TY - JOUR A1 - Klimakow, Maria A1 - Rademann, K. A1 - Emmerling, Franziska T1 - Towards novel pseudo-polymorphs of nifedipine: elucidation of a slow crystallization process JF - Crystal growth & design N2 - The crystallization of nifedipine was studied by means of synchrotron-X-ray diffraction, single-crystal X-ray structural analysis, and Raman spectroscopy. The results of slow evaporation (24 h in minimum) using dimethyl sulfoxide (DMSO) are presented. Since fast crystallization processes (typically minutes) in different solvents always led to the final formation of the thermodynamically most stable α-polymorph of nifedipine, we observed a novel pseudo-polymorph due to slow crystallization from DMSO. The single-crystal X-ray structure of the solvated species nifedipine·DMSO (1:1) is reported for the first time. In addition, the crystallization process on surfaces was followed by means of light microscopy and environmental scanning electron microscopy (ESEM) coupled with energy-dispersive X-ray spectroscopy (EDS) analysis. Different diffractions pattern and Raman spectra were observed for crystals grown from stock solution and those obtained by drying the solution on soda lime silicate surfaces. KW - Synchrotron radiation KW - Polymorphism KW - Crystallization KW - Nifedipine PY - 2010 DO - https://doi.org/10.1021/cg100186v SN - 1528-7483 VL - 10 IS - 6 SP - 2693 EP - 2698 PB - American Chemical Society CY - Washington, DC, USA AN - OPUS4-21398 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -