TY - JOUR A1 - Munir, R. A1 - Lisec, Jan A1 - Swinnen, J. V. A1 - Zaidi, N. T1 - Lipid metabolism in cancer cells under metabolic stress T2 - British Journal of Cancer N2 - Cancer cells are often exposed to a metabolically challenging environment with scarce availability of oxygen and nutrients. This metabolic stress leads to changes in the balance between the endogenous synthesis and exogenous uptake of fatty acids, which are needed by cells for membrane biogenesis, energy production and protein modification. Alterations in lipid metabolism and, consequently, lipid composition have important therapeutic implications, as they affect the survival, membrane dynamics and therapy response of cancer cells. In this article, we provide an overview of recent insights into the regulation of lipid metabolism in cancer cells under metabolic stress and discuss how this metabolic adaptation helps cancer cells thrive in a harsh tumour microenvironment. PB - Nature KW - Mass-Spectrometry KW - Lipidomics KW - Lipid metabolism KW - Cancer cells PY - 2019 UR - https://opus4.kobv.de/opus4-bam/frontdoor/index/index/docId/48005 AN - OPUS4-48005 VL - 120 IS - 12 SP - 1090 EP - 1098 AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany