TY - GEN A1 - Glaeser, J. A1 - Oberpaul, M. T1 - Exploiting termite nest microbiomes for antibiotic drug discovery by using an ultra-high throughput Microfluidics/FACS driven pipeline N2 - Bacterial infections are a global threat to human health1. Especially nosocomial infections with multidrug-resistant Gram-negative bacteria challenge public health systems and endanger successful treatment of patients in many modern medicine applications as e.g. organ transplant. In the last three decades classical approaches failed to find novel chemical scaffolds suitable for the development of antibiotics that reach the market and caused the modern antibiotics crisis1. Insect microbiomes produce potent antibiotics with low toxicity to eukaryotic cells to defend their hosts against entomopathogenic microorganisms2. In order to exploit insect microbiomes efficiently and to identify novel antibiotics producing bacteria, we implemented an ultra-high throughput Microfluidics/FACS (fluorescence-associated cell sorting) cultivation and screening pipeline. Here we present the technical aspects of our pipeline including downstream processing of identified producer strains and its suitability for antibiotics discovery. T2 - Tagung DGHM und VAAM Microbiology and Infection 2017 CY - Würzburg, Germany DA - 05.03.17 KW - Antibiotics KW - Micobiomes KW - Termites PY - 2017 UR - https://opus4.kobv.de/opus4-bam/frontdoor/index/index/docId/39903 AN - OPUS4-39903 AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany