TY - CONF A1 - Bornemann-Pfeiffer, Martin A1 - Kern, S. A1 - Wander, Lukas A1 - Meyer, Klas A1 - Maiwald, Michael T1 - Modular production involving Benchtop NMR: Current application examples driven by digitalization N2 - The demand for increasing product diversity in the chemical and pharmaceutical industry calls for new production processes that enable greater flexibility. Therefore, plants are needed which can be adapted to new processes in a fast manner and be scaled up and down easily to volatile market demands. Modular production techniques in combination with advanced process analytical technology (PAT) are considered as a promising solution able to fulfil these requirements. The success and acceptance of modular concepts in both new and existing plants is dependent of its reliability, easy applicability, and standardization. In recent past, enormous efforts were made to overcome existing barriers in a superordinate level, e.g. DEXPI [1], ENPRO [2], or MTP [3] naming just a few. Here, we’d like to present a few, more hands-on, application examples which are shown in Figure 1 aiming to increase process flexibility and applicability. This includes: a) The development of an additively manufactured mixer—flow reactor combination for the application inside of NMR instruments. [4] b) The application of automated, model-based approaches for model development and spectra evaluation. c) The application of machine-assisted spectral model building as a genuine alternative to classical model-based approaches [5] d) Improvement of NIR calibration through online available NMR reference data. [6] These examples represent miscellaneous use cases but result of the same fact: the increased use and availability of data through advanced PAT and therefore new opportunities utilizing them. T2 - SMASH - Small Molecule NMR Conference CY - Online meeting DA - 30.08.2021 KW - Process analytical technology KW - NMR spectroscopy KW - Automation PY - 2021 AN - OPUS4-53803 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -