Dokument-ID Dokumenttyp Autoren/innen Persönliche Herausgeber/innen Haupttitel Abstract Auflage Verlagsort Verlag Herausgeber (Institution) Erscheinungsjahr Titel des übergeordneten Werkes Jahrgang/Band ISBN Veranstaltung Veranstaltungsort Beginndatum der Veranstaltung Enddatum der Veranstaltung Ausgabe/Heft Erste Seite Letzte Seite URN DOI Lizenz Datum der Freischaltung OPUS4-43160 Zeitschriftenartikel Heitz, J.; Plamadeala, C.; Muck, M.; Habidzadeh, H.; Baumgartner, W.; Weth, A.; Steinwender, C.; Blessberger, H.; Kellermair, J.; Kirner, Sabrina V.; Krüger, Jörg; Bonse, Jörn; Guntner, A. S.; Hassel, A. W. Laser-induced microstructures on Ti substrates for reduced cell adhesion The abstract summarizes the poster presented at the "Kardiologie im Zentrum - Fortbildung der Klinik für Kardiologie und Intensivmedizin Kepler Universitätsklinikum Linz", held between October 20th and 31st in Linz, Austria. The poster has been awarded the 2nd place of the "Best Poster Award". Gablitz, Austria Krause & Pachernegg GmbH 2017 Journal für Kardiologie - Austrian Journal of Cardiology 24 Kardiologie im Zentrum - Fortbildung der Klinik für Kardiologie und Intensivmedizin Kepler Universitätsklinikum Linz Linz, Austria 20.10.2017 31.10.2017 11-12 292 292 2017-11-28 OPUS4-42768 Zeitschriftenartikel Heitz, J.; Plamadeala, C.; Muck, M.; Armbruster, O.; Baumgartner, W.; Weth, A.; Steinwender, C.; Plessberger, H.; Kellermair, J.; Kirner, Sabrina V.; Krüger, Jörg; Bonse, Jörn; Guntner, A. S.; Hassel, A. W. Femtosecond laser-induced microstructures on Ti substrates for reduced cell adhesion Miniaturized pacemakers with a surface consisting of a Ti alloy may have to be removed after several years from their implantation site in the heart and shall, therefore, not be completely overgrown by cells or tissue. A method to avoid this may be to create at the surface by laser-ablation self-organized sharp conical spikes, which provide too little surface for cells (i.e., fibroblasts) to grow on. For this purpose, Ti-alloy substrates were irradiated in the air by 790 nm Ti:sapphire femtosecond laser pulses at fluences above the ablation threshold. The laser irradiation resulted in pronounced microstructure formation with hierarchical surface morphologies. Murine fibroblasts were seeded onto the laser-patterned surface and the coverage by cells was evaluated after 3-21 days of cultivation by means of scanning electron microscopy. Compared to flat surfaces, the cell density on the microstructures was significantly lower, the coverage was incomplete, and the cells had a clearly different morphology. The best results regarding suppression of cell growth were obtained on spike structures which were additionally electrochemically oxidized under acidic conditions. Cell cultivation with additional shear stress could reduce further the number of adherent cells. Berlin Springer-Verlag 2017 Applied Physics A 123 12 734, 1 9 urn:nbn:de:kobv:b43-427681 10.1007/s00339-017-1352-0 http://creativecommons.org/licenses/by/3.0/de/deed.de 2017-11-09