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The Bacillus subtilis Minimal Genome Compendium

  • To better understand cellular life, it is essential to decipher the contribution of individual components and their interactions. Minimal genomes are an important tool to investigate these interactions. Here, we provide a database of 105 fully annotated genomes of a series of strains with sequential deletion steps of the industrially relevant model bacterium Bacillus subtilis starting with the laboratory wild type strain B. subtilis 168 and ending with B. subtilis PG38, which lacks approximately 40% of the original genome. The annotation is supported by sequencing of key intermediate strains as well as integration of literature knowledge for the annotation of the deletion scars and their potential effects. The strain compendium presented here represents a comprehensive genome library of the entire MiniBacillus project. This resource will facilitate the more effective application of the different strains in basic science as well as in biotechnology.

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Author: Stephan Michalik, Alexander Reder, Björn Richts, Patrick Faßhauer, Ulrike Mäder, Tiago Pedreira, Anja PoehleinORCiD, Auke van Heel, Amanda van Tilburg, Josef Altenbuchner, Anika Klewing, Daniel Reuß, Rolf DanielORCiD, Fabian M. CommichauORCiD, Oscar Kuipers, Leendert Hamoen, Uwe Völker, Jörg Stülke
URL:https://pubs.acs.org/doi/10.1021/acssynbio.1c00339
DOI:https://doi.org/10.1021/acssynbio.1c00339
ISSN:2161-5063
Title of the source (English):ACS Synthetic Biology
Document Type:Scientific journal article peer-reviewed
Language:English
Year of publication:2021
Volume/Year:10
Issue number:10
First Page:2767
Last Page:2771
Faculty/Chair:Fakultät 2 Umwelt und Naturwissenschaften / FG Synthetische Mikrobiologie
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