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Die Sprache gilt als wesentliche Schlüsselkompetenz, welche sich auf nahezu alle anderen Entwicklungsbereiche eines Kindes auswirkt. Vor diesem Hintergrund ist es nicht verwunderlich, dass die kindliche Sprachentwicklung unter besonderer elterlicher, erzieherischer und ärztlicher Beobachtung steht. In der nationalen Fachliteratur wird immer wieder zur Diskussion gestellt, dass die Zahl von Sprachentwicklungsstörungen einschließlich der daraus resultierenden Lern- und Verhaltensstörungen in den letzten Jahren drastisch angestiegen sei. Um dieser Frage nachzugehen, wurden die vollständigen Datensätze des Kinder- und Jugendärztlichen Dienstes (KJÄD) der Einschulungsuntersuchungen der Jahre 2008/2009, 2009/2010 und 2010/2011 des Gesundheitsamtes Dresden ausgewertet. Für die Erfassung von Sprachentwicklungsauffälligkeiten kommt seit dem Schuljahr 2004/05 das Screening des Entwicklungsstandes S-ENS zum Einsatz. Ziel dieser Arbeit war es, die aktuellen Prävalenzraten kindlicher Sprachentwicklungsauffälligkeiten in Dresden zu ermitteln. Für die Beurteilung möglicher sozialer Einflüsse auf die Sprachentwicklung wurde ein weiterer unabhängiger Datensatz der Kommunalen Bürgerumfrage aus dem Jahr 2010 hinzugezogen. Die Ergebnisse bestätigten im Untersuchungszeitraum einen leichten Anstieg der auffälligen Testergebnisse des KJÄD von insgesamt 2,8 Prozent, welcher zwischen den einzelnen Ortsämtern sehr stark divergiert. Der Extremgruppenvergleich zeigte anhand der Daten der KBU mögliche Hinweise für soziale Einflüsse auf die Sprachentwicklung des Kindes auf. Die Ergebnisse unterscheiden sich mit 12,5 Prozent zwischen den Punktwertresultaten des S-ENS und der Gesamtbeurteilung des Sprachergebnisses der Ärzte deutlich. Die Ergebnisse dieser Arbeit bestätigen keinen eindeutigen Anstieg der kindlichen Sprachauffälligkeiten in Dresden. Eine weitere Erfassung des Sprachstandes mit Hilfe des S-ENS sollte kritisch überdacht werden. Ein kausaler Einfluss sozioökonomischer Faktoren auf die Sprachentwicklung war anhand der Datensätze nicht beurteilbar und sollte in weiteren Studien untersucht werden.
Aktuelle Studien und populärwissenschaftliche Veröffentlichungen weisen auf einen Rückgang motorischer Fähigkeiten bei Kindern und Jugendlichen hin. Dadurch ist, forciert durch die Verfolgung unterschiedlicher Interessen, ein Bild des generellen motorischen Leistungsverlustes entstanden, das mit Blick auf die gesellschaftliche Leistungsfähigkeit unter anderem physiotherapeutische Interventionen im Vorschulbereich postuliert. Die hier vorliegende Studie widmet sich dieser Thematik und untersucht den Status konditioneller Fähigkeiten von Vorschulkindern. Dabei wurden ausgewählte Kindergärten des Großraumes Dresden mittels Deutschem Motorik – Test unter weitestgehend standardisierten Feldbedingungen analysiert. Im Ergebnis zeigt sich, dass im Bereich der konditionellen Fähigkeiten nur die Kraftausdauer der Bauchmuskulatur und die aerobe Ausdauerleistungsfähigkeit Defizite aufweisen.
Letzteres verdeutlicht sich signifikant bei 6-jährigen Vorschulkindern, die in altersgemischten Gruppen betreut werden. Insgesamt ist zu schlussfolgern, dass ein weit angelegter Einsatz physiotherapeutischer Interventionen für die gezogene Stichprobe im Bereich der Dimension „konditionelle Fähigkeiten“ nicht notwendig ist. Unter primärpräventivem Charakter ist aber die Kräftigung der Bauchmuskulatur (hier Kraftausdauer) und die Verbesserung der aeroben Ausdauerleistungsfähigkeit nachzusteuern.
Eine Vielzahl aktueller Studien und populärwissenschaftlicher
Veröffentlichungen weist auf einen Rückgang motorischer
Fähigkeiten bei Kindern und Jugendlichen hin. Dadurch ist,
forciert durch die Verfolgung unterschiedlicher Interessen, das Bild
eines generellen motorischen Leistungsverlusts entstanden, das mit
Blick auf die gesellschaftliche Leistungsfähigkeit der Kinder unter
anderem physiotherapeutische Interventionen im Vorschulbereich
postuliert. Die hier vorliegende Studie widmet sich dieser Thematik
und untersucht den Status konditioneller Fähigkeiten bei 6-jährigen
Vorschulkindern.
