TY - GEN A1 - Schreiber, Frank T1 - The BEAT-AMR consortium: Partnership against Biofilm-associated Expression, Acquisition and Transmission of Antimicrobial Resistance N2 - Here, we introduce the BEAT-AMR consortium, which is recommended for funding within the 3rd call of the Joint Programming Initiative on Antimicrobial Resistance (JPIAMR). The aim of the consortium is to investigate fundamental mechanisms that shape antimicrobial resistance in biofilms in relation to the surface and then translate those findings into clinical practice. We thereby aim to generate clinical recommendations on the combinatorial use of biomaterials coated with antimicrobials and antibiotics that avoid the occurrence and transmission of nosocomial biofilm infections with bacteria insusceptible to antibiotics. We established a Europe-wide network of experts in biofilm research, antimicrobial resistance, material sciences, and translational medicine that allows us to investigate those aspects in a coherent framework. Biofilms are structured communities of bacteria found on surfaces that become embedded within a self-produced extracellular polymeric matrix. Bacteria living in biofilms can tolerate much higher antibiotic concentrations compared to planktonic bacteria and survive long enough to evolve antimicrobial resistance (AMR). They form persistent, hard-to-treat infections and exhibit an intrinsic biology that promotes the development and transmission of AMR. The goal of our consortium is to determine how bacteria adapt to antimicrobials during biofilm formation on surfaces coated with antimicrobials, how AMR mutations are acquired and evolve within mature biofilms, and how population dynamics within biofilms affect the transmission of AMR. Our team provides facilities and clinical research governance for experimental and translational medicine. Our synergy of laboratory, clinical and translational research across Europe will ensure the development of novel and successful interventions and therapeutic outcomes. T2 - FEMS Conference 2017 CY - Valencia, Spain DA - 09.07.2017 KW - Antimicrobial Resistance KW - Antimicrobial coatings KW - Biofilms PY - 2017 UR - https://opus4.kobv.de/opus4-bam/frontdoor/index/index/docId/42913 AN - OPUS4-42913 AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany