TY - JOUR A1 - Orts Gil, Guillermo A1 - Natte, Kishore A1 - Ă–sterle, Werner T1 - Multi-parametric reference nanomaterials for toxicology: state of the art, future challenges and potential candidates T2 - RSC Advances N2 - A major requirement for the validation of methods assessing the risk associated with engineered nanoparticles (ENPs) is the use of reference materials (RMs). In the present contribution we review available RMs, ongoing projects and characterisation trends in the field. The conclusion is that actual approaches to RMs mostly deal with metrological considerations about single properties of the ENPs, typically their primary size, which can hardly be representative of nanoparticles characteristics in real testing media and therefore, not valid for reliable and comparable toxicological studies. As an alternative, we discussed the convenience and feasibility of establishing multi-parametric RMs for a series of ENPs, focusing on silica nanoparticles (SNPs). As a future perspective, the need to develop RMs based on hybrid nanoparticles is also discussed. PB - RSC Publishing CY - London KW - Referenzmaterialien KW - Nanopartikel KW - Toxikologie KW - Metrologie PY - 2013 UR - https://opus4.kobv.de/opus4-bam/frontdoor/index/index/docId/29299 AN - OPUS4-29299 UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-292997 SN - 2046-2069 VL - 3 IS - 40 SP - 18202 EP - 18215 AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany