TY - JOUR A1 - Linberg, Kevin A1 - Röder, Bettina A1 - Al-Sabbagh, Dominik A1 - Emmerling, Franziska A1 - Michalchuk, Adam T1 - Controlling polymorphism in molecular cocrystals by variable temperature ball milling T2 - Faraday Discussions N2 - Mechanochemistry offers a unique opportunity to modify and manipulate crystal forms, often providing new products as compared with conventional solution methods. While promising, there is little known about how to control the solid form through mechanochemical means, demanding dedicated investigations. Using a model organic cocrystal system (isonicotinamide:glutaric acid), we here demonstrate that with mechanochemistry, polymorphism can be induced in molecular solids under conditions seemingly different to their conventional thermodynamic (thermal) transition point. Whereas Form II converts to Form I upon heating to 363 K, the same transition can be initiated under ball milling conditions at markedly lower temperatures (348 K). Our results indicate that mechanochemical techniques can help to reduce the energy barriers to solid form transitions, offering new insights into controlling polymorphic forms. Moreover, our results suggest that the nature of mechanochemical transformations could make it difficult to interpret mechanochemical solid form landscapes using conventional equilibrium-based tools. PB - Royal Society of Chemistry KW - Mechanochemistry KW - Polymorphism KW - TRIS PY - 2022 UR - https://opus4.kobv.de/opus4-bam/frontdoor/index/index/docId/56472 AN - OPUS4-56472 UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-564728 SP - 1 EP - 16 AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany