TY - JOUR A1 - Kneipp, Janina A1 - Kneipp, H. A1 - McLaughlin, M. A1 - Brown, D. A1 - Kneipp, K. T1 - In Vivo Molecular Probing of Cellular Compartments with Gold Nanoparticles and Nanoaggregates T2 - Nano letters N2 - Surface-enhanced Raman (SERS) signatures were measured from single living cells at different times after the uptake of gold nanoparticles. The spectra are indicative of chemical changes in the environment of the nanostructures over time. The increase of the SERS signal strength and parallel TEM studies indicate the formation of nanoaggregates providing optimum SERS enhancement for ultrasensitive probing inside the endosomal compartment. The results have implications for medical and biotechnology applications of SERS nanosensors in cells. PB - American Chemical Society CY - Washington, DC PY - 2006 UR - https://opus4.kobv.de/opus4-bam/frontdoor/index/index/docId/13935 AN - OPUS4-13935 SN - 1530-6984 SN - 1530-6992 VL - 6 IS - 10 SP - 2225 EP - 2231 AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany