TY  - CONF
A1  - Resch-Genger, Ute
T1  - Standardized Measurements of Surface - Functionalities on Nanoparticles
N2  - Engineered nanoparticles (NPs) with various chemical compositions and surface functionalities are routinely fabricated for industrial applications such as medical diagnostics, drug delivery, sensing, catalysis, energy conversion and storage, optoelectronics, and information storage. NP function, interaction with biological species, and environmental fate are largely determined by surface functionalities. Reliable, reproducible, and standardized surface characterization methods are therefore vital for quality control of NPs, and mandatory to meet increasing concerns regarding their safety. Also, industry, international standardization organizations, regulatory agencies, and policymakers need validated and standardized measurement methods and reference materials. However, methodologies for determining NP surface properties, including the amount, chemical composition, and homogeneity of surface functionalities and coatings are largely non-standardized. Suitable methods for determining surface functionalities on ligand-stabilized core and core/shell NPs include advanced techniques such as traceable quantitative nuclear magnetic resonance (qNMR) as well as X-ray electron spectroscopy (XPS) and time of flight secondary ion mass spectrometry (ToF-SIMS), and simpler optical and electrochemical methods. The latter less costly methods are often used by SMEs, e.g., for quality control. To validate methods, establish measurement uncertainties, test reference materials, and produce reference data, international interlaboratory comparisons (ILC) on NP surface functionalization measurements are required and well characterized test and reference nanomaterials providing benchmark values.[1] These needs are addressed by the recently started European metrology project SMURFnano involving 12 partners from different National Metrology Institutes, designated institutes, and research institutes, two university groups as well as one large company and one SME producing NPs. This project as well as first results derived from the development of test and reference materials with a well characterized surface chemistry and ongoing interlaboratory comparisons will be presented.
T2  - eMRS
CY  - Strasbourg, France
DA  - 27.05.2025
KW  - Quality assurance
KW  - Fluorescence
KW  - Nano
KW  - Particle
KW  - Synthesis
KW  - Silica
KW  - Upconversion nanoparticles
KW  - Optical assay
KW  - qNMR
KW  - Surface analysis
KW  - Ligand
KW  - Quantification
KW  - Functional group
KW  - XPS
KW  - ToF-SIMS
KW  - Polymer particle
KW  - Surface modification
KW  - Potentiometry
KW  - Metrology
KW  - Method
KW  - Validation
KW  - ILC
PY  - 2025
AN  - OPUS4-63339
LA  - eng
AD  - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER  -