TY - JOUR A1 - Schreiber, Frank A1 - Ackermann, M. T1 - Environmental drivers of metabolic heterogeneity in clonal microbial populations T2 - Current Opinion in Biotechnology N2 - Microorganisms perform multiple metabolic functions that shape the global cycling of elements, health and disease of their host organisms, and biotechnological processes. The rates, at which different metabolic activities are performed by individual cells, can vary between genetically identical cells within clonal populations. While the molecular mechanisms that result in such metabolic heterogeneity have attracted considerable interest, the environmental conditions that shape heterogeneity and its consequences have received attention only in recent years. Here, we review the environmental drivers that lead to metabolic heterogeneity with a focus on nutrient limitation, temporal fluctuations and spatial structure, and the functional consequences of such heterogeneity. We highlight studies using single-cell methods that allow direct investigation of metabolic heterogeneity and discuss the relevance of metabolic heterogeneity in complex microbial communities. PB - Elsevier Ltd. KW - Phenotypic variation KW - NanoSIMS KW - Diversity KW - Metabolism PY - 2019 UR - https://opus4.kobv.de/opus4-bam/frontdoor/index/index/docId/50194 AN - OPUS4-50194 UR - https://www.sciencedirect.com/science/article/abs/pii/S095816691930134X?via%3Dihub VL - 62 SP - 202 EP - 211 AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany