TY  - CONF
A1  - Nordholt, Niclas
T1  - Evolution and mechanistic basis of disinfectant tolerance in E. coli
N2  - Disinfectants are important to provide hygiene in sensitive areas, to prevent the spread of infections and to preserve materials from biodeterioration. Bacteria can survive disinfection through phenotypic and genotypic adaptation. Phenotypic heterogeneity may be linked to the ability to evolve disinfectant tolerance. The genetic factors which determine the survival of disinfection remain largely unknown. Here, we investigate the effects of phenotypic heterogeneity on the evolvability of disinfectant tolerance. Furthermore, using a whole-genome CRISPRi-library, we uncover genetic determinants that are important for the survival of disifenction.
T2  - µClub Seminar Berlin
CY  - Berlin, Germany
DA  - 23.05.2025
KW  - Biocides
KW  - Heterogeneity
KW  - Biocide resistance
KW  - Evolution
KW  - Disinfectants
PY  - 2025
AN  - OPUS4-63833
LA  - eng
AD  - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER  -