TY - GEN A1 - Asadujjaman, Asad T1 - Aggregation behavior of UCST-Type poly(acrylamide-co-acrylonitrile) copolymer across the phase transition temperature N2 - Thermoresponsive polymers have shown great potential in applications such as bioseparation, drug delivery and diagnostic. Only few thermoresponsive polymers that present an upper critical solution temperature (UCST) in a relevant temperature range, i.e. Phase separate from solution upon cooling, have been reported so far. Moreover, the most studied UCST type polymers namely polybetaines are difficult to use under physiological conditions, which significantly restricts their potential applications. Therefore, UCST polymers with sharp and robust phase transition in physiological conditions (in the presence of salts, ions etc.) are highly needed in order to extend the range of applications of this class of polymers. Herein, a robust UCST-type copolymer of acrylamide (AAm) and acrylonitrile (AN) (poly(AAm-co-AN)) was prepared by reversible addition fragmentation chain Transfer (RAFT) polymerization and its thermo-induced aggregation behavior in aqueous media was studied by turbidity and dynamic light scattering measurements. At temperature below the UCST, the poly(AAm-co-AN) copolymer chains were aggregated together. The aggregate size was found to be larger with increasing AN contents and became smaller upon dilution of the copolymer solutions. While above the UCST, the poly(AAm-co-AN) copolymer chains were expanded and weekly associated in solution. The association between the copolymer chains formed smaller aggregates with increasing the AN Contents or the concentration of the solutions. A model is proposed to explain such aggregationassociation behavior of the poly(AAm-co-AN) copolymer depending on the AN Contents and concentration of the solutions. T2 - Berliner Chemie Symposium & Chemie in Praxis 2016 CY - Berlin, Germany DA - 12.04.2016 KW - Polymer KW - UCST PY - 2016 UR - https://opus4.kobv.de/opus4-bam/frontdoor/index/index/docId/35804 AN - OPUS4-35804 AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany