TY  - JOUR
A1  - Speight, Isaiah R.
A1  - Ardila-Fierro, Karen J.
A1  - Hernández, José G.
A1  - Emmerling, Franziska
A1  - Michalchuk, Adam
A1  - García, Felipe
A1  - Colacino, Evelina
A1  - Mack, James
T1  - Ball milling for mechanochemical reactions
JF  - Nature Reviews Methods Primers
N2  - Mechanochemistry is an emerging field with the potential to pave the way for sustainable chemistry. Although the use of mechanical force to initiate chemical reactions has been recognized for millennia, it has often taken a backseat to thermal and photonic methods. Over the past 30 years, mechanochemistry has seen a resurgence of interest, attracting researchers across the globe. Despite its proven ability to address numerous challenges within the chemical community, mechanochemistry remains on the periphery. This Primer serves as a valuable guide for conducting mechanochemical reactions by ball milling, offering an overview of the processes, methods, tools and terminology necessary to embark on research in this field. It also highlights persistent hurdles such as equipment standardization, understanding the impact of new discoveries and the lack of predictability of reaction outcomes. The Primer’s focus is on how mechanochemical ball milling is used in various chemical transformations, distinguishing it from other forms of mechanochemistry discussed in the literature. With a promising future, this Primer serves as a gateway for those aspiring to contribute to the field’s advancement.
KW  - Mechanochemistry
KW  - Ball milling
KW  - Upscaling
PY  - 2025
DO  - https://doi.org/10.1038/s43586-025-00401-2
SN  - 2662-8449
VL  - 5
IS  - 1
SP  - 1
EP  - 18
PB  - Springer Science and Business Media LLC
AN  - OPUS4-63447
LA  - eng
AD  - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER  -