TY  - JOUR
A1  - Falkenhagen, Jana
A1  - Dalgic, Mete-Sungur
A1  - Weidner, Steffen
T1  - Quantitative MALDI-TOF Mass Spectrometry of Star-Shaped Polylactides Based on Chromatographic Hyphenation
JF  - Journal of the American Society for Mass Spectrometry
N2  - The end groups of three- and four-arm star-shaped polylactides (PLA) with trimethylolpropane and pentaerythritol core structures were functionalized with acetic acid. Reaction products with different degrees of functionalization were analyzed by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. Additional gradient elution liquid adsorption chromatography (GELAC) measurements were performed to determine the degree of functionalization. This technique enabled clear separation and sufficient quantification of the formed species. These chromatographic data could be used inversely to quantify mass spectrometric results, which are usually biased by the unknown ionization probabilities of different polymer end group structures. Our results showed that, in this particular case, the peak intensity in the MALDITOF mass spectra can be used to semiquantitatively determine the degree of functionalization in incompletely functionalized multiarm PLA.
KW  - Polylactides
KW  - MALDI-TOF-MS
KW  - Gradient elution liquid adsorption chromatography
PY  - 2025
UR  - https://nbn-resolving.org/urn:nbn:de:kobv:b43-625292
DO  - https://doi.org/10.1021/jasms.4c00491
SN  - 1879-1123
SP  - 1
EP  - 9
PB  - American Chemical Society (ACS)
AN  - OPUS4-62529
LA  - eng
AD  - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER  -