TY - JOUR A1 - Gross, U. A1 - Müller-Mai, C. A1 - Voigt, C. A1 - Berger, Georg A1 - Spitzer, Andrea T1 - In Vivo Tests of a Highly Porous Rapidly Resorbable Dicalcium Potassium Sodium Phosphate Glass-Ceramics T2 - Key engineering materials N2 - Glass-ceramics containing Ca2KNa(PO4)2 as the main crystalline phase have a solubility which is 8 times higher than that of alpha-tricalcium phosphate ceramics. When using these compositions in drug delivery systems, especially in bone, it is necessary to create a material with a high open porosity. A Ca2KNa(PO4)2-based glass-ceramic was prepared from a borosilicate glass melt. The processed material includes minor amounts of boron which are low enough for medical application. Tissue response was studied using an animal model. Particles were implanted in rabbit femurs. Bone and soft tissue development occurred at the particle interfaces. In general, most particles were enclosed in the network of trabecular bone. The advantages of using a biomaterial with high porosity (pore size of 1-3 micron), together with rapid biodegradation, bioactivity and biocompatibility, despite traces of boron, were shown. 4 refs. PB - Trans Tech Publ. CY - Aedermannsdorf T2 - 14th International Symposium on Ceramics in Medicine CY - Palm Springs, CA, USA DA - 2001-11-14 PY - 2002 UR - https://opus4.kobv.de/opus4-bam/frontdoor/index/index/docId/1935 AN - OPUS4-1935 SN - 1013-9826 VL - 218-220 SP - 307 EP - 310 AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany