TY - JOUR A1 - Neffe, A.T. A1 - Von Ruesten-Lange, M. A1 - Braune, S. A1 - Lützow, K. A1 - Roch, T. A1 - Richau, K. A1 - Krüger, A. A1 - Becherer, T. A1 - Thünemann, Andreas A1 - Jung, F. A1 - Haag, R. A1 - Lendlein, A. T1 - Multivalent grafting of hyperbranched oligo- and polyglycerols shielding rough membranes to mediate hemocompatibility T2 - Journal of materials chemistry B N2 - Hemocompatible materials are needed for internal and extracorporeal biomedical applications, which should be realizable by reducing protein and thrombocyte adhesion to such materials. Polyethers have been demonstrated to be highly efficient in this respect on smooth surfaces. Here, we investigate the grafting of oligo- and polyglycerols to rough poly(ether imide) membranes as a polymer relevant to biomedical applications and show the reduction of protein and thrombocyte adhesion as well as thrombocyte activation. It could be demonstrated that, by performing surface grafting with oligo- and polyglycerols of relatively high polydispersity (>1.5) and several reactive groups for surface anchoring, full surface shielding can be reached, which leads to reduced protein adsorption of albumin and fibrinogen. In addition, adherent thrombocytes were not activated. This could be clearly shown by immunostaining adherent proteins and analyzing the thrombocyte covered area. The presented work provides an important strategy for the development of application relevant hemocompatible 3D structured materials. PB - Royal Soc. of Chemistry CY - Cambridge KW - Nanotechnology KW - thrombocyte adhesion KW - biomedical applications PY - 2014 UR - https://opus4.kobv.de/opus4-bam/frontdoor/index/index/docId/30819 AN - OPUS4-30819 UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-308196 SN - 2050-750X SN - 2050-7518 VL - 2 IS - 23 SP - 3626 EP - 3635 AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany