TY - JOUR A1 - Freitas, R. A1 - Almeida, Ângela A1 - Calisto, V. A1 - Velez, C. A1 - Moreira, A. A1 - Schneider, Rudolf A1 - Esteves, V.I. A1 - Wrona, F. J. A1 - Soares, A.M.V.M. A1 - Figueira, E. T1 - How life history influences the responses of the clam Scrobicularia plana to the combined impacts of carbamazepine and pH decrease T2 - Environmental pollution N2 - In the present study, the bivalve Scrobicularia plana, collected from two contrasting areas (pristine location and mercury contaminated area), was selected to assess the biochemical alterations imposed by pH decrease, carbamazepine (an antiepileptic) and the combined effect of both stressors. The effects on oxidative stress related biomarkers after 96 h exposure revealed that pH decrease and carbamazepine induced alterations on clams, with greater impacts on individuals from the contaminated area which presented higher mortality, higher lipid peroxidation and higher glutathione S-transferase activity. These results emphasize the risk of extrapolating results from one area to another, since the same species inhabiting different areas may be affected differently when exposed to the same stressors. Furthermore, the results obtained showed that, when combined, the impact of pH decrease and carbamazepine was lower than each stressor acting alone, which could be related to the defence mechanism of valves closure when bivalves are under higher stressful conditions. PB - Elsevier CY - New York, NY [u.a.] KW - Ocean acidification KW - Biomarkers KW - Oxidative stress KW - Bivalves KW - Pharmaceutical drugs PY - 2015 UR - https://opus4.kobv.de/opus4-bam/frontdoor/index/index/docId/33818 AN - OPUS4-33818 SN - 0269-7491 SN - 0013-9327 SN - 1873-6424 VL - 202 SP - 205 EP - 214 AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany