TY - JOUR A1 - Maul, Ronald A1 - Warth, B. A1 - Kant, Jill-Sandra A1 - Schebb, N.H. A1 - Krska, R. A1 - Koch, Matthias A1 - Sulyok, M. T1 - Investigation of the hepatic glucuronidation pattern of the fusarium mycotoxin deoxynivalenol in various species T2 - Chemical research in toxicology N2 - Deoxynivalenol (DON) is one of the most abundant mycotoxins contaminating food and feed worldwide. Upon absorption, the major portion of the toxin is excreted by humans and animal species as glucuronide. However, consistent in vitro data on DON glucuronidation are lacking. In the present study, the metabolism of DON was investigated using liver microsomes from humans and six different animal species. It was shown that all animal and human liver microsomes led to the formation of up to three different mono-O-glucuronides with significant interspecies differences. While the activity of human liver microsomes was low (0.8 to 2.2 pmol·min–1·mg–1), bovine liver and rat liver microsomes conjugated DON with activities of 525 pmol·min–1·mg–1 and 80 pmol·min–1·mg–1, respectively. PB - Soc. CY - Washington, DC, USA KW - Deoxynivalenol KW - Hepatic metabolism KW - Microsomes KW - Glucuronidation KW - Inter-species comparison PY - 2012 UR - https://opus4.kobv.de/opus4-bam/frontdoor/index/index/docId/27604 AN - OPUS4-27604 SN - 0893-228X SN - 1520-5010 VL - 25 IS - 12 SP - 2715 EP - 2717 AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany