. Nine NMIs or DIs participated in the comparison. Eight participants reported their results. An additional impurity was resolved from the avermectin B1a peak and was tentatively identified as an unknown impurity by NMIA (National Measurement Institute (Australia)). It was subsequently identified by NIM as a diastereoisomer of avermectin B1a at the C-26 position. Final reference value (KCRV) = 924.63 mg/g, with uncertainty (k=1) = 3.89 mg/g, and expanded uncertainty = 8.97 mg/g. The degrees of equivalence with the avermectin B1a KCRV for each participant were reported. The measurement results and degrees of equivalence should be indicative of the performance of a laboratory's measurement capability for the purity assignment of organic compounds of high structural complexity (relative molecular mass range of 500 Da -1000 Da and low polarity (-log KOW ≤ -2). 2017 Metrologia 54 2 32 10.1088/0026-1394/54/1A/08019 2018-07-05