TY  - JOUR
A1  - Schürmann, Robin
A1  - Bald, Ilko
T1  - Effect of adsorption kinetics on dissociation of DNA-nucleobases on gold nanoparticles under pulsed laser illumination
JF  - Physical Chemistry Chemical Physics
N2  - Photothermal therapy is a novel approach to destroy cancer cells by an increase of temperature due to laser illumination of gold nanoparticles (GNPs) that are incorporated into the cells. Here, we study the decomposition of DNA nucleobases via irradiation of gold nanoparticles with ns-laser pulses. The kinetics of the adsorption and decomposition process is described by a theoretical model based on the Langmuir assumptions and correlated with experimentally determined reaction rates revealing a strong influence of the nucleobase specific adsorption. Beside the four nucleobases, their brominated analogs, which are potential radiosensitizers in cancer therapy, are also investigated and show a significant modification of the decomposition rates. The fastest decomposition rates are observed for adenine, 8-bromoadenine, 8-bromoguanine and 5-bromocytosine. These results are in good agreement with the relative adsorption rates that are determined from the aggregation kinetics of the GNPs taking the effect of an inhomogeneous surface into account. For adenine and its brominated analog, the decomposition products are further analyzed by surface enhanced Raman scattering (SERS) indicating a strong fragmentation of the molecules into their smallest subunits.
KW  - Gold nanoparticle
KW  - DNA damage
KW  - Kinetics
KW  - Pulsed Laser
KW  - Physical Chemistry
PY  - 2017
DO  - https://doi.org/10.1039/c6cp08433h
SN  - 1463-9076
SN  - 1463-9084
VL  - 19
IS  - 17
SP  - 10796
EP  - 10803
AN  - OPUS4-40070
LA  - eng
AD  - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER  -