TY  - JOUR
A1  - Lopes, Chrystal
A1  - Casali, Lucia
A1  - Emmerling, Franziska
A1  - Leyssens, Tom
A1  - Dupray, Valérie
A1  - Brandel, Clement
A1  - Cartigny, Yohann
T1  - Efficient racemization of the pharmaceutical compound Levetiracetam using solvent-free mechanochemistry
JF  - RSC Mechanochemistry
N2  - We present the racemization of an active pharmaceutical ingredient Levetiracetam using a novel approach. We demonstrate the design of a 100% solvent-free process that proceeds by high energy milling inside a regular mixer mill. The kinetics of the racemization process is drastically improved compared to the solution-based approach and illustrates the tremendous potential of mechanochemistry. In this study, we highlight the importance of mixing efficiency regarding data reproducibility, and we show, in particular, that water contamination has a negative impact on the reaction rate. Moreover, in situ X-ray diffraction gives us first insights into the mechanisms involved in the solid state during the mechanochemical racemization process.
KW  - Mechanochemistry
PY  - 2025
UR  - https://nbn-resolving.org/urn:nbn:de:kobv:b43-646108
DO  - https://doi.org/10.1039/d4mr00103f
SN  - 2976-8683
VL  - 2
IS  - 1
SP  - 83
EP  - 90
PB  - Royal Society of Chemistry (RSC)
AN  - OPUS4-64610
LA  - eng
AD  - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER  -