Nach mehrjähriger Arbeit der DWA-Arbeitsgruppe HW-3.1
„Niedrigwasser“ hat die DWA im Oktober 2020 den Gelbdruck
für das Merkblatt DWA-M 541 „Statistische Analyse von
Niedrigwasserkenngrößen“ veröffentlicht. Mehr als 100 Anmerkungen
gingen zum Gelbdruck ein, die die Arbeitsgruppe akribisch
geprüft hat. Der Weißdruck des Merkblattes steht nun kurz
bevor. Der Beitrag stellt die inhaltlichen Kernpunkte des Merkblattes
vor, schildert die Entstehung des Merkblattes und bietet
einen Ausblick auf die kommenden Aufgaben der Arbeitsgruppe.
The standard screening test for the recognition of autoimmune diseases is the proof of autoantibodies in serum of patients by indirect immunofluorescence (IIF) based on HEp‐2 cells. Manual evaluation of this test is very subjective, slow, and there are no objective parameters as guidelines available. Interlaboratory tests showed occasionally large deviations in the test evaluation resulting in a high variance of results. The aim of this project is fast, objective, safe, and economical automatic analysis of HEp‐2 IIF patterns. Images of IIF patterns were completely and automatically captured using an inverse motorized fluorescence microscope. Thereby, device‐specific parameters were controlled automatically, too. For fast analysis of IIF patterns new algorithms of image processing were developed. Artifacts were recognized and excluded from analysis by the developed software. Analysis of more than 80,000 images clearly demonstrated full automatization and fast processing of IIF patterns. Additionally serum‐specific fluorescence could be easily distinguished from background. Even very weak but positive patterns can be recognized and used for diagnosis. A detailed separation into different basic patterns is possible. Objective, fast, and disease‐related economical analysis of HEp‐2 immunofluorescence patterns is feasible. The implemented software algorithms allowed a mathematical way of describing IIF patterns and can therefore be a useful tool for the needed standardization process.
Recently, it was shown that patients with Parkinson's disease (PD) who exhibit an “Alzheimer's disease (AD)-like” pattern of brain atrophy are at greater risk for future cognitive decline. This study aimed to investigate whether this association is domain-specific and whether atrophy associated with brain aging also relates to cognitive impairment in PD. SPARE-AD, an MRI index capturing AD-like atrophy, and atrophy-based estimates of brain age were computed from longitudinal structural imaging data of 178 PD patients and 84 healthy subjects from the LANDSCAPE cohort. All patients underwent an extensive neuropsychological test battery. Patients diagnosed with mild cognitive impairment or dementia were found to have higher SPARE-AD scores as compared to patients with normal cognition and healthy controls. All patient groups showed increased brain age. SPARE-AD predicted impairment in memory, language and executive functions, whereas advanced brain age was associated with deficits in attention and working memory. Data suggest that SPARE-AD and brain age are differentially related to domain-specific cognitive decline in PD. The underlying pathomechanisms remain to be determined.
We present two case studies that demonstrate how a common evaluation methodology can be used to assess the reliability of regional climate model simulations from different fields of research. In Case I, we focused on the agricultural yield loss risk for maize in Northeastern Brazil during a drought linked to an El-Niño event. In Case II, the present-day regional climatic conditions in Europe for a 10-year period are simulated. To comprehensively evaluate the model results for both kinds of investigations, we developed a general methodology. On its basis, we elaborated and implemented modules to assess the quality of model results using both advanced visualization techniques and statistical algorithms. Besides univariate approaches for individual near-surface parameters, we used multivariate statistics to investigate multiple near-surface parameters of interest together. For the latter case, we defined generalized quality measures to quantify the model's accuracy. Furthermore, we elaborated a diagnosis tool applicable for atmospheric variables to assess the model's accuracy in representing the physical processes above the surface under various aspects. By means of this evaluation approach, it could be demonstrated in Case Study I that the accuracy of the applied regional climate model resides at the same level as that we found for another regional model and a global model. Excessive precipitation during the rainy season in coastal regions could be identified as a major contribution leading to this result. In Case Study II, we also identified the accuracy of the investigated mean characteristics for near-surface temperature and precipitation to be comparable to another regional model. In this case, an artificial modulation of the used initial and boundary data during preprocessing could be identified as the major source of error in the simulation. Altogether, the achieved results for the presented investigations indicate the potential of our methodology to be applied as a common test bed to different fields of research in regional climate modeling.
