Dokument-ID Dokumenttyp Autoren/innen Persönliche Herausgeber/innen Haupttitel Abstract Auflage Verlagsort Verlag Herausgeber (Institution) Erscheinungsjahr Titel des übergeordneten Werkes Jahrgang/Band ISBN Veranstaltung Veranstaltungsort Beginndatum der Veranstaltung Enddatum der Veranstaltung Ausgabe/Heft Erste Seite Letzte Seite URN DOI Lizenz Datum der Freischaltung OPUS4-37801 Zeitschriftenartikel Schallschmidt, Kristin; Becker, Roland; Jung, Christian; Bremser, Wolfram; Nehls, Irene; Leschber, G.; Frese, S.; Walles, T.; Neudecker, J. Comparison of volatile organic compounds from lung cancer patients and healthy controls—challenges and limitations of an observational study The design and operation of an observational study on the profiles of volatile organic compounds (VOC) in the breath of 37 lung cancer patients and 23 healthy controls of similar age is outlined. The necessity to quantify each VOC considered as potential disease marker on basis of individual calibration is elaborated and the quality control measures required to maintain reproducibility in breath sampling and subsequent instrumental trace VOC analysis using SPME-GC-MS over a study period of 14 months are described. 24 VOC were quantified on basis of their previously suggested potential as cancer markers. The breath concentration levels of aromatic compounds was expectedly increased in smokers while lung cancer patients displayed significantly increased levels of oxygenated VOC such as aldehydes, 2-butanone and 1-butanol. Though sets of selected oxygenated VOC displayed sensitivities and specificities between 80 and 90% using linear discriminant analysis with leave-one-out cross validation the effective selectivity of the breath VOC approach with regard to cancer detection is clearly limited. Results were discussed against the background of the literature on volatile cancer marker investigations and the prospects to link increased VOC levels in patients' breath with approaches to employ sniffer dogs. Experiences from this study and the literature suggest that the current state of breath VOC based discrimination between cancer patients and healthy controls is hardly improvable. Observational studies tend to observe significant differences mostly in levels of certain oxygenated VOC but without resolution required for practical application. Any step towards practicable exploitation of VOC profile differences for illness detection would have to solve current restrictions set by the low and variable VOC concentrations. Further challenges are the technical complexity of studies involving breath sampling and possibly the limited capability of current analytical procedures to detect instable marker candidates. IOP Publishing 2016 Journal of Breath Research 10 4 Article 046007, 1 17 10.1088/1752-7155/10/4/046007 2016-10-14 OPUS4-38392 Beitrag zu einem Tagungsband Paul, Andrea; Breitfeld, S.; Sauer, Andreas; Becker, Roland; Kalbe, Ute; Bremser, Wolfram; Braun, Ulrike A Raman spectroscopic method for the monitoring of microplastics in soil Due to the increasing presence of microplastic particles (MP) in the Environment and the unknown risks arising from them, there is an urgent need for analytical methods that allow for an efficient identification and quantification of microplastics (MP), i.e. particles < 5 mm, in environmental samples. So far, mostly timeconsuming (micro) infrared or micro-Raman spectroscopic methods are applied. Here an faster alternative Approach is presented based on a Raman processspectrometer with fiber-optical probes in combination with multivariate data analysis. GDCh 2016 Tagungsband – 12. Kolloquium Prozessanalytik, Berlin, 28.–30. November 2016 12. Kolloquium Prozessanalytik Berlin, Germany 28.11.2016 30.11.2016 P10, 59 60 2016-11-22 OPUS4-35289 Zeitschriftenartikel Bachmann, H. J.; Bucheli, T. D.; Dieguez-Alonso, A.; Fabbri, D.; Knicker, H.; Schmidt, H.-P.; Ulbricht, A.; Becker, Roland; Buscaroli, A.; Buerge, D.; Cross, A.; Dickinson, D.; Enders, A.; Esteves, V.I.; Evangelou, M. W. H.; Fellet, G.; Friedrich, K.; Gasco Guerrero, G.; Glaser, B.; Hanke, U. M.; Hanley, K.; Hilber, I.; Kalderis, D.; Leifeld, J.; Masek, O.; Mumme, J.; Paneque Carmona, M.; Calvelo Pereira, R.; Rees, F.; Rombola, A. G.; de la Rosa, J. M.; Sakrabani, R.; Sohi, S.; Soja, G.; Valagussa, M.; Verheijen, F.; Zehetner, F. Towards the standardization of biochar analysis: the COST action TD1107 interlaboratory comparison Biochar produced by pyrolysis of organic residues is increasingly used for soil amendment and many other applications. However, analytical methods for its physical and chemical characterization are yet far from being specifically adapted, optimized, and standardized. Therefore, COST Action TD1107 conducted an interlaboratory comparison in which 22 laboratories from 12 countries analyzed three different types of biochar for 38 physical-chemical parameters (macro- and microelements, heavy metals, polycyclic aromatic hydrocarbons, pH, electrical conductivity, and specific surface area) with their preferential methods. The data were evaluated in detail using professional interlaboratory testing software. Whereas intralaboratory repeatability was generally good or at least acceptable, interlaboratory reproducibility was mostly not (20% < mean reproducibility standard deviation < 460%). This paper contributes to better comparability of biochar data published already and provides recommendations to improve and harmonize specific methods for biochar analysis in the future. Columbus, Ohio American Chemical Society 2016 Journal of agricultural and food chemistry 64 2 513 527 10.1021/acs.jafc.5b05055 2016-02-20 OPUS4-39867 misc Sauer, Andreas; Scharf, Holger; Becker, Roland Bericht zum 22. BAM-Ringversuch "Altlasten" Präsentation der Ergebnisse eines Ringversuchs zur Kompetenzbewertung von Prüflaboratorien auf dem Gebiet der anorganischen und organischen Bodenanalytik: Polyzyklische aromatische Kohlenwasserstoffe (PAK) in Boden, Mineralölkohlenwasserstoffe (MKW) in Boden, Elemente in Sediment und Gesamtcyanid in Boden. Berlin Bundesanstalt für Materialforschung und -prüfung (BAM) 2016 1 261 urn:nbn:de:kobv:b43-398676 http://www.gesetze-im-internet.de/urhg/index.html 2017-04-18