Refine
Document Type
Keywords
- COVID-19 (1)
- Microbiome (1)
- atherosclerosis (1)
- endocytosis (1)
- endothelial cell dysfunction (1)
- endothelial cells (1)
- endotheliitis (1)
- platelets (1)
- trimethylamin-N-oxide (1)
Institute
Marketing meßbar machen - Der Erfolg von speziellen Marketingmaßnahmen wird bei Upjohn quantifiziert
(1996)
Netzwerk Nagetier-übertragene Pathogene: Monitoring von Hantavirus-Infektionen in Deutschland
(2009)
COVID-19 and the endothelium
(2020)
There is growing evidence that COVID-19 not only affects the lungs but beyond that the endothelial system. Recent studies showed that this can lead to microcirculatory impairments and in consequence to functional disorders of all inner organs. The combination of endothelial dysfunction with a generalized inflammatory state and complement elements may together contribute to the overall pro-coagulative state described in COVID-19 patients leading to venular as well as to arteriolar occlusions.
Effects of gut microbial metabolite trimethylamine N-oxide (TMAO) on platelets and endothelial cells
(2020)
Thrombotic events result from different pathologies and are the underlying causes of severe diseases like stroke or myocardial infarction. Recent basic research now revealed a link between food uptake, food conversion and gut metabolism. Gut microbial production of trimethylamine N-oxide (TMAO) from dietary nutrients like choline, lecithin and L-carnitine was associated with the development of cardiovascular diseases. Within this review we give a systematic overview about the influence of TMAO on blood components like platelets and endothelial cells which both are involved as key players in thrombotic processes. In summary, a mechanistic correlation between the gut microbiome, TMAO and cardiovascular diseases becomes obvious and emphasizes to the significance of the intestinal microbiome.