Intermetallic alloys such as FeTi have attracted ever-growing attention as a safe and efficient hydrogen storage medium. However, the utilization of high-purity metals for the synthesis of such materials poses considerable concerns over the environmental sustainability of their large-scale production. Here, we report an approach for synthesizing FeTi from industrial scraps of iron (steels C45 and 316 L) and titanium (Ti alloy Grade 2) to reduce the carbon footprint associated with FeTi alloy synthesis, without compromising their hydrogen storage properties. At 50 °C and a pressure of 0 to 100 bar, the alloys obtained by using C45-Ti Grade 2 and 316L-Ti Grade 2 can absorb a maximum amount of hydrogen of 1.61 wt.% and 1.50 wt.%, respectively. Moreover, depending on the type of steel utilized, the thermodynamic properties can be modified. Our findings pave a pathway for developing high-performance, environmentally-sustainable FeTi alloys for hydrogen storage purposes using industrial metal wastes.
Purpose. The aim of this study was to assess the reproducibility and reliability of the KomPAN questionnaire among two groups of university students from Germany and Slovakia. Methods. A total of 422 individuals (mean age 21.4 years, SD 4.0), including 197 from Slovakia (men 26.2%) and 225 from Germany (men 22.3%), were tested using the self-administered (SA-Q) version of the KomPAN questionnaire and then retested two weeks later. A cross-classification analysis, kappa coefficients, Cronbach’s ɑ coefficients, and a test-retest result comparison were conducted separately for each group of students to assess the reproducibility and reliability of the questionnaire. Results. The cross-classification values were higher than 46.2% among the German students and higher than 55.8% among the Slovakian students. The kappa coefficients ranged from 0.21 to 0.90 in the German students and from 0.38 to 0.94 in the Slovakian students. Cronbach’s ɑ ranged from 0.58 to 0.78. Conclusion. The questionnaire displayed a moderate to very good reproducibility, which was slightly higher in the Slovakian group than in the German group. Therefore, the questionnaire can be recommended for further analysis and comparison of the dietary habits among Germans and Slovakians on a larger scale.
We hereby present the findings for a new technology to produce portable, flexible, long- term stable and high-resolution sensors and measuring systems for individual lactate value recording in body sweat for regenerative and sports.
A main goal of this study has been the identification of application sites according to body sweat quality and quantity, as well as easy accessibility and handling of the measurement site. For the continuous recording of the lactate value curve with integrated temperature compensation, new types of multifunctional sensor constructions and evaluation algorithms have been developed that can detect and evaluate these parameters precisely and interference-free in real time in body sweat in order to establish a diagnostic correlation with the clinical, therapeutic and sports medicine performance- oriented application scenarios. For this purpose, suitable planar sensor principles have been investigated and a planar sensor was developed. A textile-based sensor suitable for long-term use (several hours to several days of use) has been developed as a braided construction. In particular, a functionalized chitosan layer with a sensitive enzyme and several required electrodes wires have been purposefully used.
Due to a high selectivity, i.e. clear signal interpretation even in the presence of other substances in body sweat, enzymatic measuring systems in an amperometric measure- ment design were primarily investigated. The preferred solution of the developed planar sensor is to be used as a reference sensor for calibration and, together with the preferred solution of the textile sensor, is to be integrated into the demonstrators.
From the intended project results, an immediate direct benefit can be derived for SMEs in the textile manufacturing, finishing and medical products sectors and for the measurement and sensor technology sector.
Nowadays, employment takes a central role in the society, the work-related performance diagnostics are increasingly becoming the focus of attention. In consideration of the changing professional life, by mega trends like digitization, globalization and demographic change, there is a need to adapt these procedures to future-relevant conditions.
Because of that, the aim of this investigation is to fathom the importance of the work intensity for the future job market.
The sample consists of 86 persons. The first group (N = 36) encloses employed person of the first job market. The second group (N = 50) exists of people of the federal program „Social Participation in the labor market“. About a cross section elevation both groups were compared with each other as well as standard value comparisons were drawn. The upraised parameters are the state of health and the work intensity on the example of lifting force (lifting ground to waist
height). The health situation of these both groups showed significant differences in almost all parameters. The central result is the missing significance between the groups in the maximum force values while lifting. Also the standard value comparison of lifting did not produce a significant association to the group and less than half of all study participants reached the norm. Despite differences in the health status of the two groups, due to the approximate force values of lifting, a decreasing importance of this ability to participation in the future labor market can be noted. In conclusion, the existing work-related diagnostic procedures which still move the working intensity in the center of all assessments, should be reconsidered. However this results reflects initial tendencies, this has to be proven by further
investigations.