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Analytical applications of electrodes modified by gold nanoparticles: dopamine detection

  • Dopamine oxidation was studied on modified gold (nano-Au) electrodes obtained by Layer-by-Layer deposition of gold nanoparticles and polyacrylic acid. A gradual loss of electrochemical activity for the dopamine oxidation reaction is observed at pH 7. Simultaneous SPR spectroscopy and cyclic voltammetry indicate the formation of an adsorbed layer on the electrode surface at this pH value. Investigations, performed through electrochemical and SPR measurements at pH 4, give evidence for a reversible process. At this pH value both dopamine oxidation and reduction current peaks show linear dependence on the dopamine concentration and may be used for analytical applications. The use of the nano-Au electrode allows resolving the peaks corresponding to ascorbic acid and to dopamine oxidation by 240 mV thus providing a high selectively for dopamine detection in the presence of ascorbic acid. The detection limit of this electrode for dopamine is below 4 microM in the presence of 1 mM ascorbic acid. The sensitivity normalized to the macroscopicDopamine oxidation was studied on modified gold (nano-Au) electrodes obtained by Layer-by-Layer deposition of gold nanoparticles and polyacrylic acid. A gradual loss of electrochemical activity for the dopamine oxidation reaction is observed at pH 7. Simultaneous SPR spectroscopy and cyclic voltammetry indicate the formation of an adsorbed layer on the electrode surface at this pH value. Investigations, performed through electrochemical and SPR measurements at pH 4, give evidence for a reversible process. At this pH value both dopamine oxidation and reduction current peaks show linear dependence on the dopamine concentration and may be used for analytical applications. The use of the nano-Au electrode allows resolving the peaks corresponding to ascorbic acid and to dopamine oxidation by 240 mV thus providing a high selectively for dopamine detection in the presence of ascorbic acid. The detection limit of this electrode for dopamine is below 4 microM in the presence of 1 mM ascorbic acid. The sensitivity normalized to the macroscopic electrode surface is about 10 mA cm(-2) mM(-1) at sweep rate of 10 V/s.show moreshow less

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Metadaten
Author: Fredy Kurniawan, Vessela T. Tsakova, Vladimir M. MirskyORCiDGND
DOI:https://doi.org/10.1166/jnn.2009.SE13
ISSN:1533-4880
ISSN:1533-4899
Title of the source (English):Journal of Nanoscience and Nanotechnology
Document Type:Scientific journal article peer-reviewed
Language:English
Year of publication:2009
Tag:ascorbic acid; dopamine; electrochemical detection; gold nanoparticles; surface plasmon resonance
Volume/Year:9
Issue number:4
First Page:2407
Last Page:2412
Faculty/Chair:Fakultät 2 Umwelt und Naturwissenschaften / FG Nanobiotechnologie
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