Refine
Year of publication
Document Type
Way of publication
- Open Access (12)
Keywords
- Arthrospira platensis (6)
- Genotoxicity (4)
- COVID-19 (3)
- Pyrrolizidine alkaloids (3)
- endothelial cells (3)
- CPR (2)
- CYP3A4 (2)
- Cytotoxicity (2)
- HepG2 (2)
- Liver cells (2)
- Primary human hepatocytes (2)
- Spirulina (2)
- cancer (2)
- cytochrome P450 monooxygenase (2)
- fibroblasts (2)
- fibrosis (2)
- liver (2)
- morphology (2)
- p53 (2)
- temperature (2)
- γH2AX (2)
- ABC transporter (1)
- Acrolein (1)
- Aneuploidy (1)
- Atmospheric CO2 (1)
- Autoimmune disease (1)
- Benchmark dose modeling (1)
- Biocatalysis (1)
- Biomass production (1)
- Biophysics (1)
- Biotechnology (1)
- CHO-K1 (1)
- CYP (1)
- CYP1A2 (1)
- CYP450 (1)
- Carbon capturing (1)
- Carcinogenicity (1)
- Cardiovascular implants (1)
- Cell biology (1)
- Chinese hamster ovary cells (1)
- Climate change (1)
- Corona virus (1)
- Cyclophosphamide (1)
- Cytochrome P450 (1)
- DNA adducts (1)
- DNA damage (1)
- DPI (1)
- Decarbonization (1)
- Drug discovery (1)
- Erythrocytes (1)
- Estragole (1)
- FPLC (1)
- Germany (1)
- HIV (1)
- HUVEC (1)
- HepG2-CYP3A4 (1)
- Hepatoma (1)
- Human drug metabolites (1)
- Human umbilical venous endothelial cells (1)
- IMAC (1)
- Liver biotransformation (1)
- Liver metabolism (1)
- MG-132 (1)
- Ma2 (1)
- Microbiome (1)
- Micronuclei (1)
- Multidisciplinary (1)
- Mutagenicity (1)
- NADPH P450 oxidoreductase (1)
- NADPH-cytochrome P450 oxidoreductase (1)
- OCT1 (1)
- PNMA2 (1)
- PNS (1)
- POR (1)
- Peroxygenase (1)
- Phase-1 (1)
- Potency ranking (1)
- RNA sequencing (1)
- Relative potencies (1)
- SARS-CoV-2 (1)
- Sweden (1)
- T7 expression system (1)
- Taiwan (1)
- Toxicity (1)
- Transport (1)
- actin (1)
- adherent (1)
- aging (1)
- animal feeding (1)
- arterial endothelial cells (1)
- atherosclerosis (1)
- atrial fibrillation (1)
- autoantibodies (1)
- bioreactor (1)
- biotransformation (1)
- cancer cells (1)
- cardiovascular disease (1)
- cell culture (1)
- cell lines (1)
- cyclophosphamide (1)
- cytochrome P450 (1)
- cytochrome P450 enzyme (1)
- cytochrome P450 enzymes (CYP) (1)
- cytotoxicity (1)
- dietary supplements (1)
- diphenyleneiodonium (1)
- donor variability (1)
- dot blot immunoassay (1)
- drug-drug interaction (1)
- echinocytes (1)
- ecotoxicity (1)
- endocytosis (1)
- endothelial cell dysfunction (1)
- endotheliitis (1)
- ensartinib (1)
- first-pass effect (1)
- fission (1)
- fluorescence (1)
- fragmentation (1)
- growth (1)
- hammer and dance strategy (1)
- health effects (1)
- heart (1)
- hepatocytes (1)
- hepatotoxicity (1)
- herd immunity (1)
- human umbilical vein endothelial cells (1)
- human venous endothelial cells (1)
- in vitro culture systems (1)
- in vitro study (1)
- influencing factors (1)
- life cycle (1)
- light intensity (1)
- light stress (1)
- liver protection (1)
- mediator release (1)
- mesalamine (1)
- microplastic (1)
- multidrug resistance (1)
- non-adherent (1)
- nutrition (1)
- osteopontin (1)
- phase-1 biotransformation (1)
- photoinhibition (1)
- phototoxicity (1)
- platelets (1)
- senescence (1)
- serum-free (1)
- spirulina (1)
- spirulina platensis (1)
- strategy (1)
- submembraneous cytoskeleton (1)
- suspension cells (1)
- thrombosis (1)
- trimethylamin-N-oxide (1)
- viability (1)
- virus infection (1)
- von Willebrand factor (1)
- wave length (1)
- xCELLigence system (1)
Institute
BTU
Arthrospira platensis (AP) and some of its derived products have well-established biological activities as antioxidants or as agents to reduce cardiovascular disease risk factors. Furthermore, AP products have gained increasing importance as potential anti-cancer agents. However, the ingredients of the available products vary greatly with the origin, the type of production and processing, which could have significant consequences for their biological effects. Therefore, the composition and biological influence of five distinct AP powders, which were acquired commercially or produced at a public biotechnology institute, were investigated in regard to their endothelialization capacity using a cell impedance- (CI) based measurement method. The study revealed that the AP composition and especially the influence on HUVEC proliferation differed significantly between the five AP powders up to 109%.
Thus, it could be shown that the method used allows the reliable detection of quantitative differences in biological effects of different AP preparations.
Since there is growing interest throughout the world in photosynthetic microbes as a potential source of food or food supplements, an assessment of factors which influence the biomass obtained in bioreactors, protein contents and constituents is important. This work reviews the autotrophic cultivation conditions of Spirulina platensis especially the dependency on the strain, the composition of the nutrient solution, pH, temperature of the medium, light intensity and color as well as exposure rhythm, the flow rate and composition of the aerating gas mixture and the bubble size, the content of oxygen, CO₂ and HCO₃ in the medium and last but not least from the optical density of the spirulina suspension during growth.
Erythrocytes transport oxygen from the lungs to the tissues. The excess surface area together with the elasticity of the erythrocyte cell membrane provides the flexibility needed to pass through the microvasculature where the oxygen exchange occurs. Although the architecture of the red cell and its membrane-associated cytoskeletal network is known in general, the factors that control the characteristic shape change during echinocyte formation are poorly understood. In this short report we show that in echinocytes a completely reorganized membrane cytoskeleton with a box-like structure of actin filaments prevailed indicating the importance of the actin cytoskeleton during echinocyte formation.