TY - CONF A1 - Kern, Simon A1 - Michalik-Onichimowska, Aleksandra A1 - Riedel, Jens A1 - Panne, Ulrich A1 - King, Rudibert A1 - Maiwald, Michael A2 - Maiwald, Michael T1 - “Click” analytics for “click” chemistry – a simple method for calibration-free evaluation of online NMR spectra T2 - Tagungsband – 12. Kolloquium Prozessanalytik, Berlin, 28.–30. November 2016 N2 - Currently research in chemical manufacturing moves towards flexible plug-and-play approaches focusing on modular plants, capable of producing small scales on-demand with short down-times between individual cam-paigns. This approach allows for efficient use of hardware, a faster optimization of the process conditions, and thus, an accelerated introduction of new products to the market. Driven mostly by the search for chemical syntheses under biocompatible conditions, so-called “click” chemistry rapidly became a growing field of research. The re-sulting simple one-pot reactions are so far only scarcely accompanied by an adequate optimization via compara-bly straightforward and robust analysis techniques. Here we report on a fast and reliable calibration-free online high field NMR monitoring approach for technical mixtures. It combines a versatile fluidic system, continuous-flow measurement with a time interval of 20 s per spectrum, and a robust, automated algo-rithm to interpret the ob-tained data. All spectra were acquired using a 500 MHz NMR spectrometer (Varian) with a dual band flow probe having a 1/16 inch polymer tubing working as a flow cell. Single scan 1H spectra were recorded with an acquisition time of 5 s, relaxation delay of 15 s. T2 - 12. Kolloquium des Arbeitskreises Prozessanalytik CY - Berlin, Germany DA - 28.11.2016 KW - “Click” chemistry KW - Online NMR KW - Online monitoring PY - 2016 UR - https://opus4.kobv.de/opus4-bam/frontdoor/index/index/docId/38385 AN - OPUS4-38385 SP - 72 EP - 74 AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany