TY  - MANSCPT
A1  - Xing, Na
A1  - Er, Jasmin
A1  - Vidal, Ricardo M.
A1  - Khadka, Sandhya
A1  - Schusterbauer, Robert
A1  - Rosentreter, Maik
A1  - Etouki, Ranen
A1  - Ahmed, Rameez
A1  - Page, Taylor
A1  - Nickl, Philip
A1  - Bawadkji, Obida
A1  - Wiesner, Anja
A1  - Radnik, Jörg
A1  - Hodoroaba, Vasile-Dan
A1  - Ludwig, Kai
A1  - Trimpert, Jakob
A1  - Donskyi, Ievgen
T1  - Scalable covalently functionalized black phosphorus hybrids for broadspectrum virucidal activity
T2  - arxiv.org
N2  - At the onset of viral outbreaks, broad-spectrum antiviral materials are crucial before specific therapeutics become available. We report scalable, biodegradable black phosphorus (BP) hybrids that provide mutation-resilient virucidal protection. BP sheets, produced via an optimized mechanochemical process, are covalently functionalized with 2-azido-4,6-dichloro- 1,3,5-triazine to form P=N bonds. Fucoidan, a sulfated polysaccharide with intrinsic antiviral activity, and hydrophobic chains are then incorporated to achieve irreversible viral deactivation. The material exhibits strong antiviral inhibition and complete virucidal activity against multiple viruses, including recent severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants. It maintains high biocompatibility, remains effective against viral mutations, and is shelf stable for at least five month. The combination of biodegradability, scalable synthesis, and synergistic antiviral and virucidal mechanisms establishes BP-conjugates as a new class of highly efficient antivirals. They offer a broad spectrum antiviral solutions that could bridge the gap between antiviral medicines and general antiseptics.
KW  - Black phosphorus
KW  - Antiviral materials
KW  - Functionalization
KW  - Biodegradability
KW  - Sheets
PY  - 2025
UR  - https://nbn-resolving.org/urn:nbn:de:kobv:b43-652941
DO  - https://doi.org/10.48550/arXiv.2510.12854
SN  - 2331-8422
SP  - 1
EP  - 22
PB  - Cornell University
CY  - Ithaca, NY
AN  - OPUS4-65294
LA  - eng
AD  - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER  -