TY - JOUR A1 - Fischer, Franziska A1 - Fendel, Nicole A1 - Greiser, Sebastian A1 - Rademann, Klaus A1 - Emmerling, Franziska T1 - Impact is important - Systematic investigation of the influence of milling balls in mechanochemical reactions JF - Organic Process Research & Development N2 - A newly established in situ technique using Raman spectroscopy was employed for the detailed kinetic investigation of mechanochemical reaction pathways. This approach was applied for the systematic investigation of the direct influence of colliding balls on the reaction rate constants of a mechanochemical cocrystallization reaction. As a model reaction, the mechanochemical cocrystallization of felodipine and the coformer imidazole was investigated. Keeping the total ball mass constant by varying the number of milling balls, our study reveals that the impact of each single collision has a more significant influence on the reaction kinetics than expected. KW - Mechanochemistry KW - In situ KW - Cocrystal PY - 2017 UR - http://pubs.acs.org/doi/abs/10.1021/acs.oprd.6b00435 DO - https://doi.org/10.1021/acs.oprd.6b00435 SN - 1083-6160 SN - 1520-586X VL - 21 IS - 4 SP - 655 EP - 659 AN - OPUS4-40355 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -