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Colouring Fuzziness for Systems Biology

  • Snoopy is a powerful modelling and simulation tool for various types of Petri nets, which have been applied to a wide range of biochemical reaction networks. We present an enhanced version of Snoopy, now supporting coloured and uncoloured stochastic, continuous and hybrid Petri Nets with fuzzy kinetic parameters. Colour helps to cope with modelling challenges imposed by larger and more complex networks. Fuzzy parameters are specifically useful when kinetic parameter values can not be precisely measured or estimated. By running fuzzy simulation we obtain output bands of the variables of interest induced by the effect of the fuzzy kinetic parameters. Simulation is always done on the uncoloured level. For this purpose, coloured fuzzy Petri nets are automatically unfolded to their corresponding uncoloured counterparts. Combining the power of fuzzy kinetic parameters with the modelling convenience of coloured Petri nets provides a new quality in user support with sophisticated modelling and analysis features.

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Metadaten
Author: George Assaf, Monika HeinerORCiD, Fei LiuORCiD
URL:https://www.sciencedirect.com/science/article/abs/pii/S0304397521002152?via%3Dihub
DOI:https://doi.org/10.1016/j.tcs.2021.04.011
ISSN:1879-2294
ISSN:0304-3975
Title of the source (English):Theoretical Computer Science
Document Type:Scientific journal article peer-reviewed
Language:English
Year of publication:2021
Tag:Coloured fuzzy continuous, stochastic and hybrid Petri nets; Fuzzy kinetic parameters; Modelling and simulation; Modelling uncertainty; fuzzy logic
Volume/Year:875
First Page:52
Last Page:64
Faculty/Chair:Fakultät 1 MINT - Mathematik, Informatik, Physik, Elektro- und Informationstechnik / FG Datenstrukturen und Softwarezuverlässigkeit
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